Product References
Protocol for PPP1R15A-inhibited mouse model establishment with subcutaneous B16F1 tumor and single-cell analysis.
STAR protocols
Wang R,Wang M,Pei S,Zhang Y,Guo S,Guo W,Wu Z,Wang H,Li Y,Zhu Y,Meng LH,Lang J,Jin G,Xiao Y,Hu L,Kong X
Published figure using NK1.1 monoclonal antibody (Product # 25-5941-82) in Flow Cytometry
Fri Dec 15 00:00:00 EST 2023
MCL-1 Inhibitor S63845 Distinctively Affects Intramedullary and Extramedullary Hematopoiesis.
Pharmaceutics
Zhang H,Li F,Yang M,Zhang W,He M,Xu H,Wang C,Zhang Y,Wang W,Gao Y,Du X,Li Y
25-5941-82 was used in Flow cytometry/Cell sorting to demonstrate the effects of myeloid cell leukemia 1 (MCL-1) inhibitor on the intramedullary and extramedullary hematopoietic lineages, which is important for the selection of combinations of antitumor drugs and the prevention of adverse hematopoiesis-related effects.
Tue Mar 28 00:00:00 EDT 2023
MCL-1 Inhibitor S63845 Distinctively Affects Intramedullary and Extramedullary Hematopoiesis.
Pharmaceutics
Zhang H,Li F,Yang M,Zhang W,He M,Xu H,Wang C,Zhang Y,Wang W,Gao Y,Du X,Li Y
25-5941-82 was used in Flow cytometry/Cell sorting to demonstrate the effects of myeloid cell leukemia 1 (MCL-1) inhibitor on the intramedullary and extramedullary hematopoietic lineages, which is important for the selection of combinations of antitumor drugs and the prevention of adverse hematopoiesis-related effects.
Tue Mar 28 00:00:00 EDT 2023
ECSIT Is a Critical Factor for Controlling Intestinal Homeostasis and Tumorigenesis through Regulating the Translation of YAP Protein.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Jiang Y,Ma C,Hu Y,Yang Y,Ma C,Wu C,Liu L,Wen S,Moynagh PN,Wang B,Yang S
25-5941-82 was used in Flow cytometry/Cell sorting to demonstrate the important role of ECSIT in regulating YAP protein translation to control intestinal homeostasis and tumorigenesis.
Fri Sep 01 00:00:00 EDT 2023
Myeloid-intrinsic cell cycle-related kinase drives immunosuppression to promote tumorigenesis.
iScience
Zhou J,Wang H,Shu T,Wang J,Yang W,Li J,Ding L,Liu M,Sun H,Wong J,Lai PB,Tsang SW,Ward SE,Chow KL,Sung JJ,Sze-Lok Cheng A
25-5941-82 was used in Flow cytometry/Cell sorting to demonstrated that cell cycle-related kinase (CCRK) is upregulated in myeloid cells in tumor-bearing mice and in patients with hepatocellular carcinoma.
Fri Oct 20 00:00:00 EDT 2023
Peripheral Neutrophils-Derived Matrix Metallopeptidase-9 Induces Postoperative Cognitive Dysfunction in Aged Mice.
Frontiers in aging neuroscience
Huang L,Tian W,Chen X,Xu H,Dai W,Zhang Y,Wu X,Yu W,Tian J,Su D
Published figure using NK1.1 monoclonal antibody (Product # 25-5941-82) in Flow Cytometry
Mon Mar 14 00:00:00 EDT 2022
NK cells require immune checkpoint receptor LILRB4/gp49B to control neurotropic Zika virus infections in mice.
JCI insight
Lee HN,Manangeeswaran M,Lewkowicz AP,Engel K,Chowdhury M,Garige M,Eckhaus MA,Sourbier C,Ireland DD,Verthelyi D
Published figure using NK1.1 monoclonal antibody (Product # 25-5941-82) in Flow Cytometry
Tue Feb 08 00:00:00 EST 2022
Valosin-containing protein (VCP/p97) inhibition reduces viral clearance and induces toxicity associated with muscular damage.
Cell death & disease
Del Rio Oliva M,Basler M
Published figure using NK1.1 monoclonal antibody (Product # 25-5941-82) in Flow Cytometry
Thu Dec 01 00:00:00 EST 2022
Dendritic cell Piezo1 directs the differentiation of TH1 and Treg cells in cancer.
eLife
Wang Y,Yang H,Jia A,Wang Y,Yang Q,Dong Y,Hou Y,Cao Y,Dong L,Bi Y,Liu G
25-5941-82 was used in Flow cytometry/Cell sorting to demonstrate the role of the dendritic cells-based mechanical regulation of immunopathology in directing T cell lineage commitment in tumor microenvironments.
Mon Aug 22 00:00:00 EDT 2022
ACSL4-dependent ferroptosis does not represent a tumor-suppressive mechanism but ACSL4 rather promotes liver cancer progression.
Cell death & disease
Grube J,Woitok MM,Mohs A,Erschfeld S,Lynen C,Trautwein C,Otto T
25-5941-82 was used in Flow cytometry/Cell sorting to investigate the role of ferroptosis, a type of programmed cell death involving iron-dependent peroxidation of membrane phospholipids, in liver cancer (hepatocellular carcinoma) using mouse models of chronic injury-dependent HCC formation.
Sat Aug 13 00:00:00 EDT 2022
NLRP6 Inflammasome Modulates Disease Progression in a Chronic-Plus-Binge Mouse Model of Alcoholic Liver Disease.
Cells
Mainz RE,Albers S,Haque M,Sonntag R,Treichel NS,Clavel T,Latz E,Schneider KM,Trautwein C,Otto T
25-5941-82 was used in Flow cytometry/Cell sorting to evaluate a novel mouse model for ALD characterized by 8-week chronic-plus-binge ethanol administration and to investigate the role of NLRP6 inflammasome for intestinal homeostasis and ALD progression using Nlrp6-/- mice.
Thu Jan 06 00:00:00 EST 2022
Hypoxia-mediated stabilization of HIF1A in prostatic intraepithelial neoplasia promotes cell plasticity and malignant progression.
Science advances
Abu El Maaty MA,Terzic J,Keime C,Rovito D,Lutzing R,Yanushko D,Parisotto M,Grelet E,Namer IJ,Lindner V,Laverny G,Metzger D
25-5941-82 was used in Flow cytometry/Cell sorting to characterize prostatic intraepithelial neoplasia (PIN) progression and demonstrate that HIF1A is a target for PCa prevention and that TGM2 is a promising prognostic biomarker of early relapse after prostatectomy.
Fri Jul 22 00:00:00 EDT 2022
The transcription factor Bach2 negatively regulates murine natural killer cell maturation and function.
eLife
Li S,Bern MD,Miao B,Fan C,Xing X,Inoue T,Piersma SJ,Wang T,Colonna M,Kurosaki T,Yokoyama WM
25-5941-82 was used in Flow cytometry/Cell sorting to investigate the role of Bach2 in natural killer (NK) cell development, revealing that Bach2 expression peaked in immature CD27+CD11b+ cells, and its deficiency led to increased proportions of terminally differentiated NK cells with enhanced granzyme and cytokine production, as well as improved NK cell-mediated control of tumor metastasis.
