Invitrogen

CD4 Monoclonal Antibody (GK1.5), PE, eBioscience™

Advanced Verification

This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.

97 Published Figures

309 References

View all (606) CD4 antibodies

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CD4 Antibody (12-0041-82) in Flow

Staining of C57BL/6 splenocytes with Anti-Human/Mouse CD45R (B220) FITC (Product # 11-0452-82) and 0.06 µg of Rat IgG2b K Isotype Control PE (Product # 12-4031-82) (left) or 0.06 µg of Anti-Mouse CD4 PE (right). Total viable cells were used for analysis.

CD4 Antibody in Immunohistochemistry, Flow Cytometry (IHC, Flow)

Product Image Gallery

CD4 Antibody — Staining of mouse splenocytes. As expected based on known relative expression patterns, CD4 clone GK1.5 stains about 25% of total lymphocytes and does not stain CD45R (B220)+ B cells. Details: Balb/c splenocytes were surface stained with CD45R (B220, clone RA3-6B2) and Rat IgG2b Isotype Control or CD4 (clone GK1.5). Cells in the lymphocyte gate were used for analysis. {RE}

Product Details

12-0041-82

Applications

Tested Dilution

Publications

Western Blot (WB)

View 1 publication 1 publication

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Frozen) (IHC (F))

View 2 publications 2 publications

Immunocytochemistry (ICC/IF)

View 3 publications 3 publications

Flow Cytometry (Flow)

0.125 µg/test

View 294 publications 294 publications

ELISA (ELISA)

View 1 publication 1 publication

Functional Assay (Functional)

View 3 publications 3 publications

Miscellaneous PubMed (Misc)

View 2 publications 2 publications

Product Specifications

Species Reactivity

Mouse

Published species

Fish, Human, Mouse

Host/Isotype

Rat / IgG2b, kappa

Recommended Isotype Control

Rat IgG2b kappa Isotype Control (eB149/10H5), PE, eBioscience™

Class

Monoclonal

Type

Antibody

Clone

GK1.5

Conjugate

PE PE PE

Excitation/Emission Max

565/576 nm View spectra

Form

Liquid

Concentration

0.2 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.2

Contains

0.09% sodium azide

Storage conditions

4° C, store in dark, DO NOT FREEZE!

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_465506

Product Specific Information

Description: The GK1.5 monoclonal antibody reacts with the mouse CD4 molecule, a 55 kDa cell surface receptor expressed by a majority of thymocytes, subpopulation of mature T cells and dendritic cells. CD4 binds to MHC class II on the surface of antigen presenting cells and plays an important role both in T cell development and in optimal functioning of mature T cells. In T cells, CD4 associates with protein tyrosine kinase p56lck through its cytoplasmic tail. Binding of GK1.5 is blocked by RM4-5.

Applications Reported: The GK1.5 antibody has been reported for use in flow cytometric analysis.

Applications Tested: The GK1.5 antibody has been tested by flow cytometric analysis of mouse thymocytes and splenocytes. This can be used at less than or equal to 0.125 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

Excitation: 488-561 nm; Emission: 578 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser.

Filtration: 0.2 µm post-manufacturing filtered.

Target Information

The CD4 antigen is involved in the recognition of MHC class II molecules and is a co-receptor for HIV. CD4 is primarily expressed in a subset of T-lymphocytes, also referred to as T helper cells, but may also be expressed by other cells in the immune system, such as monocytes, macrophages, and dendritic cells. At the tissue level, CD4 expression may be detected in thymus, lymph nodes, tonsils, and spleen, and also in specific regions of the brain, gut, and other non-lymphoid tissues. CD4 functions to initiate or augment the early phase of T-cell activation through its association with the T-cell receptor complex and protein tyrosine kinase, Lck. It may also function as an important mediator of direct neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcripts have been identified in this gene [RefSeq, July 2017].

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

How to use the Panel Builder

Watch the video to learn how to use the Invitrogen Flow Cytometry Panel Builder to build your next flow cytometry panel in 5 easy steps.

Product References

Fasudil-modified macrophages reduce inflammation and regulate the immune response in experimental autoimmune encephalomyelitis.

Neural regeneration research

Liu C,Guo S,Liu R,Guo M,Wang Q,Chai Z,Xiao B,Ma C

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Fri Mar 01 00:00:00 EST 2024

YAP/STAT3 inhibited CD8⁺ T cells activity in the breast cancer immune microenvironment by inducing M2 polarization of tumor-associated macrophages.

Cancer medicine

Wang C,Shen N,Guo Q,Tan X,He S

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Tue Aug 01 00:00:00 EDT 2023

B cell extracellular vesicles contain monomeric IgM that binds antigen and enters target cells.

iScience

Gutknecht MF,Holodick NE,Rothstein TL

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Fri Sep 15 00:00:00 EDT 2023

Subconjunctival injection of human umbilical cord mesenchymal stem cells alleviates experimental allergic conjunctivitis via regulating T cell response.

Stem cell research & therapy

Li D,Ou Q,Shen Q,Lu MM,Xu JY,Jin C,Gao F,Wang J,Zhang J,Zhang J,Li J,Lu L,Xu GT,Tian H

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Mon Oct 02 00:00:00 EDT 2023

Tumor-secreted IFI35 promotes proliferation and cytotoxic activity of CD8⁺ T cells through PI3K/AKT/mTOR signaling pathway in colorectal cancer.

Journal of biomedical science

Li P,Zhou D,Chen D,Cheng Y,Chen Y,Lin Z,Zhang X,Huang Z,Cai J,Huang W,Lin Y,Ke H,Long J,Zou Y,Ye S,Lan P

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Wed Jun 28 00:00:00 EDT 2023

Respiratory mucosal vaccination of peptide-poloxamine-DNA nanoparticles provides complete protection against lethal SARS-CoV-2 challenge.

Biomaterials

Sun S,Li E,Zhao G,Tang J,Zuo Q,Cai L,Xu C,Sui C,Ou Y,Liu C,Li H,Ding Y,Li C,Lu D,Zhang W,Luo P,Cheng P,Gao Y,Tu C,Pitard B,Rosenecker J,Wang B,Liu Y,Zou Q,Guan S

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Sun Jan 01 00:00:00 EST 2023

HSF1 promotes CD69⁺ Treg differentiation to inhibit colitis progression.

Theranostics

Yu L,Zhou B,Zhu Y,Li L,Zhong Y,Zhu L,Wang H,Chen H,Xu J,Guo T,Feng L,Wang X,Cai Z,Wang J,Jin H

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Tue Apr 18 00:00:00 EDT 2023

LAMP2 regulates autophagy in the thymic epithelium and thymic stroma-dependent CD4 T cell development.

Autophagy

Rodrigues PM,Sousa LG,Perrod C,Maceiras AR,Ferreirinha P,Pombinho R,Romera-Cárdenas G,Gomez-Lazaro M,Senkara M,Pistolic J,Cabanes D,Klein L,Saftig P,Alves NL

12-0041-82 was used in Flow Cytometry to suggest that LAMP2 interconnects the autophagy-lysosomal axis and the processing of selecting self-peptides:MHC II complexes in cTECs, underling its implications for the generation of a broad CD4 TCR repertoire.

Wed Feb 01 00:00:00 EST 2023

Prolidase Deficiency Causes Spontaneous T Cell Activation and Lupus-like Autoimmunity.

Journal of immunology (Baltimore, Md. : 1950)

Hodgson R,Crockford TL,Bhandari A,Kepple JD,Back J,Cawthorne E,Abeler-Dörner L,Laing AG,Clare S,Speak A,Adams DJ,Dougan G,Hayday AC,Deobagkar-Lele M,Cornall RJ,Bull KR

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Wed Mar 01 00:00:00 EST 2023

A candidate subunit vaccine induces protective immunity against Mycobacterium avium subspecies paratuberculosis in mice.

NPJ vaccines

Shao M,Cui N,Tang Y,Chen F,Cui Y,Dang G,Liu S

12-0041-82 was used in ELISA to demonstrate that recombinant protein 66NC is an efficient candidate for further development into a protective vaccine in terms of inducing specific protection against MAP.

Sat May 20 00:00:00 EDT 2023

Radiotherapy combined with anti-CEACAM1 immunotherapy to induce survival advantage in glioma.

Discover oncology

Li J,Chen Y,Fan Y,Wang H,Mu W,Liu X

12-0041-82 was used in Flow Cytometry to show the effect of radiotherapy on the expression of immune checkpoint molecule CEACAM1 in patients with glioma and the therapeutical effect of radiotherapy combined with blockade of CEACAM1 in mice with intracranial gliomas.

Thu Mar 16 00:00:00 EDT 2023

Development of a Syrian hamster anti-PD-L1 monoclonal antibody enables oncolytic adenoviral immunotherapy modelling in an immunocompetent virus replication permissive setting.

Frontiers in immunology

Clubb JHA,Kudling TV,Girych M,Haybout L,Pakola S,Hamdan F,Cervera-Carrascon V,Hemmes A,Grönberg-Vähä-Koskela S,Santos JM,Quixabeira DCA,Basnet S,Heiniö C,Arias V,Jirovec E,Kaptan S,Havunen R,Sorsa S,Erikat A,Schwartz J,Anttila M,Aro K,Viitala T,Vattulainen I,Cerullo V,Kanerva A,Hemminki A

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Mon Feb 27 00:00:00 EST 2023

TCR repertoire landscape reveals macrophage-mediated clone deletion in endotoxin tolerance.

Inflammation research : official journal of the European Histamine Research Society ... [et al.]

Zhao J,Jia L,Tao Y,Zhao X,Yang J,Lu Y,Yan Y,Mao L,Hu L,Lu J,Guo M,Chen C,Zhou Y,Wen Z,He Z,Xu L

12-0041-82 was used in Flow cytometry/Cell sorting to suggest that the clone selection in thymus in Endotoxin tolerance may confer protection against microbial sepsis.

Wed Mar 01 00:00:00 EST 2023

GH18 family glycoside hydrolase Chitinase A of Salmonella enhances virulence by facilitating invasion and modulating host immune responses.

PLoS pathogens

Chandra K,Roy Chowdhury A,Chatterjee R,Chakravortty D

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Fri Apr 01 00:00:00 EDT 2022

Rotenone aggravates PD-like pathology in A53T mutant human α-synuclein transgenic mice in an age-dependent manner.

Frontiers in aging neuroscience

Chen AD,Cao JX,Chen HC,Du HL,Xi XX,Sun J,Yin J,Jing YH,Gao LP

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Fri Aug 26 00:00:00 EDT 2022

IL-33 Deficiency Attenuates Lung Inflammation by Inducing Th17 Response and Impacting the Th17/Treg Balance in LPS-Induced ARDS Mice via Dendritic Cells.

Journal of immunology research

Cheng L,Jiao Y,Jiang W,Zhang X,Zhang L,Jia G

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Tue Dec 27 00:00:00 EST 2022

Interferon-γ Stimulates Interleukin-27 Derived from Dendritic Cells to Regulate Th9 Differentiation through STAT1/3 Pathway.

Disease markers

Xiong P,Liu T,Chen Y,Xu Q,Hu X,Han F,Shi L

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Mon Oct 31 00:00:00 EDT 2022

CD4⁺ CTLs Act as a Key Effector Population for Allograft Rejection of MSCs in a Donor MHC-II Dependent Manner in Injured Liver.

Aging and disease

Shen S,Li Y,Jin M,Fan D,Pan R,Lin A,Chen Y,Xiang L,Zhao RC,Shao J

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Thu Dec 01 00:00:00 EST 2022

CD4⁺ CTLs Act as a Key Effector Population for Allograft Rejection of MSCs in a Donor MHC-II Dependent Manner in Injured Liver.

Aging and disease

Shen S,Li Y,Jin M,Fan D,Pan R,Lin A,Chen Y,Xiang L,Zhao RC,Shao J

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Thu Dec 01 00:00:00 EST 2022

Free Fatty Acid Receptor 4 (FFA4) Activation Ameliorates Imiquimod-Induced Psoriasis in Mice.

International journal of molecular sciences

Son SE,Koh JM,Im DS

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Tue Apr 19 00:00:00 EDT 2022

Valosin-containing protein (VCP/p97) inhibition reduces viral clearance and induces toxicity associated with muscular damage.

Cell death & disease

Del Rio Oliva M,Basler M

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Thu Dec 01 00:00:00 EST 2022

Exenatide regulates Th17/Treg balance via PI3K/Akt/FoxO1 pathway in db/db mice.

Molecular medicine (Cambridge, Mass.)

Xu Q,Zhang X,Li T,Shao S

12-0041-82 was used in Flow cytometry/Cell sorting to illustrate that exenatide restores systemic Th17/Treg balance via regulating FoxO1 pathway with the progression of diabetes in db/db mice.

Sat Dec 03 00:00:00 EST 2022

Ribosome-Targeting Antibiotics Impair T Cell Effector Function and Ameliorate Autoimmunity by Blocking Mitochondrial Protein Synthesis.

Immunity

Almeida L,Dhillon-LaBrooy A,Castro CN,Adossa N,Carriche GM,Guderian M,Lippens S,Dennerlein S,Hesse C,Lambrecht BN,Berod L,Schauser L,Blazar BR,Kalesse M,Müller R,Moita LF,Sparwasser T

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Tue Jan 12 00:00:00 EST 2021

Cell-mimicking nanodecoys neutralize SARS-CoV-2 and mitigate lung injury in a non-human primate model of COVID-19.

Nature nanotechnology

Li Z,Wang Z,Dinh PC,Zhu D,Popowski KD,Lutz H,Hu S,Lewis MG,Cook A,Andersen H,Greenhouse J,Pessaint L,Lobo LJ,Cheng K

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Immunocytochemistry

Sun Aug 01 00:00:00 EDT 2021

Cell-mimicking nanodecoys neutralize SARS-CoV-2 and mitigate lung injury in a non-human primate model of COVID-19.

Nature nanotechnology

Li Z,Wang Z,Dinh PC,Zhu D,Popowski KD,Lutz H,Hu S,Lewis MG,Cook A,Andersen H,Greenhouse J,Pessaint L,Lobo LJ,Cheng K

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Immunocytochemistry

Sun Aug 01 00:00:00 EDT 2021

NF-κB-inducing kinase maintains T cell metabolic fitness in antitumor immunity.

