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Custom Media QC Tests
Do you require standard pH and sterility tests, or are you interested in the tests typically performed on a Gibco catalog product? We offer a comprehensive range of tests to assess sterility, bioburden, composition, performance, and more. You select the tests, and our Quality Control Lab will take care of the rest.
Featured testing–Trace elements
Increase control and visibility to the trace element profile of your cell culture media and feeds. Proactively track historical trends and create predictive media formulations, all with a goal to reduce lot-to-lot variability.
Our trace element testing helps create a greater understanding of which trace elements your specific process or cell line may be most sensitive to. These data can provide an edge to increase your bioproduction success.
Unexpected sources of key driver trace elements have been identified in all classes of raw materials. Our trace elemental testing service offers QC validated* tests on finished good media (11 trace elements) and cell culture raw materials (16 trace elements). Services are offered on catalog and custom formulations (AGT, DPM, and liquid). Our technical team can also collaborate with customers on a case-to-case basis, to characterize cell culture media and manage raw material variability. For more details contact: BPD_CCM.TE@thermofisher.com.
Cell culture raw material testing
- Aluminum
- Arsenic
- Barium
- Cadmium
- Chromium
- Cobalt
- Copper
- Iron
- Lead
- Manganese
- Molybdenum
- Nickel
- Selenium
- Tin
- Vanadium
- Zinc
Finished goods media testing
- Chromium
- Copper
- Cobalt
- Iron
- Manganese
- Molybdenum
- Nickel
- Selenium
- Vanadium
- Tin
- Zinc
Summary of QC Tests Available
| Test | Lead Time (days) | Description |
|---|---|---|
| Trace Element testing (cell culture media and finished goods media) | 10 | QC-validated tests on finished good media (11 trace elements) and cell culture raw materials (16 trace elements) |
| 293 SFM II, CD 293 SFM, CD 293 SFM AGT Performance Assay | 30 | Biological performance assay for the testing of 293 SFM II and CD 293 SFM using suspension 293 cells |
| Activity Assay | 8 | Assay to determine activity or potency of a product |
| AE-1 Performance Assay (PFHM) | 1 | Biological performance assay for the testing of PFHM medium using AE-1 cell line |
| Amino Acid Analysis | 15 | Pre-column derivatization (Waters Accutag) followed by reverse phase HPLC analysis to analyze for amino acids and ammonia in cell culture media |
| Bioburden | 12 | To determine the approximate colony forming units (CFU) per gram in a dry powder media or chemical |
| CD CHO Performance Assay | 15 | Tests for the quality of CD CHO in supporting the growth of CHO cells |
| CD Hybridoma Performance Assay | 16 | Biological performance assay for the testing of CD Hybridoma medium using AE-1 cell line |
| Cell Growth | 3 | Biological performance assay for media using mammalian cell line(s) |
| Cell Viability | 3 | Determination of cell viability using Trypan Blue or Vi Cell |
| DMEL Performance Assay | 13 | Biological growth assay to test the performance of media in supporting the growth of D.mel-2 cells |
| Endotoxin | 8 | Limulus Amebocyte Lysate (LAL) detects and measures bacterial endotoxin, a fever producing byproduct of gram negative bacteria commonly known as pyrogen |
| Ethanolamine Quantitative | 16 | HPLC method to determine quantitative levels of ethanolamine in media |
| Express Five SFM Performance Assay (High-Five) | 13 | Tests for the quality of Express Five SFM using suspension High Five cells. |
| Freestyle 293 Expression Medium Performance Assay | 18 | Biological performance assay for the testing of FreeStyle 293 Expression Medium using suspension 293 cells. |
| Gibco Advanced Media Performance Assay | 21 | Assay to determine activity or potency of a product |
| HCV Antibody Screening | 1 | HCV virus testing for human origin components |
| Hepatitis B Surface Antigen Screening | 1 | Hepatitis B virus testing for human origin components |
| HIV 1 & 2 Antibody Screening | 1 | HIV 1 & 2 virus testing for human origin components |
| In-Vitro Bioassay | 10 | Assay to assess the quality of Trypsin, Trypsin-EDTA, TrypLE Express, and TrypLE Select in the removal of cells from a substrate |
| Mycoplasma (direct inoculation) | 40 | Positive control is used to test growth promoting capabilities of new lots of broth and agar plates. Negative control is used to ensure assay is a valid assay. Mycoplasma colonies must not be observed in this plate to be a valid test |
| Mycoplasma (indirect H stain) | 1 | Measures specific biochemical markers or other characteristics associated with mycoplasma. Mycoplasma strains that successfully propagate in cell culture can be efficiently detected using Hoechst No. 33258 (H-Stain), a fluorescent DNA stain |
| Neural Performance Assay | 26 | Biological cell growth performance assay for media and/or reagents for the culture of neurons |
| Osmolality | 1 | To determine the osmotic concentration of media, serum, and reagents |
| pH | 5 | To measure the acidity or alkalinity of a solution which can indicate the accuracy of the formulation of a product |
| Porcine Parvovirus | 10 | Virus testing performed according to 9CFR specifications for porcine origin components |
| Serum-Free Passage Number | 3 | The total number of passages cells have gone through when cultured in the serum-free media |
| Sf9 Performance Assay | 23 | Tests for the quality of Sf-900 II media, Sf-900 Plaque media, Chemically Defined Lipid Concentrate, and Yeastolate Ultrafiltrate |
| Solubility | 5 | Test to determine the degree a substance can be dissolved |
| SP2 Toxicity Assay | 10 | To assess the growth support of specific classical cell media and/or sera on cell growth and to determine if there are any cytotoxic effects of these products on cell growth |
| Sterility USP | 1 | Full sterility testing performed according to USP |
| Sterility USP Modified | 16 | Modified sterility testing performed according to USP but modification involves volume of media/reagents used |
| Total Passage Number | 3 | The total number of passages cells have gone through in our hands |
| Viable Cell Density | 3 | Number of living cells |
| Water Soluble Vitamins by HPLC | 16 | HPLC method to determine water soluble vitamins in media |
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For Research Use Only. Not for use in diagnostic procedures.
* The use or any variation of the word “validation” refers only to research-use antibodies that were subject to functional testing to confirm that the antibody can be used with the research techniques indicated. It does not ensure that the product(s) was validated for clinical or diagnostic uses.