Mon Oct 03 00:00:00 EDT 2022
The transcriptional repressor ID2 supports natural killer cell maturation by controlling TCF1 amplitude.
The Journal of experimental medicine
Li ZY,Morman RE,Hegermiller E,Sun M,Bartom ET,Maienschein-Cline M,Sigvardsson M,Kee BL
Published figure using NK1.1 monoclonal antibody (Product # 25-5941-82) in Flow Cytometry
Mon Jun 07 00:00:00 EDT 2021
Chronic T cell proliferation in brains after stroke could interfere with the efficacy of immunotherapies.
The Journal of experimental medicine
Heindl S,Ricci A,Carofiglio O,Zhou Q,Arzberger T,Lenart N,Franzmeier N,Hortobagyi T,Nelson PT,Stowe AM,Denes A,Edbauer D,Liesz A
25-5941-82 was used in Flow Cytometry to show a persistent accumulation of T cells in mice and human autopsy samples for more than 1 mo after stroke.
Mon Aug 02 00:00:00 EDT 2021
Chronic T cell proliferation in brains after stroke could interfere with the efficacy of immunotherapies.
The Journal of experimental medicine
Heindl S,Ricci A,Carofiglio O,Zhou Q,Arzberger T,Lenart N,Franzmeier N,Hortobagyi T,Nelson PT,Stowe AM,Denes A,Edbauer D,Liesz A
25-5941-82 was used in Flow Cytometry to show a persistent accumulation of T cells in mice and human autopsy samples for more than 1 mo after stroke.
Mon Aug 02 00:00:00 EDT 2021
Ablation of lysozyme M-positive cells prevents aircraft noise-induced vascular damage without improving cerebral side effects.
Basic research in cardiology
Frenis K,Helmstädter J,Ruan Y,Schramm E,Kalinovic S,Kröller-Schön S,Bayo Jimenez MT,Hahad O,Oelze M,Jiang S,Wenzel P,Sommer CJ,Frauenknecht KBM,Waisman A,Gericke A,Daiber A,Münzel T,Steven S
25-5941 was used in Flow cytometry/Cell sorting to determine the role of myeloid cells in the vascular vs. cerebral consequences of exposure to aircraft noise.
Fri Apr 30 00:00:00 EDT 2021
Peptidylprolyl isomerase C (Ppic) regulates invariant Natural Killer T cell (iNKT) differentiation in mice.
European journal of immunology
Paiva RS,Ramos CV,Azenha SR,Alves C,Basto AP,Graca L,Martins VC
25-5941-82 was used in Flow Cytometry to show that Ppic is dispensable for myeloid cells, platelets, erythrocytes, αβ and γδ T lymphocytes in vivo in the steady state, while being involved in B and iNKT cell differentiation.
Sun Aug 01 00:00:00 EDT 2021
Exosomal lncRNA SNHG10 derived from colorectal cancer cells suppresses natural killer cell cytotoxicity by upregulating INHBC.
Cancer cell international
Huang Y,Luo Y,Ou W,Wang Y,Dong D,Peng X,Luo Y
Published figure using NK1.1 monoclonal antibody (Product # 25-5941-82) in Flow Cytometry
Tue Oct 12 00:00:00 EDT 2021
Expression of CCRL2 Inhibits Tumor Growth by Concentrating Chemerin and Inhibiting Neoangiogenesis.
Cancers
Al Delbany D,Robert V,Dubois-Vedrenne I,Del Prete A,Vernimmen M,Radi A,Lefort A,Libert F,Wittamer V,Sozzani S,Parmentier M
Published figure using NK1.1 monoclonal antibody (Product # 25-5941-82) in Flow Cytometry
Tue Oct 05 00:00:00 EDT 2021
Near-infrared photoimmunotherapy targeting human-EGFR in a mouse tumor model simulating current and future clinical trials.
EBioMedicine
Okada R,Furusawa A,Vermeer DW,Inagaki F,Wakiyama H,Kato T,Nagaya T,Choyke PL,Spanos WC,Allen CT,Kobayashi H
Published figure using NK1.1 monoclonal antibody (Product # 25-5941-82) in Flow Cytometry
Sat May 01 00:00:00 EDT 2021
A novel miR1983-TLR7-IFNβ circuit licenses NK cells to kill glioma cells, and is under the control of galectin-1.
Oncoimmunology
Shah D,Comba A,Faisal SM,Kadiyala P,Baker GJ,Alghamri MS,Doherty R,Zamler D,Nuñez G,Castro MG,Lowenstein PR
Published figure using NK1.1 monoclonal antibody (Product # 25-5941-82) in Flow Cytometry
Mon Aug 02 00:00:00 EDT 2021
Transient activation of tumoral DNA damage tolerance pathway coupled with immune checkpoint blockade exerts durable tumor regression in mouse melanoma.
Pigment cell & melanoma research
Zhuo M,Gorgun FM,Tyler DS,Englander EW
25-5941-82 was used in Flow cytometry/Cell sorting to expect that this new combination protocol affords insights with clinical relevance that will help expand the range of patients who benefit from ICB therapy.
Sat May 01 00:00:00 EDT 2021
Physical restraint mouse models to assess immune responses under stress with or without habituation.
STAR protocols
Ding JX,Rudak PT,Inoue W,Haeryfar SMM
25-5941-82 was used in Flow Cytometry to provide protocols and guidelines in using three mouse restraint models, namely prolonged restraint stress, repeated restraint stress, and chronic variable stress, to examine immunological homeostasis/competence, or lack thereof, under stress with or without habituation.
Fri Dec 17 00:00:00 EST 2021
Sequencing, cloning, and antigen binding analysis of monoclonal antibodies isolated from single mouse B cells.
STAR protocols
Viant C,Escolano A,Chen ST,Nussenzweig MC
Published figure using NK1.1 monoclonal antibody (Product # 25-5941-82) in Flow Cytometry
Fri Jun 18 00:00:00 EDT 2021
The enrichment of neutrophil extracellular traps impair the placentas of systemic lupus erythematosus through accumulating decidual NK cells.
Scientific reports
Jiang M,Shen N,Zhou H,Wang Y,Lin S,Wu J,Di W
Published figure using NK1.1 monoclonal antibody (Product # 25-5941-82) in Flow Cytometry
Thu Mar 25 00:00:00 EDT 2021
DA-DRD5 signaling controls colitis by regulating colonic M1/M2 macrophage polarization.
Cell death & disease
Liu L,Wu Y,Wang B,Jiang Y,Lin L,Li X,Yang S
25-5941 was used in Flow cytometry/Cell sorting to provide demonstration of DA-DRD5 signaling in colonic macrophages controlling the development of colitis by regulating M1/M2 macrophage polarization.
