| Application | Title | Year |
|---|
| Mouse ileum, liver | Activation of PPARα decreases bile acids in livers of female mice while maintaining bile flow and biliary bile acid excretion. | 2018 |
| Influenza vaccine safety | Dicloxacillin induces CYP2C19, CYP2C9 and CYP3A4 in vivo and in vitro. | 2018 |
| Lung Cancer Metastasis | GAP43, a novel metastasis promoter in non-small cell lung cancer. | 2018 |
| Murine encephalomyelitis virus | The influence of macrophage growth factors on Theiler's Murine Encephalomyelitis Virus (TMEV) infection and activation of macrophages. | 2018 |
| Lung Transplant Bronchiolitis | Depletion of Airway Submucosal Glands and TP63+KRT5+ Basal Cells in Obliterative Bronchiolitis. | 2018 |
| Genetically-modified crops | RNase If -treated quantitative PCR for dsRNA quantitation of RNAi trait in genetically modified crops. | 2018 |
| Breast Cancer | Interindividual Regulation of the Breast Cancer Resistance Protein ABCG2 Transporter in Term Human Placentas. | 2018 |
| Bile acid homeostasis | Aryl hydrocarbon receptor (AhR) mediated short-term effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on bile acid homeostasis in mice. | 2018 |
| Influenza Vaccine Safety | In vitro marker gene expression analyses in human peripheral blood mononuclear cells: A tool to assess safety of influenza vaccines in humans. | 2018 |
| Cell Inflamed Tumor Microenvironment | The CDK4/6 Inhibitor Abemaciclib Induces a T Cell Inflamed Tumor Microenvironment and Enhances the Efficacy of PD-L1 Checkpoint Blockade. | 2018 |
| PD- /PD-L antagonist | Discovery and preclinical characterization of the antagonist anti-PD-L1 monoclonal antibody LY3300054. | 2018 |
| Acute Lymphoblastic Leukaemia | Effective Response Metric: a novel tool to predict relapse in childhood acute lymphoblastic leukaemia using time-series gene expression profiling. | 2018 |
| TGFβRI small molecule inhibitor | Targeting the TGFβ pathway with galunisertib, a TGFβRI small molecule inhibitor, promotes anti-tumor immunity leading to durable, complete responses, as monotherapy and in combination with checkpoint blockade. | 2018 |
| Mesenchymal stromal cells | Comparison of Mesenchymal Stromal Cells Isolated from Murine Adipose Tissue and Bone Marrow in the Treatment of Spinal Cord Injury. | 2018 |
| Bipolar Disorder Research | Role of the IL-6-Receptor expression in CD14+ monocytes in modulating sleep in patients with bipolar disorder. | 2018 |
| HBV inhibitors | Identification of Retinoic Acid Receptor Agonists as Potent Hepatitis B Virus Inhibitors via a Drug Repurposing Screen. | 2018 |
| Influenza vaccine adjuvant | Establishment of a novel safety assessment method for vaccine adjuvant development. | 2018 |
| Alzheimer's disease | Parahippocampal gyrus expression of endothelial and insulin receptor signaling pathway genes is modulated by Alzheimer's disease and normalized by treatment with anti-diabetic agents. | 2018 |
| Shellfish Toxins Cao-2 cells | Detection and profiling of diarrheic marine biotoxins in shellfish by mRNA analysis of exposed Caco-2 cells using qRT-PCR and multiplex magnetic bead-based assays. | 2018 |
| Human melanoma | Analysis of NRAS gain in 657 patients with melanoma and evaluation of its sensitivity to a MEK inhibitor. | 2018 |
| Mouse ileum, liver | Aryl hydrocarbon receptor (AhR) mediated short-term effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on bile acid homeostasis in mice. | 2018 |
| Mouse subcutaneous tissues | Biocompatibility of injectable resilin-based hydrogels. | 2018 |
| Human hepatocytes | Characterization of CYP2C Induction in Cryopreserved Human Hepatocytes and Its Application in the Prediction of the Clinical Consequences of the Induction. | 2018 |
| Mouse MC38 tumor | Choosing the Best Chemotherapy Agent to Boost Immune Checkpoint Inhibition Activity. | 2018 |
| Zebrafish larvae | Comparative effects of cadmium, zinc, arsenic and chromium on olfactory-mediated neurobehavior and gene expression in larval zebrafish (Danio rerio). | 2018 |
| Mouse bone marrow-derived mesenchymal stem cells | Comparison of Mesenchymal Stromal Cells Isolated from Murine Adipose Tissue and Bone Marrow in the Treatment of Spinal Cord Injury. | 2018 |
| Human HepaRG | Cytochrome P450 1A2 Messenger RNA is a More Reliable Marker than Cytochrome P450 1A2 Activity, Phenacetin O-Deethylation, for Assessment of Induction Potential of Drug-Metabolizing Enzymes Using HepaRG Cells. | 2018 |
| Ferret lung | Depletion of Airway Submucosal Glands and TP63+KRT5+ Basal Cells in Obliterative Bronchiolitis. | 2018 |
| Human Caco-2 | Detection and profiling of diarrheic marine biotoxins in shellfish by mRNA analysis of exposed Caco-2 cells using qRT-PCR and multiplex magnetic bead-based assays. | 2018 |
| Mouse lung | Development of a preclinical humanized mouse model to evaluate acute toxicity of an influenza vaccine. | 2018 |
