Product References
Distinct SARS-CoV-2 specific NLRP3 and IL-1β responses in T cells of aging patients during acute COVID-19 infection.
Frontiers in immunology
Mahalingam SS,Jayaraman S,Arunkumar A,Dudley HM,Anthony DD,Shive CL,Jacobson JM,Pandiyan P
Published figure using CD4 monoclonal antibody (Product # 14-0048-82) in Flow Cytometry
Thu Oct 12 00:00:00 EDT 2023
Estrogen Protects against Renal Ischemia-Reperfusion Injury by Regulating Th17/Treg Cell Immune Balance.
Disease markers
Zhang Y,Chang Y,Han Z,Ma K,Zeng X,Li L
Published figure using CD4 monoclonal antibody (Product # 14-0048-82) in Flow Cytometry
Tue Oct 18 00:00:00 EDT 2022
Plasma Extracellular Vesicle Subtypes May be Useful as Potential Biomarkers of Immune Activation in People With HIV.
Pathogens & immunity
Bazié WW,Boucher J,Vitry J,Goyer B,Routy JP,Tremblay C,Trottier S,Jenabian MA,Provost P,Alary M,Gilbert C
Published figure using CD4 monoclonal antibody (Product # 14-0048-82) in Flow Cytometry
Sat Apr 23 00:00:00 EDT 2022
Targeting Phosphatidylserine Enhances the Anti-tumor Response to Tumor-Directed Radiation Therapy in a Preclinical Model of Melanoma.
Cell reports
Budhu S,Giese R,Gupta A,Fitzgerald K,Zappasodi R,Schad S,Hirschhorn D,Campesato LF,De Henau O,Gigoux M,Liu C,Mazo G,Deng L,Barker CA,Wolchok JD,Merghoub T
Published figure using CD4 monoclonal antibody (Product # 14-0048-82) in Flow Cytometry
Tue Jan 12 00:00:00 EST 2021
Small-molecule antagonist of VLA-4 (GW559090) attenuated neuro-inflammation by targeting Th17 cell trafficking across the blood-retinal barrier in experimental autoimmune uveitis.
Journal of neuroinflammation
Chen YH,Eskandarpour M,Zhang X,Galatowicz G,Greenwood J,Lightman S,Calder V
Published figure using CD4 monoclonal antibody (Product # 14-0048-82) in Flow Cytometry
Thu Feb 18 00:00:00 EST 2021
A Cross-Reactive Small Protein Binding Domain Provides a Model to Study Off-Tumor CAR-T Cell Toxicity.
Molecular therapy oncolytics
Hammill JA,Kwiecien JM,Dvorkin-Gheva A,Lau VWC,Baker C,Wu Y,Bezverbnaya K,Aarts C,Heslen CW,Denisova GF,Derocher H,Milne K,Nelson BH,Bramson JL
Published figure using CD4 monoclonal antibody (Product # 14-0048-82) in Flow Cytometry
Fri Jun 26 00:00:00 EDT 2020
The Potential of Nanobody-Targeted Photodynamic Therapy to Trigger Immune Responses.
Cancers
Beltrán Hernández I,Angelier ML,Del Buono D'Ondes T,Di Maggio A,Yu Y,Oliveira S
Published figure using CD4 monoclonal antibody (Product # 14-0048-82) in Flow Cytometry
Wed Apr 15 00:00:00 EDT 2020
An Asymmetric Opening of HIV-1 Envelope Mediates Antibody-Dependent Cellular Cytotoxicity.
Cell host & microbe
Alsahafi N,Bakouche N,Kazemi M,Richard J,Ding S,Bhattacharyya S,Das D,Anand SP,Prévost J,Tolbert WD,Lu H,Medjahed H,Gendron-Lepage G,Ortega Delgado GG,Kirk S,Melillo B,Mothes W,Sodroski J,Smith AB,Kaufmann DE,Wu X,Pazgier M,Rouiller I,Finzi A,Munro JB
14-0048 was used in Flow cytometry/Cell sorting to investigate conformational changes in HIV-1 envelope glycoprotein that induce antibody-dependent cellular cytotoxicity in the presence of a small-molecule CD4-mimetic compound (CD4mc).
Wed Apr 10 00:00:00 EDT 2019
Immune Checkpoint Inhibitor-induced Reinvigoration of Tumor-infiltrating CD8+ T Cells is Determined by Their Differentiation Status in Glioblastoma.
Clinical cancer research : an official journal of the American Association for Cancer Research
Park J,Kwon M,Kim KH,Kim TS,Hong SH,Kim CG,Kang SG,Moon JH,Kim EH,Park SH,Chang JH,Shin EC
14-0048 was used in Functional assays to examine the differentiation status of CD8+ tumor-infiltrating lymphocytes (TIL) from patients with primary GBM and their reinvigoration by ICIs to understand the nature of T-cell exhaustion in GBM.
Mon Apr 15 00:00:00 EDT 2019
Calnexin Impairs the Antitumor Immunity of CD4+ and CD8+ T Cells.