Mon May 17 00:00:00 EDT 2021
NLRX1 is a key regulator of immune signaling during invasive pulmonary aspergillosis.
PLoS pathogens
Kastelberg B,Tubau-Juni N,Ayubi T,Leung A,Leber A,Hontecillas R,Bassaganya-Riera J,Kale SD
25-5941 was used in Flow cytometry/Cell sorting to point strongly towards the cell-specific and contextual function of Nlrx1 during invasive pulmonary aspergillosis and may lead to novel therapeutics to reduce Th2 responses by CD103+ DCs or heightened recruitment of neutrophils.
Tue Sep 01 00:00:00 EDT 2020
Th2 cells promote eosinophil-independent pathology in a murine model of allergic bronchopulmonary aspergillosis.
European journal of immunology
Dietschmann A,Schruefer S,Krappmann S,Voehringer D
25-5941-82 was used in Flow Cytometry to use a mouse model of ABPA to investigate the role of eosinophils and T cell-derived IL-4/IL-13 for induction of allergic lung inflammation.
Wed Jul 01 00:00:00 EDT 2020
Lysosomal Acid Lipase Is Required for Donor T Cells to Induce Graft-versus-Host Disease.
Cell reports
Nguyen HD,Ticer T,Bastian D,Kuril S,Li H,Du H,Yan C,Yu XZ
25-5941 was used in Flow cytometry/Cell sorting to reveal the role of LAL in T cell alloresponse and pathogenicity and validates LAL as a target for controlling GVHD and tumor relapse after allo-HCT.
Tue Oct 27 00:00:00 EDT 2020
Immunotherapeutic Blockade of CD47 Inhibitory Signaling Enhances Innate and Adaptive Immune Responses to Viral Infection.
Cell reports
Cham LB,Torrez Dulgeroff LB,Tal MC,Adomati T,Li F,Bhat H,Huang A,Lang PA,Moreno ME,Rivera JM,Galkina SA,Kosikova G,Stoddart CA,McCune JM,Myers LM,Weissman IL,Lang KS,Hasenkrug KJ
25-5941 was used in Flow cytometry/Cell sorting to indicate that CD47 blockade not only enhances the function of innate immune cells but also links to adaptive immune responses through improved APC function.
Tue Apr 14 00:00:00 EDT 2020
Analysis of Myeloid Cells in Mouse Tissues with Flow Cytometry.
STAR protocols
Liu Z,Gu Y,Shin A,Zhang S,Ginhoux F
Published figure using NK1.1 monoclonal antibody (Product # 25-5941-82) in Flow Cytometry
Fri Jun 19 00:00:00 EDT 2020
TLR9 Sensing of Self-DNA Controls Cell-Mediated Immunity to Listeria Infection via Rapid Conversion of Conventional CD4+ T Cells to Treg.
Cell reports
Dolina JS,Lee J,Griswold RQ,Labarta-Bajo L,Kannan S,Greenbaum JA,Bahia El Idrissi N,Pont MJ,Croft M,Schoenberger SP
25-5941 was used in Flow cytometry/Cell sorting to resolve long-standing questions regarding the conditional requirement for TH amongst pathogens and reveal a remarkable degree of plasticity in the function of CD4+ T cells, which can be quickly converted to Tregin vivo by infection-mediated immune modulation.
Tue Apr 07 00:00:00 EDT 2020
Virus infection is controlled by hematopoietic and stromal cell sensing of murine cytomegalovirus through STING.
eLife
Piersma SJ,Poursine-Laurent J,Yang L,Barber GN,Parikh BA,Yokoyama WM
25-5941 was used in Flow cytometry/Cell sorting to contrast anti-viral effects of MyD88 versus STING in distinct cell types that are infected with murine CMV (MCMV).
Wed Jul 29 00:00:00 EDT 2020
Dendritic Cells and Myeloid Derived Suppressor Cells Fully Responsive to Stimulation via Toll-Like Receptor 4 Are Rapidly Induced from Bone-Marrow Cells by Granulocyte-Macrophage Colony-Stimulating Factor.
Vaccines
Kong YY,Wilson K,Apostolopoulos V,Plebanski M
Published figure using NK1.1 monoclonal antibody (Product # 25-5941-82) in Flow Cytometry
Sat Sep 12 00:00:00 EDT 2020
MyD88-dependent signaling in non-parenchymal cells promotes liver carcinogenesis.
Carcinogenesis
Mohs A,Kuttkat N,Otto T,Youssef SA,De Bruin A,Trautwein C
25-5941-82 was used in Flow cytometry/Cell sorting to suggest that signaling of Toll-like receptors through MyD88 in non-parenchymal liver cells is required for carcinogenesis during chronic liver injury.
Wed Apr 22 00:00:00 EDT 2020
Immunization expands B cells specific to HIV-1 V3 glycan in mice and macaques.
Nature
Escolano A,Gristick HB,Abernathy ME,Merkenschlager J,Gautam R,Oliveira TY,Pai J,West AP,Barnes CO,Cohen AA,Wang H,Golijanin J,Yost D,Keeffe JR,Wang Z,Zhao P,Yao KH,Bauer J,Nogueira L,Gao H,Voll AV,Montefiori DC,Seaman MS,Gazumyan A,Silva M,McGuire AT,Stamatatos L,Irvine DJ,Wells L,Martin MA,Bjorkman PJ,Nussenzweig MC
Published figure using NK1.1 monoclonal antibody (Product # 25-5941-82) in Flow Cytometry
Sat Jun 01 00:00:00 EDT 2019
The Bone Marrow Protects and Optimizes Immunological Memory during Dietary Restriction.
Cell
Collins N,Han SJ,Enamorado M,Link VM,Huang B,Moseman EA,Kishton RJ,Shannon JP,Dixit D,Schwab SR,Hickman HD,Restifo NP,McGavern DB,Schwartzberg PL,Belkaid Y
25-5941-82 was used in Flow Cytometry to show that memory T cells collapsed in secondary lymphoid organs in the context of dietary restriction (DR) but dramatically accumulated within the bone marrow (BM), where they adopted a state associated with energy conservation.
Thu Aug 22 00:00:00 EDT 2019
Polychromic Reporter Mice Reveal Unappreciated Innate Lymphoid Cell Progenitor Heterogeneity and Elusive ILC3 Progenitors in Bone Marrow.
Immunity
Walker JA,Clark PA,Crisp A,Barlow JL,Szeto A,Ferreira ACF,Rana BMJ,Jolin HE,Rodriguez-Rodriguez N,Sivasubramaniam M,Pannell R,Cruickshank J,Daly M,Haim-Vilmovsky L,Teichmann SA,McKenzie ANJ
25-5941 was used in Flow cytometry/Cell sorting to identify a discrete ILC2-committed population and delineated transition states between early progenitors and a highly heterogeneous ILC1, ILC3, and NK precursor cell cluster.
Tue Jul 16 00:00:00 EDT 2019
Gasdermin D in peripheral myeloid cells drives neuroinflammation in experimental autoimmune encephalomyelitis.
