LipidSearch 软件 | Thermo Fisher Scientific - CN

LipidSearch Software

准确鉴定脂质

需要使用先进的软件和全面的数据库对生物样品中的脂质进行相对定量分析和准确鉴定。Thermo Scientific LipidSearch 软件可自动进行脂质鉴定，并将整个数据集整合到一份简洁的报告中，显示样品组之间的统计学差异。

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主要优点

自动鉴定脂质	全面覆盖数据库
独特的峰值检测算法专为 LC 数据依赖型 MS/MS 而定制，包括利用 Thermo Scientific Orbitrap IQ-X 和 Tribrid 质谱仪融合来自 CID/HCD 裂解碎片和 MS²/MS³ 谱的信息。产物离子搜索和注释对齐算法针对非靶向脂质鉴定进行过优化。	LipidSearch 软件数据库包含分子脂质种类（96个子类）及其预测碎片离子，并提供了覆盖范围最完整的各类样品，包括细胞、人血浆、昆虫幼虫、植物、种子油、组织和酵母。

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参考文献

R Taguchi, et al.,Precise and global identification of phospholipid molecular species by an Orbitrap mass spectrometer and automated search engine LipidSearch, J. Chrom.A, 2010, 1217, 4229–4239. doi: 10.1016/j.chroma.2010.04.034
T Yamada, et al.,Development of a lipid profiling system using reverse-phase liquid chromatography coupled to high-resolution mass spectrometry with rapid polarity switching and an automated lipid identification software, J. Chrom.A, 2013, 1292, 211-218. doi: 10.1016/j.chroma.2013.01.078
M B Trevino, et al., Perilipin 5 Regulates Islet Lipid Metabolism and Insulin Secretion in a cAMP-Dependent Manner: Implication of Its Role in the Postprandial Insulin Secretion, Diabetes, 2015; 64:1299–1310. doi: 10.2337/db14-0559
F G Tafesse, et al., (2015) Disruption of Sphingolipid Biosynthesis Blocks Phagocytosis of Candida albicans, PLoS Pathog 11(10): e1005188. doi: 10.2337/db14-0559
R Almeida, et al., Comprehensive Lipidome Analysis by Shotgun Lipidomics on a Hybrid Quadrupole-Orbitrap-Linear Ion Trap Mass Spectrometer, J. Am. Soc.Mass Spectrom.(2014). doi: 10.1007/s13361-014-1013-x
S B Breitkopf, et al., Triomics Analysis of Imatinib-Treated Myeloma Cells Connects Kinase Inhibition to RNA Processing and Decreased Lipid Biosynthesis,Anal.Chem.2015, 87, 21, 10995-11006. doi: 10.1021/acs.analchem.5b03040
M Narvaez-Rivas, et al.Comprehensive untargeted lipidomic analysis using core-shell C30 particle column and high field orbitrap mass spectrometer, J Chrom.A (2016). doi: 10.1016/j.chroma.2016.02.054
S B Breitkopf, et al., A relative quantitative positive/negative ion switching method for untargeted lipidomics via high resolution LC-MS/MS from any biological source, Metabolomics (2017) 13: 30. doi: 10.1007/s11306-016-1157-8

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