Product References
SETD2 Haploinsufficiency Enhances Germinal Center-Associated AICDA Somatic Hypermutation to Drive B-cell Lymphomagenesis.
Cancer discovery
Leung W,Teater M,Durmaz C,Meydan C,Chivu AG,Chadburn A,Rice EJ,Muley A,Camarillo JM,Arivalagan J,Li Z,Flowers CR,Kelleher NL,Danko CG,Imielinski M,Dave SS,Armstrong SA,Mason CE,Melnick AM
17-5790-82 was used in Flow cytometry/Cell sorting to define a B cell-specific oncogenic effect of SETD2 heterozygous mutation, which unleashes AICDA mutagenesis of nontemplate strand DNA in the GC reaction, resulting in lymphomas with heavy mutational burden.
Wed Jul 06 00:00:00 EDT 2022
Receptor editing constrains development of phosphatidyl choline-specific B cells in VH12-transgenic mice.
Cell reports
Worth AN,Palmer VL,Schabla NM,Perry GA,Fraser-Philbin AN,Swanson PC
17-5790-82 was used in flow cytometry to find that B1 B cells reactive to phosphatidyl choline (PtC) exhibit restricted immunoglobulin heavy chain (HC) and light chain (LC) combinations, exemplified by VH12/Vκ4/5H.
Tue Jun 14 00:00:00 EDT 2022
Continuous sensing of IFNα by hepatic endothelial cells shapes a vascular antimetastatic barrier.
eLife
Tran NL,Ferreira LM,Alvarez-Moya B,Buttiglione V,Ferrini B,Zordan P,Monestiroli A,Fagioli C,Bezzecchi E,Scotti GM,Esposito A,Leone R,Gnasso C,Brendolan A,Guidotti LG,Sitia G
17-5790-82 was used in flow cytometry to use mouse models of hepatic metastatization to demonstrate that the continuous infusion of therapeutic doses of interferon-alpha (IFNα) controls CRC invasion by acting on hepatic endothelial cells (HECs).
Tue Oct 25 00:00:00 EDT 2022
Smc3 dosage regulates B cell transit through germinal centers and restricts their malignant transformation.
Nature immunology
Rivas MA,Meydan C,Chin CR,Challman MF,Kim D,Bhinder B,Kloetgen A,Viny AD,Teater MR,McNally DR,Doane AS,Béguelin W,Fernández MTC,Shen H,Wang X,Levine RL,Chen Z,Tsirigos A,Elemento O,Mason CE,Melnick AM
17-5790-82 was used in Flow cytometry/Cell sorting to understand the significance of cohesin and architectural programming in the humoral immune response.
Mon Feb 01 00:00:00 EST 2021
The 3'-flap endonuclease XPF-ERCC1 promotes alternative end joining and chromosomal translocation during B cell class switching.
Cell reports
Bai W,Zhu G,Xu J,Chen P,Meng F,Xue H,Chen C,Dong J
17-5790-82 was used in Flow Cytometry to reveal the role of the flap endonuclease, XPF-ERCC1, in alternative end joining and oncogenic translocation in mouse B cells.
Tue Sep 28 00:00:00 EDT 2021
Conditional antibody expression to avoid central B cell deletion in humanized HIV-1 vaccine mouse models.
Proceedings of the National Academy of Sciences of the United States of America
Tian M,McGovern K,Cheng HL,Waddicor P,Rieble L,Dao M,Chen Y,Kimble MT,Cantor E,Manfredonia N,Judson R,Chapdelaine-Williams A,Cain DW,Haynes BF,Alt FW
17-5790 was used in Flow cytometry/Cell sorting to develop a new approach to test a vaccine which circumvents B cell developmental blocks.
Tue Apr 07 00:00:00 EDT 2020
Separation of mononuclear cells and identification of B lymphocytes: A comprehensive experiment for medical students.
Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology
Li J,Gao F,Jin C,Shi X,Zhang C,Jia S,Xu J,Lv L,Yang W,Xu L
17-5790-82 was used in Flow cytometry/Cell sorting to increase the ability of medical students to solve problems using flexible scientific methods, to initiate them thinking about clinical and research application.
Fri May 01 00:00:00 EDT 2020
Modest Declines in Proteome Quality Impair Hematopoietic Stem Cell Self-Renewal.