The Journal of experimental medicine
Li S,Wu Y,Yang D,Wu C,Ma C,Liu X,Moynagh PN,Wang B,Hu G,Yang S
25-5941-82 was used in Flow Cytometry to study how GSDMD deficiency in peripheral myeloid cells impaired the infiltration of immune cells into the CNS, leading to the suppression of neuroinflammation and demyelination.
Mon Nov 04 00:00:00 EST 2019
miR-181a/b-1 controls thymic selection of Treg cells and tunes their suppressive capacity.
PLoS biology
Łyszkiewicz M,Winter SJ,Witzlau K,Föhse L,Brownlie R,Puchałka J,Verheyden NA,Kunze-Schumacher H,Imelmann E,Blume J,Raha S,Sekiya T,Yoshimura A,Frueh JT,Ullrich E,Huehn J,Weiss S,Gutierrez MG,Prinz I,Zamoyska R,Ziętara N,Krueger A
25-5941-82 was used in Magnetic cell separation to propose that intrathymic miR-181a/b-1 controls development of Treg cells and imposes a developmental legacy on their peripheral function.
Fri Mar 01 00:00:00 EST 2019
Natural killer cells limit the clearance of senescent lung adenocarcinoma cells.
Oncogenesis
Stokes KL,Cortez-Retamozo V,Acosta J,Lauderback B,Robles-Oteiza C,Cicchini M,Pittet MJ,Feldser DM
Mon Apr 01 00:00:00 EDT 2019
Deletion of C-C Motif Chemokine Ligand 5 Worsens Invariant Natural Killer T-Cell-Mediated Hepatitis via Compensatory Up-regulation of CXCR2-Related Chemokine Activity.
Cellular and molecular gastroenterology and hepatology
Chen L,Gu J,Qian Y,Li M,Qian Y,Xu M,Li J,Wen Y,Xia L,Li J,Xia Q,Kong X,Wu H
Published figure using NK1.1 monoclonal antibody (Product # 25-5941-82) in Flow Cytometry
Tue Jun 04 00:00:00 EDT 2019
Synergized regulation of NK cell education by NKG2A and specific Ly49 family members.
Nature communications
Zhang X,Feng J,Chen S,Yang H,Dong Z
Published figure using NK1.1 monoclonal antibody (Product # 25-5941-82) in Flow Cytometry
Fri Nov 01 00:00:00 EDT 2019
Progranulin prevents regulatory NK cell cytotoxicity against antiviral T cells.
JCI insight
Huang A,Shinde PV,Huang J,Senff T,Xu HC,Margotta C,Häussinger D,Willnow TE,Zhang J,Pandyra AA,Timm J,Weggen S,Lang KS,Lang PA
25-5941 was used in Flow cytometry/Cell sorting to show that progranulin (PGRN) can reduce NK cell cytotoxicity through reduction of NK cell expansion, granzyme B transcription, and NK cell-mediated lysis of target cells.
Thu Sep 05 00:00:00 EDT 2019
Antitumor immunity augments the therapeutic effects of p53 activation on acute myeloid leukemia.
Nature communications
Hayashi Y,Goyama S,Liu X,Tamura M,Asada S,Tanaka Y,Fukuyama T,Wunderlich M,O'Brien E,Mizukawa B,Yamazaki S,Matsumoto A,Yamasaki S,Shibata T,Matsuda K,Sashida G,Takizawa H,Kitamura T
Published figure using NK1.1 monoclonal antibody (Product # 25-5941-82) in Flow Cytometry
Fri Oct 25 00:00:00 EDT 2019
Myeloid Cells Restrict MCMV and Drive Stress-Induced Extramedullary Hematopoiesis through STAT1.
Cell reports
Gawish R,Bulat T,Biaggio M,Lassnig C,Bago-Horvath Z,Macho-Maschler S,Poelzl A,Simonović N,Prchal-Murphy M,Rom R,Amenitsch L,Ferrarese L,Kornhoff J,Lederer T,Svinka J,Eferl R,Bosmann M,Kalinke U,Stoiber D,Sexl V,Krmpotić A,Jonjić S,Müller M,Strobl B
25-5941 was used in Flow cytometry/Cell sorting to provide genetic evidence that signaling through STAT1 in myeloid cells is required to restrict MCMV at early time points post-infection and to induce compensatory hematopoiesis in the spleen.
Tue Feb 26 00:00:00 EST 2019
Chronic alcohol consumption exacerbates murine cytomegalovirus infection via impairing nonspecific and specific NK activation in mice.
FASEB bioAdvances
Little A,Li Y,Zhang F,Zhang H
25-5941-82 was used in Flow Cytometry to demonstrate that chronic alcohol consumption exacerbates cytomegalovirus infection via impairing nonspecific and specific NK cell activation, specifically IFN-γ and perforin production.
Tue Jan 01 00:00:00 EST 2019
Visualizing the Selectivity and Dynamics of Interferon Signaling In Vivo.
Cell reports
Stifter SA,Bhattacharyya N,Sawyer AJ,Cootes TA,Stambas J,Doyle SE,Feigenbaum L,Paul WE,Britton WJ,Sher A,Feng CG
25-5941-82 was used in In vivo experiments to suggest that time- and cell-type-dependent integration of distinct IFN signals govern the specificity and magnitude of IFN responses in vivo.
Tue Dec 10 00:00:00 EST 2019
Tim-3 aggravates podocyte injury in diabetic nephropathy by promoting macrophage activation via the NF-κB/TNF-α pathway.
Molecular metabolism
Yang H,Xie T,Li D,Du X,Wang T,Li C,Song X,Xu L,Yi F,Liang X,Gao L,Yang X,Ma C
25-5941 was used in Flow cytometry/Cell sorting to study T cell immunoglobulin domain and mucin domain-3 as a regulator in renal inflammation.
Wed May 01 00:00:00 EDT 2019
Keap1-Nrf2 System Plays an Important Role in Invariant Natural Killer T Cell Development and Homeostasis.
Cell reports
Pyaram K,Kumar A,Kim YH,Noel S,Reddy SP,Rabb H,Chang CH
25-5941 was used in Flow cytometry/Cell sorting to report that T cellspecific deletion of Keap1 results in defective development and reduced numbers of invariant natural killer T (NKT) cells in the thymus and the peripheral organs in a cell-intrinsic manner.
Tue Apr 16 00:00:00 EDT 2019
Developmental Analysis of Bone Marrow Neutrophils Reveals Populations Specialized in Expansion, Trafficking, and Effector Functions.
Immunity
Evrard M,Kwok IWH,Chong SZ,Teng KWW,Becht E,Chen J,Sieow JL,Penny HL,Ching GC,Devi S,Adrover JM,Li JLY,Liong KH,Tan L,Poon Z,Foo S,Chua JW,Su IH,Balabanian K,Bachelerie F,Biswas SK,Larbi A,Hwang WYK,Madan V,Koeffler HP,Wong SC,Newell EW,Hidalgo A,Ginhoux F,Ng LG
25-5941 was used in Flow cytometry/Cell sorting to identifies specialised bone marrow granulocytic populations that ensure supply under homeostasis and stress responses.