Cancer immunology research
Chen Y,Ma D,Wang X,Fang J,Liu X,Song J,Li X,Ren X,Li Q,Li Q,Wen S,Luo L,Xia J,Cui J,Zeng G,Chen L,Cheng B,Wang Z
14-0048 was used in Flow cytometry/Cell sorting to demonstrate that T-cell antitumor responses are regulated by calnexin in tumor cells.
Tue Jan 01 00:00:00 EST 2019
CD4 Incorporation into HIV-1 Viral Particles Exposes Envelope Epitopes Recognized by CD4-Induced Antibodies.
Journal of virology
Ding S,Gasser R,Gendron-Lepage G,Medjahed H,Tolbert WD,Sodroski J,Pazgier M,Finzi A
14-0048-82 was used in Western Blot to show how CD4 incorporation has a profound impact on envelope conformation at the surface of viral particles. Incorporated CD4 exposes CD4-induced epitopes on envelopes, rendering HIV-1 susceptible to neutralization by otherwise nonneutralizing antibodies.
Fri Nov 15 00:00:00 EST 2019
Expression of CD20 after viral reactivation renders HIV-reservoir cells susceptible to Rituximab.
Nature communications
Serra-Peinado C,Grau-Expósito J,Luque-Ballesteros L,Astorga-Gamaza A,Navarro J,Gallego-Rodriguez J,Martin M,Curran A,Burgos J,Ribera E,Raventós B,Willekens R,Torrella A,Planas B,Badía R,Garcia F,Castellví J,Genescà M,Falcó V,Buzon MJ
Published figure using CD4 monoclonal antibody (Product # 14-0048-82) in Flow Cytometry
Fri Aug 16 00:00:00 EDT 2019
Deep single-cell RNA sequencing data of individual T cells from treatment-naïve colorectal cancer patients.
Scientific data
Zhang Y,Zheng L,Zhang L,Hu X,Ren X,Zhang Z
14-0048-82 was used in Flow Cytometry to investigate the basic properties of tumour-infiltrating T cells (TILs) such as the functional state, migratory capability and clonal expansion.
Wed Jul 24 00:00:00 EDT 2019
Depleting T regulatory cells by targeting intracellular Foxp3 with a TCR mimic antibody.
Oncoimmunology
Dao T,Mun SS,Scott AC,Jarvis CA,Korontsvit T,Yang Z,Liu L,Klatt MG,Guerreiro M,Selvakumar A,Brea EJ,Oh C,Liu C,Scheinberg DA
14-0048-82 was used in Flow cytometry/Cell sorting to generate a T cell receptor mimic antibody, "Foxp3-#32," recognizing a Foxp3-derived epitope in the context of HLA-A*02:01.
Tue May 09 00:00:00 EDT 2023
Antibody-Dependent Cellular Cytotoxicity (ADCC)-Mediating Antibodies Constrain Neutralizing Antibody Escape Pathway.
Frontiers in immunology
Mielke D,Bandawe G,Pollara J,Abrahams MR,Nyanhete T,Moore PL,Thebus R,Yates NL,Kappes JC,Ochsenbauer C,Garrett N,Abdool Karim S,Tomaras GD,Montefiori D,Morris L,Ferrari G,Williamson C
14-0048 was used in Flow cytometry/Cell sorting to investigate the targets of ADCC responses within HIV-1 patients.
Thu Oct 22 00:00:00 EDT 2020
The Calcineurin Inhibitor Tacrolimus Specifically Suppresses Human T Follicular Helper Cells.
Frontiers in immunology
Wallin EF,Hill DL,Linterman MA,Wood KJ
14-0048 was used in Flow cytometry/Cell sorting to study the impact of the immunosuppressive agent Tacrolimuson T follicular helper cells differentiationand function in transplant recipients.
Fri Aug 16 00:00:00 EDT 2019
Accumulation of T-helper 22 cells, interleukin-22 and myeloid-derived suppressor cells promotes gastric cancer progression in elderly patients.
Oncology letters
Chen X,Wang Y,Wang J,Wen J,Jia X,Wang X,Zhang H
Published figure using CD4 monoclonal antibody (Product # 14-0048-82) in Flow Cytometry
Sun Jul 01 00:00:00 EDT 2018
IL-6 receptor blockade corrects defects of XIAP-deficient regulatory T cells.
Nature communications
Hsieh WC,Hsu TS,Chang YJ,Lai MZ
Published figure using CD4 monoclonal antibody (Product # 14-0048-82) in Flow Cytometry
Wed Jan 31 00:00:00 EST 2018
Complement receptor CD46 co-stimulates optimal human CD8+ T cell effector function via fatty acid metabolism.
Nature communications
Arbore G,West EE,Rahman J,Le Friec G,Niyonzima N,Pirooznia M,Tunc I,Pavlidis P,Powell N,Li Y,Liu P,Servais A,Couzi L,Fremeaux-Bacchi V,Placais L,Ferraro A,Walsh PR,Kavanagh D,Afzali B,Lavender P,Lachmann HJ,Kemper C
Published figure using CD4 monoclonal antibody (Product # 14-0048-82) in Flow Cytometry
Wed Oct 10 00:00:00 EDT 2018
A gB/CD3 bispecific BiTE antibody construct for targeting Human Cytomegalovirus-infected cells.
