Product References
TLR4 is one of the receptors for Chikungunya virus envelope protein E2 and regulates virus induced pro-inflammatory responses in host macrophages.
Frontiers in immunology
Mahish C,De S,Chatterjee S,Ghosh S,Keshry SS,Mukherjee T,Khamaru S,Tung KS,Subudhi BB,Chattopadhyay S,Chattopadhyay S
12-5321-82 was used in Flow cytometry/Cell sorting to report TLR4 as one of the novel receptors to facilitate the attachment and entry of CHIKV in host macrophages, the TLR4-CHIKV-E2 interactions are essential for efficient viral entry and modulation of infection-induced pro-inflammatory responses in host macrophages, which might have translational implication for designing future therapeutics to regulate the CHIKV infection.
Thu May 18 00:00:00 EDT 2023
Establishment and Characterization of Free-Floating 3D Macrophage Programming Model in the Presence of Cancer Cell Spheroids.
International journal of molecular sciences
Korotkaja K,Jansons J,Spunde K,Rudevica Z,Zajakina A
12-5321-82 was used in Flow cytometry/Cell sorting to establish and characterized a new in vitro 3D model for macrophage programming in the presence of cancer cell spheroids.
Wed Jun 28 00:00:00 EDT 2023
Meningeal lymphatic drainage promotes T cell responses against Toxoplasma gondii but is dispensable for parasite control in the brain.
eLife
Kovacs MA,Cowan MN,Babcock IW,Sibley LA,Still K,Batista SJ,Labuzan SA,Sethi I,Harris TH
12-5321-82 was used in Flow cytometry/Cell sorting to reveal that CNS lymphatic drainage supports the development of peripheral T cell responses against T. gondii but remains dispensable for immune protection of the brain.
Wed Dec 21 00:00:00 EST 2022
Bacterial Cellulose as Drug Delivery System for Optimizing Release of Immune Checkpoint Blocking Antibodies.
Pharmaceutics
Chung CK,Beekmann U,Kralisch D,Bierau K,Chan A,Ossendorp F,Cruz LJ
12-5321-82 was used in Flow cytometry/Cell sorting to inestigate bacterial cellulose (BC) as a delivery system for optimizing checkpoint-blocking antibody delivery.
Sat Jun 25 00:00:00 EDT 2022
Endogenous retroviruses promote homeostatic and inflammatory responses to the microbiota.
Cell
Lima-Junior DS,Krishnamurthy SR,Bouladoux N,Collins N,Han SJ,Chen EY,Constantinides MG,Link VM,Lim AI,Enamorado M,Cataisson C,Gil L,Rao I,Farley TK,Koroleva G,Attig J,Yuspa SH,Fischbach MA,Kassiotis G,Belkaid Y
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 12-5321-82) in Flow Cytometry
Thu Jul 08 00:00:00 EDT 2021
Blocking IL1 Beta Promotes Tumor Regression and Remodeling of the Myeloid Compartment in a Renal Cell Carcinoma Model: Multidimensional Analyses.
Clinical cancer research : an official journal of the American Association for Cancer Research
Aggen DH,Ager CR,Obradovic AZ,Chowdhury N,Ghasemzadeh A,Mao W,Chaimowitz MG,Lopez-Bujanda ZA,Spina CS,Hawley JE,Dallos MC,Zhang C,Wang V,Li H,Guo XV,Drake CG
12-5321 was used in Flow cytometry/Cell sorting to evaluate clinically relevant combinations of anti-IL-1b plus either anti-PD-1 or the multi-targeted tyrosine kinase inhibitor (TKI) cabozantinib.
Fri Jan 15 00:00:00 EST 2021
CD11b Deficiency Exacerbates Methicillin-Resistant Staphylococcus aureus-Induced Sepsis by Upregulating Inflammatory Responses of Macrophages.
Immune network
Sim H,Jeong D,Kim HI,Pak S,Thapa B,Kwon HJ,Lee K
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 12-5321-82) in Flow Cytometry
Thu Apr 01 00:00:00 EDT 2021
Prostaglandin E2 serves a dual role in regulating the migration of dendritic cells.
International journal of molecular medicine
Diao G,Huang J,Zheng X,Sun X,Tian M,Han J,Guo J
12-5321 was used in Flow cytometry/Cell sorting to elucidate the potential regulatory mechanism of PGE2 on the migration of dendritic cells.
Fri Jan 01 00:00:00 EST 2021
Prostaglandin E2 serves a dual role in regulating the migration of dendritic cells.
International journal of molecular medicine
Diao G,Huang J,Zheng X,Sun X,Tian M,Han J,Guo J
12-5321 was used in Flow cytometry/Cell sorting to elucidate the potential regulatory mechanism of PGE2 on the migration of dendritic cells.
Fri Jan 01 00:00:00 EST 2021
Wip1 regulates the immunomodulatory effects of murine mesenchymal stem cells in type 1 diabetes mellitus via targeting IFN-α/BST2.
Cell death discovery
Zhou N,Liu W,Zhang W,Liu Y,Li X,Wang Y,Zheng R,Zhang Y
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 12-5321-82) in Flow Cytometry
Fri Oct 29 00:00:00 EDT 2021
Topical arginase inhibition decreases growth of cutaneous squamous cell carcinoma.
Scientific reports
Mittal A,Wang M,Vidyarthi A,Yanez D,Pizzurro G,Thakral D,Tracy E,Colegio OR
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 12-5321-82) in Flow Cytometry
Mon May 24 00:00:00 EDT 2021
Targeting Phosphatidylserine Enhances the Anti-tumor Response to Tumor-Directed Radiation Therapy in a Preclinical Model of Melanoma.
Cell reports
Budhu S,Giese R,Gupta A,Fitzgerald K,Zappasodi R,Schad S,Hirschhorn D,Campesato LF,De Henau O,Gigoux M,Liu C,Mazo G,Deng L,Barker CA,Wolchok JD,Merghoub T
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 12-5321-82) in Flow Cytometry
Tue Jan 12 00:00:00 EST 2021
MiR-19a-3p Suppresses M1 Macrophage Polarization by Inhibiting STAT1/IRF1 Pathway.
Frontiers in pharmacology
Zhu X,Guo Q,Zou J,Wang B,Zhang Z,Wei R,Zhao L,Zhang Y,Chu C,Fu X,Li X
12-5321 was used in Flow cytometry/Cell sorting to confirm that miR-19a-3p, as a direct regulator of STAT1, inhibited M1 macrophages polarization.
Sun May 23 00:00:00 EDT 2021
Smek1 deficiency exacerbates experimental autoimmune encephalomyelitis by activating proinflammatory microglia and suppressing the IDO1-AhR pathway.
Journal of neuroinflammation
Duan RN,Yang CL,Du T,Liu A,Wang AR,Sun WJ,Li X,Li JX,Yan CZ,Liu QJ
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 12-5321-82) in Flow Cytometry
Mon Jun 28 00:00:00 EDT 2021
Frequent amplification of HDAC genes and efficacy of HDAC inhibitor chidamide and PD-1 blockade combination in soft tissue sarcoma.
Journal for immunotherapy of cancer
Que Y,Zhang XL,Liu ZX,Zhao JJ,Pan QZ,Wen XZ,Xiao W,Xu BS,Hong DC,Guo TH,Shen LJ,Fan WJ,Chen HY,Weng DS,Xu HR,Zhou PH,Zhang YZ,Niu XH,Zhang X
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 12-5321-82) in Flow Cytometry
Mon Feb 01 00:00:00 EST 2021
Early activation of the cardiac CX3CL1/CX3CR1 axis delays β-adrenergic-induced heart failure.
Scientific reports
Flamant M,Mougenot N,Balse E,Le Fèvre L,Atassi F,Gautier EL,Le Goff W,Keck M,Nadaud S,Combadière C,Boissonnas A,Pavoine C
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 12-5321-82) in Flow Cytometry
Thu Sep 09 00:00:00 EDT 2021
A two-adjuvant multiantigen candidate vaccine induces superior protective immune responses against SARS-CoV-2 challenge.
Cell reports
Jiang W,Shi L,Cai L,Wang X,Li J,Li H,Liang J,Gu Q,Ji G,Li J,Liu L,Sun M
12-5321-82 was used in Flow cytometry/Cell sorting to suggest that the developed vaccine can elicit a multifaceted immune response and induce robust viral clearance in the URT, which makes it a potential vaccine for preventing disease and infection of SARS-CoV-2.
Tue Dec 14 00:00:00 EST 2021
PP2Cδ Controls the Differentiation and Function of Dendritic Cells Through Regulating the NSD2/mTORC2/ACLY Pathway.
Frontiers in immunology
Lv N,Jin S,Liang Z,Wu X,Kang Y,Su L,Dong Y,Wang B,Ma T,Shi L
12-5321-82 was used in Flow Cytometry to show that the phosphatase PP2Cδ played a pivotal role in regulating dendritic cells (DC) activation and function, as PP2Cδ ablation caused aberrant maturation, activation, and Th1/Th17-priming of DCs, and hence induced onset of exacerbated experimental autoimmune encephalomyelitis.
Mon Feb 28 00:00:00 EST 2022
PP2Cδ Controls the Differentiation and Function of Dendritic Cells Through Regulating the NSD2/mTORC2/ACLY Pathway.
Frontiers in immunology
Lv N,Jin S,Liang Z,Wu X,Kang Y,Su L,Dong Y,Wang B,Ma T,Shi L
12-5321-82 was used in Flow Cytometry to show that the phosphatase PP2Cδ played a pivotal role in regulating dendritic cells (DC) activation and function, as PP2Cδ ablation caused aberrant maturation, activation, and Th1/Th17-priming of DCs, and hence induced onset of exacerbated experimental autoimmune encephalomyelitis.
Mon Feb 28 00:00:00 EST 2022
Epinephrine Production in Th17 Cells and Experimental Autoimmune Encephalitis.
Frontiers in immunology
Yang P,Tian H,Zou YR,Chambon P,Ichinose H,Honig G,Diamond B,Kim SJ
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 12-5321-82) in Flow Cytometry
Mon Jul 05 00:00:00 EDT 2021
The subunits of IL-12, originating from two distinct cells, can functionally synergize to protect against pathogen dissemination in vivo.
Cell reports
Gerber AN,Abdi K,Singh NJ
12-5321-82 was used in Flow cytometry/Cell sorting to suggest that early secretion of IL-12p40 monomers by sentinel cells at the infection site may help prepare distal host tissues for potential pathogen arrival.
Tue Oct 12 00:00:00 EDT 2021
Serum Amyloid A Proteins Induce Pathogenic Th17 Cells and Promote Inflammatory Disease.
Cell
Lee JY,Hall JA,Kroehling L,Wu L,Najar T,Nguyen HH,Lin WY,Yeung ST,Silva HM,Li D,Hine A,Loke P,Hudesman D,Martin JC,Kenigsberg E,Merad M,Khanna KM,Littman DR
12-5321 was used in Flow cytometry/Cell sorting to suggest that serum amyloid A proteins direct a pathogenic pro-inflammatory Th17 cell differentiation program and promote Th17-mediated inflammatory diseases.
Thu Jan 09 00:00:00 EST 2020
The Cytokine TGF-β Induces Interleukin-31 Expression from Dermal Dendritic Cells to Activate Sensory Neurons and Stimulate Wound Itching.