Tue Feb 20 00:00:00 EST 2018
An OX40/OX40L interaction directs successful immunity to hepatitis B virus.
Science translational medicine
Publicover J,Gaggar A,Jespersen JM,Halac U,Johnson AJ,Goodsell A,Avanesyan L,Nishimura SL,Holdorf M,Mansfield KG,Judge JB,Koshti A,Croft M,Wakil AE,Rosenthal P,Pai E,Cooper S,Baron JL
25-5941 was used in Flow cytometry/Cell sorting to study the mechanistic action of the immune pathways and cells necessary for HBV immunity and identify potential therapeutic targets for resolving chronic HBV infection.
Wed Mar 21 00:00:00 EDT 2018
CD8+ T cells mediate the antitumor activity of frankincense and myrrh in hepatocellular carcinoma.
Journal of translational medicine
Xu C,Lu X,Liu W,Chen A,Meng G,Zhang H,Li B,Zhang Y,Wu J,Wei J
Published figure using NK1.1 monoclonal antibody (Product # 25-5941-82) in Flow Cytometry
Mon May 21 00:00:00 EDT 2018
Plasmodium co-infection protects against chikungunya virus-induced pathologies.
Nature communications
Teo TH,Lum FM,Ghaffar K,Chan YH,Amrun SN,Tan JJL,Lee CYP,Chua TK,Carissimo G,Lee WWL,Claser C,Rajarethinam R,Rénia L,Ng LFP
Published figure using NK1.1 monoclonal antibody (Product # 25-5941-82) in Flow Cytometry
Tue Sep 25 00:00:00 EDT 2018
Dysregulated invertebrate tropomyosin-dectin-1 interaction confers susceptibility to allergic diseases.
Science immunology
Gour N,Lajoie S,Smole U,White M,Hu D,Goddard P,Huntsman S,Eng C,Mak A,Oh S,Kim JH,Sharma A,Plante S,Salem IH,Resch Y,Xiao X,Yao N,Singh A,Vrtala S,Chakir J,Burchard EG,Lane AP,Wills-Karp M
25-5941 was used in Flow cytometry/Cell sorting to uncover a previously unrecognized mechanism of protection against allergy to a conserved recognition element omnipresent in our environment.
Fri Feb 23 00:00:00 EST 2018
Complement Activation Contributes to Severe Acute Respiratory Syndrome Coronavirus Pathogenesis.
mBio
Gralinski LE,Sheahan TP,Morrison TE,Menachery VD,Jensen K,Leist SR,Whitmore A,Heise MT,Baric RS
25-5941 was used in Flow cytometry/Cell sorting to study complement signalling as regulating a proinflammatory response to SARS-CoV infection.
Tue Oct 09 00:00:00 EDT 2018
Group 2 Innate Lymphoid Cells Attenuate Inflammatory Arthritis and Protect from Bone Destruction in Mice.
Cell reports
Omata Y,Frech M,Primbs T,Lucas S,Andreev D,Scholtysek C,Sarter K,Kindermann M,Yeremenko N,Baeten DL,Andreas N,Kamradt T,Bozec A,Ramming A,Krönke G,Wirtz S,Schett G,Zaiss MM
25-5941 was used in Flow cytometry/Cell sorting to elucidate the role of group 2 innate lymphoid cells in arthritis.
Tue Jul 03 00:00:00 EDT 2018
Peroxisomal β-oxidation regulates whole body metabolism, inflammatory vigor, and pathogenesis of nonalcoholic fatty liver disease.
JCI insight
Moreno-Fernandez ME,Giles DA,Stankiewicz TE,Sheridan R,Karns R,Cappelletti M,Lampe K,Mukherjee R,Sina C,Sallese A,Bridges JP,Hogan SP,Aronow BJ,Hoebe K,Divanovic S
25-5941 was used in Flow cytometry/Cell sorting to demonstrate that β-oxidation links metabolism and immune responsiveness.
Thu Mar 22 00:00:00 EDT 2018
Mechanical strain determines the site-specific localization of inflammation and tissue damage in arthritis.
Nature communications
Cambré I,Gaublomme D,Burssens A,Jacques P,Schryvers N,De Muynck A,Meuris L,Lambrecht S,Carter S,de Bleser P,Saeys Y,Van Hoorebeke L,Kollias G,Mack M,Simoens P,Lories R,Callewaert N,Schett G,Elewaut D
25-5941 was used in Flow cytometry/Cell sorting to study the role of mechanical strain in controlling site-specific localisation of inflammation and tissue damage in arthritis.
Mon Nov 05 00:00:00 EST 2018
IL-7 treatment augments and prolongs sepsis-induced expansion of IL-10-producing B lymphocytes and myeloid-derived suppressor cells.
PloS one
Kulkarni U,Herrmenau C,Win SJ,Bauer M,Kamradt T
25-5941 was used in Flow cytometry/Cell sorting to investigate the expansion of immunoregulatory cells as long-term sequelae of sepsis with or without IL-7 treatment.
Mon Apr 09 00:00:00 EDT 2018
Stabilization of cytokine mRNAs in iNKT cells requires the serine-threonine kinase IRE1alpha.
Nature communications
Govindarajan S,Gaublomme D,Van der Cruyssen R,Verheugen E,Van Gassen S,Saeys Y,Tavernier S,Iwawaki T,Bloch Y,Savvides SN,Lambrecht BN,Janssens S,Elewaut D,Drennan MB
25-5941 was used in Flow cytometry/Cell sorting to examine the role of the IRE1α-dependent signalling cascade in coupling constitutive cytokine mRNA expression to the rapid induction of cytokine secretion and effector functions in activated iNKT cells.
Mon Dec 17 00:00:00 EST 2018
Thermoneutral housing exacerbates nonalcoholic fatty liver disease in mice and allows for sex-independent disease modeling.
Nature medicine
Giles DA,Moreno-Fernandez ME,Stankiewicz TE,Graspeuntner S,Cappelletti M,Wu D,Mukherjee R,Chan CC,Lawson MJ,Klarquist J,Sünderhauf A,Softic S,Kahn CR,Stemmer K,Iwakura Y,Aronow BJ,Karns R,Steinbrecher KA,Karp CL,Sheridan R,Shanmukhappa SK,Reynaud D,Haslam DB,Sina C,Rupp J,Hogan SP,Divanovic S
25-5941 was used in Flow cytometry/Cell sorting to show thermoneutral housing provides a sex-independent model of exacerbated NAFLD in mice and represents a novel approach for interrogation of the cellular and molecular mechanisms underlying disease pathogenesis.
Sat Jul 01 00:00:00 EDT 2017
Differentiation of human and murine induced pluripotent stem cells to microglia-like cells.