Scientific reports
Brey CU,Proff J,Teufert N,Salzer B,Brozy J,Münz M,Pendzialek J,Ensser A,Holter W,Lehner M
14-0048 was used in Flow cytometry/Cell sorting to study the functionality of a novel bispecific T cell engager antibody construct targeting a human cytomegalovirus-encoded glycoprotein for inhibiting HCMV replication in infected cells.
Wed Nov 28 00:00:00 EST 2018
Non-neutralizing Antibodies Alter the Course of HIV-1 Infection In Vivo.
Cell
Horwitz JA,Bar-On Y,Lu CL,Fera D,Lockhart AAK,Lorenzi JCC,Nogueira L,Golijanin J,Scheid JF,Seaman MS,Gazumyan A,Zolla-Pazner S,Nussenzweig MC
Thu Aug 10 00:00:00 EDT 2017
Expression of a Chimeric Antigen Receptor Specific for Donor HLA Class I Enhances the Potency of Human Regulatory T Cells in Preventing Human Skin Transplant Rejection.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Boardman DA,Philippeos C,Fruhwirth GO,Ibrahim MA,Hannen RF,Cooper D,Marelli-Berg FM,Watt FM,Lechler RI,Maher J,Smyth LA,Lombardi G
14004882 was used in flow cytometry to observe that the use of chimeric antigen receptor technology is a clinically applicable refinement of regulatory T cell therapy for organ transplantation
Sat Apr 01 00:00:00 EDT 2017
Ex vivo culture of human atherosclerotic plaques: A model to study immune cells in atherogenesis.
Atherosclerosis
Lebedeva A,Vorobyeva D,Vagida M,Ivanova O,Felker E,Fitzgerald W,Danilova N,Gontarenko V,Shpektor A,Vasilieva E,Margolis L
Published figure using CD4 monoclonal antibody (Product # 14-0048-82) in Flow Cytometry
Fri Dec 01 00:00:00 EST 2017
Hormonal vitamin D up-regulates tissue-specific PD-L1 and PD-L2 surface glycoprotein expression in humans but not mice.
The Journal of biological chemistry
Dimitrov V,Bouttier M,Boukhaled G,Salehi-Tabar R,Avramescu RG,Memari B,Hasaj B,Lukacs GL,Krawczyk CM,White JH
Published figure using CD4 monoclonal antibody (Product # 14-0048-82) in Flow Cytometry
Fri Dec 15 00:00:00 EST 2017
Single-cell profiling reveals GPCR heterogeneity and functional patterning during neuroinflammation.
JCI insight
Tischner D,Grimm M,Kaur H,Staudenraus D,Carvalho J,Looso M,Günther S,Wanke F,Moos S,Siller N,Breuer J,Schwab N,Zipp F,Waisman A,Kurschus FC,Offermanns S,Wettschureck N
Published figure using CD4 monoclonal antibody (Product # 14-0048-82) in Flow Cytometry
Thu Aug 03 00:00:00 EDT 2017
Targeted Disruption of TCF12 Reveals HEB as Essential in Human Mesodermal Specification and Hematopoiesis.
Stem cell reports
Li Y,Brauer PM,Singh J,Xhiku S,Yoganathan K,Zúñiga-Pflücker JC,Anderson MK
Published figure using CD4 monoclonal antibody (Product # 14-0048-82) in Flow Cytometry
Tue Sep 12 00:00:00 EDT 2017
Virion incorporation of integrin α4β7 facilitates HIV-1 infection and intestinal homing.
Science immunology
Guzzo C,Ichikawa D,Park C,Phillips D,Liu Q,Zhang P,Kwon A,Miao H,Lu J,Rehm C,Arthos J,Cicala C,Cohen MS,Fauci AS,Kehrl JH,Lusso P
14-0048 was used in Flow cytometry/Cell sorting to demonstrate that HIV-1 intestinal homing is mediated by α4β7 integrin internalisation and in vivo treatment with anti-α4β7 antibodies promotes viral control.
Fri May 12 00:00:00 EDT 2017
Virion incorporation of integrin α4β7 facilitates HIV-1 infection and intestinal homing.
Science immunology
Guzzo C,Ichikawa D,Park C,Phillips D,Liu Q,Zhang P,Kwon A,Miao H,Lu J,Rehm C,Arthos J,Cicala C,Cohen MS,Fauci AS,Kehrl JH,Lusso P
14-0048 was used in Flow cytometry/Cell sorting to demonstrate that HIV-1 intestinal homing is mediated by α4β7 integrin internalisation and in vivo treatment with anti-α4β7 antibodies promotes viral control.
Fri May 12 00:00:00 EDT 2017
PD-L1 expression and prognostic impact in glioblastoma.
Neuro-oncology
Nduom EK,Wei J,Yaghi NK,Huang N,Kong LY,Gabrusiewicz K,Ling X,Zhou S,Ivan C,Chen JQ,Burks JK,Fuller GN,Calin GA,Conrad CA,Creasy C,Ritthipichai K,Radvanyi L,Heimberger AB
Published figure using CD4 monoclonal antibody (Product # 14-0048-82) in Flow Cytometry
Mon Feb 01 00:00:00 EST 2016
Patients with MS under daclizumab therapy mount normal immune responses to influenza vaccination.