Immunity
Xu J,Zanvit P,Hu L,Tseng PY,Liu N,Wang F,Liu O,Zhang D,Jin W,Guo N,Han Y,Yin J,Cain A,Hoon MA,Wang S,Chen W
12-5321 was used in Flow cytometry/Cell sorting to investigate the mechanisms underlying itching associated with cutaneous wound healing, focusing on the contribution of soluble factors released during healing.
Tue Aug 18 00:00:00 EDT 2020
Glufosinate constrains synchronous and metachronous metastasis by promoting anti-tumor macrophages.
EMBO molecular medicine
Menga A,Serra M,Todisco S,Riera-Domingo C,Ammarah U,Ehling M,Palmieri EM,Di Noia MA,Gissi R,Favia M,Pierri CL,Porporato PE,Castegna A,Mazzone M
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 12-5321-82) in Flow Cytometry
Wed Oct 07 00:00:00 EDT 2020
Thermosensitive hydrogels as sustained drug delivery system for CTLA-4 checkpoint blocking antibodies.
Journal of controlled release : official journal of the Controlled Release Society
Chung CK,Fransen MF,van der Maaden K,Campos Y,García-Couce J,Kralisch D,Chan A,Ossendorp F,Cruz LJ
12-5321-82 was used in Flow Cytometry to conclude that P407 hydrogels represent promising delivery systems for the optimization of CTLA-4 blocking therapy.
Fri Jul 10 00:00:00 EDT 2020
Podocytes present antigen to activate specific T cell immune responses in inflammatory renal disease.
The Journal of pathology
Li S,Liu Y,He Y,Rong W,Zhang M,Li L,Liu Z,Zen K
12-5321-82 was used in Flow cytometry/Cell sorting to report that inflammatory cytokine-promoted antigen presentation by podocytes is a key for recruiting and activating specific T cells.
Thu Oct 01 00:00:00 EDT 2020
Podocytes present antigen to activate specific T cell immune responses in inflammatory renal disease.
The Journal of pathology
Li S,Liu Y,He Y,Rong W,Zhang M,Li L,Liu Z,Zen K
12-5321-82 was used in Flow cytometry/Cell sorting to report that inflammatory cytokine-promoted antigen presentation by podocytes is a key for recruiting and activating specific T cells.
Thu Oct 01 00:00:00 EDT 2020
Regulating colonic dendritic cells by commensal glycosylated large surface layer protein A to sustain gut homeostasis against pathogenic inflammation.
Mucosal immunology
Ge Y,Gong M,Zadeh M,Li J,Abbott JR,Li W,Morel L,Sonon R,Supekar NT,Azadi P,Wang Y,Jones DP,Li S,Mohamadzadeh M
12-5321 was used in Flow cytometry/Cell sorting to study the molecular mechanisms responsible for regulating gut homeostasis.
Wed Jan 01 00:00:00 EST 2020
E6‑regulated overproduction of prostaglandin E2 may inhibit migration of dendritic cells in human papillomavirus 16‑positive cervical lesions.
International journal of oncology
Huang J,Diao G,Zhang Q,Chen Y,Han J,Guo J
12-5321 was used in Flow cytometry/Cell sorting to study whether E6 increases the expression levels of PGE2 in cervical lesions, which could eventually induce inhibition of the migration of DCs.
Wed Apr 01 00:00:00 EDT 2020
E6‑regulated overproduction of prostaglandin E2 may inhibit migration of dendritic cells in human papillomavirus 16‑positive cervical lesions.
International journal of oncology
Huang J,Diao G,Zhang Q,Chen Y,Han J,Guo J
12-5321 was used in Flow cytometry/Cell sorting to study whether E6 increases the expression levels of PGE2 in cervical lesions, which could eventually induce inhibition of the migration of DCs.
Wed Apr 01 00:00:00 EDT 2020
Induced pluripotent stem cells reprogrammed from primary dendritic cells provide an abundant source of immunostimulatory dendritic cells for use in immunotherapy.
Stem cells (Dayton, Ohio)
Horton C,Davies TJ,Lahiri P,Sachamitr P,Fairchild PJ
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 12-5321-82) in Flow Cytometry
Wed Jan 01 00:00:00 EST 2020
Induced pluripotent stem cells reprogrammed from primary dendritic cells provide an abundant source of immunostimulatory dendritic cells for use in immunotherapy.
Stem cells (Dayton, Ohio)
Horton C,Davies TJ,Lahiri P,Sachamitr P,Fairchild PJ
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 12-5321-82) in Flow Cytometry
Wed Jan 01 00:00:00 EST 2020
Senescence-associated secretory phenotype promotes chronic ocular graft-vs-host disease in mice and humans.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Yamane M,Sato S,Shimizu E,Shibata S,Hayano M,Yaguchi T,Kamijuku H,Ogawa M,Suzuki T,Mukai S,Shimmura S,Okano H,Takeuchi T,Kawakami Y,Ogawa Y,Tsubota K
12-5321-82 was used in Immunohistochemistry to elucidate an additional pathway of chronic ocular chronic graft-vs-host disease.
Sat Aug 01 00:00:00 EDT 2020
FAT10 localises in dendritic cell aggresome-like induced structures and contributes to their disassembly.
Journal of cell science
Schregle R,Mueller S,Legler DF,Rossy J,Krueger WA,Groettrup M
12-5321 was used in Flow cytometry/Cell sorting to report further evidence that FAT10 is involved in antigen processing, which may provide a functional rationale as to why FAT10 is selectively induced upon DC maturation.
Thu Jul 16 00:00:00 EDT 2020
Antitumor immunity targeting fibroblast activation protein-α in a mouse Lewis lung carcinoma model.
Oncology letters
Xie J,Yuan S,Peng L,Li H,Niu L,Xu H,Guo X,Yang M,Duan F
12-5321 was used in Flow cytometry/Cell sorting to investigate the use of CAFs-targeted immunotherapy to fibroblast activation protein-α (FAP-α) expressed in CAFs.
Wed Jul 01 00:00:00 EDT 2020
IFN-β signalling regulates RAW 264.7 macrophage activation, cytokine production, and killing activity.
Innate immunity
Karimi Y,Giles EC,Vahedi F,Chew MV,Nham T,Loukov D,Lee AJ,Bowdish DM,Ashkar AA
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 12-5321-82) in Flow Cytometry
Wed Apr 01 00:00:00 EDT 2020
Dietary Glucose Consumption Promotes RALDH Activity in Small Intestinal CD103+CD11b+ Dendritic Cells.
Frontiers in immunology
Ko HJ,Hong SW,Verma R,Jung J,Lee M,Kim N,Kim D,Surh CD,Kim KS,Rudra D,Im SH
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 12-5321-82) in Flow Cytometry
Mon Apr 19 00:00:00 EDT 2021
GDF3 Protects Mice against Sepsis-Induced Cardiac Dysfunction and Mortality by Suppression of Macrophage Pro-Inflammatory Phenotype.
Cells
Wang L,Li Y,Wang X,Wang P,Essandoh K,Cui S,Huang W,Mu X,Liu Z,Wang Y,Peng T,Fan GC
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 12-5321-82) in Flow Cytometry
Fri Jan 03 00:00:00 EST 2020
Diversity in medullary thymic epithelial cells controls the activity and availability of iNKT cells.
Nature communications
Lucas B,White AJ,Cosway EJ,Parnell SM,James KD,Jones ND,Ohigashi I,Takahama Y,Jenkinson WE,Anderson G
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 12-5321-82) in Flow Cytometry
Mon May 04 00:00:00 EDT 2020
Smooth muscle-derived progenitor cell myofibroblast differentiation through KLF4 downregulation promotes arterial remodeling and fibrosis.
JCI insight
Lu S,Jolly AJ,Strand KA,Dubner AM,Mutryn MF,Moulton KS,Nemenoff RA,Majesky MW,Weiser-Evans MC
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 12-5321-82) in Flow Cytometry
Thu Dec 03 00:00:00 EST 2020
Hyaluronan Degradation by Cemip Regulates Host Defense against Staphylococcus aureus Skin Infection.
Cell reports
Dokoshi T,Zhang LJ,Li F,Nakatsuji T,Butcher A,Yoshida H,Shimoda M,Okada Y,Gallo RL
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 12-5321-82) in Flow Cytometry
Tue Jan 07 00:00:00 EST 2020
Ly6cLo non-classical monocytes promote resolution of rhesus rotavirus-mediated perinatal hepatic inflammation.
Scientific reports
Alkhani A,Levy CS,Tsui M,Rosenberg KA,Polovina K,Mattis AN,Mack M,Van Dyken S,Wang BM,Maher JJ,Nijagal A
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 12-5321-82) in Flow Cytometry
Tue Apr 28 00:00:00 EDT 2020
MiR-103 protects from recurrent spontaneous abortion via inhibiting STAT1 mediated M1 macrophage polarization.
International journal of biological sciences
Zhu X,Liu H,Zhang Z,Wei R,Zhou X,Wang Z,Zhao L,Guo Q,Zhang Y,Chu C,Wang L,Li X
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 12-5321-82) in Flow Cytometry
Fri Nov 12 00:00:00 EST 2021
MiR-103 protects from recurrent spontaneous abortion via inhibiting STAT1 mediated M1 macrophage polarization.
International journal of biological sciences
Zhu X,Liu H,Zhang Z,Wei R,Zhou X,Wang Z,Zhao L,Guo Q,Zhang Y,Chu C,Wang L,Li X
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 12-5321-82) in Flow Cytometry
Fri Nov 12 00:00:00 EST 2021
Cancer cell-intrinsic expression of MHC II in lung cancer cell lines is actively restricted by MEK/ERK signaling and epigenetic mechanisms.
Journal for immunotherapy of cancer
Neuwelt AJ,Kimball AK,Johnson AM,Arnold BW,Bullock BL,Kaspar RE,Kleczko EK,Kwak JW,Wu MH,Heasley LE,Doebele RC,Li HY,Nemenoff RA,Clambey ET
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 12-5321-82) in Flow Cytometry
Wed Apr 01 00:00:00 EDT 2020
Immunomodulatory Effects of Recombinant Mycobacterium smegmatis Expressing Antigen-85B Epitopes in Infected J774A.1 Murine Macrophages.
Pathogens (Basel, Switzerland)
Kadir NA,Acosta A,Sarmiento ME,Norazmi MN
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 12-5321-82) in Flow Cytometry
Sun Nov 29 00:00:00 EST 2020
Immunomodulatory Effects of Recombinant Mycobacterium smegmatis Expressing Antigen-85B Epitopes in Infected J774A.1 Murine Macrophages.
Pathogens (Basel, Switzerland)
Kadir NA,Acosta A,Sarmiento ME,Norazmi MN
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 12-5321-82) in Flow Cytometry
Sun Nov 29 00:00:00 EST 2020
Artificial Mini Dendritic Cells Boost T Cell-Based Immunotherapy for Ovarian Cancer.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Cheng S,Xu C,Jin Y,Li Y,Zhong C,Ma J,Yang J,Zhang N,Li Y,Wang C,Yang Z,Wang Y
12-5321-82 was used in Flow Cytometry to suggest that mini dendritic cell (DC) may serve as a facile and potent vaccine to boost anticancer immunotherapy.