Nature neuroscience
Pandya H,Shen MJ,Ichikawa DM,Sedlock AB,Choi Y,Johnson KR,Kim G,Brown MA,Elkahloun AG,Maric D,Sweeney CL,Gossa S,Malech HL,McGavern DB,Park JK
Published figure using NK1.1 monoclonal antibody (Product # 25-5941-82) in Flow Cytometry
Mon May 01 00:00:00 EDT 2017
A TLR7 agonist enhances the antitumor efficacy of obinutuzumab in murine lymphoma models via NK cells and CD4 T cells.
Leukemia
Cheadle EJ,Lipowska-Bhalla G,Dovedi SJ,Fagnano E,Klein C,Honeychurch J,Illidge TM
Published figure using NK1.1 monoclonal antibody (Product # 25-5941-82) in Flow Cytometry
Sat Jul 01 00:00:00 EDT 2017
Bacillus anthracis lethal toxin negatively modulates ILC3 function through perturbation of IL-23-mediated MAPK signaling.
PLoS pathogens
Seshadri S,Allan DSJ,Carlyle JR,Zenewicz LA
25-5941 was used in Flow cytometry/Cell sorting to study the effects of MAPK signalling pathways in group 3 innate immune lymphocytes using Bacillus anthracis.
Sun Oct 01 00:00:00 EDT 2017
Expression and Function of Granzymes A and B in Escherichia coli Peritonitis and Sepsis.
Mediators of inflammation
García-Laorden MI,Stroo I,Terpstra S,Florquin S,Medema JP,van T Veer C,de Vos AF,van der Poll T
Mon Apr 30 00:00:00 EDT 2018
IL-2/Anti-IL-2 Complex Attenuates Inflammation and BBB Disruption in Mice Subjected to Traumatic Brain Injury.
Frontiers in neurology
Gao W,Li F,Zhou Z,Xu X,Wu Y,Zhou S,Yin D,Sun D,Xiong J,Jiang R,Zhang J
Published figure using NK1.1 monoclonal antibody (Product # 25-5941-82) in Flow Cytometry
Thu Oct 01 00:00:00 EDT 2020
Loss of HIF-1α in natural killer cells inhibits tumour growth by stimulating non-productive angiogenesis.
Nature communications
Krzywinska E,Kantari-Mimoun C,Kerdiles Y,Sobecki M,Isagawa T,Gotthardt D,Castells M,Haubold J,Millien C,Viel T,Tavitian B,Takeda N,Fandrey J,Vivier E,Sexl V,Stockmann C
Published figure using NK1.1 monoclonal antibody (Product # 25-5941-82) in Flow Cytometry
Fri Nov 17 00:00:00 EST 2017
Modulation of Innate Immunity by lignin-Carbohydrate, a Novel TLR4 Ligand, Results in Augmentation of Mucosal IgA and Systemic IgG Production.
International journal of molecular sciences
Tsuji R,Ikado K,Fujiwara D
25-5941 was used in Flow cytometry/Cell sorting to investigate immune-stimulatory activity of lignin-rich enzyme lignin in vivo.
Tue Dec 26 00:00:00 EST 2017
Loss of MAPK-activated protein kinase 2 enables potent dendritic cell-driven anti-tumour T cell response.
Scientific reports
Soukup K,Halfmann A,Dillinger B,Poyer F,Martin K,Blauensteiner B,Kauer M,Kuttke M,Schabbauer G,Dohnal AM
25-5941 was used in Flow cytometry/Cell sorting to suggest that MAPK-activated protein kinase 2 deletion leads to an expansion of stimulatory CD103+ dendritic cells, mounting a potent CD8+ T cell anti-tumour response in mice.
Mon Sep 18 00:00:00 EDT 2017
Co-inhibition of CD73 and A2AR Adenosine Signaling Improves Anti-tumor Immune Responses.
Cancer cell
Young A,Ngiow SF,Barkauskas DS,Sult E,Hay C,Blake SJ,Huang Q,Liu J,Takeda K,Teng MWL,Sachsenmeier K,Smyth MJ
25-5941 was used in Flow cytometry/Cell sorting to identify that co-blockade of the ectonucleotidase that generates adenosine CD73 and the A2A adenosine receptor that mediates adenosine signalling in leuokocytes limits tumour initiation, growth and metastasis.
Mon Sep 12 00:00:00 EDT 2016
The breast tumor microenvironment alters the phenotype and function of natural killer cells.
Cellular & molecular immunology
Krneta T,Gillgrass A,Chew M,Ashkar AA
Published figure using NK1.1 monoclonal antibody (Product # 25-5941-82) in Flow Cytometry
Thu Sep 01 00:00:00 EDT 2016
NKT sublineage specification and survival requires the ubiquitin-modifying enzyme TNFAIP3/A20.
The Journal of experimental medicine
Drennan MB,Govindarajan S,Verheugen E,Coquet JM,Staal J,McGuire C,Taghon T,Leclercq G,Beyaert R,van Loo G,Lambrecht BN,Elewaut D
25-5941 was used in Flow cytometry/Cell sorting to show that negative regulation of TCR signalling during NKT development controls the differentiation and survival of NKT1 and NKT2 cells.
Mon Sep 19 00:00:00 EDT 2016
Hypoxia-Inducible Factor-2α Limits Natural Killer T Cell Cytotoxicity in Renal Ischemia/Reperfusion Injury.
Journal of the American Society of Nephrology : JASN
Zhang J,Han C,Dai H,Hou J,Dong Y,Cui X,Xu L,Zhang M,Xia Q
Published figure using NK1.1 monoclonal antibody (Product # 25-5941-82) in Flow Cytometry
Fri Jan 01 00:00:00 EST 2016
NK cell development requires Tsc1-dependent negative regulation of IL-15-triggered mTORC1 activation.
Nature communications
Yang M,Chen S,Du J,He J,Wang Y,Li Z,Liu G,Peng W,Zeng X,Li D,Xu P,Guo W,Chang Z,Wang S,Tian Z,Dong Z
Published figure using NK1.1 monoclonal antibody (Product # 25-5941-82) in Flow Cytometry
Wed Sep 07 00:00:00 EDT 2016
Regulation of Inflammation by IL-17A and IL-17F Modulates Non-Alcoholic Fatty Liver Disease Pathogenesis.
PloS one
Giles DA,Moreno-Fernandez ME,Stankiewicz TE,Cappelletti M,Huppert SS,Iwakura Y,Dong C,Shanmukhappa SK,Divanovic S
25-5941 was used in Flow cytometry/Cell sorting to indicate that the IL-17 axis also plays a role in a MCDD-induced model of NAFLD pathogenesis.
Tue Jul 19 00:00:00 EDT 2016
A role for multiple chimeric antigen receptor-expressing leukocytes in antigen-specific responses to cancer.
Oncotarget
Yong CS,John LB,Devaud C,Prince MH,Johnstone RW,Trapani JA,Darcy PK,Kershaw MH
25-5941 was used in Flow cytometry/Cell sorting to characterise the function of leukocytes from transgenic mice expressing a chimeric antigen receptor under the control of vav, and determine the ability of these mice to respond to ERB-expressing tumours.