Nature immunology

Gu M,Zhou X,Sohn JH,Zhu L,Jie Z,Yang JY,Zheng X,Xie X,Yang J,Shi Y,Brightbill HD,Kim JB,Wang J,Cheng X,Sun SC

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Mon Feb 01 00:00:00 EST 2021

Porphyromonas gingivalis exacerbates ulcerative colitis via Porphyromonas gingivalis peptidylarginine deiminase.

International journal of oral science

Zhao X,Liu J,Zhang C,Yu N,Lu Z,Zhang S,Li Y,Li Q,Liu J,Liu D,Pan Y

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Thu Sep 30 00:00:00 EDT 2021

Uncovering a novel role of PLCβ4 in selectively mediating TCR signaling in CD8+ but not CD4+ T cells.

The Journal of experimental medicine

Sasai M,Ma JS,Okamoto M,Nishino K,Nagaoka H,Takashima E,Pradipta A,Lee Y,Kosako H,Suh PG,Yamamoto M

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Mon Jul 05 00:00:00 EDT 2021

High Ambient Temperature Aggravates Experimental Autoimmune Uveitis Symptoms.

Frontiers in cell and developmental biology

Pan S,Tan H,Chang R,Wang Q,Zhu Y,Chen L,Li H,Su G,Zhou C,Cao Q,Kijlstra A,Yang P

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Tue Apr 13 00:00:00 EDT 2021

Dynamic changes in the systemic immune responses of spinal cord injury model mice.

Neural regeneration research

Gao TY,Huang FF,Xie YY,Wang WQ,Wang LD,Mu D,Cui Y,Wang B

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Mon Feb 01 00:00:00 EST 2021

Generation of a Novel Oncolytic Vaccinia Virus Using the IHD-W Strain.

Human gene therapy

Shin J,Hong SO,Kim M,Lee H,Choi H,Kim J,Hong J,Kang H,Lee E,Lee S,Kong B,Kim M,Choi H,Kim S

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Sat May 01 00:00:00 EDT 2021

CXCR3 alleviates renal ischemia‑reperfusion injury via increase of Tregs.

Molecular medicine reports

Xian W,Wu J,Li Q,Du X,Wang N,Chen D,Gao W,Cao J

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Thu Jul 01 00:00:00 EDT 2021

Irradiated whole-cell vaccine suppresses hepatocellular carcinoma growth in mice via Th9 cells.

Oncology letters

Chen J,Ding Y,Huang F,Lan R,Wang Z,Huang W,Chen R,Wu B,Fu L,Yang Y,Liu J,Hong J,Zhang W,Zhang L

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Sat May 01 00:00:00 EDT 2021

Preliminary analysis of immunoregulatory mechanism of hyperhomocysteinemia-induced brain injury in Wistar-Kyoto rats.

Experimental and therapeutic medicine

Zhang Y,Wang L,Li X,Geng J

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Sat May 01 00:00:00 EDT 2021

Estrogen receptor beta signaling in CD8⁺ T cells boosts T cell receptor activation and antitumor immunity through a phosphotyrosine switch.

Journal for immunotherapy of cancer

Yuan B,Clark CA,Wu B,Yang J,Drerup JM,Li T,Jin VX,Hu Y,Curiel TJ,Li R

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Fri Jan 01 00:00:00 EST 2021

Neuroimmune Consequences of eIF4E Phosphorylation on Chemotherapy-Induced Peripheral Neuropathy.

Frontiers in immunology

Agalave NM,Mody PH,Szabo-Pardi TA,Jeong HS,Burton MD

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Mon Sep 20 00:00:00 EDT 2021

Alphavirus-Driven Interferon Gamma (IFNg) Expression Inhibits Tumor Growth in Orthotopic 4T1 Breast Cancer Model.

Vaccines

Trofimova O,Korotkaja K,Skrastina D,Jansons J,Spunde K,Isaguliants M,Zajakina A

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Wed Oct 27 00:00:00 EDT 2021

A lymph node-targeted Amphiphile vaccine induces potent cellular and humoral immunity to SARS-CoV-2.

Science advances

Steinbuck MP,Seenappa LM,Jakubowski A,McNeil LK,Haqq CM,DeMuth PC

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Mon Feb 01 00:00:00 EST 2021

IDO1 Expression in Ovarian Cancer Induces PD-1 in T Cells via Aryl Hydrocarbon Receptor Activation.

Frontiers in immunology

Amobi-McCloud A,Muthuswamy R,Battaglia S,Yu H,Liu T,Wang J,Putluri V,Singh PK,Qian F,Huang RY,Putluri N,Tsuji T,Lugade AA,Liu S,Odunsi K

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Fri Oct 29 00:00:00 EDT 2021

Mesenchymal stem cell exosome-derived miR-223 alleviates acute graft-versus-host disease via reducing the migration of donor T cells.

Stem cell research & therapy

Liu W,Zhou N,Liu Y,Zhang W,Li X,Wang Y,Zheng R,Zhang Y

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Fri Feb 26 00:00:00 EST 2021

Mesenchymal stem cell exosome-derived miR-223 alleviates acute graft-versus-host disease via reducing the migration of donor T cells.

Stem cell research & therapy

Liu W,Zhou N,Liu Y,Zhang W,Li X,Wang Y,Zheng R,Zhang Y

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Fri Feb 26 00:00:00 EST 2021

G-MDSCs promote aging-related cardiac fibrosis by activating myofibroblasts and preventing senescence.

Cell death & disease

Sun SN,Ni SH,Li Y,Liu X,Deng JP,Chen ZX,Li H,Feng WJ,Huang YS,Li DN,Xian SX,Yang ZQ,Wang LJ,Lu L

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Tue Jun 08 00:00:00 EDT 2021

Butyrate Improves Skin/Lung Fibrosis and Intestinal Dysbiosis in Bleomycin-Induced Mouse Models.

International journal of molecular sciences

Park HJ,Jeong OY,Chun SH,Cheon YH,Kim M,Kim S,Lee SI

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Tue Mar 09 00:00:00 EST 2021

Mapping Rora expression in resting and activated CD4+ T cells.

PloS one

Haim-Vilmovsky L,Henriksson J,Walker JA,Miao Z,Natan E,Kar G,Clare S,Barlow JL,Charidemou E,Mamanova L,Chen X,Proserpio V,Pramanik J,Woodhouse S,Protasio AV,Efremova M,Griffin JL,Berriman M,Dougan G,Fisher J,Marioni JC,McKenzie ANJ,Teichmann SA

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Fri Nov 12 00:00:00 EST 2021

Type 2 diabetic mice enter a state of spontaneous hibernation-like suspended animation following accumulation of uric acid.

The Journal of biological chemistry

Zhao Y,Cheng R,Zhao Y,Ge W,Yang Y,Ding Z,Xu X,Wang Z,Wu Z,Zhang J

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Fri Oct 01 00:00:00 EDT 2021

Targeting Ovarian Carcinoma with TSP-1:CD47 Antagonist TAX2 Activates Anti-Tumor Immunity.

Cancers

Jeanne A,Sarazin T,Charlé M,Moali C,Fichel C,Boulagnon-Rombi C,Callewaert M,Andry MC,Diesis E,Delolme F,Rioult D,Dedieu S

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Thu Oct 07 00:00:00 EDT 2021

Targeting Ovarian Carcinoma with TSP-1:CD47 Antagonist TAX2 Activates Anti-Tumor Immunity.

Cancers

Jeanne A,Sarazin T,Charlé M,Moali C,Fichel C,Boulagnon-Rombi C,Callewaert M,Andry MC,Diesis E,Delolme F,Rioult D,Dedieu S

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Thu Oct 07 00:00:00 EDT 2021

A nanounit strategy reverses immune suppression of exosomal PD-L1 and is associated with enhanced ferroptosis.

Nature communications

Wang G,Xie L,Li B,Sang W,Yan J,Li J,Tian H,Li W,Zhang Z,Tian Y,Dai Y

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Thu Sep 30 00:00:00 EDT 2021

Oxygen-Enriched Metal-Phenolic X-Ray Nanoprocessor for Cancer Radio-Radiodynamic Therapy in Combination with Checkpoint Blockade Immunotherapy.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Sang W,Xie L,Wang G,Li J,Zhang Z,Li B,Guo S,Deng CX,Dai Y

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Mon Feb 01 00:00:00 EST 2021

Systemic Delivery of Oncolytic Adenovirus to Tumors Using Tumor-Infiltrating Lymphocytes as Carriers.

Cells

Santos J,Heiniö C,Quixabeira D,Zafar S,Clubb J,Pakola S,Cervera-Carrascon V,Havunen R,Kanerva A,Hemminki A

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Thu Apr 22 00:00:00 EDT 2021

Milk-derived extracellular vesicles alleviate ulcerative colitis by regulating the gut immunity and reshaping the gut microbiota.

Theranostics

Tong L,Hao H,Zhang Z,Lv Y,Liang X,Liu Q,Liu T,Gong P,Zhang L,Cao F,Pastorin G,Lee CN,Chen X,Wang JW,Yi H

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Fri Jan 28 00:00:00 EST 2022

Inducible T-Cell Costimulator Mediates Lymphocyte/Macrophage Interactions During Liver Repair.

Frontiers in immunology

Ramavath NN,Gadipudi LL,Provera A,Gigliotti LC,Boggio E,Bozzola C,Albano E,Dianzani U,Sutti S

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Mon Feb 14 00:00:00 EST 2022

Remote Limb Ischemic Postconditioning Protects Against Ischemic Stroke by Promoting Regulatory T Cells Thriving.

Journal of the American Heart Association

Yu HH,Ma XT,Ma X,Chen M,Chu YH,Wu LJ,Wang W,Qin C,Tian DS

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Tue Nov 16 00:00:00 EST 2021

Sequential Treatment of Bioresponsive Nanoparticles Elicits Antiangiogenesis and Apoptosis and Synergizes with a CD40 Agonist for Antitumor Immunity.

ACS nano

Ling X,Jiang X,Li Y,Han W,Rodriguez M,Xu Z,Lin W

12-0041-82 was used in flow cytometry to sequential delivery of antiangiogenic and chemotherapeutic agents with bioresponsive NPs activates tumor microenvironments and synergizes with CD40 agonist to regress transplanted tumors and inhibit disseminated tumors in a lung cancer mouse model.

Tue Jan 26 00:00:00 EST 2021

EGCG Inhibits Tumor Growth in Melanoma by Targeting JAK-STAT Signaling and Its Downstream PD-L1/PD-L2-PD1 Axis in Tumors and Enhancing Cytotoxic T-Cell Responses.

Pharmaceuticals (Basel, Switzerland)

Ravindran Menon D,Li Y,Yamauchi T,Osborne DG,Vaddi PK,Wempe MF,Zhai Z,Fujita M

12-0041-82 was used in Flow cytometry/Cell sorting to demonstrate that EGCG enhances anti-tumor immune responses by inhibiting JAK-STAT signaling in melanoma.

Tue Oct 26 00:00:00 EDT 2021

Immune-tolerance to human iPS-derived neural progenitors xenografted into the immature cerebellum is overridden by species-specific differences in differentiation timing.

Scientific reports

Nato G,Corti A,Parmigiani E,Jachetti E,Lecis D,Colombo MP,Delia D,Buffo A,Magrassi L

12-0041-82 was used in Flow Cytometry to monitor xeno-transplanted human neural precursor cells derived from induced pluripotent stem cells into the cerebellum and brainstem of mice and rats during prenatal development or the first postnatal week.

Tue Jan 12 00:00:00 EST 2021

Placenta-Expanded Stromal Cell Therapy in a Rodent Model of Simulated Weightlessness.

Cells

Rubinstein L,Paul AM,Houseman C,Abegaz M,Tabares Ruiz S,O'Neil N,Kunis G,Ofir R,Cohen J,Ronca AE,Globus RK,Tahimic CGT

12-0041-82 was used in Flow Cytometry to support the therapeutic potential of placenta-derived stromal cells for select physiological deficits during simulated spaceflight.

Mon Apr 19 00:00:00 EDT 2021

Epinephrine Production in Th17 Cells and Experimental Autoimmune Encephalitis.

Frontiers in immunology

Yang P,Tian H,Zou YR,Chambon P,Ichinose H,Honig G,Diamond B,Kim SJ

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Mon Jul 05 00:00:00 EDT 2021

Aging-dependent mitochondrial dysfunction mediated by ceramide signaling inhibits antitumor T cell response.

Cell reports

Vaena S,Chakraborty P,Lee HG,Janneh AH,Kassir MF,Beeson G,Hedley Z,Yalcinkaya A,Sofi MH,Li H,Husby ML,Stahelin RV,Yu XZ,Mehrotra S,Ogretmen B

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Immunocytochemistry

Tue May 04 00:00:00 EDT 2021

Antagonistic Inflammatory Phenotypes Dictate Tumor Fate and Response to Immune Checkpoint Blockade.

Immunity

Bonavita E,Bromley CP,Jonsson G,Pelly VS,Sahoo S,Walwyn-Brown K,Mensurado S,Moeini A,Flanagan E,Bell CR,Chiang SC,Chikkanna-Gowda CP,Rogers N,Silva-Santos B,Jaillon S,Mantovani A,Reis e Sousa C,Guerra N,Davis DM,Zelenay S

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Tue Dec 15 00:00:00 EST 2020

Splenic Capture and In Vivo Intracellular Biodegradation of Biological-Grade Graphene Oxide Sheets.

ACS nano

Newman L,Jasim DA,Prestat E,Lozano N,de Lazaro I,Nam Y,Assas BM,Pennock J,Haigh SJ,Bussy C,Kostarelos K

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Tue Aug 25 00:00:00 EDT 2020

Splenic Capture and In Vivo Intracellular Biodegradation of Biological-Grade Graphene Oxide Sheets.

ACS nano

Newman L,Jasim DA,Prestat E,Lozano N,de Lazaro I,Nam Y,Assas BM,Pennock J,Haigh SJ,Bussy C,Kostarelos K

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Tue Aug 25 00:00:00 EDT 2020

Deregulated Notch and Wnt signaling activates early-stage myeloid regeneration pathways in leukemia.

