Affinity Resins—Biosimilars and Recombinant Proteins

We have developed a unique portfolio of affinity resins to help you develop biosimilars, biobetters, and other types of recombinant proteins. These affinity resins can be used for clinical and commercial production.

CaptureSelect Affinity resin benefits:

High selectivity─high purity in a single capture step, independent of feedstock
Mild elution conditions─retention of biological activity of target
Reduction of process steps─helps reduce costs, allows higher yields
Efficient clearance of impurities

To complement each affinity resin, we offer product-specific ELISAs to measure any ligand potentially leaching from the column.

CaptureSelect affinity matrices:

CaptureSelect Product	Resin characteristics
FSH affinity matrix	Binds intact Follicle Stimulating Hormone (FSH) at the alpha/beta chain interface
Human Albumin Affinity matrix	Mild elution properties allowing gentle elution of albumin fusion proteins
hCG affinity matrix	Selectively binds human chorionic gonadotropin without cross reactivity to other gonadotropins such as FSH, LH, and TSH
Human Growth Hormone Affinity matrix	Selective purification of HGH with retained activity of the protein
Factor X affinity matrix	Binds Factor X and Factor Xa in the presence of calcium. Efficient purification with retained activity of the protein and no cross binding to other plasma proteins.
tPA affinity matrix	Binds tPA in the presence of magnesium chloride at neutral pH
TSH affinity matrix	Selectively binds TSH without cross reactivity to other gonadotropins such as FSH, LH, and HCG
C-tagXL affinity matrix	Unique selectivity for the 4-amino acid tag: C-tag Used for the efficient purification of C-tagged proteins, i.e. vaccine development
POROS CaptureSelect C1-InhXL Affinity Resin	Designed for the purification of human C1 esterase inhibitor from recombinant and plasma/serum sources Higher flowrates and efficient binding of larger biomolecules

Quantitate the yield of your proteins during the production process with our analytical columns or develop your own analytical assay with CaptureSelect Ligand Conjugates.

When your specific process needs cannot be met with current products, our custom chromatography services are available to build you a unique solution. For more information, please visit Custom Capabilities.

CaptureSelect Leakage ELISAs

Products incorporating CaptureSelect technology are used for clinical and commercial manufacturing of a variety of biologics. To complement each affinity resin, we offer product specific ELISAs to measure any ligand potentially leaching from the column. Click on the product table below to see all available ELISAs.

CaptureSelect Leakage ELISA’s

CaptureSelect Leakage ELISA's for Select Resins

These leakage ELISAs are developed to accompany Select resins.

Bioprocess Resin Selection Tool

Use this interactive decision-making tool to determine the right chromatography resin for your purification process.

Screenshot of categories available within resin selection tool

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Chromatography Learning Lab

Check out the new Chromatography Learning Lab from Thermo Fisher Scientific, providing a robust range of webinars, articles, eBooks, infographics, and other digital resources to help you optimize the use of our purification products in your process.

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