Cell reports
Hidalgo San Jose L,Sunshine MJ,Dillingham CH,Chua BA,Kruta M,Hong Y,Hatters DM,Signer RAJ
17-5790 was used in Flow cytometry/Cell sorting to show that hematopoietic stem cells (HSCs) are dependent on low protein synthesis to maintain proteostasis, which promotes their self-renewal.
Tue Jan 07 00:00:00 EST 2020
Increased sensitivity of BCR-ABL-induced B-ALL to imatinib by releasing leukemia B cell differentiation blockage.
International journal of clinical and experimental pathology
Wang Z,Li Y,Lu X,Yuan J,Qiu Q,Pan C
17-5790 was used in Flow cytometry/Cell sorting to investigate whether it was possible to promote pro/pre-B cell maturation beyond this phase and make them sensitive to imatinib treatment by overexpressing immunoregulatory tyrosine activation motif (ITAM) with BCR-ABL in a Ph+ B-ALL mouse model.
Wed Dec 09 00:00:00 EST 2020
Fundamental roles of chromatin loop extrusion in antibody class switching.
Nature
Zhang X,Zhang Y,Ba Z,Kyritsis N,Casellas R,Alt FW
17-5790 was used in Flow cytometry/Cell sorting to study the role of chromatin loop extrusion in deletional antibody class switch recombination.
Fri Nov 01 00:00:00 EDT 2019
Fetal liver Mll-AF4+ hematopoietic stem and progenitor cells respond directly to poly(I:C), but not to a single maternal immune activation.
Experimental hematology
Malouf C,Ottersbach K
17-5790-82 was used in Flow Cytometry to assess if the cell-of-origin of t(4;11) MLL-AF4 acute leukemia is sensitive to a viral or bacterial mimic and if maternal immune activation can lead to a full-blown leukemia.
Thu Aug 01 00:00:00 EDT 2019
Single Cell Imaging of Nuclear Architecture Changes.
Frontiers in cell and developmental biology
Morrish RB,Hermes M,Metz J,Stone N,Pagliara S,Chahwan R,Palombo F
17-5790-82 was used in Flow cytometry/Cell sorting to report the use of FTIR imaging and microfluidic cell-stretcher chips to assess changes to chromatin architecture and its effect on the mechanical properties of the nucleus in immune cells.
Sun Jan 10 00:00:00 EST 2021
Complement Factor H Modulates Splenic B Cell Development and Limits Autoantibody Production.
Frontiers in immunology
Kiss MG,Ozsvár-Kozma M,Porsch F,Göderle L,Papac-Miličević N,Bartolini-Gritti B,Tsiantoulas D,Pickering MC,Binder CJ
17-5790-82 was used in Flow Cytometry to indicate that CFH, through its function as a complement repressor, acts as a negative regulator of BCR signaling and limits autoimmunity.
Tue Oct 13 00:00:00 EDT 2020
TET2 Deficiency Causes Germinal Center Hyperplasia, Impairs Plasma Cell Differentiation, and Promotes B-cell Lymphomagenesis.
Cancer discovery
Dominguez PM,Ghamlouch H,Rosikiewicz W,Kumar P,Béguelin W,Fontán L,Rivas MA,Pawlikowska P,Armand M,Mouly E,Torres-Martin M,Doane AS,Calvo Fernandez MT,Durant M,Della-Valle V,Teater M,Cimmino L,Droin N,Tadros S,Motanagh S,Shih AH,Rubin MA,Tam W,Aifantis I,Levine RL,Elemento O,Inghirami G,Green MR,Figueroa ME,Bernard OA,Aoufouchi S,Li S,Shaknovich R,Melnick AM
17-5790 was used in Flow cytometry/Cell sorting to demonstrate the impact of TET2 in the germinal center reaction.
Sat Dec 01 00:00:00 EST 2018
Anti‑IL‑39 (IL‑23p19/Ebi3) polyclonal antibodies ameliorate autoimmune symptoms in lupus‑like mice.
Molecular medicine reports
Wang X,Zhang Y,Wang Z,Liu X,Zhu G,Han G,Chen G,Hou C,Wang T,Shen B,Li Y,Xiao H,Ma N,Wang R
17-5790 was used in Flow cytometry/Cell sorting to show that anti-IL-39 polyclonal antibodies ameliorate autoimmune symptoms in lupus-like mice.