The Journal of experimental medicine

Kang YA,Pietras EM,Passegué E

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Mon Mar 02 00:00:00 EST 2020

Notch dimerization and gene dosage are important for normal heart development, intestinal stem cell maintenance, and splenic marginal zone B-cell homeostasis during mite infestation.

PLoS biology

Kobia FM,Preusse K,Dai Q,Weaver N,Hass MR,Chaturvedi P,Stein SJ,Pear WS,Yuan Z,Kovall RA,Kuang Y,Eafergen N,Sprinzak D,Gebelein B,Brunskill EW,Kopan R

12-0041 was used in Flow cytometry/Cell sorting to highlight the role of the environment in malignancy and colitis and is consistent with Notch-dependent anti-parasite immune responses being compromised in Notch dimer-deficient animals.

Thu Oct 01 00:00:00 EDT 2020

Runx proteins mediate protective immunity against Leishmania donovani infection by promoting CD40 expression on dendritic cells.

PLoS pathogens

Akhtar MN,Mishra M,Yadav V,Yadav M,Gujar R,Lal S,Kumar R,Khatri N,Sen P

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Tue Dec 01 00:00:00 EST 2020

Enhanced alleviation of aGVHD by TGF-β1-modified mesenchymal stem cells in mice through shifting MΦ into M2 phenotype and promoting the differentiation of Treg cells.

Journal of cellular and molecular medicine

Wu R,Liu C,Deng X,Chen L,Hao S,Ma L

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Wed Jan 01 00:00:00 EST 2020

DEK-targeting aptamer DTA-64 attenuates bronchial EMT-mediated airway remodelling by suppressing TGF-β1/Smad, MAPK and PI3K signalling pathway in asthma.

Journal of cellular and molecular medicine

Song Y,Wang Z,Jiang J,Piao Y,Li L,Xu C,Piao H,Li L,Yan G

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Tue Dec 01 00:00:00 EST 2020

IL-17A-producing T cells exacerbate fine particulate matter-induced lung inflammation and fibrosis by inhibiting PI3K/Akt/mTOR-mediated autophagy.

Journal of cellular and molecular medicine

Cong LH,Li T,Wang H,Wu YN,Wang SP,Zhao YY,Zhang GQ,Duan J

12-0041 was used in Flow cytometry/Cell sorting to suggest that PM2.5 could inhibit autophagy of bronchial epithelial cells and promote pulmonary inflammation and fibrosis by inducing the secretion of IL-17A in γδT and Th17 cells and regulating the PI3K/Akt/mTOR signalling pathway.

Sat Aug 01 00:00:00 EDT 2020

HDAC Inhibitor, CG-745, Enhances the Anti-Cancer Effect of Anti-PD-1 Immune Checkpoint Inhibitor by Modulation of the Immune Microenvironment.

Journal of Cancer

Kim YD,Park SM,Ha HC,Lee AR,Won H,Cha H,Cho S,Cho JM

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Mon Sep 28 00:00:00 EDT 2020

HDAC Inhibitor, CG-745, Enhances the Anti-Cancer Effect of Anti-PD-1 Immune Checkpoint Inhibitor by Modulation of the Immune Microenvironment.

Journal of Cancer

Kim YD,Park SM,Ha HC,Lee AR,Won H,Cha H,Cho S,Cho JM

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Mon Sep 28 00:00:00 EDT 2020

Effects of combined treatment with PD‑L1 Ig and CD40L mAb on immune tolerance in the CBA/J x DBA/2 mouse model.

Molecular medicine reports

Li G,Yang L,Li D,Zhang J,Du L,Xia L,Liu Y,Hu W

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Wed Apr 01 00:00:00 EDT 2020

FUT1 deficiency elicits immune dysregulation and corneal opacity in steady state and under stress.

Cell death & disease

Kim KW,Ryu JS,Ko JH,Kim JY,Kim HJ,Lee HJ,Oh JH,Chung JH,Oh JY

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Fri Apr 24 00:00:00 EDT 2020

Elevated granulocytic myeloid-derived suppressor cells are closely related with elevation of Th17 cells in mice with experimental asthma.

International journal of biological sciences

Xue F,Yu M,Li L,Zhang W,Ma Y,Dong L,Shan W,Zheng Y,Wang T,Feng D,Lv J,Wang X

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Fri Nov 12 00:00:00 EST 2021

Comparative Analysis of Age-Related Changes in Lacrimal Glands and Meibomian Glands of a C57BL/6 Male Mouse Model.

International journal of molecular sciences

Yoon CH,Ryu JS,Hwang HS,Kim MK

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Thu Jun 11 00:00:00 EDT 2020

Truncated PPM1D Prevents Apoptosis in the Murine Thymus and Promotes Ionizing Radiation-Induced Lymphoma.

Cells

Martinikova AS,Burocziova M,Stoyanov M,Macurek L

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Thu Sep 10 00:00:00 EDT 2020

Artificial Mini Dendritic Cells Boost T Cell-Based Immunotherapy for Ovarian Cancer.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Cheng S,Xu C,Jin Y,Li Y,Zhong C,Ma J,Yang J,Zhang N,Li Y,Wang C,Yang Z,Wang Y

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Wed Apr 01 00:00:00 EDT 2020

Ovarian granulosa cell tumor characterization identifies FOXL2 as an immunotherapeutic target.

JCI insight

Pierini S,Tanyi JL,Simpkins F,George E,Uribe-Herranz M,Drapkin R,Burger R,Morgan MA,Facciabene A

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Thu Aug 20 00:00:00 EDT 2020

Tankyrase inhibition sensitizes melanoma to PD-1 immune checkpoint blockade in syngeneic mouse models.

Communications biology

Waaler J,Mygland L,Tveita A,Strand MF,Solberg NT,Olsen PA,Aizenshtadt A,Fauskanger M,Lund K,Brinch SA,Lycke M,Dybing E,Nygaard V,Bøe SL,Heintz KM,Hovig E,Hammarström C,Corthay A,Krauss S

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Fri Apr 24 00:00:00 EDT 2020

Immunotherapeutic Blockade of CD47 Inhibitory Signaling Enhances Innate and Adaptive Immune Responses to Viral Infection.

Cell reports

Cham LB,Torrez Dulgeroff LB,Tal MC,Adomati T,Li F,Bhat H,Huang A,Lang PA,Moreno ME,Rivera JM,Galkina SA,Kosikova G,Stoddart CA,McCune JM,Myers LM,Weissman IL,Lang KS,Hasenkrug KJ

12-0041 was used in Flow cytometry/Cell sorting to indicate that CD47 blockade not only enhances the function of innate immune cells but also links to adaptive immune responses through improved APC function.

Tue Apr 14 00:00:00 EDT 2020

The Proteomic Landscape of Resting and Activated CD4+ T Cells Reveal Insights into Cell Differentiation and Function.

International journal of molecular sciences

Subbannayya Y,Haug M,Pinto SM,Mohanty V,Meås HZ,Flo TH,Prasad TSK,Kandasamy RK

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Tue Dec 29 00:00:00 EST 2020

ICOS agonism by JTX-2011 (vopratelimab) requires initial T cell priming and Fc cross-linking for optimal T cell activation and anti-tumor immunity in preclinical models.

PloS one

Hanson A,Elpek K,Duong E,Shallberg L,Fan M,Johnson C,Wallace M,Mabry GR,Sazinsky S,Pepper L,Shu CJ,Sathyanarayanan S,Zuerndorfer S,Simpson T,Gostissa M,Briskin M,Law D,Michaelson J,Harvey CJ

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Mon Nov 16 00:00:00 EST 2020

Tregitopes regulate the tolerogenic immune response and decrease the foetal death rate in abortion-prone mouse matings.

Scientific reports

Kedzierska AE,Lorek D,Slawek A,Chelmonska-Soyta A

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Mon Jun 29 00:00:00 EDT 2020

Id1 and Id3 Maintain Steady-State Hematopoiesis by Promoting Sinusoidal Endothelial Cell Survival and Regeneration.

Cell reports

Gadomski S,Singh SK,Singh S,Sarkar T,Klarmann KD,Berenschot M,Seaman S,Jakubison B,Gudmundsson KO,Lockett S,Keller JR

12-0041 was used in Flow cytometry/Cell sorting to investigate the effects of loss of ld genes on adult endothelial cell.

Tue Apr 28 00:00:00 EDT 2020

Bixin Attenuates Experimental Autoimmune Encephalomyelitis by Suppressing TXNIP/NLRP3 Inflammasome Activity and Activating NRF2 Signaling.

Frontiers in immunology

Yu Y,Wu DM,Li J,Deng SH,Liu T,Zhang T,He M,Zhao YY,Xu Y

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Mon Jun 21 00:00:00 EDT 2021

Long-term ex vivo haematopoietic-stem-cell expansion allows nonconditioned transplantation.

Nature

Wilkinson AC,Ishida R,Kikuchi M,Sudo K,Morita M,Crisostomo RV,Yamamoto R,Loh KM,Nakamura Y,Watanabe M,Nakauchi H,Yamazaki S

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Mon Jul 01 00:00:00 EDT 2019

Natural Killer Cells Degenerate Intact Sensory Afferents following Nerve Injury.

Cell

Davies AJ,Kim HW,Gonzalez-Cano R,Choi J,Back SK,Roh SE,Johnson E,Gabriac M,Kim MS,Lee J,Lee JE,Kim YS,Bae YC,Kim SJ,Lee KM,Na HS,Riva P,Latremoliere A,Rinaldi S,Ugolini S,Costigan M,Oh SB

12-0041 was used in Flow cytometry/Cell sorting to suggest the therapeutic potential of modulating NK cell function to resolve painful neuropathy through the clearance of partially damaged nerves.

Thu Feb 07 00:00:00 EST 2019

Characterization of immune cell subtypes in three commonly used mouse strains reveals gender and strain-specific variations.

Laboratory investigation; a journal of technical methods and pathology

Hensel JA,Khattar V,Ashton R,Ponnazhagan S

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Tue Jan 01 00:00:00 EST 2019

Bryostatin-1 ameliorated experimental colitis in Il-10^-/- Mice by protecting the intestinal barrier and limiting immune dysfunction.

Journal of cellular and molecular medicine

Zuo L,Li J,Ge S,Ge Y,Shen M,Wang Y,Zhou C,Wu R,Hu J

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Thu Aug 01 00:00:00 EDT 2019

Lactobacillus rhamnosus GG attenuates tenofovir disoproxil fumarate-induced bone loss in male mice via gut-microbiota-dependent anti-inflammation.

Therapeutic advances in chronic disease

Liu H,Gu R,Li W,Zhou W,Cong Z,Xue J,Liu Y,Wei Q,Zhou Y

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Sat Apr 09 00:00:00 EDT 2022

Interleukin 10 Gene-Modified Bone Marrow-Derived Dendritic Cells Attenuate Liver Fibrosis in Mice by Inducing Regulatory T Cells and Inhibiting the TGF-β/Smad Signaling Pathway.

Mediators of inflammation

Xu Y,Tang X,Yang M,Zhang S,Li S,Chen Y,Liu M,Guo Y,Lu M

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Tue Jun 11 00:00:00 EDT 2019

PD-1 inhibitors dependent CD8⁺ T cells inhibit mouse colon cancer cell metastasis.

OncoTargets and therapy

Gao CE,Zhang M,Song Q,Dong J

12-0041-82 was used in Flow Cytometry to investigate the function of PD-1 inhibitor on the metastasisi of mouse colon cancer cells.

Mon Apr 11 00:00:00 EDT 2022

IL-31 plays dual roles in lung inflammation in an OVA-induced murine asthma model.

Biology open

Huang J,Yue H,Jiang T,Gao J,Shi Y,Shi B,Wu X,Gou X

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Tue Jan 15 00:00:00 EST 2019

Antitumor and immunomodulatory effects of a novel multitarget inhibitor, CS2164, in mouse hepatocellular carcinoma models.

Anti-cancer drugs

Zhou Y,Fu C,Kong Y,Pan D,Wang Y,Huang S,Li Z,Ning Z,Lu X,Shan S,Xin L

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Tue Oct 01 00:00:00 EDT 2019

An attenuated Zika virus NS4B protein mutant is a potent inducer of antiviral immune responses.

NPJ vaccines

Li G,Adam A,Luo H,Shan C,Cao Z,Fontes-Garfias CR,Sarathy VV,Teleki C,Winkelmann ER,Liang Y,Sun J,Bourne N,Barrett ADT,Shi PY,Wang T

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Thu Oct 01 00:00:00 EDT 2020

Next Generation Sequencing for Long Non-coding RNAs Profile for CD4⁺ T Cells in the Mouse Model of Acute Asthma.

Frontiers in genetics

Wang Z,Ji N,Chen Z,Wu C,Sun Z,Yu W,Hu F,Huang M,Zhang M

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Fri Apr 08 00:00:00 EDT 2022

Sex Differences in Mouse Popliteal Lymph Nodes.

Scientific reports

Dill-Garlow R,Chen KE,Walker AM

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Wed Jan 30 00:00:00 EST 2019

TLR1/2 Specific Small-Molecule Agonist Suppresses Leukemia Cancer Cell Growth by Stimulating Cytotoxic T Lymphocytes.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Cen X,Zhu G,Yang J,Yang J,Guo J,Jin J,Nandakumar KS,Yang W,Yin H,Liu S,Cheng K

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Fri May 17 00:00:00 EDT 2019

Molecular Profiling and Functional Analysis of Macrophage-Derived Tumor Extracellular Vesicles.

Cell reports

Cianciaruso C,Beltraminelli T,Duval F,Nassiri S,Hamelin R,Mozes A,Gallart-Ayala H,Ceada Torres G,Torchia B,Ries CH,Ivanisevic J,De Palma M

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Tue Jun 04 00:00:00 EDT 2019

ER stress-induced mediator C/EBP homologous protein thwarts effector T cell activity in tumors through T-bet repression.

Nature communications

Cao Y,Trillo-Tinoco J,Sierra RA,Anadon C,Dai W,Mohamed E,Cen L,Costich TL,Magliocco A,Marchion D,Klar R,Michel S,Jaschinski F,Reich RR,Mehrotra S,Cubillos-Ruiz JR,Munn DH,Conejo-Garcia JR,Rodriguez PC

12-0041-82 was used in Flow Cytometry to study the intrinsic mediators that render CD8+T cells dysfunctional in the tumour microenvironment.