Wed Apr 01 00:00:00 EDT 2020
Optimized Protocol for Isolation of Small Extracellular Vesicles from Human and Murine Lymphoid Tissues.
International journal of molecular sciences
Bordas M,Genard G,Ohl S,Nessling M,Richter K,Roider T,Dietrich S,Maaß KK,Seiffert M
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 12-5321-82) in Flow Cytometry
Tue Aug 04 00:00:00 EDT 2020
Skeletal muscle healing by M1-like macrophages produced by transient expression of exogenous GM-CSF.
Stem cell research & therapy
Martins L,Gallo CC,Honda TSB,Alves PT,Stilhano RS,Rosa DS,Koh TJ,Han SW
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 12-5321-82) in Flow Cytometry
Fri Nov 06 00:00:00 EST 2020
Blockade of the AHR restricts a Treg-macrophage suppressive axis induced by L-Kynurenine.
Nature communications
Campesato LF,Budhu S,Tchaicha J,Weng CH,Gigoux M,Cohen IJ,Redmond D,Mangarin L,Pourpe S,Liu C,Zappasodi R,Zamarin D,Cavanaugh J,Castro AC,Manfredi MG,McGovern K,Merghoub T,Wolchok JD
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 12-5321-82) in Flow Cytometry
Tue Aug 11 00:00:00 EDT 2020
Identification of atypical mitogen-activated protein kinase MAPK4 as a novel regulator in acute lung injury.
Cell & bioscience
Mao L,Zhou Y,Chen L,Hu L,Liu S,Zheng W,Zhao J,Guo M,Chen C,He Z,Xu L
12-5321-82 was used in Flow Cytometry to reveal an unknown role of atypical MAPKs member MAPK4 in the pathology of acute lung injury.
Sun Apr 17 00:00:00 EDT 2022
Lactobacillus reuteri 5454 and Bifidobacterium animalis ssp. lactis 5764 improve colitis while differentially impacting dendritic cells maturation and antimicrobial responses.
Scientific reports
Hrdý J,Alard J,Couturier-Maillard A,Boulard O,Boutillier D,Delacre M,Lapadatescu C,Cesaro A,Blanc P,Pot B,Ryffel B,Chamaillard M,Grangette C
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 12-5321-82) in Flow Cytometry
Tue Mar 24 00:00:00 EDT 2020
Nuclear imaging-guided PD-L1 blockade therapy increases effectiveness of cancer immunotherapy.
Journal for immunotherapy of cancer
Gao H,Wu Y,Shi J,Zhang X,Liu T,Hu B,Jia B,Wan Y,Liu Z,Wang F
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 12-5321-82) in Flow Cytometry
Sun Nov 01 00:00:00 EDT 2020
Analysis of Myeloid Cells in Mouse Tissues with Flow Cytometry.
STAR protocols
Liu Z,Gu Y,Shin A,Zhang S,Ginhoux F
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 12-5321-82) in Flow Cytometry
Fri Jun 19 00:00:00 EDT 2020
CDK4/6 inhibition promotes immune infiltration in ovarian cancer and synergizes with PD-1 blockade in a B cell-dependent manner.
Theranostics
Zhang QF,Li J,Jiang K,Wang R,Ge JL,Yang H,Liu SJ,Jia LT,Wang L,Chen BL
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 12-5321-82) in Flow Cytometry
Tue Jun 01 00:00:00 EDT 2021
Tregitopes regulate the tolerogenic immune response and decrease the foetal death rate in abortion-prone mouse matings.
Scientific reports
Kedzierska AE,Lorek D,Slawek A,Chelmonska-Soyta A
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 12-5321-82) in Flow Cytometry
Mon Jun 29 00:00:00 EDT 2020
Manipulation of the tumor microenvironment by cytokine gene transfection enhances dendritic cell-based immunotherapy.
FASEB bioAdvances
Wijesekera DPH,Yuba E,De Silva NH,Watanabe SI,Tsukamoto M,Ichida C,Izawa T,Itoh K,Kanegi R,Hatoya S,Yamate J,Inaba T,Sugiura K
12-5321-82 was used in Flow Cytometry to manipulate the microenvironment so as to elicit activation of T helper type 1 (Th1) responses and the maturation of dendritic cells (DCs).
Wed Jan 01 00:00:00 EST 2020
Polyanhydride Nanoparticles Induce Low Inflammatory Dendritic Cell Activation Resulting in CD8+ T Cell Memory and Delayed Tumor Progression.
International journal of nanomedicine
Darling R,Senapati S,Christiansen J,Liu L,Ramer-Tait AE,Narasimhan B,Wannemuehler M
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 12-5321-82) in Flow Cytometry
Mon Dec 07 00:00:00 EST 2020
Neutrophil Extracellular Traps Confine Pseudomonas aeruginosa Ocular Biofilms and Restrict Brain Invasion.
Cell host & microbe
Thanabalasuriar A,Scott BNV,Peiseler M,Willson ME,Zeng Z,Warrener P,Keller AE,Surewaard BGJ,Dozier EA,Korhonen JT,Cheng LI,Gadjeva M,Stover CK,DiGiandomenico A,Kubes P
12-5321 was used in Flow cytometry/Cell sorting to conclude that blocking both Psl and T3SS together with antibiotic treatment broke down the biofilm and reversed keratitis, suggesting future therapeutic strategies for this intractable infection.
Wed Apr 10 00:00:00 EDT 2019
cGAS/STING axis mediates a topoisomerase II inhibitor-induced tumor immunogenicity.
The Journal of clinical investigation
Wang Z,Chen J,Hu J,Zhang H,Xu F,He W,Wang X,Li M,Lu W,Zeng G,Zhou P,Huang P,Chen S,Li W,Xia LP,Xia X
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 12-5321-82) in Flow Cytometry
Tue Aug 13 00:00:00 EDT 2019
Classical dendritic cells regulate acute lung inflammation and injury in mice with lipopolysaccharide‑induced acute respiratory distress syndrome.
International journal of molecular medicine
Li L,Dong L,Zhao D,Gao F,Yan J
12-5321-82 was used in Flow Cytometry to explore the regulatory effects of pulmonary cDCs on acute lung inflammation and injury in lipopolysaccharide (LPS)‚induced ARDS.
Thu Aug 01 00:00:00 EDT 2019
Antiallodynic Effects of Cannabinoid Receptor 2 (CB2R) Agonists on Retrovirus Infection-Induced Neuropathic Pain.
Pain research & management
Sheng WS,Chauhan P,Hu S,Prasad S,Lokensgard JR
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 12-5321-82) in Flow Cytometry
Mon Dec 16 00:00:00 EST 2019
MDM2 inhibitor APG-115 synergizes with PD-1 blockade through enhancing antitumor immunity in the tumor microenvironment.
Journal for immunotherapy of cancer
Fang DD,Tang Q,Kong Y,Wang Q,Gu J,Fang X,Zou P,Rong T,Wang J,Yang D,Zhai Y
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 12-5321-82) in Flow Cytometry
Thu Nov 28 00:00:00 EST 2019
Selective HDAC6 inhibitors improve anti-PD-1 immune checkpoint blockade therapy by decreasing the anti-inflammatory phenotype of macrophages and down-regulation of immunosuppressive proteins in tumor cells.
Scientific reports
Knox T,Sahakian E,Banik D,Hadley M,Palmer E,Noonepalle S,Kim J,Powers J,Gracia-Hernandez M,Oliveira V,Cheng F,Chen J,Barinka C,Pinilla-Ibarz J,Lee NH,Kozikowski A,Villagra A
12-5321-82 was used in Flow Cytometry to reveal the cellular components that mediate the effect selective inhibition of HDAC6 on decreasing tumour growth in several malignancies.
Tue Apr 16 00:00:00 EDT 2019
Mutations in topoisomerase IIβ result in a B cell immunodeficiency.
Nature communications
Broderick L,Yost S,Li D,McGeough MD,Booshehri LM,Guaderrama M,Brydges SD,Kucharova K,Patel NC,Harr M,Hakonarson H,Zackai E,Cowell IG,Austin CA,Hügle B,Gebauer C,Zhang J,Xu X,Wang J,Croker BA,Frazer KA,Putnam CD,Hoffman HM
12-5321-82 was used in Flow Cytometry to identify mutations in type II topoisomerase as a driver of defective proliferation and survival of B2 cells, leading to a B cell immunodeficiency.
Tue Aug 13 00:00:00 EDT 2019
Bacteroides fragilis polysaccharide A induces IL-10 secreting B and T cells that prevent viral encephalitis.
Nature communications
Ramakrishna C,Kujawski M,Chu H,Li L,Mazmanian SK,Cantin EM
12-5321 was used in Flow cytometry/Cell sorting to study polysaccharide A as an immunomodulatory symbiosis factor whcih coordinates anti-inflammatory responses during viral infections.
Tue May 14 00:00:00 EDT 2019
Evaluation of antiviral - passive - active immunization ("sandwich") therapeutic strategy for functional cure of chronic hepatitis B in mice.
EBioMedicine
Shi B,Wu Y,Wang C,Li X,Yu F,Wang B,Yang Z,Li J,Liang M,Wen Y,Ying T,Yuan Z
12-5321 was used in Immunohistochemistry-immunofluorescence to show "sandwich" combination therapy consisting of antiviral, passive and active immunization may be effective for chronic hepatitis B as it efficiently decreases HBsAg and HBV DNA levels and induces cellular and humoral immunity.
Fri Nov 01 00:00:00 EDT 2019
Initiation of Antiviral B Cell Immunity Relies on Innate Signals from Spatially Positioned NKT Cells.
Cell
Gaya M,Barral P,Burbage M,Aggarwal S,Montaner B,Warren Navia A,Aid M,Tsui C,Maldonado P,Nair U,Ghneim K,Fallon PG,Sekaly RP,Barouch DH,Shalek AK,Bruckbauer A,Strid J,Batista FD
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 12-5321-82) in Flow Cytometry
Thu Jan 25 00:00:00 EST 2018
CNS lymphatic drainage and neuroinflammation are regulated by meningeal lymphatic vasculature.
Nature neuroscience
Louveau A,Herz J,Alme MN,Salvador AF,Dong MQ,Viar KE,Herod SG,Knopp J,Setliff JC,Lupi AL,Da Mesquita S,Frost EL,Gaultier A,Harris TH,Cao R,Hu S,Lukens JR,Smirnov I,Overall CC,Oliver G,Kipnis J
12-5321 was used in Flow cytometry/Cell sorting to demonstrate that meningeal lymphatics fulfill two critical criteria: they assist in the drainage of cerebrospinal fluid components and enable immune cells to enter draining lymph nodes in a CCR7-dependent manner.
Mon Oct 01 00:00:00 EDT 2018
Macrophage-specific MHCII expression is regulated by a remote Ciita enhancer controlled by NFAT5.
The Journal of experimental medicine
Buxadé M,Huerga Encabo H,Riera-Borrull M,Quintana-Gallardo L,López-Cotarelo P,Tellechea M,Martínez-Martínez S,Redondo JM,Martín-Caballero J,Flores JM,Bosch E,Rodríguez-Fernández JL,Aramburu J,López-Rodríguez C
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 12-5321-82) in Flow Cytometry
Mon Nov 05 00:00:00 EST 2018
Functional antagonism of sphingosine-1-phosphate receptor 1 prevents cuprizone-induced demyelination.