Neurology(R) neuroimmunology & neuroinflammation
Lin YC,Winokur P,Blake A,Wu T,Manischewitz J,King LR,Romm E,Golding H,Bielekova B
14-0048 was used in Flow cytometry/Cell sorting to explore the effect of Daclizumab-treatment on the activation of CD8(+) T cells and B cells and the development of immune responses to the influenza vaccine.
Mon Feb 01 00:00:00 EST 2016
Tax and Semaphorin 4D Released from Lymphocytes Infected with Human Lymphotropic Virus Type 1 and Their Effect on Neurite Growth.
AIDS research and human retroviruses
Quintremil S,Alberti C,Rivera M,Medina F,Puente J,Cartier L,Ramírez E,Tanaka Y,Valenzuela MA
Published figure using CD4 monoclonal antibody (Product # 14-0048-82) in Flow Cytometry
Fri Jan 01 00:00:00 EST 2016
Tumor-derived exosomes regulate expression of immune function-related genes in human T cell subsets.
Scientific reports
Muller L,Mitsuhashi M,Simms P,Gooding WE,Whiteside TL
Published figure using CD4 monoclonal antibody (Product # 14-0048-82) in Flow Cytometry
Thu Feb 04 00:00:00 EST 2016
Small CD4 Mimetics Prevent HIV-1 Uninfected Bystander CD4 + T Cell Killing Mediated by Antibody-dependent Cell-mediated Cytotoxicity.
EBioMedicine
Richard J,Veillette M,Ding S,Zoubchenok D,Alsahafi N,Coutu M,Brassard N,Park J,Courter JR,Melillo B,Smith AB,Shaw GM,Hahn BH,Sodroski J,Kaufmann DE,Finzi A
14-0048 was used in Immunocytochemistry to study the mechanisms underlying CD4+ T-cell depletion in HIV-1 pathogenesis.
Fri Jan 01 00:00:00 EST 2016
Small CD4 Mimetics Prevent HIV-1 Uninfected Bystander CD4 + T Cell Killing Mediated by Antibody-dependent Cell-mediated Cytotoxicity.
EBioMedicine
Richard J,Veillette M,Ding S,Zoubchenok D,Alsahafi N,Coutu M,Brassard N,Park J,Courter JR,Melillo B,Smith AB,Shaw GM,Hahn BH,Sodroski J,Kaufmann DE,Finzi A
14-0048 was used in Immunocytochemistry to study the mechanisms underlying CD4+ T-cell depletion in HIV-1 pathogenesis.
Fri Jan 01 00:00:00 EST 2016
Mucosal-associated invariant T cell alterations in obese and type 2 diabetic patients.
The Journal of clinical investigation
Magalhaes I,Pingris K,Poitou C,Bessoles S,Venteclef N,Kiaf B,Beaudoin L,Da Silva J,Allatif O,Rossjohn J,Kjer-Nielsen L,McCluskey J,Ledoux S,Genser L,Torcivia A,Soudais C,Lantz O,Boitard C,Aron-Wisnewsky J,Larger E,Clément K,Lehuen A
14-0048 was used in Flow cytometry/Cell sorting to analyse MAIT cells in the blood and adipose tissues of patients with type 2 diabetes and/or severe obesity.
Wed Apr 01 00:00:00 EDT 2015
The catalytic activity of the kinase ZAP-70 mediates basal signaling and negative feedback of the T cell receptor pathway.
Science signaling
Goodfellow HS,Frushicheva MP,Ji Q,Cheng DA,Kadlecek TA,Cantor AJ,Kuriyan J,Chakraborty AK,Salomon A,Weiss A
14-0048 was used in Functional assays to study the contribution of ZAP-70 catalytic activity to the temporal dynamics of phosphorylation leading to T cell activation.
Tue May 19 00:00:00 EDT 2015
The HIV-1 gp120 CD4-bound conformation is preferentially targeted by antibody-dependent cellular cytotoxicity-mediating antibodies in sera from HIV-1-infected individuals.
Journal of virology
Veillette M,Coutu M,Richard J,Batraville LA,Dagher O,Bernard N,Tremblay C,Kaufmann DE,Roger M,Finzi A
14-0048 was used in Flow cytometry/Cell sorting to investigate the sera of HIV-1 infected individuals.
Thu Jan 01 00:00:00 EST 2015
Wide-scale quantitative phosphoproteomic analysis reveals that cold treatment of T cells closely mimics soluble antibody stimulation.
Journal of proteome research
Ji Q,Salomon AR
14-0048 was used in Functional assays to investigate the mechanism by which T cell receptor signalling initiation occurs in response to low temperature, demonstrating that signalling patterns initiated by cold treatment are nearly identical to those initiated by soluble antibodies.
Fri May 01 00:00:00 EDT 2015
Higher Frequency of NK and CD4+ T-Cells in Mucosa and Potent Cytotoxic Response in HIV Controllers.
PloS one
Taborda NA,González SM,Alvarez CM,Correa LA,Montoya CJ,Rugeles MT
14-0048 was used in Flow cytometry/Cell sorting to investigate the frequency, phenotype and activity of T and NK cells in HIV controllers, showing higher frequencies of NK and CD4+ T-Cells and potent cytotoxic response.