Wed Mar 20 00:00:00 EDT 2019

Aryl hydrocarbon receptor activation modulates γδ intestinal intraepithelial lymphocytes and protects against ischemia/reperfusion injury in the murine small intestine.

Molecular medicine reports

Zhang Z,Pu A,Yu M,Xiao W,Sun L,Cai Y,Yang H

12-0041-82 was used in Flow cytometry/Cell sorting to suggest that the AhR plays an important role in protecting the small intestine from I/R and increasing the γδIEL population by decreasing apoptosis of γδIELs.

Fri Mar 01 00:00:00 EST 2019

Tissue-Restricted Adaptive Type 2 Immunity Is Orchestrated by Expression of the Costimulatory Molecule OX40L on Group 2 Innate Lymphoid Cells.

Immunity

Halim TYF,Rana BMJ,Walker JA,Kerscher B,Knolle MD,Jolin HE,Serrao EM,Haim-Vilmovsky L,Teichmann SA,Rodewald HR,Botto M,Vyse TJ,Fallon PG,Li Z,Withers DR,McKenzie ANJ

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Tue Jun 19 00:00:00 EDT 2018

CD38-NAD⁺Axis Regulates Immunotherapeutic Anti-Tumor T Cell Response.

Cell metabolism

Chatterjee S,Daenthanasanmak A,Chakraborty P,Wyatt MW,Dhar P,Selvam SP,Fu J,Zhang J,Nguyen H,Kang I,Toth K,Al-Homrani M,Husain M,Beeson G,Ball L,Helke K,Husain S,Garrett-Mayer E,Hardiman G,Mehrotra M,Nishimura MI,Beeson CC,Bupp MG,Wu J,Ogretmen B,Paulos CM,Rathmell J,Yu XZ,Mehrotra S

Tue Jan 09 00:00:00 EST 2018

Nox2 in regulatory T cells promotes angiotensin II-induced cardiovascular remodeling.

The Journal of clinical investigation

Emmerson A,Trevelin SC,Mongue-Din H,Becker PD,Ortiz C,Smyth LA,Peng Q,Elgueta R,Sawyer G,Ivetic A,Lechler RI,Lombardi G,Shah AM

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Mon Jul 02 00:00:00 EDT 2018

Pre-existing Immunity to Oncolytic Virus Potentiates Its Immunotherapeutic Efficacy.

Molecular therapy : the journal of the American Society of Gene Therapy

Ricca JM,Oseledchyk A,Walther T,Liu C,Mangarin L,Merghoub T,Wolchok JD,Zamarin D

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Wed Apr 04 00:00:00 EDT 2018

Proapoptotic BIM Impacts B Lymphoid Homeostasis by Limiting the Survival of Mature B Cells in a Cell-Autonomous Manner.

Frontiers in immunology

Liu R,King A,Bouillet P,Tarlinton DM,Strasser A,Heierhorst J

12-0041 was used in Flow cytometry/Cell sorting to indicate that BIM regulates B cell homeostasis predominantly by limiting the life span of non-activated mature B cells.

Wed May 01 00:00:00 EDT 2019

MicroRNA-126 deficiency enhanced the activation and function of CD4⁺ T cells by elevating IRS-1 pathway.

Clinical and experimental immunology

Chu F,Hu Y,Zhou Y,Guo M,Lu J,Zheng W,Xu H,Zhao J,Xu L

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Thu Feb 01 00:00:00 EST 2018

Impact of hyperglycemia on autoimmune pancreatitis and regulatory T-cells.

World journal of gastroenterology

Müller-Graff FT,Fitzner B,Jaster R,Vollmar B,Zechner D

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Sat Jul 28 00:00:00 EDT 2018

Human Interleukin-32γ Plays a Protective Role in an Experimental Model of Visceral Leishmaniasis in Mice.

Infection and immunity

Gomes RS,Silva MVT,Dos Santos JC,van Linge C,Reis JM,Teixeira MM,Pinto SA,Dorta ML,Bai X,Chan ED,Dinarello CA,Oliveira MAP,Joosten LAB,Ribeiro-Dias F

12-0041 was used in Flow cytometry/Cell sorting to study the role of interleukin-32γ in potentiating the Th1/Th17 immune response during experimental visceral leishmaniasis.

Tue May 01 00:00:00 EDT 2018

Effect of immune tolerance induced by immature dendritic cells and CTLA4-Ig on systemic lupus erythematosus: An in vivo study.

Experimental and therapeutic medicine

Huang C,Zhang L,Ling F,Wen S,Luo Y,Liu H,Liu J,Zheng W,Liang M,Sun J,Lin YK

12-0041-82 was used in Flow Cytometry to suggest that combined treatment with IL-10-DCs and CTLA4-Ig may be a promising novel therapeutic strategy for the treatment of SLE.

Thu Mar 01 00:00:00 EST 2018

Baicalin Downregulates RLRs Signaling Pathway to Control Influenza A Virus Infection and Improve the Prognosis.

Evidence-based complementary and alternative medicine : eCAM

Pang P,Zheng K,Wu S,Xu H,Deng L,Shi Y,Chen X

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Thu Oct 01 00:00:00 EDT 2020

A stochastic epigenetic switch controls the dynamics of T-cell lineage commitment.

eLife

Ng KK,Yui MA,Mehta A,Siu S,Irwin B,Pease S,Hirose S,Elowitz MB,Rothenberg EV,Kueh HY

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Tue Nov 20 00:00:00 EST 2018

Microglia prevent peripheral immune cell invasion and promote an anti-inflammatory environment in the brain of APP-PS1 transgenic mice.

Journal of neuroinflammation

Unger MS,Schernthaner P,Marschallinger J,Mrowetz H,Aigner L

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Fri Sep 21 00:00:00 EDT 2018

Plasmodium co-infection protects against chikungunya virus-induced pathologies.

Nature communications

Teo TH,Lum FM,Ghaffar K,Chan YH,Amrun SN,Tan JJL,Lee CYP,Chua TK,Carissimo G,Lee WWL,Claser C,Rajarethinam R,Rénia L,Ng LFP

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Tue Sep 25 00:00:00 EDT 2018

Apigenin suppresses PD-L1 expression in melanoma and host dendritic cells to elicit synergistic therapeutic effects.

Journal of experimental & clinical cancer research : CR

Xu L,Zhang Y,Tian K,Chen X,Zhang R,Mu X,Wu Y,Wang D,Wang S,Liu F,Wang T,Zhang J,Liu S,Zhang Y,Tu C,Liu H

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Mon Oct 29 00:00:00 EDT 2018

Sipa1 deficiency unleashes a host-immune mechanism eradicating chronic myelogenous leukemia-initiating cells.

Nature communications

Xu Y,Ikeda S,Sumida K,Yamamoto R,Tanaka H,Minato N

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Fri Mar 02 00:00:00 EST 2018

Pyruvate dehydrogenase complex stimulation promotes immunometabolic homeostasis and sepsis survival.

JCI insight

McCall CE,Zabalawi M,Liu T,Martin A,Long DL,Buechler NL,Arts RJW,Netea M,Yoza BK,Stacpoole PW,Vachharajani V

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Thu Aug 09 00:00:00 EDT 2018

CD4⁺ T cells are activated in regional lymph nodes and migrate to skin to initiate lymphedema.

Nature communications

García Nores GD,Ly CL,Cuzzone DA,Kataru RP,Hespe GE,Torrisi JS,Huang JJ,Gardenier JC,Savetsky IL,Nitti MD,Yu JZ,Rehal S,Mehrara BJ

12-0041 was used in Flow cytometry/Cell sorting to demonstrate that blocking T cell release from lymph nodes using a sphingosine-1-phosphate receptor modulator prevents lymphedema.

Thu May 17 00:00:00 EDT 2018

Glutathione de novo synthesis but not recycling process coordinates with glutamine catabolism to control redox homeostasis and directs murine T cell differentiation.

eLife

Lian G,Gnanaprakasam JR,Wang T,Wu R,Chen X,Liu L,Shen Y,Yang M,Yang J,Chen Y,Vasiliou V,Cassel TA,Green DR,Liu Y,Fan TW,Wang R

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Mon Sep 10 00:00:00 EDT 2018

STIM1 and STIM2 Mediate Cancer-Induced Inflammation in T Cell Acute Lymphoblastic Leukemia.

Cell reports

Saint Fleur-Lominy S,Maus M,Vaeth M,Lange I,Zee I,Suh D,Liu C,Wu X,Tikhonova A,Aifantis I,Feske S

12-0041 was used in Flow cytometry/Cell sorting to investigate the role of store-operated Ca2+ entry mediated by ORAI1, and STIM1 and STIM2 in T-cell acute lymphoblastic leukaemia.

Tue Sep 11 00:00:00 EDT 2018

Inflammation caused by peripheral immune cells across into injured mouse blood brain barrier can worsen postoperative cognitive dysfunction induced by isoflurane.

BMC cell biology

Zhu H,Liu W,Fang H

12-0041 was used in Flow cytometry/Cell sorting to study the underlying mechanism by which blood-brain barrier disruption promotes postoperative cognitive dysfunction in the elderly population.

Sat Sep 29 00:00:00 EDT 2018

A cancer vaccine-mediated postoperative immunotherapy for recurrent and metastatic tumors.

Nature communications

Wang T,Wang D,Yu H,Feng B,Zhou F,Zhang H,Zhou L,Jiao S,Li Y

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Wed Apr 18 00:00:00 EDT 2018

Photosensitizer Micelles Together with IDO Inhibitor Enhance Cancer Photothermal Therapy and Immunotherapy.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Peng J,Xiao Y,Li W,Yang Q,Tan L,Jia Y,Qu Y,Qian Z

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Tue May 01 00:00:00 EDT 2018

Differential cell-intrinsic regulations of germinal center B and T cells by miR-146a and miR-146b.

Nature communications

Cho S,Lee HM,Yu IS,Choi YS,Huang HY,Hashemifar SS,Lin LL,Chen MC,Afanasiev ND,Khan AA,Lin SW,Rudensky AY,Crotty S,Lu LF

12-0041 was used in Immunohistochemistry to reveal differential cell-intrinsic regulations of GC B and Tfh cells by miR-146a and miR-146b.

Mon Jul 16 00:00:00 EDT 2018

The Chaperone UNC93B1 Regulates Toll-like Receptor Stability Independently of Endosomal TLR Transport.

Immunity

Pelka K,Bertheloot D,Reimer E,Phulphagar K,Schmidt SV,Christ A,Stahl R,Watson N,Miyake K,Hacohen N,Haas A,Brinkmann MM,Marshak-Rothstein A,Meissner F,Latz E

12-0041-82 was used in Flow Cytometry to report that UNC93B1 regulates a step upstream of the differential TLR trafficking process.

Tue May 15 00:00:00 EDT 2018

Macrophage Depletion Protects against Cigarette Smoke-Induced Inflammatory Response in the Mouse Colon and Lung.

Frontiers in physiology

Lim D,Kim W,Lee C,Bae H,Kim J

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Wed Sep 30 00:00:00 EDT 2020

Live imaging and tracking of genome regions in CRISPR/dCas9 knock-in mice.

Genome biology

Duan J,Lu G,Hong Y,Hu Q,Mai X,Guo J,Si X,Wang F,Zhang Y

12-0041 was used in Flow cytometry/Cell sorting to generate and characterise a mouse strain with dCas9-EGFP ubiquitously expressed in various tissues.

Thu Nov 08 00:00:00 EST 2018

Inhibiting Glycogen Synthase Kinase 3 Reverses Obesity-Induced White Adipose Tissue Inflammation by Regulating Apoptosis Inhibitor of Macrophage/CD5L-Mediated Macrophage Migration.

Arteriosclerosis, thrombosis, and vascular biology

Wang L,Wang Y,Zhang C,Li J,Meng Y,Dou M,Noguchi CT,Di L

12-0041-82 was used in Flow cytometry/Cell sorting to examine the potential mechanism by which GSK3 in modulating obesity-induced visceral adipose tissue (VAT) inflammation.

Sat Sep 01 00:00:00 EDT 2018

CD24-p53 axis suppresses diethylnitrosamine-induced hepatocellular carcinogenesis by sustaining intrahepatic macrophages.

Cell discovery

Li D,Hu M,Liu Y,Ye P,Du P,Li CS,Cheng L,Liu P,Jiang J,Su L,Wang S,Zheng P,Liu Y

12-0041-82 was used in Flow cytometry/Cell sorting to show that targeted mutation of Cd24 dramatically increased HCC burden while reducing intrahepatic macrophages and DEN-induced hepatocyte apoptosis.

Thu Oct 01 00:00:00 EDT 2020

Microbiota Reconstitution Does Not Cause Bone Loss in Germ-Free Mice.

mSphere

Quach D,Collins F,Parameswaran N,McCabe L,Britton RA

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Wed Nov 20 00:00:00 EST 2019

CD4 T cell autophagy is integral to memory maintenance.

Scientific reports

Murera D,Arbogast F,Arnold J,Bouis D,Muller S,Gros F

12-0041 was used in Flow cytometry/Cell sorting to propose that memory CD4+ T-cells rely on autophagy for their survival to regulate toxicity of mitochondrial activity and lipid overload.

Fri Apr 13 00:00:00 EDT 2018

Transcription factors early growth response gene (Egr) 2 and 3 control inflammatory responses of tolerant T cells.

Immunity, inflammation and disease

Omodho B,Miao T,Symonds ALJ,Singh R,Li S,Wang P

12-0041 was used in Flow cytometry/Cell sorting to show that despite impaired proliferation and IL2 production, tolerant T cells can display inflammatory responses in response to antigen stimulation and this is controlled at least partly by Egr2 and 3.

Fri Jun 01 00:00:00 EDT 2018

Interleukin-33-Activated Islet-Resident Innate Lymphoid Cells Promote Insulin Secretion through Myeloid Cell Retinoic Acid Production.

Immunity

Dalmas E,Lehmann FM,Dror E,Wueest S,Thienel C,Borsigova M,Stawiski M,Traunecker E,Lucchini FC,Dapito DH,Kallert SM,Guigas B,Pattou F,Kerr-Conte J,Maechler P,Girard JP,Konrad D,Wolfrum C,Böni-Schnetzler M,Finke D,Donath MY

12-0041 was used in Flow cytometry/Cell sorting to provide evidence that an immunometabolic crosstalk between islet-derived IL-33, ILC2s, and myeloid cells fosters insulin secretion.