Glia
Kim S,Bielawski J,Yang H,Kong Y,Zhou B,Li J
12-5321-82 was used in Immunohistochemistry to identify functional antagonism of S1PR1 as a major mechanism for the protective effect of FTY720 in the cuprizone model and suggests pathogenic contributions of astrocyte S1PR1 signaling in primary demyelination and its potential as a therapeutic target for CNS inflammation.
Thu Mar 01 00:00:00 EST 2018
Effect of immune tolerance induced by immature dendritic cells and CTLA4-Ig on systemic lupus erythematosus: An in vivo study.
Experimental and therapeutic medicine
Huang C,Zhang L,Ling F,Wen S,Luo Y,Liu H,Liu J,Zheng W,Liang M,Sun J,Lin YK
12-5321-82 was used in Flow Cytometry to suggest that combined treatment with IL-10-DCs and CTLA4-Ig may be a promising novel therapeutic strategy for the treatment of SLE.
Thu Mar 01 00:00:00 EST 2018
FACS isolation of live mouse eosinophils at high purity via a protocol that does not target Siglec F.
Journal of immunological methods
Geslewitz WE,Percopo CM,Rosenberg HF
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 12-5321-82) in Flow Cytometry
Thu Mar 01 00:00:00 EST 2018
Myeloid apolipoprotein E controls dendritic cell antigen presentation and T cell activation.
Nature communications
Bonacina F,Coe D,Wang G,Longhi MP,Baragetti A,Moregola A,Garlaschelli K,Uboldi P,Pellegatta F,Grigore L,Da Dalt L,Annoni A,Gregori S,Xiao Q,Caruso D,Mitro N,Catapano AL,Marelli-Berg FM,Norata GD
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 12-5321-82) in Flow Cytometry
Mon Aug 06 00:00:00 EDT 2018
CD4+ T cells are activated in regional lymph nodes and migrate to skin to initiate lymphedema.
Nature communications
García Nores GD,Ly CL,Cuzzone DA,Kataru RP,Hespe GE,Torrisi JS,Huang JJ,Gardenier JC,Savetsky IL,Nitti MD,Yu JZ,Rehal S,Mehrara BJ
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 12-5321-82) in Flow Cytometry
Thu May 17 00:00:00 EDT 2018
Lin-CCR2+ hematopoietic stem and progenitor cells overcome resistance to PD-1 blockade.
Nature communications
Flores CT,Wildes TJ,Drake JA,Moore GL,Dean BD,Abraham RS,Mitchell DA
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 12-5321-82) in Flow Cytometry
Wed Oct 17 00:00:00 EDT 2018
Streamlining volumetric multi-channel image cytometry using hue-saturation-brightness-based surface creation.
Communications biology
Tan Y,Li JLY,Goh CC,Lee BTK,Kwok IWH,Ng WJ,Evrard M,Poidinger M,Tey HL,Ng LG
12-5321 was used in Flow cytometry/Cell sorting to streamline volumetric multi-channel image cytometry using hue-saturation-brightness-based surface creation.
Sat Jan 11 00:00:00 EST 2020
Dichotomous Expression of TNF Superfamily Ligands on Antigen-Presenting Cells Controls Post-priming Anti-viral CD4+ T Cell Immunity.
Immunity
Chang YH,Wang KC,Chu KL,Clouthier DL,Tran AT,Torres Perez MS,Zhou AC,Abdul-Sater AA,Watts TH
12-5321-82 was used in Flow Cytometry to investigate how different subtypes of T cell antigen-presenting cell contribute to determining viral set point and disease outcome.
Tue Nov 21 00:00:00 EST 2017
A CCR4 antagonist reverses the tumor-promoting microenvironment of renal cancer.
The Journal of clinical investigation
Berlato C,Khan MN,Schioppa T,Thompson R,Maniati E,Montfort A,Jangani M,Canosa M,Kulbe H,Hagemann UB,Duncan AR,Fletcher L,Wilkinson RW,Powles T,Quezada SA,Balkwill FR
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 12-5321-82) in Flow Cytometry
Wed Mar 01 00:00:00 EST 2017
Biopolymers codelivering engineered T cells and STING agonists can eliminate heterogeneous tumors.
The Journal of clinical investigation
Smith TT,Moffett HF,Stephan SB,Opel CF,Dumigan AG,Jiang X,Pillarisetty VG,Pillai SPS,Wittrup KD,Stephan MT
12-5321 was used in Flow cytometry/Cell sorting to evaluate a novel biopolymer codelivery device for CAR T cell immunotherapy and stimulator of IFN genes agonists on solid tumour clearance in mice.
Thu Jun 01 00:00:00 EDT 2017
Anti-CD137 Suppresses Tumor Growth by Blocking Reverse Signaling by CD137 Ligand.
Cancer research
Kang SW,Lee SC,Park SH,Kim J,Kim HH,Lee HW,Seo SK,Kwon BS,Cho HR,Kwon B
12-5321-82 was used in Flow Cytometry to report findings related to reverse signaling by CD137 ligand (CD137L) in antigen-presenting dendritic cells (DC) in tumors that address these paradoxical results.
Wed Nov 01 00:00:00 EDT 2017
Prolonged Deleterious Influences of Chemotherapeutic Agent CPT-11 on Resident Peritoneal Macrophages and B1 Cells.
Frontiers in immunology
Bai WJ,Li CG,Zhang CC,Xu LH,Zeng QZ,Hu B,Hong Z,He XH,Ouyang DY
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 12-5321-82) in Flow Cytometry
Wed Nov 20 00:00:00 EST 2019
Early Microglia Activation Precedes Photoreceptor Degeneration in a Mouse Model of CNGB1-Linked Retinitis Pigmentosa.
Frontiers in immunology
Blank T,Goldmann T,Koch M,Amann L,Schön C,Bonin M,Pang S,Prinz M,Burnet M,Wagner JE,Biel M,Michalakis S
12-5321 was used in Flow cytometry/Cell sorting to study microglia activation in the development of retinitis pigmentosa.
Wed Nov 20 00:00:00 EST 2019
Peripheral administration of the soluble TNF inhibitor XPro1595 modifies brain immune cell profiles, decreases beta-amyloid plaque load, and rescues impaired long-term potentiation in 5xFAD mice.
Neurobiology of disease
MacPherson KP,Sompol P,Kannarkat GT,Chang J,Sniffen L,Wildner ME,Norris CM,Tansey MG
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 12-5321-82) in Flow Cytometry
Thu Jun 01 00:00:00 EDT 2017
VAMP8-mediated NOX2 recruitment to endosomes is necessary for antigen release.
European journal of cell biology
Dingjan I,Paardekooper LM,Verboogen DRJ,von Mollard GF,Ter Beest M,van den Bogaart G
12-5321 was used in Flow cytometry/Cell sorting to show VAMP8-mediates trafficking of NOX2 to endosomes and phagosomes and this promotes induction of cytolytic T cell immune responses.
Sun Oct 01 00:00:00 EDT 2017
TRAIL signaling is proinflammatory and proviral in a murine model of rhinovirus 1B infection.
American journal of physiology. Lung cellular and molecular physiology
Girkin JL,Hatchwell LM,Collison AM,Starkey MR,Hansbro PM,Yagita H,Foster PS,Mattes J
12-5321 was used in Flow cytometry/Cell sorting to elucidate the role of TRAIL during rhinovirus infection in vivo.
Sun Jan 01 00:00:00 EST 2017
Discrimination of the heterogeneity of bone marrow‑derived dendritic cells.
Molecular medicine reports
Wang J,Dai X,Hsu C,Ming C,He Y,Zhang J,Wei L,Zhou P,Wang CY,Yang J,Gong N
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 12-5321-82) in Flow Cytometry
Wed Nov 01 00:00:00 EDT 2017
Loss of IRF2BP2 in Microglia Increases Inflammation and Functional Deficits after Focal Ischemic Brain Injury.
Frontiers in cellular neuroscience
Cruz SA,Hari A,Qin Z,Couture P,Huang H,Lagace DC,Stewart AFR,Chen HH
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 12-5321-82) in Flow Cytometry
Thu Mar 17 00:00:00 EDT 2022
Role of a novel immune modulating DDR2-expressing population in silica-induced pulmonary fibrosis.
PloS one
McDonald LT,Johnson SD,Russell DL,Young MRI,LaRue AC
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 12-5321-82) in Flow Cytometry
Mon Sep 25 00:00:00 EDT 2017
Paeoniflorin Ameliorates Experimental Autoimmune Encephalomyelitis via Inhibition of Dendritic Cell Function and Th17 Cell Differentiation.
Scientific reports
Zhang H,Qi Y,Yuan Y,Cai L,Xu H,Zhang L,Su B,Nie H
12532182 was used in flow cytometry to test the effect of paeoniflorin in experimental autoimmune encephalomyelitis, an animal model for multiple sclerosis
Mon Feb 06 00:00:00 EST 2017
Azacytidine prevents experimental xenogeneic graft-versus-host disease without abrogating graft-versus-leukemia effects.
Oncoimmunology
Ehx G,Fransolet G,de Leval L,D'Hondt S,Lucas S,Hannon M,Delens L,Dubois S,Drion P,Beguin Y,Humblet-Baron S,Baron F
12-5321 was used in Flow cytometry/Cell sorting to investigate the impact of 5-azacytidine on xenogeneic graft-vs.-host disease and graft-vs.-leukaemia effects in a humanised murine model of transplantation.
Tue Jan 12 00:00:00 EST 2021
IL-7-dependent STAT1 activation limits homeostatic CD4+ T cell expansion.
JCI insight
Le Saout C,Luckey MA,Villarino AV,Smith M,Hasley RB,Myers TG,Imamichi H,Park JH,O'Shea JJ,Lane HC,Catalfamo M
12-5321 was used in Flow cytometry/Cell sorting to propose a model in which T cells undergoing lymphopenia-induced proliferation upregulate STAT1 protein, switching on an alternate IL-7-dependent program.
Thu Nov 16 00:00:00 EST 2017
Tumor-derived exosomes educate dendritic cells to promote tumor metastasis via HSP72/HSP105-TLR2/TLR4 pathway.
Oncoimmunology
Shen Y,Guo D,Weng L,Wang S,Ma Z,Yang Y,Wang P,Wang J,Cai Z
12-5321-82 was used in Flow Cytometry to reveal a novel mechanism for the tumour-derived exosome(TEX)-mediated education of dendritic cells.
Tue Jan 12 00:00:00 EST 2021
IL-27R signaling controls myeloid cells accumulation and antigen-presentation in atherosclerosis.
Scientific reports
Peshkova IO,Fatkhullina AR,Mikulski Z,Ley K,Koltsova EK
12-5321 was used in Flow cytometry/Cell sorting to study the role of IL-27R in controlling myeloid cell accumulation and activation in atherosclerosis.
Tue May 23 00:00:00 EDT 2017
IL-27R signaling controls myeloid cells accumulation and antigen-presentation in atherosclerosis.
Scientific reports
Peshkova IO,Fatkhullina AR,Mikulski Z,Ley K,Koltsova EK
12-5321 was used in Flow cytometry/Cell sorting to study the role of IL-27R in controlling myeloid cell accumulation and activation in atherosclerosis.