Fri May 13 00:00:00 EDT 2016
A single-residue change in the HIV-1 V3 loop associated with maraviroc resistance impairs CCR5 binding affinity while increasing replicative capacity.
Retrovirology
Garcia-Perez J,Staropoli I,Azoulay S,Heinrich JT,Cascajero A,Colin P,Lortat-Jacob H,Arenzana-Seisdedos F,Alcami J,Kellenberger E,Lagane B
14-0048 was used in Flow cytometry/Cell sorting to indicate that changes in the V3 loop of maraviroc-resistant viruses can augment the efficiency of CCR5-dependent steps of viral entry.
Thu Jun 18 00:00:00 EDT 2015
SRC homology 2 domain-containing leukocyte phosphoprotein of 76 kDa (SLP-76) N-terminal tyrosine residues regulate a dynamic signaling equilibrium involving feedback of proximal T-cell receptor (TCR) signaling.
Molecular & cellular proteomics : MCP
Ji Q,Ding Y,Salomon AR
14-0048 was used in Functional assays to expand our knowledge of the role of N-terminal phosphorylation of SLP-76 from three previously studied tyrosine sites.
Thu Jan 01 00:00:00 EST 2015
CCR5/CD4/CXCR4 oligomerization prevents HIV-1 gp120IIIB binding to the cell surface.
Proceedings of the National Academy of Sciences of the United States of America
Martínez-Muñoz L,Barroso R,Dyrhaug SY,Navarro G,Lucas P,Soriano SF,Vega B,Costas C,Muñoz-Fernández MÁ,Santiago C,Rodríguez Frade JM,Franco R,Mellado M
14-0048 was used in Western Blotting to highlight the dimerisation of T cell surface receptors as a potential therapeutic approach for AIDS intervention.
Tue May 13 00:00:00 EDT 2014
CD4 ligation on human blood monocytes triggers macrophage differentiation and enhances HIV infection.
Journal of virology
Zhen A,Krutzik SR,Levin BR,Kasparian S,Zack JA,Kitchen SG
14-0048 was used in Flow cytometry/Cell sorting to investigate the role of the CD4 molecule in human monocyte development and function, showing that CD4 ligation triggers macrophage differentiation and enhances HIV infection.
Mon Sep 01 00:00:00 EDT 2014
CD4 ligation on human blood monocytes triggers macrophage differentiation and enhances HIV infection.
Journal of virology
Zhen A,Krutzik SR,Levin BR,Kasparian S,Zack JA,Kitchen SG
14-0048 was used in Flow cytometry/Cell sorting to investigate the role of the CD4 molecule in human monocyte development and function, showing that CD4 ligation triggers macrophage differentiation and enhances HIV infection.
Mon Sep 01 00:00:00 EDT 2014
Aging and cytomegalovirus infection differentially and jointly affect distinct circulating T cell subsets in humans.
Journal of immunology (Baltimore, Md. : 1950)
Wertheimer AM,Bennett MS,Park B,Uhrlaub JL,Martinez C,Pulko V,Currier NL,Nikolich-Žugich D,Kaye J,Nikolich-Žugich J
Published figure using CD4 monoclonal antibody (Product # 14-0048-82) in Flow Cytometry
Sat Mar 01 00:00:00 EST 2014
The antiangiogenic insulin receptor substrate-1 antisense oligonucleotide aganirsen impairs AU-rich mRNA stability by reducing 14-3-3β-tristetraprolin protein complex, reducing inflammation and psoriatic lesion size in patients.
The Journal of pharmacology and experimental therapeutics
Colin S,Darné B,Kadi A,Ferry A,Favier M,Lesaffre C,Conduzorgues JP,Al-Mahmood S,Doss N
14-0048 was used in Immunohistochemistry to demonstrate that aganirsen is the first of a new generation of antiangiogenic medicines combining anti-inflammatory activities.
Tue Apr 01 00:00:00 EDT 2014
An increased abundance of tumor-infiltrating regulatory T cells is correlated with the progression and prognosis of pancreatic ductal adenocarcinoma.
PloS one
Tang Y,Xu X,Guo S,Zhang C,Tang Y,Tian Y,Ni B,Lu B,Wang H
Published figure using CD4 monoclonal antibody (Product # 14-0048-82) in Immunohistochemistry
Tue Jan 06 00:00:00 EST 2015
High avidity CD8+ T cells efficiently eliminate motile HIV-infected targets and execute a locally focused program of anti-viral function.
PloS one
Foley MH,Forcier T,McAndrew E,Gonzalez M,Chen H,Juelg B,Walker BD,Irvine DJ
14-0048 was used in Functional assays to study the impact of infected target cell migration on antigen recognition by HIV-specific CD8(+) T cells in a 3D collagen model of peripheral tissue.
Tue Oct 14 00:00:00 EDT 2014
CD40L expression permits CD8+ T cells to execute immunologic helper functions.
Blood
Frentsch M,Stark R,Matzmohr N,Meier S,Durlanik S,Schulz AR,Stervbo U,Jürchott K,Gebhardt F,Heine G,Reuter MA,Betts MR,Busch D,Thiel A
14-0048 was used in Flow cytometry/Cell sorting to investigate the role of CD40L in CD8+ T cells, showing that expression permits CD8+ T cells to execute immunologic helper functions.