Tue Nov 21 00:00:00 EST 2017

Store-Operated Ca²⁺ Entry Controls Clonal Expansion of T Cells through Metabolic Reprogramming.

Immunity

Vaeth M,Maus M,Klein-Hessling S,Freinkman E,Yang J,Eckstein M,Cameron S,Turvey SE,Serfling E,Berberich-Siebelt F,Possemato R,Feske S

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Tue Oct 17 00:00:00 EDT 2017

Eradication of Tumors through Simultaneous Ablation of CD276/B7-H3-Positive Tumor Cells and Tumor Vasculature.

Cancer cell

Seaman S,Zhu Z,Saha S,Zhang XM,Yang MY,Hilton MB,Morris K,Szot C,Morris H,Swing DA,Tessarollo L,Smith SW,Degrado S,Borkin D,Jain N,Scheiermann J,Feng Y,Wang Y,Li J,Welsch D,DeCrescenzo G,Chaudhary A,Zudaire E,Klarmann KD,Keller JR,Dimitrov DS,St Croix B

12-0041 was used in Flow cytometry/Cell sorting to demonstrate that the cell surface protein CD276/B7-H3 is broadly over-expressed by multiple tumour types on both cancer cells and tumour-infiltrating blood vessels, making it a potentially ideal dual-compartment therapeutic target.

Mon Apr 10 00:00:00 EDT 2017

Dectin-2 Deficiency Modulates Th1 Differentiation and Improves Wound Healing After Myocardial Infarction.

Circulation research

Yan X,Zhang H,Fan Q,Hu J,Tao R,Chen Q,Iwakura Y,Shen W,Lu L,Zhang Q,Zhang R

12-0041 was used in Flow cytometry/Cell sorting to determine whether Dectin-2 signalling is involved in the healing process and cardiac remodelling after myocardial infarction and to elucidate the underlying molecular mechanisms.

Fri Mar 31 00:00:00 EDT 2017

A CCR4 antagonist reverses the tumor-promoting microenvironment of renal cancer.

The Journal of clinical investigation

Berlato C,Khan MN,Schioppa T,Thompson R,Maniati E,Montfort A,Jangani M,Canosa M,Kulbe H,Hagemann UB,Duncan AR,Fletcher L,Wilkinson RW,Powles T,Quezada SA,Balkwill FR

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Wed Mar 01 00:00:00 EST 2017

Egr2 and 3 control adaptive immune responses by temporally uncoupling expansion from T cell differentiation.

The Journal of experimental medicine

Miao T,Symonds ALJ,Singh R,Symonds JD,Ogbe A,Omodho B,Zhu B,Li S,Wang P

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Mon Jun 05 00:00:00 EDT 2017

Oncolytic Adenovirus and Tumor-Targeting Immune Modulatory Therapy Improve Autologous Cancer Vaccination.

Cancer research

Jiang H,Rivera-Molina Y,Gomez-Manzano C,Clise-Dwyer K,Bover L,Vence LM,Yuan Y,Lang FF,Toniatti C,Hossain MB,Fueyo J

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Sat Jul 15 00:00:00 EDT 2017

Engineered erythrocytes covalently linked to antigenic peptides can protect against autoimmune disease.

Proceedings of the National Academy of Sciences of the United States of America

Pishesha N,Bilate AM,Wibowo MC,Huang NJ,Li Z,Deshycka R,Bousbaine D,Li H,Patterson HC,Dougan SK,Maruyama T,Lodish HF,Ploegh HL

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Tue Mar 21 00:00:00 EDT 2017

Betulin from Hedyotis hedyotidea ameliorates concanavalin A-induced and T cell-mediated autoimmune hepatitis in mice.

Acta pharmacologica Sinica

Zhou YQ,Weng XF,Dou R,Tan XS,Zhang TT,Fang JB,Wu XW

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Wed Feb 01 00:00:00 EST 2017

Cornea lymphatics drive the CD8⁺ T-cell response to herpes simplex virus-1.

Immunology and cell biology

Gurung HR,Carr MM,Carr DJ

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Sun Jan 01 00:00:00 EST 2017

ADAR1 deletion induces NFκB and interferon signaling dependent liver inflammation and fibrosis.

RNA biology

Ben-Shoshan SO,Kagan P,Sultan M,Barabash Z,Dor C,Jacob-Hirsch J,Harmelin A,Pappo O,Marcu-Malina V,Ben-Ari Z,Amariglio N,Rechavi G,Goldstein I,Safran M

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Thu May 04 00:00:00 EDT 2017

Location of tumor affects local and distant immune cell type and number.

Immunity, inflammation and disease

Hensel JA,Khattar V,Ashton R,Lee C,Siegal GP,Ponnazhagan S

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Wed Mar 01 00:00:00 EST 2017

Human amnion cells reverse acute and chronic pulmonary damage in experimental neonatal lung injury.

Stem cell research & therapy

Zhu D,Tan J,Maleken AS,Muljadi R,Chan ST,Lau SN,Elgass K,Leaw B,Mockler J,Chambers D,Leeman KT,Kim CF,Wallace EM,Lim R

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Fri Nov 10 00:00:00 EST 2017

The Phytochemical Bergenin Enhances T Helper 1 Responses and Anti-Mycobacterial Immunity by Activating the MAP Kinase Pathway in Macrophages.

Frontiers in cellular and infection microbiology

Dwivedi VP,Bhattacharya D,Yadav V,Singh DK,Kumar S,Singh M,Ojha D,Ranganathan A,Van Kaer L,Chattopadhyay D,Das G

12-0041 was used in Flow cytometry/Cell sorting to study the role of bergenin in the activation of MAP kinase and ERK pathways in macrophages for host protection against TB.

Wed Dec 27 00:00:00 EST 2017

MicroRNA expression profiles in human CD3⁺ T cells following stimulation with anti-human CD3 antibodies.

BMC research notes

Sousa IG,do Almo MM,Simi KC,Bezerra MA,Andrade RV,Maranhão AQ,Brigido MM

12-0041 was used in Flow cytometry/Cell sorting to study the immunoregulatory mechanism of anti-CD3 antibodies.

Tue Mar 14 00:00:00 EDT 2017

MSC-derived Extracellular Vesicles Attenuate Immune Responses in Two Autoimmune Murine Models: Type 1 Diabetes and Uveoretinitis.

Stem cell reports

Shigemoto-Kuroda T,Oh JY,Kim DK,Jeong HJ,Park SY,Lee HJ,Park JW,Kim TW,An SY,Prockop DJ,Lee RH

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Tue May 09 00:00:00 EDT 2017

Traditional Herbal Medicine-Derived Sulforaphene LFS-01 Reverses Colitis in Mice by Selectively Altering the Gut Microbiota and Promoting Intestinal Gamma-Delta T Cells.

Frontiers in pharmacology

Li M,Gao J,Tang Y,Liu M,Wu S,Qu K,Long X,Li H,Liu M,Liu Y,Yuan J,Mao L,Liu Y,Zheng X,Wang E,Wang J,Yang Y

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Wed Sep 30 00:00:00 EDT 2020

Rottlerin as a therapeutic approach in psoriasis: Evidence from in vitro and in vivo studies.

PloS one

Min M,Yan BX,Wang P,Landeck L,Chen JQ,Li W,Cai SQ,Zheng M,Man XY

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Tue Jan 16 00:00:00 EST 2018

Compensatory upregulation of PD-1, LAG-3, and CTLA-4 limits the efficacy of single-agent checkpoint blockade in metastatic ovarian cancer.

Oncoimmunology

Huang RY,Francois A,McGray AR,Miliotto A,Odunsi K

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Tue Jan 12 00:00:00 EST 2021

Combined Blockade of T Cell Immunoglobulin and Mucin Domain 3 and Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 Results in Durable Therapeutic Efficacy in Mice with Intracranial Gliomas.

Medical science monitor : international medical journal of experimental and clinical research

Li J,Liu X,Duan Y,Liu Y,Wang H,Lian S,Zhuang G,Fan Y

12-0041 was used in Flow cytometry/Cell sorting to indicate that combined blockade of T cell immunoglobulin and mucin domain 3 and carcinoembryonic antigen-related cell adhesion molecule 1 generates robust therapeutic efficacy in mice with intracranial tumours.

Mon Jul 24 00:00:00 EDT 2017

Irgm1 coordinately regulates autoimmunity and host defense at select mucosal surfaces.

JCI insight

Azzam KM,Madenspacher JH,Cain DW,Lai L,Gowdy KM,Rai P,Janardhan K,Clayton N,Cunningham W,Jensen H,Patel PS,Kearney JF,Taylor GA,Fessler MB

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Thu Aug 17 00:00:00 EDT 2017

Intratumoral modulation of the inducible co-stimulator ICOS by recombinant oncolytic virus promotes systemic anti-tumour immunity.

Nature communications

Zamarin D,Holmgaard RB,Ricca J,Plitt T,Palese P,Sharma P,Merghoub T,Wolchok JD,Allison JP

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Mon Feb 13 00:00:00 EST 2017

A Multistage Subunit Vaccine Effectively Protects Mice Against Primary Progressive Tuberculosis, Latency and Reactivation.

EBioMedicine

Ma J,Teng X,Wang X,Fan X,Wu Y,Tian M,Zhou Z,Li L

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Tue Aug 01 00:00:00 EDT 2017

Host-Protozoan Interactions Protect from Mucosal Infections through Activation of the Inflammasome.

Cell

Chudnovskiy A,Mortha A,Kana V,Kennard A,Ramirez JD,Rahman A,Remark R,Mogno I,Ng R,Gnjatic S,Amir ED,Solovyov A,Greenbaum B,Clemente J,Faith J,Belkaid Y,Grigg ME,Merad M

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Thu Oct 06 00:00:00 EDT 2016

Foxp3 and Toll-like receptor signaling balance T_reg cell anabolic metabolism for suppression.

Nature immunology

Gerriets VA,Kishton RJ,Johnson MO,Cohen S,Siska PJ,Nichols AG,Warmoes MO,de Cubas AA,MacIver NJ,Locasale JW,Turka LA,Wells AD,Rathmell JC

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Thu Dec 01 00:00:00 EST 2016

Lymphatic vessels regulate immune microenvironments in human and murine melanoma.

The Journal of clinical investigation

Lund AW,Wagner M,Fankhauser M,Steinskog ES,Broggi MA,Spranger S,Gajewski TF,Alitalo K,Eikesdal HP,Wiig H,Swartz MA

12-0041 was used in Flow cytometry/Cell sorting to suggest that the establishment of tumour-associated inflammation and immunity critically depends on lymphatic vessel remodelling and drainage.

Thu Sep 01 00:00:00 EDT 2016

An Effective Immuno-PET Imaging Method to Monitor CD8-Dependent Responses to Immunotherapy.

Cancer research

Tavaré R,Escuin-Ordinas H,Mok S,McCracken MN,Zettlitz KA,Salazar FB,Witte ON,Ribas A,Wu AM

12-0041 was used in Flow cytometry/Cell sorting to investigate anti-CD8 immuno-PET as a sensitive tool for tracking systemic and tumour-infiltrating CD8+ T cell expression in tumour immunotherapy models.

Fri Jan 01 00:00:00 EST 2016

The 4E-BP-eIF4E axis promotes rapamycin-sensitive growth and proliferation in lymphocytes.

Science signaling

So L,Lee J,Palafox M,Mallya S,Woxland CG,Arguello M,Truitt ML,Sonenberg N,Ruggero D,Fruman DA

12-0041 was used in Flow cytometry/Cell sorting to investigate the mechanism by which rapamycin leads to selective immunosupression of lymphocytes, showing that the 4E-BP-efF4E axis promotes growth and proliferation of lymphocytes and is uniquely sensitive to rapamycin in these cells.

Tue May 31 00:00:00 EDT 2016

MicroRNA-7 Deficiency Ameliorates the Pathologies of Acute Lung Injury through Elevating KLF4.

Frontiers in immunology

Zhao J,Chen C,Guo M,Tao Y,Cui P,Zhou Y,Qin N,Zheng J,Zhang J,Xu L

12-0041 was used in Flow cytometry/Cell sorting to study the role of microRNA-7 in acute lung injury, allowing the development of new therapeutic strategies against inflammatory lung disease.

Wed Mar 16 00:00:00 EDT 2022

Distinctive Expression of Bcl-2 Factors in Regulatory T Cells Determines a Pharmacological Target to Induce Immunological Tolerance.

Frontiers in immunology

Gabriel SS,Bon N,Chen J,Wekerle T,Bushell A,Fehr T,Cippà PE

12-0041 was used in Flow cytometry/Cell sorting to show that blocking the intrinsic apoptosis pathway with a Bcl-2/Bcl-xL inhibitor (ABT-737) caused a selective depletion of effector T cells and a relative enrichment of Tregs in vivo.

Mon Mar 14 00:00:00 EDT 2016

Macrophages transfer antigens to dendritic cells by releasing exosomes containing dead-cell-associated antigens partially through a ceramide-dependent pathway to enhance CD4(+) T-cell responses.

Immunology

Xu Y,Liu Y,Yang C,Kang L,Wang M,Hu J,He H,Song W,Tang H

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Sat Oct 01 00:00:00 EDT 2016

p(⁷⁰S⁶K¹) in the TORC1 pathway is essential for the differentiation of Th17 Cells, but not Th1, Th2, or Treg cells in mice.

European journal of immunology

Sasaki CY,Chen G,Munk R,Eitan E,Martindale J,Longo DL,Ghosh P

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Fri Jan 01 00:00:00 EST 2016

Resident T Cells Are Unable To Control Herpes Simplex Virus-1 Activity in the Brain Ependymal Region during Latency.

Journal of immunology (Baltimore, Md. : 1950)

Menendez CM,Jinkins JK,Carr DJ

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Mon Aug 15 00:00:00 EDT 2016

G-CSF-Induced Suppressor IL-10+ Neutrophils Promote Regulatory T Cells That Inhibit Graft-Versus-Host Disease in a Long-Lasting and Specific Way.