Tue May 23 00:00:00 EDT 2017
Heavy Chain-Hyaluronan/Pentraxin 3 from Amniotic Membrane Suppresses Inflammation and Scarring in Murine Lacrimal Gland and Conjunctiva of Chronic Graft-versus-Host Disease.
Scientific reports
Ogawa Y,He H,Mukai S,Imada T,Nakamura S,Su CW,Mahabole M,Tseng SC,Tsubota K
12-5321 was used in Western Blotting to help prove the concept that subcutaneous and subconjunctival injection of HC-HA/PTX3 is a novel approach to prevent dry eye disease caused by cGVHD.
Mon Feb 06 00:00:00 EST 2017
Geldanamycin Reduces Acute Respiratory Distress Syndrome and Promotes the Survival of Mice Infected with the Highly Virulent H5N1 Influenza Virus.
Frontiers in cellular and infection microbiology
Wang C,Liu P,Luo J,Ding H,Gao Y,Sun L,Luo F,Liu X,He H
12-5321 was used in Flow cytometry/Cell sorting to show geldanamycin plays an important role in attenuating virus infection-induced acute lung injury/acute respiratory distress syndrome by reducing the host's inflammatory responses.
Mon Feb 26 00:00:00 EST 2018
Microglial brain region-dependent diversity and selective regional sensitivities to aging.
Nature neuroscience
Grabert K,Michoel T,Karavolos MH,Clohisey S,Baillie JK,Stevens MP,Freeman TC,Summers KM,McColl BW
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 12-5321-82) in Flow Cytometry
Tue Mar 01 00:00:00 EST 2016
Tetraspanin CD37 protects against the development of B cell lymphoma.
The Journal of clinical investigation
de Winde CM,Veenbergen S,Young KH,Xu-Monette ZY,Wang XX,Xia Y,Jabbar KJ,van den Brand M,van der Schaaf A,Elfrink S,van Houdt IS,Gijbels MJ,van de Loo FA,Bennink MB,Hebeda KM,Groenen PJ,van Krieken JH,Figdor CG,van Spriel AB
12-5321 was used in Flow cytometry/Cell sorting to show that CD37 deficiency drives B cell lymphomagenesis through constitutive activation of the IL-6 pathway, highlighting a possible therapeutic intervention.
Mon Feb 01 00:00:00 EST 2016
Mesenchymal stromal cell-derived extracellular vesicles rescue radiation damage to murine marrow hematopoietic cells.
Leukemia
Wen S,Dooner M,Cheng Y,Papa E,Del Tatto M,Pereira M,Deng Y,Goldberg L,Aliotta J,Chatterjee D,Stewart C,Carpanetto A,Collino F,Bruno S,Camussi G,Quesenberry P
12-5321 was used in Flow cytometry/Cell sorting to evaluate the capacity of mesenchymal stromal cell-derived extracellular vesicles to rescue murine marrow hematopoietic cells damage following exposure to radiation, showing that damage could be reversed using both murine and human MSC-EVs.
Tue Nov 01 00:00:00 EDT 2016
MicroRNA-7 Deficiency Ameliorates the Pathologies of Acute Lung Injury through Elevating KLF4.
Frontiers in immunology
Zhao J,Chen C,Guo M,Tao Y,Cui P,Zhou Y,Qin N,Zheng J,Zhang J,Xu L
12-5321 was used in Flow cytometry/Cell sorting to study the role of microRNA-7 in acute lung injury, allowing the development of new therapeutic strategies against inflammatory lung disease.
Wed Mar 16 00:00:00 EDT 2022
Opposite Effects of Coinjection and Distant Injection of Mesenchymal Stem Cells on Breast Tumor Cell Growth.
Stem cells translational medicine
Zheng H,Zou W,Shen J,Xu L,Wang S,Fu YX,Fan W
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 12-5321-82) in Flow Cytometry
Thu Sep 01 00:00:00 EDT 2016
Recruited monocytes modulate malaria-induced lung injury through CD36-mediated clearance of sequestered infected erythrocytes.
Journal of leukocyte biology
Lagassé HA,Anidi IU,Craig JM,Limjunyawong N,Poupore AK,Mitzner W,Scott AL
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 12-5321-82) in Flow Cytometry
Sun May 01 00:00:00 EDT 2016
Resident T Cells Are Unable To Control Herpes Simplex Virus-1 Activity in the Brain Ependymal Region during Latency.
Journal of immunology (Baltimore, Md. : 1950)
Menendez CM,Jinkins JK,Carr DJ
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 12-5321-82) in Flow Cytometry
Mon Aug 15 00:00:00 EDT 2016
Survival of Igα-Deficient Mature B Cells Requires BAFF-R Function.
Journal of immunology (Baltimore, Md. : 1950)
Levit-Zerdoun E,Becker M,Pohlmeyer R,Wilhelm I,Maity PC,Rajewsky K,Reth M,Hobeika E
12-5321 was used in Flow cytometry/Cell sorting to assess the importance of the expression of a functional B-cell receptor for B cell maintenance.
Tue Mar 01 00:00:00 EST 2016
Effects of ketanserin on experimental colitis in mice and macrophage function.
International journal of molecular medicine
Xiao J,Shao L,Shen J,Jiang W,Feng Y,Zheng P,Liu F
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 12-5321-82) in Flow Cytometry
Tue Mar 01 00:00:00 EST 2016
Repulsive guidance molecule a blockade exerts the immunoregulatory function in DCs stimulated with ABP and LPS.
Human vaccines & immunotherapeutics
Xu X,Gao Y,Zhai Z,Zhang S,Shan F,Feng J
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 12-5321-82) in Flow Cytometry
Tue Aug 02 00:00:00 EDT 2016
Thiol peroxiredoxin, a novel allergen from Bombyx mori, modulates functions of macrophages and dendritic cells.
American journal of translational research
Wang H,Hu W,Liang Z,Zeng L,Li J,Yan H,Yang P,Liu Z,Wang L
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 12-5321-82) in Flow Cytometry
Thu Oct 01 00:00:00 EDT 2020
Development of a diet-induced murine model of diabetes featuring cardinal metabolic and pathophysiological abnormalities of type 2 diabetes.
Biology open
Morris JL,Bridson TL,Alim MA,Rush CM,Rudd DM,Govan BL,Ketheesan N
12-5321 was used in Flow cytometry/Cell sorting to develop a novel murine model, based on an energy-dense diet, which closely simulates the development of type 2 diabetes.
Mon Aug 15 00:00:00 EDT 2016
Stroke sensitivity in the aged: sex chromosome complement vs. gonadal hormones.
Aging
McCullough LD,Mirza MA,Xu Y,Bentivegna K,Steffens EB,Ritzel R,Liu F
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 12-5321-82) in Flow Cytometry
Fri Jul 01 00:00:00 EDT 2016
Epidermal RAF prevents allergic skin disease.
eLife
Raguz J,Jeric I,Niault T,Nowacka JD,Kuzet SE,Rupp C,Fischer I,Biggi S,Borsello T,Baccarini M
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 12-5321-82) in Flow Cytometry
Tue Jul 19 00:00:00 EDT 2016
Internalization and presentation of myelin antigens by the brain endothelium guides antigen-specific T cell migration.
eLife
Lopes Pinheiro MA,Kamermans A,Garcia-Vallejo JJ,van Het Hof B,Wierts L,O'Toole T,Boeve D,Verstege M,van der Pol SM,van Kooyk Y,de Vries HE,Unger WW
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 12-5321-82) in Flow Cytometry
Thu Jun 23 00:00:00 EDT 2016
Proteomic Analysis of Excretory-Secretory Products of Mesocestoides corti Metacestodes Reveals Potential Suppressors of Dendritic Cell Functions.
PLoS neglected tropical diseases
Vendelova E,Camargo de Lima J,Lorenzatto KR,Monteiro KM,Mueller T,Veepaschit J,Grimm C,Brehm K,Hrčková G,Lutz MB,Ferreira HB,Nono JK
12-5321 was used in Flow cytometry/Cell sorting to study the immunomodulatory effects of excretory-secretory products derived from M. corti tetrathyridia.
Sat Oct 01 00:00:00 EDT 2016
Real-time 3D stabilization of a super-resolution microscope using an electrically tunable lens.
Optics express
Tafteh R,Abraham L,Seo D,Lu HY,Gold MR,Chou KC
12532182 was used in blocking or activating experiment to image endosomal transferrin receptors in B-lymphocytes.
Mon Oct 03 00:00:00 EDT 2016
Loss of the Ubiquitin-conjugating Enzyme UBE2W Results in Susceptibility to Early Postnatal Lethality and Defects in Skin, Immune, and Male Reproductive Systems.
The Journal of biological chemistry
Wang B,Merillat SA,Vincent M,Huber AK,Basrur V,Mangelberger D,Zeng L,Elenitoba-Johnson K,Miller RA,Irani DN,Dlugosz AA,Schnell S,Scaglione KM,Paulson HL
12-5321 was used in Flow cytometry/Cell sorting to establish that UBE2W is an important protein for early postnatal survival and the normal functioning of multiple organ systems.
Fri Feb 05 00:00:00 EST 2016
Anti-GD2 mAb and Vorinostat synergize in the treatment of neuroblastoma.
Oncoimmunology
Kroesen M,Büll C,Gielen PR,Brok IC,Armandari I,Wassink M,Looman MW,Boon L,den Brok MH,Hoogerbrugge PM,Adema GJ
12-5321 was used in Flow cytometry/Cell sorting to discover a basis for clinical testing of anti-GD2 plus Vorinostat combination therapy in NBL patients.
Wed Jun 01 00:00:00 EDT 2016
Adaptive Immune Regulation of Mammary Postnatal Organogenesis.
Developmental cell
Plaks V,Boldajipour B,Linnemann JR,Nguyen NH,Kersten K,Wolf Y,Casbon AJ,Kong N,van den Bijgaart RJ,Sheppard D,Melton AC,Krummel MF,Werb Z
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 12-5321-82) in Flow Cytometry
Mon Sep 14 00:00:00 EDT 2015
Toll-like receptor 7 governs interferon and inflammatory responses to rhinovirus and is suppressed by IL-5-induced lung eosinophilia.
Thorax
Hatchwell L,Collison A,Girkin J,Parsons K,Li J,Zhang J,Phipps S,Knight D,Bartlett NW,Johnston SL,Foster PS,Wark PA,Mattes J
12-5321 was used in Flow cytometry/Cell sorting to investigate the importance of intact Toll-like receptor 7 signalling in vivo during rhinovirus exacerbation.
Tue Sep 01 00:00:00 EDT 2015
The late endosomal adaptor molecule p14 (LAMTOR2) regulates TGFβ1-mediated homeostasis of Langerhans cells.
The Journal of investigative dermatology
Sparber F,Tripp CH,Komenda K,Scheffler JM,Clausen BE,Huber LA,Romani N,Stoitzner P
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 12-5321-82) in Flow Cytometry
Thu Jan 01 00:00:00 EST 2015
Intratumoral INF-γ triggers an antiviral state in GL261 tumor cells: a major hurdle to overcome for oncolytic vaccinia virus therapy of cancer.
Molecular therapy oncolytics
Kober C,Weibel S,Rohn S,Kirscher L,Szalay AA
12-5321 was used in Flow cytometry/Cell sorting to identify microenvironmental factors, which may be decisive for failure or success of oncolytic VACV therapy.