Mon Jan 01 00:00:00 EST 2018
IgM and IgD B cell receptors differentially respond to endogenous antigens and control B cell fate.
eLife
Noviski M,Mueller JL,Satterthwaite A,Garrett-Sinha LA,Brombacher F,Zikherman J
17-5790-82 was used in Flow Cytometry to study how IgM and IgD B cell receptors differentially respond to endogenous antigens and control B cell fate.
Fri Mar 09 00:00:00 EST 2018
Modulation of Innate Immunity by lignin-Carbohydrate, a Novel TLR4 Ligand, Results in Augmentation of Mucosal IgA and Systemic IgG Production.
International journal of molecular sciences
Tsuji R,Ikado K,Fujiwara D
17-5790 was used in Flow cytometry/Cell sorting to investigate immune-stimulatory activity of lignin-rich enzyme lignin in vivo.
Tue Dec 26 00:00:00 EST 2017
Extrafollicular CD4+ T-B interactions are sufficient for inducing autoimmune-like chronic graft-versus-host disease.
Nature communications
Deng R,Hurtz C,Song Q,Yue C,Xiao G,Yu H,Wu X,Muschen M,Forman S,Martin PJ,Zeng D
17-5790 was used in Flow cytometry/Cell sorting to support that Stat3- and BCL6-dependent extrafollicular CD4+ T and B interactions play critical functions in the pathogenesis of chronic graft-versus-host disease.
Tue Oct 17 00:00:00 EDT 2017
Lunatic, Manic, and Radical Fringe Each Promote T and B Cell Development.
Journal of immunology (Baltimore, Md. : 1950)
Song Y,Kumar V,Wei HX,Qiu J,Stanley P
17-5790 was used in Flow cytometry/Cell sorting to investigate the roles for maniac fringe (MFNG) and radical fringe (RFNG) in T cell development, RFNG in B cell development, and Fringes in T and B cell activation, showing that they promote T and B cell development.
Fri Jan 01 00:00:00 EST 2016
Prolactin Rescues Immature B-Cells from Apoptosis Induced by B-Cell Receptor Cross-Linking.
Journal of immunology research
Flores-Fernández R,Blanco-Favela F,Fuentes-Pananá EM,Chávez-Sánchez L,Gorocica-Rosete P,Pizaña-Venegas A,Chávez-Rueda AK
17-5790 was used in Flow cytometry/Cell sorting to determine the effect of prolactin in an in vitro system of B-cell tolerance, showing that it rescues immature B-cells from apoptosis induced by B-cell receptor cross-linking.
Mon Mar 06 00:00:00 EST 2017
BAFF blockade prevents anti-drug antibody formation in a mouse model of Pompe disease.
Clinical immunology (Orlando, Fla.)
Doerfler PA,Nayak S,Herzog RW,Morel L,Byrne BJ
17-5790 was used in Flow cytometry/Cell sorting to assess the potential of BAFF as a novel drug candidate for use in protein replacement therapies.
Mon Jun 01 00:00:00 EDT 2015
Enterocolitis causes profound lymphoid depletion in endothelin receptor B- and endothelin 3-null mouse models of Hirschsprung-associated enterocolitis.
European journal of immunology
Frykman PK,Cheng Z,Wang X,Dhall D
17-5790 was used in Flow cytometry/Cell sorting to investigate how enterocolitis in the Ednrb(-/-) and Edn3(-/-) mice lead to thymic involution, splenic lymphopenia, and suppression of B lymphopoiesis as a consequence of colonic aganglionosis.
Sun Mar 01 00:00:00 EST 2015
Circulating microparticles carry oxidation-specific epitopes and are recognized by natural IgM antibodies.
Journal of lipid research
Tsiantoulas D,Perkmann T,Afonyushkin T,Mangold A,Prohaska TA,Papac-Milicevic N,Millischer V,Bartel C,Hörkkö S,Boulanger CM,Tsimikas S,Fischer MB,Witztum JL,Lang IM,Binder CJ
17-5790 was used in Flow cytometry/Cell sorting to demonstrate a novel mechanism by which anti-OxLDL IgM antibodies could mediate protective functions in CVD.
Sun Feb 01 00:00:00 EST 2015
VprBP Is Required for Efficient Editing and Selection of Igκ+ B Cells, but Is Dispensable for Igλ+ and Marginal Zone B Cell Maturation and Selection.
Journal of immunology (Baltimore, Md. : 1950)
Palmer VL,Aziz-Seible R,Kassmeier MD,Rothermund M,Perry GA,Swanson PC
17-5790 was used in Flow cytometry/Cell sorting to determine the contribution of the protein, VprBP, to B cell development and selection.