Thu Jul 18 00:00:00 EDT 2013
B and T lymphocyte attenuator expression on CD4+ T-cells associates with sepsis and subsequent infections in ICU patients.
Critical care (London, England)
Shubin NJ,Monaghan SF,Heffernan DS,Chung CS,Ayala A
14-0048 was used in Flow cytometry/Cell sorting to evaluate the role of B and T lymphocyte attenuator, an immune-regulatory receptor, in driving lymphocyte dysfunction and apoptosis during sepsis.
Fri Nov 29 00:00:00 EST 2013
Somatostatin expression in human hair follicles and its potential role in immune privilege.
The Journal of investigative dermatology
Breitkopf T,Lo BK,Leung G,Wang E,Yu M,Carr N,Zloty D,Cowan B,Shapiro J,McElwee KJ
14-0048 was used in Flow cytometry/Cell sorting to demonstrate and quantify the functional immune privilege properties apparent in human hair follicles.
Mon Jul 01 00:00:00 EDT 2013
Phosphoantigen/IL2 expansion and differentiation of Vγ2Vδ2 T cells increase resistance to tuberculosis in nonhuman primates.
PLoS pathogens
Chen CY,Yao S,Huang D,Wei H,Sicard H,Zeng G,Jomaa H,Larsen MH,Jacobs WR,Wang R,Letvin N,Shen Y,Qiu L,Shen L,Chen ZW
14-0048 was used in Flow cytometry/Cell sorting to assess the potential of γδ T-cell-targeted treatment of established TB.
Thu Aug 01 00:00:00 EDT 2013
Rate of AIDS progression is associated with gastrointestinal dysfunction in simian immunodeficiency virus-infected pigtail macaques.
Journal of immunology (Baltimore, Md. : 1950)
Canary LA,Vinton CL,Morcock DR,Pierce JB,Estes JD,Brenchley JM,Klatt NR
14-0048 was used in Flow cytometry/Cell sorting to determine whether pre-existing GI-associated mucosal damage affects the progression of AIDS following HIV infection.
Fri Mar 15 00:00:00 EDT 2013
Dysregulation of anti-inflammatory annexin A1 expression in progressive Crohns Disease.
PloS one
Sena A,Grishina I,Thai A,Goulart L,Macal M,Fenton A,Li J,Prindiville T,Oliani SM,Dandekar S,Goulart L,Sankaran-Walters S
14-0048 was used in Flow cytometry/Cell sorting to examine the association between ANXA1 and IBD, and the effects of Infliximab therapy on ANXA1 expression.
Tue Jun 24 00:00:00 EDT 2014
CD137L-stimulated dendritic cells are more potent than conventional dendritic cells at eliciting cytotoxic T-cell responses.
Oncoimmunology
Harfuddin Z,Kwajah S,Chong Nyi Sim A,Macary PA,Schwarz H
14-0048 was used in Flow cytometry/Cell sorting to develop improved dendritic cell-based immunotherapy using CD137 signalling.
Fri Nov 01 00:00:00 EDT 2013
Increased soluble CD4 in serum of rheumatoid arthritis patients is generated by matrix metalloproteinase (MMP)-like proteinases.
PloS one
Tseng WY,Huang YS,Chiang NY,Chou YP,Wu YJ,Luo SF,Kuo CF,Lin KM,Lin HH
14-0048 was used in an ELISA assay to explore how, and why, higher levels of soluble CD4 are produced in patients of infectious and chronic inflammatory diseases.
Mon Nov 25 00:00:00 EST 2013
Increased soluble CD4 in serum of rheumatoid arthritis patients is generated by matrix metalloproteinase (MMP)-like proteinases.
PloS one
Tseng WY,Huang YS,Chiang NY,Chou YP,Wu YJ,Luo SF,Kuo CF,Lin KM,Lin HH
14-0048 was used in an ELISA assay to explore how, and why, higher levels of soluble CD4 are produced in patients of infectious and chronic inflammatory diseases.
Mon Nov 25 00:00:00 EST 2013
HIV-1 autologous antibody neutralization associates with mother to child transmission.
PloS one
Baan E,de Ronde A,Stax M,Sanders RW,Luchters S,Vyankandondera J,Lange JM,Pollakis G,Paxton WA
14-0048 was used in in vitro experiments to investigate the HIV-1 gp160 envelope proteins from mothers with HIV.
Thu Mar 06 00:00:00 EST 2014
Dynamics of simian immunodeficiency virus SIVmac239 infection in pigtail macaques.
Journal of virology
Klatt NR,Canary LA,Vanderford TH,Vinton CL,Engram JC,Dunham RM,Cronise HE,Swerczek JM,Lafont BA,Picker LJ,Silvestri G,Brenchley JM
14-0048 was used in Flow cytometry/Cell sorting to investigate the dynamics of simian immunodeficiency virus infection in Pigtail macaques.
Sun Jan 01 00:00:00 EST 2012
Engagement of T-cell antigen receptor and CD4/CD8 co-receptors induces prolonged STAT activation through autocrine/paracrine stimulation in human primary T cells.
