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Drug Screening and Confirmation
Close your uncertainty gap
We can enable your laboratory with the right solutions to improve confidence in results and meet your everyday forensic toxicology lab demands. With an increasing number of drug intoxications reported annually, new legislation and more workplace testing, forensic scientists, law enforcement agencies, and drug testing laboratories require faster screen-to-confirmation methods to address case loads. Improving routine compound screening and confirmation turnaround time while staying ahead of tomorrow’s illicit drug compounds isn’t easy.
We offer a variety of solutions to meet your budget and operational needs; while helping your laboratory analysts with first-time analysis success.
Solve your case backlog and achieve best data quality and implement workflows with unparalleled ease for every molecule, every matrix, every user.
Dr. Giampietro Frison of the LIATF discusses how he addresses his growing load of forensic toxicology cases using Orbitrap HRAM LC-MS.
In this video LC-MS experts - Lawrence Andrade, Dr. Barbara Bjoko, Dr. Ana Celia Grenier, Dr. Marilyn Huestis, Claudio De Nardi, and Dr. Michael Vogeser, and discuss the advantages of LC-MS over immunoassay in providing solutions for drug monitoring research and to combat the opioid epidemic.
Drug screening and confirmation workflow
Our solutions are designed to integrate into your existing operations whether you need to optimize throughput, sensitivity or build your lab of the future—from component to full workflow options. Where high sample throughput and turn-around time pressure exists, LC-MS is increasingly the preferred method of analysis over traditional techniques—offering the ability to eliminate “send-outs”. Toxicologists are able to obtain sensitivity and specificity, in less time.
Sample collection and labeling
Sample collection and storage conditions for routine drug testing and/or forensic case investigation are quite critical to maintain the integrity of these samples. Collection of oral samples requires specialized tools that are simple and easy to use yet allows enough sample collection for further downstream analysis. Forensic samples upon collection need to be stored in a well labeled container throughout the analysis process to maintain a continuous chain of custody. Thermo Scientific offers efficient tools to collect and store samples that are a requirement for many forensic labs.
Simplify the collection of oral samples for routine drug testing with our Thermo Scientific™ Oral-Eze™ Oral Fluid collection device. It provides all the advantages of previous collection systems with the added benefit of our indicator window technology—taking the guesswork out of sample collection.
Additional resources
Sample preparation
For laboratories using GC and GC-MS applications for screening and/or confirmation and identification, improve separation and detection with our selection of GC derivatization reagents. For applications requiring solid phase extraction (SPE), Thermo Scientific sample preparation products reduce time and repetitive functions you need to perform, while providing consistency and accuracy of results. We offer a broad range of manual and semi-automated SPE consumable solutions.
Get greater reproducibility and cleaner, more consistent extracts with the first-ever fritless cartridges and plates.
Screening
Rely on our drugs of abuse screening solutions as part of your drug screening and confirmation testing program. Thermo Scientific offers a variety of screening options to be used as stand-alone instruments or integrated into your laboratory automation workflow. Our systems are designed to offer you the best solution to support your unique laboratory challenges while improving operational efficiency and result integrity. Our portfolio of products is used in a variety of municipalities including drug courts, correctional institutions, city, county, state, country, and national laboratories.
- Rapidly screen urine
- Easy to use for new analysts
- Process 120 samples per hour
- Fully automated
- Methods traceable to international reference methods and materials
- Rapidly screen urine
- Easy to use for new analysts
- Process 190 samples per hour
- Fully automated
- Methods traceable to international reference methods and materials
- Screen, quantify, and confirm with the sensitivity & specificity for your routine lab demands
- Low to medium sample volume
- Performance within budget
- Ideal for applications with volatiles and non-polar compounds
| LC-MS Solutions |  Orbitrap HRAM MS | Q Exactive MS |  TSQ Triple Quadrupole MS |
|---|---|---|---|
| Non targeted screening |  | | |
| Targeted screening | | | |
| Non-targeted and targeted screening | | | |
| Retrospective analysis | | |
 = Not applicable |  = Poor |  = Good |  = Better | = Best |
Related products
- Reagents, calibrators, controls and collection devices
- Chemistry analyzers
- Sample derivitization solutions
- GC and LC columns & consumables
- GC-MS quadrupole solutions
- LC-MS solutions
- Further optimization performance with our specialty ion sources; including DART (Direct Analysis in Real Time)
- For clinical laboratories, see our diagnostic instruments
Simplified drugs of abuse testing
Solve your case backlog and achieve best data quality and implement workflows with unparalleled ease for every molecule, every matrix, every user.
Application notes, posters and presentations
Screening reagent kits
Drug screening laboratories around the world test with confidence using our gold standard Thermo Scientific™ CEDIA™ and Thermo Scientific™ DRI™ technologies, widely accepted as the leading methods for testing urine samples. With our drugs of abuse testing solutions, you can obtain accurate and reliable results rapidly on a wide range of clinical chemistry analyzers. Streamline your laboratory’s productivity with our convenient, liquid, ready-to-use DRI assays.