Sat Aug 15 00:00:00 EDT 2015
Processing of CD74 by the Intramembrane Protease SPPL2a Is Critical for B Cell Receptor Signaling in Transitional B Cells.
Journal of immunology (Baltimore, Md. : 1950)
Hüttl S,Kläsener K,Schweizer M,Schneppenheim J,Oberg HH,Kabelitz D,Reth M,Saftig P,Schröder B
17-5790 was used in Flow cytometry/Cell sorting to demonstrate that tonic as well as BCR-induced activation of the PI3K/Akt pathway is massively compromised in SPPL2a(-/-) B cells.
Sat Aug 15 00:00:00 EDT 2015
Elucidation of the enigmatic IgD class-switch recombination via germline deletion of the IgH 3' regulatory region.
The Journal of experimental medicine
Rouaud P,Saintamand A,Saad F,Carrion C,Lecardeur S,Cogné M,Denizot Y
Mon May 05 00:00:00 EDT 2014
Intravascular staining for discrimination of vascular and tissue leukocytes.
Nature protocols
Anderson KG,Mayer-Barber K,Sung H,Beura L,James BR,Taylor JJ,Qunaj L,Griffith TS,Vezys V,Barber DL,Masopust D
17-5790 was used in Flow cytometry/Cell sorting to outline a protocol for the validation and use of intravascular staining to define innate and adaptive immune cells in mice.
Wed Jan 01 00:00:00 EST 2014
Reactive oxygen species deficiency induces autoimmunity with type 1 interferon signature.
Antioxidants & redox signaling
Kelkka T,Kienhöfer D,Hoffmann M,Linja M,Wing K,Sareila O,Hultqvist M,Laajala E,Chen Z,Vasconcelos J,Neves E,Guedes M,Marques L,Krönke G,Helminen M,Kainulainen L,Olofsson P,Jalkanen S,Lahesmaa R,Souto-Carneiro MM,Holmdahl R
17-5790 was used in Flow cytometry/Cell sorting to explore the connection between reactive oxygen species deficiencies and increased susceptibility to autoimmunity.
Mon Dec 01 00:00:00 EST 2014
The Eμ enhancer region influences H chain expression and B cell fate without impacting IgVH repertoire and immune response in vivo.
Journal of immunology (Baltimore, Md. : 1950)
Marquet M,Garot A,Bender S,Carrion C,Rouaud P,Lecardeur S,Denizot Y,Cogné M,Pinaud E
17-5790 was used in Flow cytometry/Cell sorting to study the VH gene repertoire and IgH expression in developing B-lineage cells.
Fri Aug 01 00:00:00 EDT 2014
B cell activation involves nanoscale receptor reorganizations and inside-out signaling by Syk.
eLife
Kläsener K,Maity PC,Hobeika E,Yang J,Reth M
17-5790 was used in Flow cytometry/Cell sorting to provide direct evidence for the opening of B cell antigen receptor dimers during B cell activation.
Tue Jun 24 00:00:00 EDT 2014
B lymphocytes trigger monocyte mobilization and impair heart function after acute myocardial infarction.
Nature medicine
Zouggari Y,Ait-Oufella H,Bonnin P,Simon T,Sage AP,Guérin C,Vilar J,Caligiuri G,Tsiantoulas D,Laurans L,Dumeau E,Kotti S,Bruneval P,Charo IF,Binder CJ,Danchin N,Tedgui A,Tedder TF,Silvestre JS,Mallat Z
17-5790 was used in Flow cytometry/Cell sorting to identify the interaction between mature B lymphocytes and monocytes as a potential therapeutic target after a heart attack.
Tue Oct 01 00:00:00 EDT 2013
Prolactin levels correlate with abnormal B cell maturation in MRL and MRL/lpr mouse models of systemic lupus erythematosus-like disease.
Clinical & developmental immunology
Legorreta-Haquet MV,Flores-Fernández R,Blanco-Favela F,Fuentes-Pananá EM,Chávez-Sánchez L,Hernández-González R,Tesoro-Cruz E,Arriaga-Pizano L,Chávez-Rueda AK
17-5790 was used in Flow cytometry/Cell sorting to determine the level of PRL receptor expression during bone-marrow B-cell development and assess relevance in disease outcomes in lupus-prone murine models.