Wed Apr 27 00:00:00 EDT 2016
Ca2+ Signaling but Not Store-Operated Ca2+ Entry Is Required for the Function of Macrophages and Dendritic Cells.
Journal of immunology (Baltimore, Md. : 1950)
Vaeth M,Zee I,Concepcion AR,Maus M,Shaw P,Portal-Celhay C,Zahra A,Kozhaya L,Weidinger C,Philips J,Unutmaz D,Feske S
12-5321 was used in Flow cytometry/Cell sorting to investigate the role of STIM1, STIM2 and SOCE on effector functions of macrophages and dendritic cells, and how these affect CRAC channel inhibition.
Sat Aug 01 00:00:00 EDT 2015
A genome-wide analysis identifies a notch-RBP-Jκ-IL-7Rα axis that controls IL-17-producing γδ T cell homeostasis in mice.
Journal of immunology (Baltimore, Md. : 1950)
Nakamura M,Shibata K,Hatano S,Sato T,Ohkawa Y,Yamada H,Ikuta K,Yoshikai Y
12-5321 was used in Flow cytometry/Cell sorting to investigate additional roles for the Notch axis in the homeostasis of γδ T cells.
Thu Jan 01 00:00:00 EST 2015
Reducing progression of experimental lupus nephritis via inhibition of the B7/CD28 signaling pathway.
Molecular medicine reports
Huang L,Kong Y,Wang J,Sun J,Shi Q,Qiu YH
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 12-5321-82) in Flow Cytometry
Tue Sep 01 00:00:00 EDT 2015
Macrophages Contribute to the Spermatogonial Niche in the Adult Testis.
Cell reports
DeFalco T,Potter SJ,Williams AV,Waller B,Kan MJ,Capel B
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 12-5321-82) in Flow Cytometry
Tue Aug 18 00:00:00 EDT 2015
Toll-like receptor ligands sensitize B-cell receptor signalling by reducing actin-dependent spatial confinement of the receptor.
Nature communications
Freeman SA,Jaumouillé V,Choi K,Hsu BE,Wong HS,Abraham L,Graves ML,Coombs D,Roskelley CD,Das R,Grinstein S,Gold MR
12-5321 was used in Western Blotting to show that lipopolysaccharide and CpG DNA can enhance signalling by the B-cell antigen receptor.
Tue Feb 03 00:00:00 EST 2015
Distinct in vitro properties of embryonic and extraembryonic fibroblast-like cells are reflected in their in vivo behavior following grafting in the adult mouse brain.
Cell transplantation
Costa R,Bergwerf I,Santermans E,De Vocht N,Praet J,Daans J,Le Blon D,Hoornaert C,Reekmans K,Hens N,Goossens H,Berneman Z,Parolini O,Alviano F,Ponsaerts P
12-5321-82 was used in Flow cytometry/Cell sorting to suggest that physiological differences between fibroblast-like cell populations might lie at the basis of variations in histopathological and/or clinical outcome following cell grafting in mouse brain.
Mon Nov 16 00:00:00 EST 2015
Microglia and astrocytes attenuate the replication of the oncolytic vaccinia virus LIVP 1.1.1 in murine GL261 gliomas by acting as vaccinia virus traps.
Journal of translational medicine
Kober C,Rohn S,Weibel S,Geissinger U,Chen NG,Szalay AA
12-5321 was used in Flow cytometry/Cell sorting to indicate that microglia and astrocytes, dependent on their activation state, may preferentially clear viral particles by immediate uptake after delivery.
Tue Jul 07 00:00:00 EDT 2015
Intronic regulation of Aire expression by Jmjd6 for self-tolerance induction in the thymus.
Nature communications
Yanagihara T,Sanematsu F,Sato T,Uruno T,Duan X,Tomino T,Harada Y,Watanabe M,Wang Y,Tanaka Y,Nakanishi Y,Suyama M,Yoshinori F
12-5321 was used in Flow cytometry/Cell sorting to study the regulation of Aire expression in medullary thymic epithelial cells.
Wed Nov 04 00:00:00 EST 2015
High-fat-diet-mediated dysbiosis promotes intestinal carcinogenesis independently of obesity.
Nature
Schulz MD,Atay C,Heringer J,Romrig FK,Schwitalla S,Aydin B,Ziegler PK,Varga J,Reindl W,Pommerenke C,Salinas-Riester G,Böck A,Alpert C,Blaut M,Polson SC,Brandl L,Kirchner T,Greten FR,Polson SW,Arkan MC
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 12-5321-82) in Flow Cytometry
Thu Oct 23 00:00:00 EDT 2014
Autophagy regulates the therapeutic potential of mesenchymal stem cells in experimental autoimmune encephalomyelitis.
Autophagy
Dang S,Xu H,Xu C,Cai W,Li Q,Cheng Y,Jin M,Wang RX,Peng Y,Zhang Y,Wu C,He X,Wan B,Zhang Y
12-5321 was used in Flow cytometry/Cell sorting to study how inflammatory microenvironment-induced autophagy can downregulate the immunosuppressive function of mesenchymal stem cells.
Tue Jul 01 00:00:00 EDT 2014
The glycosylated Rv1860 protein of Mycobacterium tuberculosis inhibits dendritic cell mediated TH1 and TH17 polarization of T cells and abrogates protective immunity conferred by BCG.
PLoS pathogens
Satchidanandam V,Kumar N,Jumani RS,Challu V,Elangovan S,Khan NA
12-5321 was used in Flow cytometry/Cell sorting to investigate the effect of BCG-TB1860 on both the adaptive and innate immune responses.
Sun Jun 01 00:00:00 EDT 2014
VB-201, an oxidized phospholipid small molecule, inhibits CD14- and Toll-like receptor-2-dependent innate cell activation and constrains atherosclerosis.
Clinical and experimental immunology
Mendel I,Feige E,Yacov N,Salem Y,Levi I,Propheta-Meiran O,Shoham A,Ishai E,George J,Harats D,Breitbart E
12-5321-82 was used in In vitro experiments to demonstrate that VB-201 inhibits Toll-like receptor (TLR) signalling restricted to TLR-2 and TLR-4 in human and mouse monocytes and dendritic cells.
Wed Jan 01 00:00:00 EST 2014
The NF-κB regulator Bcl-3 governs dendritic cell antigen presentation functions in adaptive immunity.
Journal of immunology (Baltimore, Md. : 1950)
Tassi I,Claudio E,Wang H,Tang W,Ha HL,Saret S,Ramaswamy M,Siegel R,Siebenlist U
12-5321 was used in Flow cytometry/Cell sorting to study the role of Bcl-3 in dendritic cell survival and the generation of adaptive immunity.
Sat Nov 01 00:00:00 EDT 2014
Cutting edge: The transcription factor Bob1 counteracts B cell activation and regulates miR-146a in B cells.
Journal of immunology (Baltimore, Md. : 1950)
Lindner JM,Kayo H,Hedlund S,Fukuda Y,Fukao T,Nielsen PJ
12-5321 was used in Flow cytometry/Cell sorting to investigate the role of Bob1 in B cells.
Thu May 15 00:00:00 EDT 2014
Nizatidine, a small molecular compound, enhances killed H5N1 vaccine cell-mediated responses and protects mice from lethal viral challenge.
Human vaccines & immunotherapeutics
Wang S,Wu B,Xue J,Wang M,Chen R,Wang B
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 12-5321-82) in Flow Cytometry
Mon Jan 05 00:00:00 EST 2015
BCG vaccine mediated reduction in the MHC-II expression of macrophages and dendritic cells is reversed by activation of Toll-like receptors 7 and 9.
Cellular immunology
Bakhru P,Sirisaengtaksin N,Soudani E,Mukherjee S,Khan A,Jagannath C
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 12-5321-82) in Flow Cytometry
Wed Jan 01 00:00:00 EST 2014
γδ T cells recognize the insulin B:9-23 peptide antigen when it is dimerized through thiol oxidation.
Molecular immunology
Aydintug MK,Zhang L,Wang C,Liang D,Wands JM,Michels AW,Hirsch B,Day BJ,Zhang G,Sun D,Eisenbarth GS,O'Brien RL,Born WK
12-5321 was used in Flow cytometry/Cell sorting to determine why γδ T cells require a secondary amino acid recognition site on the insulin peptide, B:9-23.
Fri Aug 01 00:00:00 EDT 2014
Key role of Toll-like receptor 2 in the inflammatory response and major histocompatibility complex class ii downregulation in Brucella abortus-infected alveolar macrophages.
Infection and immunity
Ferrero MC,Hielpos MS,Carvalho NB,Barrionuevo P,Corsetti PP,Giambartolomei GH,Oliveira SC,Baldi PC
12-5321 was used in Flow cytometry/Cell sorting to suggest that Brucella abortus survives in alveolar macrophages after inhalatory infection despite the TLR2-mediated inflammatory response.
Sat Feb 01 00:00:00 EST 2014
More efficient induction of antitumor T cell immunity by exosomes from CD40L gene-modified lung tumor cells.
Molecular medicine reports
Wang J,Wang L,Lin Z,Tao L,Chen M
12-5321 was used in Flow cytometry/Cell sorting to investigate more efficient methods for inducing anti-tumour T cell immunity against lung cancer.
Wed Jan 01 00:00:00 EST 2014
Amniotic fluid stem cells prevent follicle atresia and rescue fertility of mice with premature ovarian failure induced by chemotherapy.
PloS one
Xiao GY,Liu IH,Cheng CC,Chang CC,Lee YH,Cheng WT,Wu SC
12-5321 was used in Flow cytometry/Cell sorting to demonstrate the therapeutic effects of AFSCs and suggest the use of AFSCs for treating infertility and POF.
Thu May 28 00:00:00 EDT 2015
Assessing the role of STAT3 in DC differentiation and autologous DC immunotherapy in mouse models of GBM.
PloS one
Assi H,Espinosa J,Suprise S,Sofroniew M,Doherty R,Zamler D,Lowenstein PR,Castro MG
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 12-5321-82) in Flow Cytometry
Fri Jan 23 00:00:00 EST 2015
Hemozoin induces hepatic inflammation in mice and is differentially associated with liver pathology depending on the Plasmodium strain.
PloS one
Deroost K,Lays N,Pham TT,Baci D,Van den Eynde K,Komuta M,Prato M,Roskams T,Schwarzer E,Opdenakker G,Van den Steen PE
12-5321 was used in Flow cytometry/Cell sorting to elucidate the contribution of hemozoin to hepatic injury in mouse malaria models.
Tue Jan 26 00:00:00 EST 2016
IL-27 acts on DCs to suppress the T cell response and autoimmunity by inducing expression of the immunoregulatory molecule CD39.
Nature immunology
Mascanfroni ID,Yeste A,Vieira SM,Burns EJ,Patel B,Sloma I,Wu Y,Mayo L,Ben-Hamo R,Efroni S,Kuchroo VK,Robson SC,Quintana FJ
12-5321 was used in Flow cytometry/Cell sorting to assess the regulation of T cells by dendritic cells.
Tue Oct 01 00:00:00 EDT 2013
Rhamnogalacturonan II is a Toll-like receptor 4 agonist that inhibits tumor growth by activating dendritic cell-mediated CD8+ T cells.