Tue Jun 07 00:00:00 EDT 2016
Inflammasome-independent role of AIM2 in suppressing colon tumorigenesis via DNA-PK and Akt.
Nature medicine
Wilson JE,Petrucelli AS,Chen L,Koblansky AA,Truax AD,Oyama Y,Rogers AB,Brickey WJ,Wang Y,Schneider M,Mühlbauer M,Chou WC,Barker BR,Jobin C,Allbritton NL,Ramsden DA,Davis BK,Ting JP
25-5941 was used in Flow cytometry/Cell sorting to show AIM2 regulates colon tumorigenesis by reducing activation of both DNA-PK and Akt, suggesting that Akt inhibitors could be used in treatment of certain cancers.
Sat Aug 01 00:00:00 EDT 2015
Activated NKT cells imprint NK-cell differentiation, functionality and education.
European journal of immunology
Riese P,Trittel S,May T,Cicin-Sain L,Chambers BJ,Guzmán CA
25-5941 was used in Flow cytometry/Cell sorting to study the cellular cross-talk between natural killer T cells and natural killer cells.
Mon Jun 01 00:00:00 EDT 2015
Favorable alteration of tumor microenvironment by immunomodulatory cytokines for efficient T-cell therapy in solid tumors.
PloS one
Tähtinen S,Kaikkonen S,Merisalo-Soikkeli M,Grönberg-Vähä-Koskela S,Kanerva A,Parviainen S,Vähä-Koskela M,Hemminki A
Published figure using NK1.1 monoclonal antibody (Product # 25-5941-82) in Flow Cytometry
Thu Apr 28 00:00:00 EDT 2016
Metronomic cyclophosphamide eradicates large implanted GL261 gliomas by activating antitumor Cd8+ T-cell responses and immune memory.
Oncoimmunology
Wu J,Waxman DJ
Published figure using NK1.1 monoclonal antibody (Product # 25-5941-82) in Flow Cytometry
Wed Apr 01 00:00:00 EDT 2015
Bi-Allelic TCRα or β Recombination Enhances T Cell Development but Is Dispensable for Antigen Responses and Experimental Autoimmune Encephalomyelitis.
PloS one
Schuldt NJ,Auger JL,Hogquist KA,Binstadt BA
25-5941 was used in Flow cytometry/Cell sorting to investigate dual TCRβ expression in T cells.
Thu Jun 23 00:00:00 EDT 2016
Natural Killer Cells Mediate Protection against Yersinia pseudotuberculosis in the Mesenteric Lymph Nodes.
PloS one
Rosenheinrich M,Heine W,Schmühl CM,Pisano F,Dersch P
25-5941 was used in Flow cytometry/Cell sorting to characterise the role of natural killer cells in the response to the extracellular bacterial pathogen, yersiniae.
Tue May 10 00:00:00 EDT 2016
Expression of a Chimeric Antigen Receptor in Multiple Leukocyte Lineages in Transgenic Mice.
PloS one
Yong CS,Westwood JA,Schröder J,Papenfuss AT,von Scheidt B,Moeller M,Devaud C,Darcy PK,Kershaw MH
25-5941 was used in Flow cytometry/Cell sorting to generate a mouse model expressing chimeric antigen receptors (CARs) specific for a tumour antigen under a pan-hematopoietic promoter.
Wed Jun 08 00:00:00 EDT 2016
Natural Killer Cells-Produced IFN-γ Improves Bone Marrow-Derived Hepatocytes Regeneration in Murine Liver Failure Model.
Scientific reports
Li L,Zeng Z,Qi Z,Wang X,Gao X,Wei H,Sun R,Tian Z
25-5941 was used in Flow cytometry/Cell sorting to elucidate the mechanisms underlying bone marrow-derived hepatocyte generation.
Tue Sep 08 00:00:00 EDT 2015
Rhinovirus-induced IL-25 in asthma exacerbation drives type 2 immunity and allergic pulmonary inflammation.
Science translational medicine
Beale J,Jayaraman A,Jackson DJ,Macintyre JDR,Edwards MR,Walton RP,Zhu J,Man Ching Y,Shamji B,Edwards M,Westwick J,Cousins DJ,Yi Hwang Y,McKenzie A,Johnston SL,Bartlett NW
25-5941 was used in Flow cytometry/Cell sorting to demonstrate asthmatic epithelial cells have an increased intrinsic capacity for expression of a pro-type 2 cytokine in response to a viral infection.
Wed Oct 01 00:00:00 EDT 2014
Microbiota modulate tumoral immune surveillance in lung through a γδT17 immune cell-dependent mechanism.
Cancer research
Cheng M,Qian L,Shen G,Bian G,Xu T,Xu W,Shen G,Hu S
25-5941 was used in Flow cytometry/Cell sorting to investigate the mechanism by which commensal bacteria modulate the efficiency of tumoral immune surveillance in mucosal tissues.
Fri Aug 01 00:00:00 EDT 2014
T helper cell IL-4 drives intestinal Th2 priming to oral peanut antigen, under the control of OX40L and independent of innate-like lymphocytes.
Mucosal immunology
Chu DK,Mohammed-Ali Z,Jiménez-Saiz R,Walker TD,Goncharova S,Llop-Guevara A,Kong J,Gordon ME,Barra NG,Gillgrass AE,Van Seggelen H,Khan WI,Ashkar AA,Bramson JL,Humbles AA,Kolbeck R,Waserman S,Jordana M
25-5941 was used in Flow cytometry/Cell sorting to reveal intestinal Th2 priming is initiated by an autocrine/paracrine acting CD4(+) Th cell-intrinsic IL-4 program that is controlled by DC OX40L.
Sat Nov 01 00:00:00 EDT 2014
An essential role for medullary thymic epithelial cells during the intrathymic development of invariant NKT cells.
Journal of immunology (Baltimore, Md. : 1950)
White AJ,Jenkinson WE,Cowan JE,Parnell SM,Bacon A,Jones ND,Jenkinson EJ,Anderson G
25-5941 was used in Flow cytometry/Cell sorting to investigate whether thymus microenvironments are required in iNKT cell development, showing that medullary thymic epithelial cells are essential for intrathymic development of iNKT cells.
Sat Mar 15 00:00:00 EDT 2014
Central role of conventional dendritic cells in regulation of bone marrow release and survival of neutrophils.
Journal of immunology (Baltimore, Md. : 1950)
Jiao J,Dragomir AC,Kocabayoglu P,Rahman AH,Chow A,Hashimoto D,Leboeuf M,Kraus T,Moran T,Carrasco-Avino G,Friedman SL,Merad M,Aloman C
25-5941 was used in Flow cytometry/Cell sorting to investigate the role of dendritic cells in neutrophil homeostasis, showing a central role in regulation of bone marrow release and survival of neutrophils.
Tue Apr 01 00:00:00 EDT 2014
Leukocyte population dynamics and detection of IL-9 as a major cytokine at the mouse fetal-maternal interface.