Mon Aug 04 00:00:00 EDT 2014
IKKα-mediated signaling circuitry regulates early B lymphopoiesis during hematopoiesis.
Blood
Balkhi MY,Willette-Brown J,Zhu F,Chen Z,Liu S,Guttridge DC,Karin M,Hu Y
17-5790-82 was used in Flow Cytometry to demonstrate that IKKα regulates B-lineage commitment via combined canonical and noncanonical NF-κB transcriptional activities to target Pax5 expression during hematopoiesis.
Thu Jun 07 00:00:00 EDT 2012
ZBTB1 is a determinant of lymphoid development.
The Journal of experimental medicine
Siggs OM,Li X,Xia Y,Beutler B
17-5790 was used in Flow cytometry/Cell sorting to identify a mutation causative of complete and cell-intrinsic T cell deficiency.
Mon Jan 16 00:00:00 EST 2012
Activation-induced cytidine deaminase-initiated off-target DNA breaks are detected and resolved during S phase.
Journal of immunology (Baltimore, Md. : 1950)
Hasham MG,Snow KJ,Donghia NM,Branca JA,Lessard MD,Stavnezer J,Shopland LS,Mills KD
17-5790 was used in Flow cytometry/Cell sorting to elucidate when off-target DNA breaks initiated by AID are detected and resolved.
Sat Sep 01 00:00:00 EDT 2012
Increased levels of prolactin receptor expression correlate with the early onset of lupus symptoms and increased numbers of transitional-1 B cells after prolactin treatment.
BMC immunology
Ledesma-Soto Y,Blanco-Favela F,Fuentes-Pananá EM,Tesoro-Cruz E,Hernández-González R,Arriaga-Pizano L,Legorreta-Haquet MV,Montoya-Diaz E,Chávez-Sánchez L,Castro-Mussot ME,Chávez-Rueda AK
17-5790 was used in Flow cytometry/Cell sorting to determine if different splenic B cell subsets express the prolactin receptor and if the presence of prolactin influences these B cell subsets and correlates with development of lupus.
Fri Mar 09 00:00:00 EST 2012
B cell depletion reduces the development of atherosclerosis in mice.
The Journal of experimental medicine
Ait-Oufella H,Herbin O,Bouaziz JD,Binder CJ,Uyttenhove C,Laurans L,Taleb S,Van Vré E,Esposito B,Vilar J,Sirvent J,Van Snick J,Tedgui A,Tedder TF,Mallat Z
17-5790 was used in Flow cytometry/Cell sorting to challenge the current paradigm that B cell activation plays an overall protective role in atherogenesis, and identify new antiatherogenic strategies based on B cell modulation.
Mon Aug 02 00:00:00 EDT 2010
Aldehyde dehydrogenase 1a1 is dispensable for stem cell function in the mouse hematopoietic and nervous systems.
Blood
Levi BP,Yilmaz OH,Duester G,Morrison SJ
17-5790 was used in Flow cytometry/Cell sorting to demonstrate Aldh1a1 is not a critical regulator of adult stem cell function or Aldefluor staining in mice.
Thu Feb 19 00:00:00 EST 2009
Homologous recombination is necessary for normal lymphocyte development.
Molecular and cellular biology
Caddle LB,Hasham MG,Schott WH,Shirley BJ,Mills KD
17-5790 was used in Flow cytometry/Cell sorting to discover that homologous recombination is necessary for normal lymphocyte development.
Tue Apr 01 00:00:00 EDT 2008
miR-150, a microRNA expressed in mature B and T cells, blocks early B cell development when expressed prematurely.
Proceedings of the National Academy of Sciences of the United States of America
Zhou B,Wang S,Mayr C,Bartel DP,Lodish HF
17-5790 was used in Immunofluorescence to study how miR-150 can down-regulate mRNAs important for B cell function, and how it can block further B cell development when expressed prematurely.
Tue Apr 24 00:00:00 EDT 2007
miR-150, a microRNA expressed in mature B and T cells, blocks early B cell development when expressed prematurely.
Proceedings of the National Academy of Sciences of the United States of America
Zhou B,Wang S,Mayr C,Bartel DP,Lodish HF
17-5790 was used in Immunofluorescence to study how miR-150 can down-regulate mRNAs important for B cell function, and how it can block further B cell development when expressed prematurely.
Tue Apr 24 00:00:00 EDT 2007