Journal of immunology (Baltimore, Md. : 1950)

Perobelli SM,Mercadante AC,Galvani RG,Gonçalves-Silva T,Alves AP,Pereira-Neves A,Benchimol M,Nóbrega A,Bonomo A

12-0041 was used in Flow cytometry/Cell sorting to study the role of incoming IL-10+ neutrophils from G-CSF-treated donor spleen in inhibiting acute graft-versus-host disease.

Tue Nov 01 00:00:00 EDT 2016

B cells establish, but do not maintain, long-lived murine anti-peanut IgE(a).

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology

Moutsoglou DM,Dreskin SC

12-0041 was used in Flow cytometry/Cell sorting to study the role of CD20+ cells in maintaining lifelong anti-peanut IgE levels.

Fri Apr 01 00:00:00 EDT 2016

Rapamycin ameliorates CCl4-induced liver fibrosis in mice through reciprocal regulation of the Th17/Treg cell balance.

Molecular medicine reports

Gu L,Deng WS,Sun XF,Zhou H,Xu Q

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Mon Aug 01 00:00:00 EDT 2016

PRDM14 promotes RAG-dependent Notch1 driver mutations in mouse T-ALL.

Biology open

Carofino BL,Ayanga B,Tracey LJ,Brooke-Bisschop T,Justice MJ

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Sun May 15 00:00:00 EDT 2016

IgE-mediated enhancement of CD4(+) T cell responses requires antigen presentation by CD8α(-) conventional dendritic cells.

Scientific reports

Ding Z,Dahlin JS,Xu H,Heyman B

12-0041 was used in Flow cytometry/Cell sorting to elucidate the dendritic cell population involved in the presentation of IgE-Ag complexes during enhanced specific antibody and CD4+ T cell responses.

Thu Jun 16 00:00:00 EDT 2016

Treg engage lymphotoxin beta receptor for afferent lymphatic transendothelial migration.

Nature communications

Brinkman CC,Iwami D,Hritzo MK,Xiong Y,Ahmad S,Simon T,Hippen KL,Blazar BR,Bromberg JS

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Tue Jun 21 00:00:00 EDT 2016

Murine Splenic Natural Killer Cells Do Not Develop Immunological Memory after Re-Encounter with Mycobacterium bovis BCG.

PloS one

Kawahara M,Hasegawa N,Takaku H

12-0041 was used in Flow cytometry/Cell sorting to examine the manner of activation of, and the acquisition of specific memory by, natural killer cells following Bacillus Calmette-Guérin vaccination.

Sun Jul 31 00:00:00 EDT 2016

Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis.

Nature communications

Ruhland MK,Loza AJ,Capietto AH,Luo X,Knolhoff BL,Flanagan KC,Belt BA,Alspach E,Leahy K,Luo J,Schaffer A,Edwards JR,Longmore G,Faccio R,DeNardo DG,Stewart SA

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Wed Jun 08 00:00:00 EDT 2016

p21^Cip1 plays a critical role in the physiological adaptation to fasting through activation of PPARα.

Scientific reports

Lopez-Guadamillas E,Fernandez-Marcos PJ,Pantoja C,Muñoz-Martin M,Martínez D,Gómez-López G,Campos-Olivas R,Valverde AM,Serrano M

12-0041 was used in Flow cytometry/Cell sorting to examine the expression of several tumour suppressors upon fasting in mice.

Mon Oct 10 00:00:00 EDT 2016

Interleukin-10 deficiency impairs regulatory T cell-derived neuropilin-1 functions and promotes Th1 and Th17 immunity.

Scientific reports

Wang S,Gao X,Shen G,Wang W,Li J,Zhao J,Wei YQ,Edwards CK

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Thu Apr 14 00:00:00 EDT 2016

NFATc1 supports imiquimod-induced skin inflammation by suppressing IL-10 synthesis in B cells.

Nature communications

Alrefai H,Muhammad K,Rudolf R,Pham DA,Klein-Hessling S,Patra AK,Avots A,Bukur V,Sahin U,Tenzer S,Goebeler M,Kerstan A,Serfling E

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Wed May 25 00:00:00 EDT 2016

Epigallocatechin-3-gallate (EGCG) inhibits imiquimod-induced psoriasis-like inflammation of BALB/c mice.

BMC complementary and alternative medicine

Zhang S,Liu X,Mei L,Wang H,Fang F

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Wed Aug 31 00:00:00 EDT 2016

Adjuvanted multi-epitope vaccines protect HLA-A*11:01 transgenic mice against Toxoplasma gondii.

JCI insight

El Bissati K,Chentoufi AA,Krishack PA,Zhou Y,Woods S,Dubey JP,Vang L,Lykins J,Broderick KE,Mui E,Suzuki Y,Sa Q,Bi S,Cardona N,Verma SK,Fraczek L,Reardon CA,Sidney J,Alexander J,Sette A,Vedvick T,Fox C,Guderian JA,Reed S,Roberts CW,McLeod R

12-0041 was used in Flow cytometry/Cell sorting to develop multi-epitope DNA or protein vaccines with TLR4 ligand emulsion adjuvant to protect against Toxoplasma gondii.

Thu Sep 22 00:00:00 EDT 2016

Flagellin is a strong vaginal adjuvant of a therapeutic vaccine for genital cancer.

Oncoimmunology

Lee SE,Hong SH,Verma V,Lee YS,Duong TN,Jeong K,Uthaman S,Sung YC,Lee JT,Park IK,Min JJ,Rhee JH

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Mon Feb 01 00:00:00 EST 2016

A Diet Mimicking Fasting Promotes Regeneration and Reduces Autoimmunity and Multiple Sclerosis Symptoms.

Cell reports

Choi IY,Piccio L,Childress P,Bollman B,Ghosh A,Brandhorst S,Suarez J,Michalsen A,Cross AH,Morgan TE,Wei M,Paul F,Bock M,Longo VD

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Tue Jun 07 00:00:00 EDT 2016

TNF-Mediated Restriction of Arginase 1 Expression in Myeloid Cells Triggers Type 2 NO Synthase Activity at the Site of Infection.

Cell reports

Schleicher U,Paduch K,Debus A,Obermeyer S,König T,Kling JC,Ribechini E,Dudziak D,Mougiakakos D,Murray PJ,Ostuni R,Körner H,Bogdan C

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Tue May 03 00:00:00 EDT 2016

Immune adjuvant effect of a Toxoplasma gondii profilin-like protein in autologous whole-tumor-cell vaccination in mice.

Oncotarget

Pyo KH,Lee YW,Lim SM,Shin EH

12-0041 was used in Flow cytometry/Cell sorting to explore the potential of TgPLP as an adjuvant in autologous whole-tumour-cell vaccines.

Tue Nov 08 00:00:00 EST 2016

Diet-dependent, microbiota-independent regulation of IL-10-producing lamina propria macrophages in the small intestine.

Scientific reports

Ochi T,Feng Y,Kitamoto S,Nagao-Kitamoto H,Kuffa P,Atarashi K,Honda K,Teitelbaum DH,Kamada N

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Wed Jun 15 00:00:00 EDT 2016

CEACAM1 regulates TIM-3-mediated tolerance and exhaustion.

Nature

Huang YH,Zhu C,Kondo Y,Anderson AC,Gandhi A,Russell A,Dougan SK,Petersen BS,Melum E,Pertel T,Clayton KL,Raab M,Chen Q,Beauchemin N,Yazaki PJ,Pyzik M,Ostrowski MA,Glickman JN,Rudd CE,Ploegh HL,Franke A,Petsko GA,Kuchroo VK,Blumberg RS

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Thu Jan 15 00:00:00 EST 2015

Injectable, spontaneously assembling, inorganic scaffolds modulate immune cells in vivo and increase vaccine efficacy.

Nature biotechnology

Kim J,Li WA,Choi Y,Lewin SA,Verbeke CS,Dranoff G,Mooney DJ

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Thu Jan 01 00:00:00 EST 2015

Phosphatase Wip1 controls antigen-independent B-cell development in a p53-dependent manner.

Blood

Yi W,Hu X,Chen Z,Liu L,Tian Y,Chen H,Cong YS,Yang F,Zhang L,Rudolph KL,Zhang Z,Zhao Y,Ju Z

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Thu Jul 30 00:00:00 EDT 2015

CD93 Marks a Non-Quiescent Human Leukemia Stem Cell Population and Is Required for Development of MLL-Rearranged Acute Myeloid Leukemia.

Cell stem cell

Iwasaki M,Liedtke M,Gentles AJ,Cleary ML

12-0041 was used in Flow cytometry/Cell sorting to study how CD93 expression may indicate leukaemia initiating stem cells that have a MLL gene rearrangement.

Thu Oct 01 00:00:00 EDT 2015

Aging-associated inflammation promotes selection for adaptive oncogenic events in B cell progenitors.

The Journal of clinical investigation

Henry CJ,Casás-Selves M,Kim J,Zaberezhnyy V,Aghili L,Daniel AE,Jimenez L,Azam T,McNamee EN,Clambey ET,Klawitter J,Serkova NJ,Tan AC,Dinarello CA,DeGregori J

12-0041 was used in Flow cytometry/Cell sorting to conclude that chronic inflammatory microenvironments in old age lead to reductions in the fitness of B cell progenitor populations.

Tue Dec 01 00:00:00 EST 2015

IKKβ acts as a tumor suppressor in cancer-associated fibroblasts during intestinal tumorigenesis.

The Journal of experimental medicine

Pallangyo CK,Ziegler PK,Greten FR

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Mon Dec 14 00:00:00 EST 2015

Adaptive Immune Regulation of Mammary Postnatal Organogenesis.

Developmental cell

Plaks V,Boldajipour B,Linnemann JR,Nguyen NH,Kersten K,Wolf Y,Casbon AJ,Kong N,van den Bijgaart RJ,Sheppard D,Melton AC,Krummel MF,Werb Z

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Mon Sep 14 00:00:00 EDT 2015

Mitochondrial ATP transporter Ant2 depletion impairs erythropoiesis and B lymphopoiesis.

Cell death and differentiation

Cho J,Seo J,Lim CH,Yang L,Shiratsuchi T,Lee MH,Chowdhury RR,Kasahara H,Kim JS,Oh SP,Lee YJ,Terada N

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Tue Sep 01 00:00:00 EDT 2015

Mice lacking Axl and Mer tyrosine kinase receptors are susceptible to experimental autoimmune orchitis induction.

Immunology and cell biology

Li N,Liu Z,Zhang Y,Chen Q,Liu P,Cheng CY,Lee WM,Chen Y,Han D

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Sun Mar 01 00:00:00 EST 2015

The Ubiquitin-like Modifier FAT10 Is Selectively Expressed in Medullary Thymic Epithelial Cells and Modifies T Cell Selection.

Journal of immunology (Baltimore, Md. : 1950)

Buerger S,Herrmann VL,Mundt S,Trautwein N,Groettrup M,Basler M

12-0041 was used in Flow cytometry/Cell sorting to assess the role of FAT10 in modification of thymic Ag presentation and epitope-dependent elimination of self-reactive T cells.

Sun Nov 01 00:00:00 EDT 2015

B cell Rab7 mediates induction of activation-induced cytidine deaminase expression and class-switching in T-dependent and T-independent antibody responses.

Journal of immunology (Baltimore, Md. : 1950)

Pone EJ,Lam T,Lou Z,Wang R,Chen Y,Liu D,Edinger AL,Xu Z,Casali P

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Wed Apr 01 00:00:00 EDT 2015

MicroRNA-15b/16 Enhances the Induction of Regulatory T Cells by Regulating the Expression of Rictor and mTOR.

Journal of immunology (Baltimore, Md. : 1950)

Singh Y,Garden OA,Lang F,Cobb BS

12-0041 was used in Flow cytometry/Cell sorting to understand miRNA function in Treg development..

Tue Dec 15 00:00:00 EST 2015

Histone deacetylation of memory T lymphocytes by You-Gui-Wan alleviates allergen-induced eosinophilic airway inflammation in asthma.

Chinese medicine

Zhang HP,Fu JJ,Fan T,Zhang WB,Wang ZL,Wang L,Wang G

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Mon Jun 15 00:00:00 EDT 2015

Programmed cell death receptor ligand 1 modulates the regulatory T cells' capacity to repress shock/sepsis-induced indirect acute lung injury by recruiting phosphatase SRC homology region 2 domain-containing phosphatase 1.

Shock (Augusta, Ga.)

Tang L,Bai J,Chung CS,Lomas-Neira J,Chen Y,Huang X,Ayala A

12-0041 was used in Flow cytometry/Cell sorting to investigate the mechanisms by which the programmed cell death receptor 1 ligand suppresses lung injury.

Thu Jan 01 00:00:00 EST 2015

Mannan-modified adenovirus targeting TERT and VEGFR-2: A universal tumour vaccine.

Scientific reports

Wang Y,Zhang J,Wu Y,Ding ZY,Luo XM,Liu J,Zhong WN,Deng GH,Xia XY,Deng YT,Wei YQ,Jiang Y

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Thu Jun 18 00:00:00 EDT 2015

Distinct in vitro properties of embryonic and extraembryonic fibroblast-like cells are reflected in their in vivo behavior following grafting in the adult mouse brain.

Cell transplantation

Costa R,Bergwerf I,Santermans E,De Vocht N,Praet J,Daans J,Le Blon D,Hoornaert C,Reekmans K,Hens N,Goossens H,Berneman Z,Parolini O,Alviano F,Ponsaerts P

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Mon Nov 16 00:00:00 EST 2015

Intranasal Administration of Lentiviral miR-135a Regulates Mast Cell and Allergen-Induced Inflammation by Targeting GATA-3.

PloS one

Deng YQ,Yang YQ,Wang SB,Li F,Liu MZ,Hua QQ,Tao ZZ

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Tue May 31 00:00:00 EDT 2016

H9N2 influenza whole inactivated virus combined with polyethyleneimine strongly enhances mucosal and systemic immunity after intranasal immunization in mice.

Clinical and vaccine immunology : CVI

Qin T,Yin Y,Huang L,Yu Q,Yang Q

12-0041 was used in Flow cytometry/Cell sorting to investigate the immune activity of polyethyleneimine with H9N2 influenza whole inactivated virus, showing that it enhances mucosal and systemic immunity after intranasal immunization.