PloS one
Habbeddine M,Verbeke P,Karaz S,Bobé P,Kanellopoulos-Langevin C
Published figure using NK1.1 monoclonal antibody (Product # 25-5941-82) in Flow Cytometry
Wed Jun 10 00:00:00 EDT 2015
Dendritic cell subset distributions in the aorta in healthy and atherosclerotic mice.
PloS one
Busch M,Westhofen TC,Koch M,Lutz MB,Zernecke A
25-5941 was used in Flow cytometry/Cell sorting to perform a systematic analysis of dendritic cells and their accumulation characteristics during atherogenesis.
Tue Oct 21 00:00:00 EDT 2014
Dose-dense chemotherapy improves mechanisms of antitumor immune response.
Cancer research
Chang CL,Hsu YT,Wu CC,Lai YZ,Wang C,Yang YC,Wu TC,Hung CF
25-5941 was used in Flow cytometry/Cell sorting to assess whether a low or high dose DD combinatorial regimen of cisplatin and paclitaxel is more effective for the treatment of ovarian cancer.
Tue Jan 01 00:00:00 EST 2013
VEGF receptor inhibitors block the ability of metronomically dosed cyclophosphamide to activate innate immunity-induced tumor regression.
Cancer research
Doloff JC,Waxman DJ
Published figure using NK1.1 monoclonal antibody (Product # 25-5941-82) in Flow Cytometry
Thu Mar 01 00:00:00 EST 2012
Cutting edge: tumor-targeting antibodies enhance NKG2D-mediated NK cell cytotoxicity by stabilizing NK cell-tumor cell interactions.
Journal of immunology (Baltimore, Md. : 1950)
Deguine J,Breart B,Lemaître F,Bousso P
25-5941 was used in Flow cytometry/Cell sorting to investigate how natural killer cells integrate signals from antibody-coated targets and stress ligands on tumour cells.
Sat Dec 15 00:00:00 EST 2012
Ly49D-mediated ITAM signaling in immature thymocytes impairs development by bypassing the pre-TCR checkpoint.
Journal of immunology (Baltimore, Md. : 1950)
Merck E,Lees RK,Voyle RB,Held W,MacDonald HR
25-5941 was used in Flow cytometry/Cell sorting to investigate the role of Ly49D-mediated ITAM signaling, showing that it impairs development by bypassing the pre-TCR checkpoint.
Fri Jul 01 00:00:00 EDT 2011
Granzyme B regulates antiviral CD8+ T cell responses.
Journal of immunology (Baltimore, Md. : 1950)
Salti SM,Hammelev EM,Grewal JL,Reddy ST,Zemple SJ,Grossman WJ,Grayson MH,Verbsky JW
25-5941 was used in Flow cytometry/Cell sorting to investigate the role of granzyme B in immune regulation in response to viral infections, showing it regulates antiviral CD8+ T cell responses.
Thu Dec 15 00:00:00 EST 2011
Interleukin-17 contributes to generation of Th1 immunity and neutrophil recruitment during Chlamydia muridarum genital tract infection but is not required for macrophage influx or normal resolution of infection.
Infection and immunity
Scurlock AM,Frazer LC,Andrews CW,O'Connell CM,Foote IP,Bailey SL,Chandra-Kuntal K,Kolls JK,Darville T
25-5941 was used in Flow cytometry/Cell sorting to investigate the role of IL-17 during C. muridarum genital tract infection.
Tue Mar 01 00:00:00 EST 2011
Conditional regulatory T-cell depletion releases adaptive immunity preventing carcinogenesis and suppressing established tumor growth.
Cancer research
Teng MW,Ngiow SF,von Scheidt B,McLaughlin N,Sparwasser T,Smyth MJ
25-5941 was used in Flow cytometry/Cell sorting to suggest that effective transient Treg depletion strategies may be therapeutic in at least a proportion of spontaneous tumors developing in the host.
Fri Oct 15 00:00:00 EDT 2010
Dysregulated macrophage-inflammatory protein-2 expression drives illness in bacterial superinfection of influenza.
Journal of immunology (Baltimore, Md. : 1950)
Zavitz CC,Bauer CM,Gaschler GJ,Fraser KM,Strieter RM,Hogaboam CM,Stampfli MR
25-5941 was used in Flow cytometry/Cell sorting to suggest that pulmonary inflammation is the key threat during bacterial superinfection of influenza.
Mon Feb 15 00:00:00 EST 2010
Prevention of diabetes in NOD mice by repeated exposures to a contact allergen inducing a sub-clinical dermatitis.
PloS one
Engkilde K,Buschard K,Hansen AK,Menné T,Johansen JD
25-5941 was used in Flow cytometry/Cell sorting to study the effect of contact allergens on the development of diabetes in NOD mice, and on murine natural killer T cells.
Tue May 11 00:00:00 EDT 2010
Differential contribution of chemotaxis and substrate restriction to segregation of immature and mature thymocytes.
Immunity
Ehrlich LI,Oh DY,Weissman IL,Lewis RS
25-5941 was used in Flow cytometry/Cell sorting to study mechanisms governing the segregation of thymocyte subsets to distinct thymic microenvironments.
Fri Dec 18 00:00:00 EST 2009
Enhanced development of CD4+ gammadelta T cells in the absence of Itk results in elevated IgE production.
Blood
Qi Q,Xia M,Hu J,Hicks E,Iyer A,Xiong N,August A
25-5941 was used in Flow cytometry/Cell sorting to investigate the effect of Itk on T cell populations, showing that development of CD4+ gammadelta T cells is enhanced and IgE production is elevated in the absence of Itk.
Thu Jul 16 00:00:00 EDT 2009
iNKT cell development is orchestrated by different branches of TGF-beta signaling.
The Journal of experimental medicine
Doisne JM,Bartholin L,Yan KP,Garcia CN,Duarte N,Le Luduec JB,Vincent D,Cyprian F,Horvat B,Martel S,Rimokh R,Losson R,Benlagha K,Marie JC
25-5941 was used in Flow cytometry/Cell sorting to show that TGF-beta controls the differentiation program of iNKT cells.
Mon Jun 08 00:00:00 EDT 2009
c-Myb is required for pro-B cell differentiation.
Journal of immunology (Baltimore, Md. : 1950)
Fahl SP,Crittenden RB,Allman D,Bender TP
25-5941 was used in Flow cytometry/Cell sorting to demonstrate that c-Myb is absolutely required for the survival and differentiation of CD19(+) B-lineage cells.
Sun Nov 01 00:00:00 EDT 2009
MHC class I Dk locus and Ly49G2+ NK cells confer H-2k resistance to murine cytomegalovirus.
Journal of immunology (Baltimore, Md. : 1950)
Xie X,Stadnisky MD,Brown MG
25-5941 was used in Flow cytometry/Cell sorting to investigate resistance to murine cytomegalovirus, showing that the MHC class I Dk locus and Ly49G2+ NK cells confer H-2k resistance.
Mon Jun 01 00:00:00 EDT 2009