Biochemical and biophysical research communications
Chueh FY,Yu CL
14-0048 was used in Functional assays to determine the extent of STAT protein involvement in T-cell antigen receptor signalling.
Fri Sep 21 00:00:00 EDT 2012
Novel serial positive enrichment technology enables clinical multiparameter cell sorting.
PloS one
Stemberger C,Dreher S,Tschulik C,Piossek C,Bet J,Yamamoto TN,Schiemann M,Neuenhahn M,Martin K,Schlapschy M,Skerra A,Schmidt T,Edinger M,Riddell SR,Germeroth L,Busch DH
14-0048 was used in Flow cytometry/Cell sorting to exhibit novel, low-affinity antibody-derived Fab-fragments for use in clinical cell preparations and research.
Mon Aug 27 00:00:00 EDT 2012
Quantitative phosphoproteomics reveals SLP-76 dependent regulation of PAG and Src family kinases in T cells.
PloS one
Cao L,Ding Y,Hung N,Yu K,Ritz A,Raphael BJ,Salomon AR
14-0048 was used in Immunoprecipitation to characterise SLP-76-dependent phosphorylation events in TCR signalling.
Tue Apr 02 00:00:00 EDT 2013
Significant mobilization of both conventional and regulatory T cells with AMD3100.
Blood
Kean LS,Sen S,Onabajo O,Singh K,Robertson J,Stempora L,Bonifacino AC,Metzger ME,Promislow DE,Mattapallil JJ,Donahue RE
14-0048 was used in Flow cytometry/Cell sorting to indicate that AMD3100 may mobilize a GVHD-protective T-cell repertoire.
Thu Dec 15 00:00:00 EST 2011
CD4-like immunological function by CD4- T cells in multiple natural hosts of simian immunodeficiency virus.
Journal of virology
Vinton C,Klatt NR,Harris LD,Briant JA,Sanders-Beer BE,Herbert R,Woodward R,Silvestri G,Pandrea I,Apetrei C,Hirsch VM,Brenchley JM
14-0048 was used in Flow cytometry/Cell sorting to demonstrate that coevolution with SIV has, in several cases, involved downregulation of receptors for the virus by otherwise-susceptible host target cells.
Thu Sep 01 00:00:00 EDT 2011
CD4-like immunological function by CD4- T cells in multiple natural hosts of simian immunodeficiency virus.
Journal of virology
Vinton C,Klatt NR,Harris LD,Briant JA,Sanders-Beer BE,Herbert R,Woodward R,Silvestri G,Pandrea I,Apetrei C,Hirsch VM,Brenchley JM
14-0048 was used in Flow cytometry/Cell sorting to demonstrate that coevolution with SIV has, in several cases, involved downregulation of receptors for the virus by otherwise-susceptible host target cells.
Thu Sep 01 00:00:00 EDT 2011
An inducible cell-cell fusion system with integrated ability to measure the efficiency and specificity of HIV-1 entry inhibitors.
PloS one
Herschhorn A,Finzi A,Jones DM,Courter JR,Sugawara A,Smith AB,Sodroski JG
14-0048 was used in Flow cytometry/Cell sorting to develop an inducible cell-cell fusion system to test efficiency of HIV-1 entry inhibitors.
Fri Mar 16 00:00:00 EDT 2012
C-terminal hydrophobic region in human bone marrow stromal cell antigen 2 (BST-2)/tetherin protein functions as second transmembrane motif.
The Journal of biological chemistry
Andrew AJ,Kao S,Strebel K
14-0048 was used in Western Blotting to investigate the functional importance of the C-terminal glycosylphosphatidylinositol anchor motif in BST-2.
Fri Nov 18 00:00:00 EST 2011
DNA methylation prevents CTCF-mediated silencing of the oncogene BCL6 in B cell lymphomas.
The Journal of experimental medicine
Lai AY,Fatemi M,Dhasarathy A,Malone C,Sobol SE,Geigerman C,Jaye DL,Mav D,Shah R,Li L,Wade PA
14-0048 was used in Functional assays to investigate roles of DNA methylation in cancer, showing that it prevents CTCF-mediated silencing of the oncogene BCL6 in B cell lymphomas.
Mon Aug 30 00:00:00 EDT 2010
An MHC-defined primate model reveals significant rejection of bone marrow after mixed chimerism induction despite full MHC matching.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Larsen CP,Page A,Linzie KH,Russell M,Deane T,Stempora L,Strobert E,Penedo MC,Ward T,Wiseman R,O'Connor D,Miller W,Sen S,Singh K,Kean LS
14-0048 was used in Flow cytometry/Cell sorting to study mixed hematopoietic chimerism and immune tolerance in a novel MHC-defined rhesus macaque model.
Mon Nov 01 00:00:00 EDT 2010
The length of and nonhydrophobic residues in the transmembrane domain of dengue virus envelope protein are critical for its retention and assembly in the endoplasmic reticulum.
Journal of virology
Hsieh SC,Tsai WY,Wang WK
14-0048 was used in Immunoprecipitation to investigate determinants in the E protein of dengue virus for its retention and assembly in the endoplasmic reticulum.
Sat May 01 00:00:00 EDT 2010
Multicolor flow cytometry analyses of cellular immune response in rhesus macaques.