Wed Apr 01 00:00:00 EDT 2015

dNP2 is a blood-brain barrier-permeable peptide enabling ctCTLA-4 protein delivery to ameliorate experimental autoimmune encephalomyelitis.

Nature communications

Lim S,Kim WJ,Kim YH,Lee S,Koo JH,Lee JA,Yoon H,Kim DH,Park HJ,Kim HM,Lee HG,Yun Kim J,Lee JU,Hun Shin J,Kyun Kim L,Doh J,Kim H,Lee SK,Bothwell ALM,Suh M,Choi JM

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Tue Sep 15 00:00:00 EDT 2015

Interleukin-25 Mediates Transcriptional Control of PD-L1 via STAT3 in Multipotent Human Mesenchymal Stromal Cells (hMSCs) to Suppress Th17 Responses.

Stem cell reports

Wang WB,Yen ML,Liu KJ,Hsu PJ,Lin MH,Chen PM,Sudhir PR,Chen CH,Chen CH,Sytwu HK,Yen BL

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Tue Sep 08 00:00:00 EDT 2015

HGF Gene Modification in Mesenchymal Stem Cells Reduces Radiation-Induced Intestinal Injury by Modulating Immunity.

PloS one

Wang H,Sun RT,Li Y,Yang YF,Xiao FJ,Zhang YK,Wang SX,Sun HY,Zhang QW,Wu CT,Wang LS

12-0041 was used in Flow cytometry/Cell sorting to evaluate the therapeutic effect of hepatocyte growth factor-gene-modified MSCs on radiation-induced intestinal injury.

Tue Jan 26 00:00:00 EST 2016

Infection with Salmonella enterica Serovar Typhimurium Leads to Increased Proportions of F4/80+ Red Pulp Macrophages and Decreased Proportions of B and T Lymphocytes in the Spleen.

PloS one

Rosche KL,Aljasham AT,Kipfer JN,Piatkowski BT,Konjufca V

12-0041 was used in Flow cytometry/Cell sorting to investigate the cause of Salmonella-induced splenomegaly, showing that significantly increased proportions of F4/80+ red pulp macrophages likely play a major role.

Thu Apr 21 00:00:00 EDT 2016

Sphingosine-1-phosphate receptor 3 promotes leukocyte rolling by mobilizing endothelial P-selectin.

Nature communications

Nussbaum C,Bannenberg S,Keul P,Gräler MH,Gonçalves-de-Albuquerque CF,Korhonen H,von Wnuck Lipinski K,Heusch G,de Castro Faria Neto HC,Rohwedder I,Göthert JR,Prasad VP,Haufe G,Lange-Sperandio B,Offermanns S,Sperandio M,Levkau B

12-0041 was used in Flow cytometry/Cell sorting to investigate how sphingosine-1-phosphate receptor 3 promotes leukocyte rolling by mobilising endothelial P-selectin.

Thu Apr 02 00:00:00 EDT 2015

Identifying gut microbe-host phenotype relationships using combinatorial communities in gnotobiotic mice.

Science translational medicine

Faith JJ,Ahern PP,Ridaura VK,Cheng J,Gordon JI

12-0041 was used in Flow cytometry/Cell sorting to describe a method in which a clonally arrayed collection of cultured, sequenced bacteria was generated from one of several human fecal microbiota samples found to transmit a particular phenotype to recipient germ-free mice.

Wed Jan 22 00:00:00 EST 2014

CCDC88B is a novel regulator of maturation and effector functions of T cells during pathological inflammation.

The Journal of experimental medicine

Kennedy JM,Fodil N,Torre S,Bongfen SE,Olivier JF,Leung V,Langlais D,Meunier C,Berghout J,Langat P,Schwartzentruber J,Majewski J,Lathrop M,Vidal SM,Gros P

12-0041 was used in Flow cytometry/Cell sorting to suggest that CCDC88B is the morbid gene underlying the pleiotropic effect of the 11q13 locus on inflammation.

Mon Dec 15 00:00:00 EST 2014

CCR10 regulates balanced maintenance and function of resident regulatory and effector T cells to promote immune homeostasis in the skin.

The Journal of allergy and clinical immunology

Xia M,Hu S,Fu Y,Jin W,Yi Q,Matsui Y,Yang J,McDowell MA,Sarkar S,Kalia V,Xiong N

12-0041 was used in Flow cytometry/Cell sorting to investigate the functional importance of CCR10/CCL27 in vivo, showing that CCR10 regulates maintenance and function of regulatory and effector T cells to promote immune homeostasis.

Mon Sep 01 00:00:00 EDT 2014

Autophagy regulates the therapeutic potential of mesenchymal stem cells in experimental autoimmune encephalomyelitis.

Autophagy

Dang S,Xu H,Xu C,Cai W,Li Q,Cheng Y,Jin M,Wang RX,Peng Y,Zhang Y,Wu C,He X,Wan B,Zhang Y

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Tue Jul 01 00:00:00 EDT 2014

Experimental cerebral malaria pathogenesis--hemodynamics at the blood brain barrier.

PLoS pathogens

Nacer A,Movila A,Sohet F,Girgis NM,Gundra UM,Loke P,Daneman R,Frevert U

12-0041 was used in Immunofluorescence to show that significantly more CD8(+) T cells, neutrophils, and macrophages are recruited to postcapillary venules during ECM compared to hyperparasitemia.

Mon Dec 01 00:00:00 EST 2014

Mast cells expedite control of pulmonary murine cytomegalovirus infection by enhancing the recruitment of protective CD8 T cells to the lungs.

PLoS pathogens

Ebert S,Becker M,Lemmermann NA,Büttner JK,Michel A,Taube C,Podlech J,Böhm V,Freitag K,Thomas D,Holtappels R,Reddehase MJ,Stassen M

12-0041 was used in Flow cytometry/Cell sorting to explore the role of mast cells in the recruitment of protective CD8 T cells to the lungs during systemic infection.

Tue Apr 01 00:00:00 EDT 2014

Malaria-induced NLRP12/NLRP3-dependent caspase-1 activation mediates inflammation and hypersensitivity to bacterial superinfection.

PLoS pathogens

Ataide MA,Andrade WA,Zamboni DS,Wang D,Souza Mdo C,Franklin BS,Elian S,Martins FS,Pereira D,Reed G,Fitzgerald KA,Golenbock DT,Gazzinelli RT

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Wed Jan 01 00:00:00 EST 2014

Cycloamylose-nanogel drug delivery system-mediated intratumor silencing of the vascular endothelial growth factor regulates neovascularization in tumor microenvironment.

Cancer science

Fujii H,Shin-Ya M,Takeda S,Hashimoto Y,Mukai SA,Sawada S,Adachi T,Akiyoshi K,Miki T,Mazda O

12-0041 was used in Flow cytometry/Cell sorting to develop hydrogel polymer nanoparticles as drug delivery systems.

Mon Dec 01 00:00:00 EST 2014

Active players in resolution of shock/sepsis induced indirect lung injury: immunomodulatory effects of Tregs and PD-1.

Journal of leukocyte biology

Tang L,Bai J,Chung CS,Lomas-Neira J,Chen Y,Huang X,Ayala A

12-0041 was used in Flow cytometry/Cell sorting to explore the ability of Tregs to modify the innate immune response induced by experimental iALI.

Sat Nov 01 00:00:00 EDT 2014

Depletion of myeloid-derived suppressor cells during interleukin-12 immunogene therapy does not confer a survival advantage in experimental malignant glioma.

Cancer gene therapy

Thaci B,Ahmed AU,Ulasov IV,Wainwright DA,Nigam P,Auffinger B,Tobias AL,Han Y,Zhang L,Moon KS,Lesniak MS

12-0041 was used in Flow cytometry/Cell sorting to investigate how MDSC depletion can affect glioma immunotherapy, showing that it does not confer a survival advantage.

Wed Jan 01 00:00:00 EST 2014

Kinetics of IFN-γ and IL-17 Production by CD4 and CD8 T Cells during Acute Graft-versus-Host Disease.

Immune network

Ju JM,Lee H,Oh K,Lee DS,Choi EY

12-0041 was used in Flow cytometry/Cell sorting to study production of IFN-γ and IL-17 by CD4 and CD8 T cells during graft-versus-host disease progression.

Tue Apr 01 00:00:00 EDT 2014

Innate IL-17A-producing leukocytes promote acute kidney injury via inflammasome and Toll-like receptor activation.

The American journal of pathology

Chan AJ,Alikhan MA,Odobasic D,Gan PY,Khouri MB,Steinmetz OM,Mansell AS,Kitching AR,Holdsworth SR,Summers SA

12-0041 was used in Immunohistochemistry on frozen tissues to investigate the pathogenic role of IL-17A in cisplatin-induced acute kidney injury.

Thu May 01 00:00:00 EDT 2014

Site-specific chemokine expression regulates central nervous system inflammation and determines clinical phenotype in autoimmune encephalomyelitis.

Journal of immunology (Baltimore, Md. : 1950)

Stoolman JS,Duncker PC,Huber AK,Segal BM

12-0041 was used in Flow cytometry/Cell sorting to investigate the role of CXCL2 in atypical EAE, showing that site-specific chemokine expression regulates CNS inflammation and determines clinical phenotype.

Tue Jul 15 00:00:00 EDT 2014

IFN-γ-producing and IL-17-producing γδ T cells differentiate at distinct developmental stages in murine fetal thymus.

Journal of immunology (Baltimore, Md. : 1950)

Shibata K,Yamada H,Nakamura M,Hatano S,Katsuragi Y,Kominami R,Yoshikai Y

12-0041 was used in Flow cytometry/Cell sorting to compare the functions of γδ T cells derived from double-negative 2 and double-negative 3 cells in the murine fetal thymus.

Sat Mar 01 00:00:00 EST 2014

Mouse mast cell protease-6 and MHC are involved in the development of experimental asthma.

Journal of immunology (Baltimore, Md. : 1950)

Cui Y,Dahlin JS,Feinstein R,Bankova LG,Xing W,Shin K,Gurish MF,Hallgren J

12-0041 was used in Flow cytometry/Cell sorting to compare the immune responses of BALB/c mice to mMCP-6(-/-) and mMCP-6(-/-)/H-2bc mice in a mouse model of experimental asthma.

Sat Nov 15 00:00:00 EST 2014

Regulation of cyp26a1 on Th17 cells in mouse peri-implantation.

Journal of cellular and molecular medicine

Liu HY,Chao H,Liu ZK,Xia HF,Song Z,Yang Y,Peng JP

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Sat Mar 01 00:00:00 EST 2014

Nizatidine, a small molecular compound, enhances killed H5N1 vaccine cell-mediated responses and protects mice from lethal viral challenge.

Human vaccines & immunotherapeutics

Wang S,Wu B,Xue J,Wang M,Chen R,Wang B

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Mon Jan 05 00:00:00 EST 2015

γδ T cells recognize the insulin B:9-23 peptide antigen when it is dimerized through thiol oxidation.

Molecular immunology

Aydintug MK,Zhang L,Wang C,Liang D,Wands JM,Michels AW,Hirsch B,Day BJ,Zhang G,Sun D,Eisenbarth GS,O'Brien RL,Born WK

12-0041 was used in Flow cytometry/Cell sorting to determine why γδ T cells require a secondary amino acid recognition site on the insulin peptide, B:9-23.

Fri Aug 01 00:00:00 EDT 2014

High-dose interferon-γ promotes abortion in mice by suppressing Treg and Th17 polarization.

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research

Liu HY,Liu ZK,Chao H,Li Z,Song Z,Yang Y,Peng JP

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Thu May 01 00:00:00 EDT 2014

Mechanisms of the immunosuppressive effects of mouse adipose tissue-derived mesenchymal stromal cells on mouse alloreactively stimulated spleen cells.

Experimental and therapeutic medicine

Nagaya R,Mizuno-Kamiya M,Takayama E,Kawaki H,Onoe I,Tanabe T,Nagahara K,Kondoh N

12-0041 was used in Flow cytometry/Cell sorting to demonstrate that adipose tissue-derived mesenchymal stromal cells have significant immune modulatory effects on alloreactively stimulated spleen cells.

Wed Jan 01 00:00:00 EST 2014

Cellular immunotherapy using irradiated lung cancer cell vaccine co-expressing GM-CSF and IL-18 can induce significant antitumor effects.

BMC cancer

Tian H,Shi G,Yang G,Zhang J,Li Y,Du T,Wang J,Xu F,Cheng L,Zhang X,Dai L,Chen X,Zhang S,Yang Y,Yu D,Wei Y,Deng H

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Wed Jan 29 00:00:00 EST 2014

Reduced immunogenicity of induced pluripotent stem cells derived from Sertoli cells.

PloS one

Wang X,Qin J,Zhao RC,Zenke M

12-0041 was used in Flow cytometry/Cell sorting to compare immunogenicity of fibroblast- and sertoli cell-derived iPS cells, showing that sertoli cell-derived iPS cells have lower immunogenicity.

Tue Nov 17 00:00:00 EST 2015

Chronic thoracic spinal cord injury impairs CD8+ T-cell function by up-regulating programmed cell death-1 expression.

Journal of neuroinflammation

Zha J,Smith A,Andreansky S,Bracchi-Ricard V,Bethea JR

12-0041 was used in Flow cytometry/Cell sorting to investigate CD8+ T-cell function by up-regulating programmed cell death-1 expression in chronic thoracic spinal cord injury.

Tue Apr 01 00:00:00 EDT 2014

A chitin-like component on sclerotic cells of Fonsecaea pedrosoi inhibits Dectin-1-mediated murine Th17 development by masking β-glucans.

PloS one

Dong B,Li D,Li R,Chen SC,Liu W,Liu W,Chen L,Chen Y,Zhang X,Tong Z,Xia Y,Xia P,Wang Y,Duan Y

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Mon Sep 28 00:00:00 EDT 2015

Autophagy is a critical regulator of memory CD8(+) T cell formation.

eLife

Puleston DJ,Zhang H,Powell TJ,Lipina E,Sims S,Panse I,Watson AS,Cerundolo V,Townsend AR,Klenerman P,Simon AK

12-0041 was used in Flow cytometry/Cell sorting to show that mice lacking the autophagy gene Atg7 in T cells failed to establish CD8(+) T cell memory to influenza and MCMV infection.