Our most popular drugs of abuse applications
CEDIA drugs of abuse assays
Confirmation and identification
When accurate, reproducible, and rapid separations are critical, choose from our solutions to help you successfully analyze compounds limited in amount or availability amid complex matrices. Mass Spectrometry (MS) is increasingly used in forensic toxicology because it is versatile, fast, and accurate. Thermo Fisher Scientific offers a family of MS technologies to deliver the accuracy, sensitivity and throughput your lab requires and work within your budget and workflow needs. Our portfolio of products is used in a variety of municipalities including drug courts, medical examiner, city, county, state, country, and national laboratories.
- Quantify and confirm for your every day demands
- Low to medium sample volume
- Performance within budget
- Ideal for volatiles and non-polar compounds
| LC-MS Solutions | Q Exactive MS | TSQ Triple Quadrupole MS |
|---|---|---|
| Non targeted screening | | |
| Targeted screening | | |
| Non-targeted and targeted screening | | |
| Targeted quantitation | | |
| Retrospective analysis | |
| = Not applicable | = Poor | = Good | = Better | = Best |
Related Products
- GC-MS sample derivitization solutions
- GC and LC columns & consumables
- Further optimization performance with our specialty ion sources including DART (Direct Analysis in Real Time)
- Need more dynamic range and sensitivity, see our full line of LC-MS research solutions
- Empower your chromatographers, see our GC-MS single quadrupole & LC-MS single quadrupole solutions
- For clinical laboratories, see our diagnostic instruments
Application notes, posters and presentations
- Analysis of Synthetic Cannabinoids (Spice) in Urine Utilizing HRAM
- Quantitation of Opiates to Low ng/mL Levels in Urine for Forensic Use using an Affordable, High-Resolution Accurate Mass Spectrometer
- Demonstrating High-Performance Quantitative Analysis of Benzodiazepines using Multiplexed SIM and HRAMS Q Exactive
Publications & citations
Analysis software solutions for your screening workflows; including identification, quantification & confirmation
Rather than taking a one-size-fits-all approach, Thermo Scientific is committed to developing products to meet the needs of our research to routine Toxicology laboratory professionals.
| Needs | Compound Discoverer | TraceFinder | Chromeleon CDS |
|---|---|---|---|
| Non-targeted screening (unknown knowns and unknown unknowns) | | | |
| Targeted screening (known unknowns) | | | |
| Non-targeted and targeted quantitation | | | |
| Targeted quantitation only (known knowns) | | | |
| Complex targeted panel analysis | | | |
| GxP/21 CFR Part 11 compliance capable | | | |
| Library compatibility | | | |
| Thermo Scientific Chromatography and source compatibility | | | |
| Third Party Instrument Control | | | |
| = Not applicable | = Poor | = Good | = Better | = Best |
Additional resources
If you are struggling with identifying unknowns due to low quality data, learn more about the following solutions:
- mzCLoud - the world’s largest (in terms of total spectra and data per compound) and most extensively curated mass spectral library delivers powerful unknown identification capabilities.
- mzVault offline advanced mass spectral database - access and search mzCloud’s MS2-level spectral data off-line, or to store your own spectral library information
- mzLogic data analysis algorithm - provides the best candidates for true unknowns through spectral similarity and sub structural information
Sample collection and labeling
Sample collection and storage conditions for routine drug testing and/or forensic case investigation are quite critical to maintain the integrity of these samples. Collection of oral samples requires specialized tools that are simple and easy to use yet allows enough sample collection for further downstream analysis. Forensic samples upon collection need to be stored in a well labeled container throughout the analysis process to maintain a continuous chain of custody. Thermo Scientific offers efficient tools to collect and store samples that are a requirement for many forensic labs.
Simplify the collection of oral samples for routine drug testing with our Thermo Scientific™ Oral-Eze™ Oral Fluid collection device. It provides all the advantages of previous collection systems with the added benefit of our indicator window technology—taking the guesswork out of sample collection.
Additional resources
Sample preparation
For laboratories using GC and GC-MS applications for screening and/or confirmation and identification, improve separation and detection with our selection of GC derivatization reagents. For applications requiring solid phase extraction (SPE), Thermo Scientific sample preparation products reduce time and repetitive functions you need to perform, while providing consistency and accuracy of results. We offer a broad range of manual and semi-automated SPE consumable solutions.
Get greater reproducibility and cleaner, more consistent extracts with the first-ever fritless cartridges and plates.
Screening
Rely on our drugs of abuse screening solutions as part of your drug screening and confirmation testing program. Thermo Scientific offers a variety of screening options to be used as stand-alone instruments or integrated into your laboratory automation workflow. Our systems are designed to offer you the best solution to support your unique laboratory challenges while improving operational efficiency and result integrity. Our portfolio of products is used in a variety of municipalities including drug courts, correctional institutions, city, county, state, country, and national laboratories.