Journal of visualized experiments : JoVE
He H,Courtney AN,Wieder E,Sastry KJ
14-0048 was used in Flow cytometry/Cell sorting to describe a method for the detailed phenotypic and functional analyses of cellular immune responses.
Thu Apr 22 00:00:00 EDT 2010
Novel role of plasmacytoid dendritic cells in humans: induction of interleukin-10-producing Treg cells by plasmacytoid dendritic cells in patients with rheumatoid arthritis responding to therapy.
Arthritis and rheumatism
Kavousanaki M,Makrigiannakis A,Boumpas D,Verginis P
14-0048-82 was used in Flow Cytometry to explore the contribution of dendritic cells to the development of regulatory T cells in a human autoimmune disease setting.
Fri Jan 01 00:00:00 EST 2010
Lung dendritic cell expression of maturation molecules increases with worsening chronic obstructive pulmonary disease.
American journal of respiratory and critical care medicine
Freeman CM,Martinez FJ,Han MK,Ames TM,Chensue SW,Todt JC,Arenberg DA,Meldrum CA,Getty C,McCloskey L,Curtis JL
14-0048 was used in Flow cytometry/Cell sorting to determine the expression of maturation molecules by individual DC subsets in relationship to COPD stage.
Tue Dec 15 00:00:00 EST 2009
CD4-CCR5 interaction in intracellular compartments contributes to receptor expression at the cell surface.
Blood
Achour L,Scott MG,Shirvani H,Thuret A,Bismuth G,Labbé-Jullié C,Marullo S
Published figure using CD4 monoclonal antibody (Product # 14-0048-82) in Immunofluorescence
Thu Feb 26 00:00:00 EST 2009
CD4-CCR5 interaction in intracellular compartments contributes to receptor expression at the cell surface.
Blood
Achour L,Scott MG,Shirvani H,Thuret A,Bismuth G,Labbé-Jullié C,Marullo S
Published figure using CD4 monoclonal antibody (Product # 14-0048-82) in Immunofluorescence
Thu Feb 26 00:00:00 EST 2009
CD4-CCR5 interaction in intracellular compartments contributes to receptor expression at the cell surface.
Blood
Achour L,Scott MG,Shirvani H,Thuret A,Bismuth G,Labbé-Jullié C,Marullo S
Published figure using CD4 monoclonal antibody (Product # 14-0048-82) in Immunofluorescence
Thu Feb 26 00:00:00 EST 2009
CD4-CCR5 interaction in intracellular compartments contributes to receptor expression at the cell surface.
Blood
Achour L,Scott MG,Shirvani H,Thuret A,Bismuth G,Labbé-Jullié C,Marullo S
Published figure using CD4 monoclonal antibody (Product # 14-0048-82) in Immunofluorescence
Thu Feb 26 00:00:00 EST 2009
Gammadelta T cell immune manipulation during chronic phase of simian-human immunodeficiency virus infection [corrected] confers immunological benefits.
Journal of immunology (Baltimore, Md. : 1950)
Ali Z,Yan L,Plagman N,Reichenberg A,Hintz M,Jomaa H,Villinger F,Chen ZW
14-0048-82 was used in Flow Cytometry to investigate whether a well-defined phosphoantigen-4-hydroxy-3-methyl-but-2-enyl pyrophosphate/IL-2 therapeutic regimen can overcome HIV-mediated immune suppression to massively expand polyfunctional Vgamma2Vdelta2 T cells.
Thu Oct 15 00:00:00 EDT 2009
Construction and preclinical evaluation of an anti-CD19 chimeric antigen receptor.
Journal of immunotherapy (Hagerstown, Md. : 1997)
Kochenderfer JN,Feldman SA,Zhao Y,Xu H,Black MA,Morgan RA,Wilson WH,Rosenberg SA
14-0048 was used in Flow cytometry/Cell sorting to construct and compare two chimaeric antigen receptors containing a single chain variable region moiety that recognises CD19.
Tue Sep 01 00:00:00 EDT 2009
The Mi-2/NuRD complex associates with pericentromeric heterochromatin during S phase in rapidly proliferating lymphoid cells.
Chromosoma
Helbling Chadwick L,Chadwick BP,Jaye DL,Wade PA
14-0048 was used in Flow cytometry/Cell sorting to propose that Mi-2/NuRD constitutes an enzymatic component of a pathway for assembly and maturation of chromatin.
Sat Aug 01 00:00:00 EDT 2009
Abnormally high levels of virus-infected IFN-gamma+ CCR4+ CD4+ CD25+ T cells in a retrovirus-associated neuroinflammatory disorder.
PloS one
Yamano Y,Araya N,Sato T,Utsunomiya A,Azakami K,Hasegawa D,Izumi T,Fujita H,Aratani S,Yagishita N,Fujii R,Nishioka K,Jacobson S,Nakajima T
14-0048 was used in Flow cytometry/Cell sorting to distinguish the HTLV-1 infected T cell subset contributing to neuroinflammation in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP).
Wed Aug 05 00:00:00 EDT 2009
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.jpg?time=20220826?time=20220826 "CD4 Antibody (14-0048-82) in Flow")
