Enabling your oligonucleotide synthesis for diagnostic and therapeutic development

Succinates are used for the derivatization of controlled pore glass, polystyrene, or other supports for solid-phase oligonucleotide synthesis. Our DNA succinates are formulated as triethylammonium (TEA) salts with standard base protection. They provide the high quality and stringent manufacturing controls required for bench and therapeutic applications.

Our DNA succinates are backed by:

  • Technical expertise—over 40 years of partnership, customization, and scale-up experience
  • Secure and consistent supply—5x capacity expansion in 2022 to support emerging therapeutics and diagnostic assays
  • Service excellence—48 hours or less response to orders, >98% delivery to customer at promised date†
  • Flexible packaging—custom and bulk packaging available upon request
  • Refined quality—ISO 9001:2015–certified quality management system that has been refined in partnership with our customers since 1995

† May not be applicable in all regions.

Quality manufacturing and documentation

Processes are monitored from material procurement through final QC and product release for batch-to-batch reproducibility. Purity of each product lot is assessed by HPLC, MS, and NMR. Our rigorously controlled manufacturing processes help minimize levels of impurities which could be incorporated into the oligonucleotide during synthesis and result in the accumulation of by-products.

DNA succinates

Thermo Scientific Bz dA, Bz dC, iBu dG, and T succinates are available as TEA salts with standard base protection.

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 Bz dA succinateBz dC succinateiBu dG succinateT succinate
Cat. No.27-003027-003227-003427-0036
Chemical name5′-O-(4,4'-dimethoxytrityl)-N6-(benzoyl)-2′-deoxyadenosine-3′-succinate, triethylammonium salt5′-O-(4,4'-dimethoxytrityl)-N4-(benzoyl)-2′-deoxycytidine-3′-succinate, triethylammonium salt5′-O-(4,4'-dimethoxytrityl)-N2-(isobutyryl)-2′-deoxyguanosine-3′-succinate, triethylammonium salt5′-O-(4,4'-dimethoxytrityl)-thymidine-3′-succinate, triethylammonium salt
FormulaC48H54N6O9C47H54N4O10C45H56N6O10C43H51N3O10
Molecular weight859 g/mol835 g/mol841 g/mol746 g/mol
HPLC purity≥98.0%≥98.0%≥95.0%≥98.0%
Shipping / storage conditionAmbient / –20°C
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For quotes, flexible/bulk packaging, custom services, or items not listed above, please contact us or submit your inquiry.

Resources

For Research Use Only. Not for use in diagnostic procedures.