- Rapidly screen urine
- Easy to use for new analysts
- Process 120 samples per hour
- Fully automated
- Methods traceable to international reference methods and materials
- Rapidly screen urine
- Easy to use for new analysts
- Process 190 samples per hour
- Fully automated
- Methods traceable to international reference methods and materials
- Screen, quantify, and confirm with the sensitivity & specificity for your routine lab demands
- Low to medium sample volume
- Performance within budget
- Ideal for applications with volatiles and non-polar compounds
| LC-MS Solutions | Orbitrap HRAM MS | Q Exactive MS | TSQ Triple Quadrupole MS |
|---|---|---|---|
| Non targeted screening | | | |
| Targeted screening | | | |
| Non-targeted and targeted screening | | | |
| Retrospective analysis | | |
| = Not applicable | = Poor | = Good | = Better | = Best |
Related products
- Reagents, calibrators, controls and collection devices
- Chemistry analyzers
- Sample derivitization solutions
- GC and LC columns & consumables
- GC-MS quadrupole solutions
- LC-MS solutions
- Further optimization performance with our specialty ion sources; including DART (Direct Analysis in Real Time)
- For clinical laboratories, see our diagnostic instruments
Simplified drugs of abuse testing
Solve your case backlog and achieve best data quality and implement workflows with unparalleled ease for every molecule, every matrix, every user.
Application notes, posters and presentations
Screening reagent kits
Drug screening laboratories around the world test with confidence using our gold standard Thermo Scientific™ CEDIA™ and Thermo Scientific™ DRI™ technologies, widely accepted as the leading methods for testing urine samples. With our drugs of abuse testing solutions, you can obtain accurate and reliable results rapidly on a wide range of clinical chemistry analyzers. Streamline your laboratory’s productivity with our convenient, liquid, ready-to-use DRI assays.
Our most popular drugs of abuse applications
CEDIA drugs of abuse assays
Confirmation and identification
When accurate, reproducible, and rapid separations are critical, choose from our solutions to help you successfully analyze compounds limited in amount or availability amid complex matrices. Mass Spectrometry (MS) is increasingly used in forensic toxicology because it is versatile, fast, and accurate. Thermo Fisher Scientific offers a family of MS technologies to deliver the accuracy, sensitivity and throughput your lab requires and work within your budget and workflow needs. Our portfolio of products is used in a variety of municipalities including drug courts, medical examiner, city, county, state, country, and national laboratories.
- Quantify and confirm for your every day demands
- Low to medium sample volume
- Performance within budget
- Ideal for volatiles and non-polar compounds
| LC-MS Solutions | Q Exactive MS | TSQ Triple Quadrupole MS |
|---|---|---|
| Non targeted screening | | |
| Targeted screening | | |
| Non-targeted and targeted screening | | |
| Targeted quantitation | | |
| Retrospective analysis | |
| = Not applicable | = Poor | = Good | = Better | = Best |
Related Products
- GC-MS sample derivitization solutions
- GC and LC columns & consumables
- Further optimization performance with our specialty ion sources including DART (Direct Analysis in Real Time)
- Need more dynamic range and sensitivity, see our full line of LC-MS research solutions
- Empower your chromatographers, see our GC-MS single quadrupole & LC-MS single quadrupole solutions
- For clinical laboratories, see our diagnostic instruments
Application notes, posters and presentations
- Analysis of Synthetic Cannabinoids (Spice) in Urine Utilizing HRAM
- Quantitation of Opiates to Low ng/mL Levels in Urine for Forensic Use using an Affordable, High-Resolution Accurate Mass Spectrometer
- Demonstrating High-Performance Quantitative Analysis of Benzodiazepines using Multiplexed SIM and HRAMS Q Exactive
Publications & citations
Analysis software solutions for your screening workflows; including identification, quantification & confirmation
Rather than taking a one-size-fits-all approach, Thermo Scientific is committed to developing products to meet the needs of our research to routine Toxicology laboratory professionals.
| Needs | Compound Discoverer | TraceFinder | Chromeleon CDS |
|---|---|---|---|
| Non-targeted screening (unknown knowns and unknown unknowns) | | | |
| Targeted screening (known unknowns) | | | |
| Non-targeted and targeted quantitation | | | |
| Targeted quantitation only (known knowns) | | | |
| Complex targeted panel analysis | | | |
| GxP/21 CFR Part 11 compliance capable | | | |
| Library compatibility | | | |
| Thermo Scientific Chromatography and source compatibility | | | |
| Third Party Instrument Control | | | |
| = Not applicable | = Poor | = Good | = Better | = Best |
Additional resources
If you are struggling with identifying unknowns due to low quality data, learn more about the following solutions:
- mzCLoud - the world’s largest (in terms of total spectra and data per compound) and most extensively curated mass spectral library delivers powerful unknown identification capabilities.
- mzVault offline advanced mass spectral database - access and search mzCloud’s MS2-level spectral data off-line, or to store your own spectral library information
- mzLogic data analysis algorithm - provides the best candidates for true unknowns through spectral similarity and sub structural information
Resources