Experimental & molecular medicine
Park SN,Noh KT,Jeong YI,Jung ID,Kang HK,Cha GS,Lee SJ,Seo JK,Kang DH,Hwang TH,Lee EK,Kwon B,Park YM
12-5321 was used in Flow cytometry/Cell sorting to evaluate the effectiveness of RG-II-stimulated BMDC vaccination on the induction of antitumor immunity, showing that it inhibits tumor growth by activating dendritic cell-mediated CD8+ T cells.
Fri Feb 08 00:00:00 EST 2013
Traumatic brain injury induces macrophage subsets in the brain.
European journal of immunology
Hsieh CL,Kim CC,Ryba BE,Niemi EC,Bando JK,Locksley RM,Liu J,Nakamura MC,Seaman WE
12-5321 was used in Flow cytometry/Cell sorting to better understand the mechanisms involved in the innate inflammatory responses to brain injury.
Thu Aug 01 00:00:00 EDT 2013
NK cells are necessary for recovery of corneal CD11c+ dendritic cells after epithelial abrasion injury.
Journal of leukocyte biology
Gao Y,Li Z,Hassan N,Mehta P,Burns AR,Tang X,Smith CW
12-5321 was used in Immunofluorescence to investigate the mechanisms controlling CD11c(+) MHCII(+) DCs during corneal epithelial wound healing.
Thu Aug 01 00:00:00 EDT 2013
Dynamics of dendritic cell-derived vesicles: high-resolution flow cytometric analysis of extracellular vesicle quantity and quality.
Journal of leukocyte biology
Nolte-'t Hoen EN,van der Vlist EJ,de Boer-Brouwer M,Arkesteijn GJ,Stoorvogel W,Wauben MH
12-5321 was used in Flow cytometry/Cell sorting to study the dynamics of extracellular vesicle secretion and composition from dendritic cells..
Fri Mar 01 00:00:00 EST 2013
Galectin-3 negatively regulates dendritic cell production of IL-23/IL-17-axis cytokines in infection by Histoplasma capsulatum.
Journal of immunology (Baltimore, Md. : 1950)
Wu SY,Yu JS,Liu FT,Miaw SC,Wu-Hsieh BA
12-5321 was used in Flow cytometry/Cell sorting to investigate the cytokine immunoregulatory functions of gal3 in response to infection.
Mon Apr 01 00:00:00 EDT 2013
Endothelial cells provide an instructive niche for the differentiation and functional polarization of M2-like macrophages.
Blood
He H,Xu J,Warren CM,Duan D,Li X,Wu L,Iruela-Arispe ML
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 12-5321-82) in Flow Cytometry
Thu Oct 11 00:00:00 EDT 2012
Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2.
The Journal of experimental medicine
Yokosuka T,Takamatsu M,Kobayashi-Imanishi W,Hashimoto-Tane A,Azuma M,Saito T
12-5321 was used in Blocking experiments to investigate the molecular mechanisms of PD-1-mediated suppression of T cell activation, showing that it inhibits T cell receptor signalling via SHP2.
Mon Jun 04 00:00:00 EDT 2012
Vaccination with irradiated tumor cells pulsed with an adjuvant that stimulates NKT cells is an effective treatment for glioma.
Clinical cancer research : an official journal of the American Association for Cancer Research
Hunn MK,Farrand KJ,Broadley KW,Weinkove R,Ferguson P,Miller RJ,Field CS,Petersen T,McConnell MJ,Hermans IF
12-5321 was used in Flow cytometry/Cell sorting to use the implantable GL261 murine glioma model to investigate the therapeutic potential of a vaccine for glioblastoma multiforme.
Sat Dec 01 00:00:00 EST 2012
Epithelial cell-derived IL-25, but not Th17 cell-derived IL-17 or IL-17F, is crucial for murine asthma.
Journal of immunology (Baltimore, Md. : 1950)
Suzukawa M,Morita H,Nambu A,Arae K,Shimura E,Shibui A,Yamaguchi S,Suzukawa K,Nakanishi W,Oboki K,Kajiwara N,Ohno T,Ishii A,Körner H,Cua DJ,Suto H,Yoshimoto T,Iwakura Y,Yamasoba T,Ohta K,Sudo K,Saito H,Okumura K,Broide DH,Matsumoto K,Nakae S
12-5321 was used in Flow cytometry/Cell sorting to study how airway structural cell-derived IL-25-rather than Th17 cell-derived IL-17A and IL-17F-is responsible for induction of local inflammation.
Mon Oct 01 00:00:00 EDT 2012
Isolation and characterization of novel murine epiphysis derived mesenchymal stem cells.
PloS one
Cheng CC,Lian WS,Hsiao FS,Liu IH,Lin SP,Lee YH,Chang CC,Xiao GY,Huang HY,Cheng CF,Cheng WT,Wu SC
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 12-5321-82) in Flow Cytometry
Fri Sep 07 00:00:00 EDT 2012
Urea amidolyase (DUR1,2) contributes to virulence and kidney pathogenesis of Candida albicans.
PloS one
Navarathna DH,Lionakis MS,Lizak MJ,Munasinghe J,Nickerson KW,Roberts DD
12-5321 was used in Flow cytometry/Cell sorting to demonstrate that Dur1,2p is important for kidney colonisation during disseminated candidiasis and contributes to subsequent renal failure.
Tue Aug 26 00:00:00 EDT 2014
Virotherapy of canine tumors with oncolytic vaccinia virus GLV-1h109 expressing an anti-VEGF single-chain antibody.
PloS one
Patil SS,Gentschev I,Adelfinger M,Donat U,Hess M,Weibel S,Nolte I,Frentzen A,Szalay AA
12-5321 was used in Flow cytometry/Cell sorting to analyse oncolytic vaccinia virus-mediated delivery and production of scAb GLAF-1 and the oncolytic and immunological effects on canine cancer.
Thu Mar 28 00:00:00 EDT 2013
Deleterious effect of the IL-23/IL-17A axis and γδT cells on left ventricular remodeling after myocardial infarction.
Journal of the American Heart Association
Yan X,Shichita T,Katsumata Y,Matsuhashi T,Ito H,Ito K,Anzai A,Endo J,Tamura Y,Kimura K,Fujita J,Shinmura K,Shen W,Yoshimura A,Fukuda K,Sano M
12-5321 was used in Flow cytometry/Cell sorting to explore potential immune pathways involved in left ventricular remodelling as possible preventative therapeutic options.
Mon Oct 01 00:00:00 EDT 2012
Donor lung derived myeloid and plasmacytoid dendritic cells differentially regulate T cell proliferation and cytokine production.
Respiratory research
Benson HL,Suzuki H,Lott J,Fisher AJ,Walline C,Heidler KM,Brutkiewicz R,Blum JS,Wilkes DS
12-5321 was used in Flow cytometry/Cell sorting to show that allorecognition by donor lung plasmacytoid dendritic cells and myeloid dendritic cells, alter T cell proliferation and cytokine production.
Tue Mar 20 00:00:00 EDT 2012
Schistosoma japonicum soluble egg antigens attenuate IFN-γ-induced MHC class II expression in RAW 264.7 macrophages.
PloS one
Tang GX,Zhou HJ,Xu JW,Xu JM,Ji MJ,Wu HW,Wu GL
12-5321 was used in Flow cytometry/Cell sorting to elucidate the innate immune-related molecular events involved in the interaction between S. japonicum and its host.
Tue May 07 00:00:00 EDT 2013
Elevated epidermal ornithine decarboxylase activity suppresses contact hypersensitivity.
The Journal of investigative dermatology
Keough MP,Hayes CS,DeFeo K,Gilmour SK
12-5321 was used in Flow cytometry/Cell sorting to suggest that the immunosuppression promoted by increased epidermal ODC is mediated by a reduction in cytokine levels, which suppresses DC migration and reduces immune cell infiltration to the site of hapten application.
Sat Jan 01 00:00:00 EST 2011
Anti-tumour synergy of cytotoxic chemotherapy and anti-CD40 plus CpG-ODN immunotherapy through repolarization of tumour-associated macrophages.
Immunology
Buhtoiarov IN,Sondel PM,Wigginton JM,Buhtoiarova TN,Yanke EM,Mahvi DA,Rakhmilevich AL
12-5321 was used in Flow cytometry/Cell sorting to show that chemotherapy and anti-CD40 + CpG-ODN IT synergise in the induction of anti-tumour effects which are associated with the phenotypic repolarisation of tumour-associated Mφ.
Tue Feb 01 00:00:00 EST 2011
Myeloid-derived suppressor cells infiltrate the heart in acute Trypanosoma cruzi infection.
Journal of immunology (Baltimore, Md. : 1950)
Cuervo H,Guerrero NA,Carbajosa S,Beschin A,De Baetselier P,Gironès N,Fresno M
12-5321 was used in Flow cytometry/Cell sorting to purify and characterise the phenotype and function of CD11b(+) myeloid cells from the hearts of Trypanosoma cruzi-infected mice.
Thu Sep 01 00:00:00 EDT 2011
Topical imiquimod has therapeutic and immunomodulatory effects against intracranial tumors.
Journal of immunotherapy (Hagerstown, Md. : 1997)
Xiong Z,Ohlfest JR
12-5321 was used in Flow cytometry/Cell sorting to demonstrate that topical application of the TLR7 agonist imiquimod can enhance T-cell responses to intracranial tumors as a single agent in mice.
Fri Apr 01 00:00:00 EDT 2011
Mechanisms by which chronic ethanol feeding limits the ability of dendritic cells to stimulate T-cell proliferation.
Alcoholism, clinical and experimental research
Fan J,Edsen-Moore MR,Turner LE,Cook RT,Legge KL,Waldschmidt TJ,Schlueter AJ
12-5321 was used in Flow cytometry/Cell sorting to assess the functional capability of ethanol-exposed dendritic cells, using a murine model of chronic alcohol abuse.
Sat Jan 01 00:00:00 EST 2011
Expression of the Mycobacterium tuberculosis PPE37 protein in Mycobacterium smegmatis induces low tumour necrosis factor alpha and interleukin 6 production in murine macrophages.
Journal of medical microbiology
Daim S,Kawamura I,Tsuchiya K,Hara H,Kurenuma T,Shen Y,Dewamitta SR,Sakai S,Nomura T,Qu H,Mitsuyama M
12-5321 was used in Flow cytometry/Cell sorting to suggest a potential role of PPE37 in interfering with the pro-inflammatory cytokine response of infected macrophages.
Sun May 01 00:00:00 EDT 2011
Vaccination with Human Induced Pluripotent Stem Cells Creates an Antigen-Specific Immune Response Against HIV-1 gp160.
Frontiers in microbiology
Yoshizaki S,Nishi M,Kondo A,Kojima Y,Yamamoto N,Ryo A
12-5321 was used in Flow cytometry/Cell sorting to investigate whether human iPSCs (hiPSCs) have the ability to enhance specific immune responses against a HIV-1 antigen in a xenogenic mouse model.
Thu Jul 14 00:00:00 EDT 2011
Surfactant protein A (SP-A)-mediated clearance of Staphylococcus aureus involves binding of SP-A to the staphylococcal adhesin eap and the macrophage receptors SP-A receptor 210 and scavenger receptor class A.