| Mouse lung | Development of screening method for intranasal influenza vaccine and adjuvant safety in preclinical study. | 2018 |
| Human hepatocytes | Dicloxacillin induces CYP2C19, CYP2C9 and CYP3A4 in vivo and in vitro. | 2018 |
| Human cultured malaria-infected red blood cells | Direct Detection of Unamplified Pathogen RNA in Blood Lysate using an Integrated Lab-in-a-Stick Device and Ultrabright SERS Nanorattles. | 2018 |
| Human CD4 T cell-dendritic cell coculture | Discovery and preclinical characterization of the antagonist anti-PD-L1 monoclonal antibody LY3300054. | 2018 |
| Human THP-1 | Discovery of a Novel Microtubule Targeting Agent as an Adjuvant for Cancer Immunotherapy. | 2018 |
| Human blood | Effective Response Metric: a novel tool to predict relapse in childhood acute lymphoblastic leukaemia using time-series gene expression profiling. | 2018 |
| Human nasal-associated lymphoid tissue | Establishment of a novel safety assessment method for vaccine adjuvant development. | 2018 |
| Human liver | EXO1 overexpression is associated with poor prognosis of hepatocellular carcinoma patients. | 2018 |
| Mouse cornea | Fibroblast growth factor-2 drives and maintains progressive corneal neovascularization following HSV-1 infection. | 2018 |
| Human non-small cell lung cancer | GAP43, a novel metastasis promoter in non-small cell lung cancer. | 2018 |
| Human meniscus | Gene expression profiles of the meniscus avascular phenotype: A guide for meniscus tissue engineering. | 2018 |
| Human blood | Genome-wide association study of telomere length among South Asians identifies a second RTEL1 association signal. | 2018 |
| Human gastrointestinal stromal tumor | Hydroxysteroid 11-Beta Dehydrogenase 1 Overexpression with Copy-Number Gain and Missense Mutations in Primary Gastrointestinal Stromal Tumors. | 2018 |
| Human hepatocytes | Identification of Retinoic Acid Receptor Agonists as Potent Hepatitis B Virus Inhibitors via a Drug Repurposing Screen. | 2018 |
| Human PBMC | In vitro marker gene expression analyses in human peripheral blood mononuclear cells: A tool to assess safety of influenza vaccines in humans. | 2018 |
| Human acral melanoma | Increased AURKA Gene Copy Number Correlates with Poor Prognosis and Predicts the Efficacy of High-dose Interferon Therapy in Acral Melanoma. | 2018 |
| Human PBMC | Integrative analysis reveals CD38 as a therapeutic target for plasma cell-rich pre-disease and established rheumatoid arthritis and systemic lupus erythematosus. | 2018 |
| Human placenta | Interindividual Regulation of the Breast Cancer Resistance Protein ABCG2 Transporter in Term Human Placentas. | 2018 |
| Mouse lung | Modeling for influenza vaccines and adjuvants profile for safety prediction system using gene expression profiling and statistical tools. | 2018 |
| Mouse skeletal muscle | Multiplex Quantification Identifies Novel Exercise-regulated Myokines/Cytokines in Plasma and in Glycolytic and Oxidative Skeletal Muscle. | 2018 |
| Human breast cancer | Optimization of a Multiplex RNA-based Expression Assay Using Breast Cancer Archival Material. | 2018 |
| Mouse kidney | Ozanimod (RPC1063), a selective S1PR1 and S1PR5 modulator, reduces chronic inflammation and alleviates kidney pathology in murine systemic lupus erythematosus. | 2018 |
| Human brain | Parahippocampal gyrus expression of endothelial and insulin receptor signaling pathway genes is modulated by Alzheimer's disease and normalized by treatment with anti-diabetic agents. | 2018 |
| Rat kidney | Pharmacological Characterization of IW-1973, a Novel Soluble Guanylate Cyclase Stimulator with Extensive Tissue Distribution, Antihypertensive, Anti-Inflammatory, and Antifibrotic Effects in Preclinical Models of Disease. | 2018 |
| Rat kidney | Prevention of chronic renal allograft rejection by AS2553627, a novel JAK inhibitor, in a rat transplantation model. | 2018 |
| Maize leaf | RNase If -treated quantitative PCR for dsRNA quantitation of RNAi trait in genetically modified crops. | 2018 |
| Human monocytes | Role of the IL-6-Receptor expression in CD14+ monocytes in modulating sleep in patients with bipolar disorder. | 2018 |
| Mouse CT26 tumor | Targeting the TGFβ pathway with galunisertib, a TGFβRI small molecule inhibitor, promotes anti-tumor immunity leading to durable, complete responses, as monotherapy and in combination with checkpoint blockade. | 2018 |
| Human melanoma | TERT copy gain predicts the outcome of high-dose interferon α-2b therapy in acral melanoma. | 2018 |
| Mouse CT26 tumor, EMT6 tumor, MC38 tumor | The CDK4/6 Inhibitor Abemaciclib Induces a T Cell Inflamed Tumor Microenvironment and Enhances the Efficacy of PD-L1 Checkpoint Blockade. | 2018 |
| Mouse bone marrow-derived macrophages | The influence of macrophage growth factors on Theiler's Murine Encephalomyelitis Virus (TMEV) infection and activation of macrophages. | 2018 |