The Journal of biological chemistry
Sever-Chroneos Z,Krupa A,Davis J,Hasan M,Yang CH,Szeliga J,Herrmann M,Hussain M,Geisbrecht BV,Kobzik L,Chroneos ZC
12-5321 was used in Flow cytometry/Cell sorting to investigate the role of surfactant protein A in opsonisation and clearance of Staphylococcus aureus.
Fri Feb 11 00:00:00 EST 2011
Neutrophil-derived CCL3 is essential for the rapid recruitment of dendritic cells to the site of Leishmania major inoculation in resistant mice.
PLoS pathogens
Charmoy M,Brunner-Agten S,Aebischer D,Auderset F,Launois P,Milon G,Proudfoot AE,Tacchini-Cottier F
12-5321 was used in Flow cytometry/Cell sorting to determine that the selective release of neutrophil-secreted chemokines may regulate the development of immune responses to pathogens.
Fri Feb 05 00:00:00 EST 2010
T cell immunoglobulin- and mucin-domain-containing molecule-4 attenuates concanavalin A-induced hepatitis by regulating macrophage.
Journal of leukocyte biology
Xu L,Qi J,Zhao P,Liang X,Ju Y,Liu P,Liu B,Guo C,Zhang L,Ma C,Gao L
12-5321 was used in Flow cytometry/Cell sorting to study how Tim-4 plays an important role in alleviating liver damage through inhibition of macrophage activity.
Sun Aug 01 00:00:00 EDT 2010
Dendritic cells continue to capture and present antigens after maturation in vivo.
Journal of immunology (Baltimore, Md. : 1950)
Drutman SB,Trombetta ES
12-5321 was used in Flow cytometry/Cell sorting to study the dynamics of Ag capture and presentation in situ, showing that dendritic cells continue to capture and present antigens after maturation.
Sun Aug 15 00:00:00 EDT 2010
Monocyte trafficking to hepatic sites of bacterial infection is chemokine independent and directed by focal intercellular adhesion molecule-1 expression.
Journal of immunology (Baltimore, Md. : 1950)
Shi C,Velázquez P,Hohl TM,Leiner I,Dustin ML,Pamer EG
12-5321 was used in Flow cytometry/Cell sorting to demonstrate that Ly6C(high) monocyte recruitment from the bloodstream to L. monocytogenes-infected liver is dependent on integrin and extracellular matrix-mediated monocyte adhesion.
Tue Jun 01 00:00:00 EDT 2010
Chemoimmunotherapy reduces the progression of multiple myeloma in a mouse model.
Cancer prevention research (Philadelphia, Pa.)
Sharabi A,Laronne-Bar-On A,Meshorer A,Haran-Ghera N
12-5321 was used in Flow cytometry/Cell sorting to determine the effects, and their modes of action, of CYC treatment on MM progression.
Fri Oct 01 00:00:00 EDT 2010
Antigen presenting cells may be able to distinguish between normal and radiated Schistosoma japonicum cercaria: an in vitro observation.
Journal of biomedical research
Tang G,Ji M,Wu H,Wu G
12-5321 was used in Flow cytometry/Cell sorting to study the discrepancies in responses induced by Schistosoma japonicum normal cercaria antigen and ultraviolet-radiation-attenuated cercaria antigen in an in vitro system.
Thu Jul 01 00:00:00 EDT 2010
Combination of all-trans retinoic acid and a human papillomavirus therapeutic vaccine suppresses the number and function of immature myeloid cells and enhances antitumor immunity.
Cancer science
Song X,Ye D,Liu B,Cui J,Zhao X,Yi L,Liang J,Song J,Zhang Z,Zhao Q
12-5321-82 was used in Flow Cytometry to suggest potential clinical benefits for the combined use of ATRA and HPV therapeutic vaccines.
Sun Feb 01 00:00:00 EST 2009
Allogeneic stromal cell implantation in brain tissue leads to robust microglial activation.
Immunology and cell biology
Tambuyzer BR,Bergwerf I,De Vocht N,Reekmans K,Daans J,Jorens PG,Goossens H,Ysebaert DK,Chatterjee S,Van Marck E,Berneman ZN,Ponsaerts P
12-5321 was used in Flow cytometry/Cell sorting to describe the immunological mechanism leading to rejection of allogeneic BM-SCs after implantation in murine CNS.
Fri Jun 19 00:00:00 EDT 2009
Deficiency of type I IFN receptor in lupus-prone New Zealand mixed 2328 mice decreases dendritic cell numbers and activation and protects from disease.
Journal of immunology (Baltimore, Md. : 1950)
Agrawal H,Jacob N,Carreras E,Bajana S,Putterman C,Turner S,Neas B,Mathian A,Koss MN,Stohl W,Kovats S,Jacob CO
12-5321 was used in Flow cytometry/Cell sorting to show that type I IFN receptor signalling increases dendritic cell numbers, acquisition of Ag presentation competence, and proinflammatory function before clinical lupus disease presentation.
Sun Nov 01 00:00:00 EDT 2009
Hypercostimulation through 4-1BB distorts homeostasis of immune cells.
Journal of immunology (Baltimore, Md. : 1950)
Lee SW,Salek-Ardakani S,Mittler RS,Croft M
12-5321 was used in Flow cytometry/Cell sorting to investigate the potential side effects of immunotherapeutic strategies using Abs against costimulatory molecules.
Mon Jun 01 00:00:00 EDT 2009
Dendritic cells matured by inflammation induce CD86-dependent priming of naive CD8+ T cells in the absence of their cognate peptide antigen.
Journal of immunology (Baltimore, Md. : 1950)
Maroof A,Beattie L,Kirby A,Coles M,Kaye PM
12-5321 was used in Flow cytometry/Cell sorting to study how inflammation-matured DCs can induce Ag-independent T cell proliferation.
Tue Dec 01 00:00:00 EST 2009
Mycobacterium bovis BCG decreases MHC-II expression in vivo on murine lung macrophages and dendritic cells during aerosol infection.
Cellular immunology
Pecora ND,Fulton SA,Reba SM,Drage MG,Simmons DP,Urankar-Nagy NJ,Boom WH,Harding CV
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 12-5321-82) in Flow Cytometry
Fri Jan 02 00:00:00 EST 2009
Chlamydia muridarum-specific CD4 T-cell clones recognize infected reproductive tract epithelial cells in an interferon-dependent fashion.
Infection and immunity
Jayarapu K,Kerr MS,Katschke A,Johnson RM
12-5321 was used in Flow cytometry/Cell sorting to investigate the recognition of Chlamydia-infected epithelial cells by CD4 T-cell clones.
Thu Oct 01 00:00:00 EDT 2009
Wolbachia lipoprotein stimulates innate and adaptive immunity through Toll-like receptors 2 and 6 to induce disease manifestations of filariasis.
The Journal of biological chemistry
Turner JD,Langley RS,Johnston KL,Gentil K,Ford L,Wu B,Graham M,Sharpley F,Slatko B,Pearlman E,Taylor MJ
12-5321 was used in Flow cytometry/Cell sorting to investigate the role of Wolbachia lipoprotein in pathogenesis of filariasis, showing that it stimulates innate and adaptive immunity through Toll-like receptors 2 and 6.
Fri Aug 14 00:00:00 EDT 2009
Dynamics of lung macrophage activation in response to helminth infection.
Journal of leukocyte biology
Siracusa MC,Reece JJ,Urban JF,Scott AL
12-5321 was used in Flow cytometry/Cell sorting to study the dynamics of lung macrophage activation in response to helminth infection.
Mon Dec 01 00:00:00 EST 2008
Synergistic antitumor effects of CpG oligodeoxynucleotide and STAT3 inhibitory agent JSI-124 in a mouse melanoma tumor model.
Immunology and cell biology
Molavi O,Ma Z,Hamdy S,Lai R,Lavasanifar A,Samuel J
12-5321 was used in Flow cytometry/Cell sorting to provide the proof-of-principle for combining CpG and JSI-124 to enhance anti-tumour immune responses.
Mon Oct 20 00:00:00 EDT 2008
Recruitment and in situ renewal regulate rapid accumulation of CD11c+ cells in the lung following intranasal superantigen challenge.
International archives of allergy and immunology
Muralimohan G,Rossi RJ,Vella AT
12-5321 was used in Flow cytometry/Cell sorting to investigate how staphylococcal enterotoxins regulate innate immune cells, showing that it leads to rapid accumulation of CD11c+ cells in the lung following superantigen challenge.
Tue Sep 09 00:00:00 EDT 2008
CD83 influences cell-surface MHC class II expression on B cells and other antigen-presenting cells.
International immunology
Kuwano Y,Prazma CM,Yazawa N,Watanabe R,Ishiura N,Kumanogoh A,Okochi H,Tamaki K,Fujimoto M,Tedder TF
12-5321 was used in Flow cytometry/Cell sorting to investigate the role of CD83 in B cells and antigen-presenting cells.
Wed Aug 01 00:00:00 EDT 2007
The mouse mammary carcinoma 4T1: characterization of the cellular landscape of primary tumours and metastatic tumour foci.
International journal of experimental pathology
DuPré SA,Redelman D,Hunter KW
12-5321-82 was used in Flow cytometry/Cell sorting to demonstrate that 4T1 tumour-bearing mice have mixed myeloid cell infiltrates of primary tumours and granulocytic infiltrates of metastatic organs.
Mon Oct 01 00:00:00 EDT 2007
Isolation and characterization of kidney-derived stem cells.
Journal of the American Society of Nephrology : JASN
Gupta S,Verfaillie C,Chmielewski D,Kren S,Eidman K,Connaire J,Heremans Y,Lund T,Blackstad M,Jiang Y,Luttun A,Rosenberg ME
12-5321 was used in Immunohistochemistry to study how MRPC participate in the regenerative response of the kidney to acute injury.
Wed Nov 01 00:00:00 EST 2006
MafB is essential for renal development and F4/80 expression in macrophages.
Molecular and cellular biology
Moriguchi T,Hamada M,Morito N,Terunuma T,Hasegawa K,Zhang C,Yokomizo T,Esaki R,Kuroda E,Yoh K,Kudo T,Nagata M,Greaves DR,Engel JD,Yamamoto M,Takahashi S
12-5321 was used in Flow cytometry/Cell sorting to demonstrate that MafB is essential for podocyte differentiation, renal tubule survival, and F4/80 maturation in nonadherent mature macrophages.
Tue Aug 01 00:00:00 EDT 2006
Soluble type II transforming growth factor-beta receptor inhibits established murine malignant mesothelioma tumor growth by augmenting host antitumor immunity.
Clinical cancer research : an official journal of the American Association for Cancer Research
Suzuki E,Kapoor V,Cheung HK,Ling LE,DeLong PA,Kaiser LR,Albelda SM
12-5321 was used in Flow cytometry/Cell sorting to suggest that TGF-beta blockade of established TGF-beta-secreting MM should be explored as a promising strategy to treat patients with tumors that produce TGF-beta.
Wed Sep 01 00:00:00 EDT 2004
Murine oviduct epithelial cell cytokine responses to Chlamydia muridarum infection include interleukin-12-p70 secretion.
Infection and immunity
Johnson RM
12-5321 was used in Flow cytometry/Cell sorting to provide evidence that oviduct epithelial cells contribute directly to innate and adaptive immunity during Chlamydia trachomatis infections.
Thu Jul 01 00:00:00 EDT 2004