Tue Nov 11 00:00:00 EST 2014

Elongated TCR alpha chain CDR3 favors an altered CD4 cytokine profile.

BMC biology

Reynolds C,Chong D,Raynsford E,Quigley K,Kelly D,Llewellyn-Hughes J,Altmann D,Boyton R

12-0041 was used in Flow cytometry/Cell sorting to study how the conformation of TCR alpha chain CDR3 favours different CD4 cytokine profiles.

Fri May 09 00:00:00 EDT 2014

Simultaneous inhibition of T helper 2 and T regulatory cell differentiation by small molecules enhances Bacillus Calmette-Guerin vaccine efficacy against tuberculosis.

The Journal of biological chemistry

Bhattacharya D,Dwivedi VP,Kumar S,Reddy MC,Van Kaer L,Moodley P,Das G

12-0041 was used in Flow cytometry/Cell sorting to study the inhibition of Th2 cells and Tregs and the subsequent enhancement of the BCG vaccine efficacy.

Fri Nov 28 00:00:00 EST 2014

ASK1 promotes the contact hypersensitivity response through IL-17 production.

Scientific reports

Mizukami J,Sato T,Camps M,Ji H,Rueckle T,Swinnen D,Tsuboi R,Takeda K,Ichijo H

12-0041 was used in Flow cytometry/Cell sorting to study the role of ASK1 in the contact hypersensitivity response.

Wed Apr 16 00:00:00 EDT 2014

Small molecule-directed immunotherapy against recurrent infection by Mycobacterium tuberculosis.

The Journal of biological chemistry

Bhattacharya D,Dwivedi VP,Maiga M,Maiga M,Van Kaer L,Bishai WR,Das G

12-0041 was used in Flow cytometry/Cell sorting to investigate small molecule-directed immunotherapy against Th2 and regulatory T cell subsets to reduce recurrent Mycobacterium tuberculosis infection and drug resistance.

Fri Jun 06 00:00:00 EDT 2014

LAMTOR2 regulates dendritic cell homeostasis through FLT3-dependent mTOR signalling.

Nature communications

Scheffler JM,Sparber F,Tripp CH,Herrmann C,Humenberger A,Blitz J,Romani N,Stoitzner P,Huber LA

12-0041 was used in Flow cytometry/Cell sorting to define the effects from the conditional ablation of LAMTOR2 for the dendritic cell compartment in mice.

Wed Oct 22 00:00:00 EDT 2014

Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3⁺ regulatory T cells.

Nature immunology

Pierson W,Cauwe B,Policheni A,Schlenner SM,Franckaert D,Berges J,Humblet-Baron S,Schönefeldt S,Herold MJ,Hildeman D,Strasser A,Bouillet P,Lu LF,Matthys P,Freitas AA,Luther RJ,Weaver CT,Dooley J,Gray DH,Liston A

12-0041 was used in Flow cytometry/Cell sorting to study the regulation of the Foxp3+ T cell pool by proliferation and apoptosis, and specifically the role of antiapoptoic Mcl-1 in T cell survival.

Sun Sep 01 00:00:00 EDT 2013

Moderate aerobic exercise alters migration patterns of antigen specific T helper cells within an asthmatic lung.

Brain, behavior, and immunity

Dugger KJ,Chrisman T,Jones B,Chastain P,Watson K,Estell K,Zinn K,Schwiebert L

12-0041 was used in Flow cytometry/Cell sorting to study how aerobic exercise training can reduce antigen specific Th cell migration into asthmatic lungs.

Fri Nov 01 00:00:00 EDT 2013

The thymic medulla is required for Foxp3+ regulatory but not conventional CD4+ thymocyte development.

The Journal of experimental medicine

Cowan JE,Parnell SM,Nakamura K,Caamano JH,Lane PJ,Jenkinson EJ,Jenkinson WE,Anderson G

12-0041 was used in Flow cytometry/Cell sorting to demonstrate a differential requirement for the thymic medulla in relation to CD4 conventional and Foxp3(+) thymocyte lineages.

Mon Apr 08 00:00:00 EDT 2013

Irf8-regulated genomic responses drive pathological inflammation during cerebral malaria.

PLoS pathogens

Berghout J,Langlais D,Radovanovic I,Tam M,MacMicking JD,Stevenson MM,Gros P

12-0041 was used in Flow cytometry/Cell sorting to show that inactivation of Irf8 confers protection against the development of cerebral malaria.

Tue Feb 18 00:00:00 EST 2014

Therapeutic evaluation of ex vivo-generated versus natural regulatory T-cells in a mouse model of chronic gut inflammation.

Inflammatory bowel diseases

Karlsson F,Martinez NE,Gray L,Zhang S,Tsunoda I,Grisham MB

12-0041 was used in Flow cytometry/Cell sorting to study the effect of ex vivo-generated and isolated Treg cells on a mouse model of chronic colitis, showing that ex-vivo Tregs were more potent at attenuating colitis, likely due to the associated decrease in IL-6 and IL-17A expression in the colon.

Tue Oct 01 00:00:00 EDT 2013

Cbx4 regulates the proliferation of thymic epithelial cells and thymus function.

Development (Cambridge, England)

Liu B,Liu YF,Du YR,Mardaryev AN,Yang W,Chen H,Xu ZM,Xu CQ,Zhang XR,Botchkarev VA,Zhang Y,Xu GL

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Fri Feb 01 00:00:00 EST 2013

Absence of CXCL10 aggravates herpes stromal keratitis with reduced primary neutrophil influx in mice.

Journal of virology

Shen FH,Wang SW,Yeh TM,Tung YY,Hsu SM,Chen SH

12-0041 was used in Flow cytometry/Cell sorting to investigate the role of the chemokine CXCL10 in the development of herpetic stromal keratitis.

Thu Aug 01 00:00:00 EDT 2013

A mouse model for inducible overexpression of Prdm14 results in rapid-onset and highly penetrant T-cell acute lymphoblastic leukemia (T-ALL).

Disease models & mechanisms

Carofino BL,Ayanga B,Justice MJ

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Fri Nov 01 00:00:00 EDT 2013

A pathogenic role for CD4+ T cells during Chikungunya virus infection in mice.

Journal of immunology (Baltimore, Md. : 1950)

Teo TH,Lum FM,Claser C,Lulla V,Lulla A,Merits A,Rénia L,Ng LF

12-0041 was used in Flow cytometry/Cell sorting to assess the roles of T cells in Chikungunya virus infection using immunodeficient mice.

Tue Jan 01 00:00:00 EST 2013

n3 PUFAs reduce mouse CD4+ T-cell ex vivo polarization into Th17 cells.

The Journal of nutrition

Monk JM,Hou TY,Turk HF,McMurray DN,Chapkin RS

12-0041 was used in Flow cytometry/Cell sorting to discern the effect of n3 PUFAs on the CD4+ T-cells of mice.

Sun Sep 01 00:00:00 EDT 2013

Interleukin-22 as a molecular adjuvant facilitates IL-17-producing CD8+ T cell responses against a HBV DNA vaccine in mice.

Human vaccines & immunotherapeutics

Wu B,Zou Q,Hu Y,Wang B

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Tue Oct 01 00:00:00 EDT 2013

Ontogeny and localization of the cells produce IL-2 in healthy animals.

Cytokine

Yamamoto M,Seki Y,Iwai K,Ko I,Martin A,Tsuji N,Miyagawa S,Love RB,Iwashima M

12-0041 was used in Flow cytometry/Cell sorting to study how a group of Tr1 cells may have additional roles in immune homeostasis through IL-2 production to aid in the maintenance of other regulatory T cells..

Fri Mar 01 00:00:00 EST 2013

Enhanced immune response against HIV-1 induced by a heterologous DNA prime-adenovirus boost vaccination using mannosylated polyethyleneimine as DNA vaccine adjuvant.

International journal of nanomedicine

Li M,Jiang Y,Xu C,Zhang Z,Sun X

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Wed Apr 02 00:00:00 EDT 2014

Distinct translational control in CD4+ T cell subsets.

PLoS genetics

Bjur E,Larsson O,Yurchenko E,Zheng L,Gandin V,Topisirovic I,Li S,Wagner CR,Sonenberg N,Piccirillo CA

12-0041 was used in Flow cytometry/Cell sorting to unveil a unique translational signature which imprints subset-specific protein expression in CD4(+) T cell subsets.

Wed May 01 00:00:00 EDT 2013

Nod2 activates NF-kB in CD4+ T cells but its expression is dispensable for T cell-induced colitis.

PloS one

Zanello G,Goethel A,Forster K,Geddes K,Philpott DJ,Croitoru K

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Thu Jul 31 00:00:00 EDT 2014

Resistance to malaria by enhanced phagocytosis of erythrocytes in LMP7-deficient mice.

PloS one

Duan X,Imai T,Chou B,Tu L,Himeno K,Suzue K,Hirai M,Taniguchi T,Okada H,Shimokawa C,Hisaeda H

12-0041 was used in Flow cytometry/Cell sorting to study how RBCs of LMP7-deficient mice were more likely to deform in response to infection with malaria parasites.

Tue Sep 17 00:00:00 EDT 2013

Targeted deletion of FGL2 leads to increased early viral replication and enhanced adaptive immunity in a murine model of acute viral hepatitis caused by LCMV WE.

PloS one

Khattar R,Luft O,Yavorska N,Shalev I,Phillips MJ,Adeyi O,Gao D,Bartczak A,Urbanellis P,Shyu W,Zhang J,Manuel J,Levy GA,Selzner N

12-0041 was used in Flow cytometry/Cell sorting to demonstrate that targeting FGL2 may enhance the efficacy of current anti-viral therapies for hepatotropic viruses.

Thu Jul 24 00:00:00 EDT 2014

The oxidase activity of vascular adhesion protein-1 (VAP-1) is essential for function.

American journal of clinical and experimental immunology

Noonan T,Lukas S,Peet GW,Pelletier J,Panzenbeck M,Hanidu A,Mazurek S,Wasti R,Rybina I,Roma T,Kronkaitis A,Shoultz A,Souza D,Jiang H,Nabozny G,Modis LK

12-0041 was used in Flow cytometry/Cell sorting to assess the relative contribution of the features of vascular adhesion protein-1 to its function.

Thu Jul 25 00:00:00 EDT 2013

The early activation marker CD69 regulates the expression of chemokines and CD4 T cell accumulation in intestine.

PloS one

Radulovic K,Rossini V,Manta C,Holzmann K,Kestler HA,Niess JH

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Thu Jan 23 00:00:00 EST 2014

Transcription factor RORα is critical for nuocyte development.

Nature immunology

Wong SH,Walker JA,Jolin HE,Drynan LF,Hams E,Camelo A,Barlow JL,Neill DR,Panova V,Koch U,Radtke F,Hardman CS,Hwang YY,Fallon PG,McKenzie AN

12-0041 was used in Flow cytometry/Cell sorting to study how nuocytes arose in the bone marrow and differentiated from common lymphoid progenitors, indicating they are a distinct, previously unknown member of the lymphoid lineage.

Sun Jan 22 00:00:00 EST 2012

PGD2-CRTH2 pathway promotes tubulointerstitial fibrosis.

Journal of the American Society of Nephrology : JASN

Ito H,Yan X,Nagata N,Aritake K,Katsumata Y,Matsuhashi T,Nakamura M,Hirai H,Urade Y,Asano K,Kubo M,Utsunomiya Y,Hosoya T,Fukuda K,Sano M

12-0041 was used in Flow cytometry/Cell sorting to explore the contribution of L-PGDS to the development of chronic kidney disease.

Thu Nov 01 00:00:00 EDT 2012

Myeloid-specific tristetraprolin deficiency in mice results in extreme lipopolysaccharide sensitivity in an otherwise minimal phenotype.

Journal of immunology (Baltimore, Md. : 1950)

Qiu LQ,Stumpo DJ,Blackshear PJ

12-0041 was used in Flow cytometry/Cell sorting to show that myeloid-specific TTP deficiency does not phenocopy complete TTP deficiency in C57BL/6 mice.

Tue May 15 00:00:00 EDT 2012

In vivo imaging of differences in early donor cell proliferation in graft-versus-host disease hosts with different pre-conditioning doses.

Molecules and cells

Song MG,Kang B,Jeon JY,Chang J,Lee S,Min CK,Youn H,Choi EY

12-0041 was used in Flow cytometry/Cell sorting to explore the effects of preconditioning irradiation doses on donor cell dynamics in allogeneic graft-versus-host disease hosts.

Sun Jan 01 00:00:00 EST 2012

Genetic control of susceptibility to infection with Plasmodium chabaudi chabaudi AS in inbred mouse strains.

Genes and immunity

Laroque A,Min-Oo G,Tam M,Radovanovic I,Stevenson MM,Gros P

12-0041 was used in Flow cytometry/Cell sorting to identify genetic effects modulating the blood stage replication of the malarial parasite.

Wed Feb 01 00:00:00 EST 2012

Augmentation of natural cytotoxicity by chronic low-dose ionizing radiation in murine natural killer cells primed by IL-2.

Journal of radiation research

Sonn CH,Choi JR,Kim TJ,Yu YB,Kim K,Shin SC,Park GH,Shirakawa T,Kim HS,Lee KM

12-0041 was used in Magnetic cell separation to demonstrate how exposure to LDR can lead to subtle immune-enhancing effects on NK cells.

Thu Nov 01 00:00:00 EDT 2012

SA-4-1BBL costimulation inhibits conversion of conventional CD4+ T cells into CD4+ FoxP3+ T regulatory cells by production of IFN-γ.

PloS one

Madireddi S,Schabowsky RH,Srivastava AK,Sharma RK,Yolcu ES,Shirwan H

12-0041 was used in Flow cytometry/Cell sorting to investigate whether 4-1BBL can prevent the conversion of effector CD4+ cells into induced T regulatory cells in tumour settings.

Tue Feb 19 00:00:00 EST 2013

Interleukin-7 influences FOXP3+CD4+ regulatory T cells peripheral homeostasis.

PloS one

Simonetta F,Gestermann N,Martinet KZ,Boniotto M,Tissières P,Seddon B,Bourgeois C

12-0041 was used in Flow cytometry/Cell sorting to elucidate the mechanisms governing Treg cell survival and homeostasis.

Wed Sep 26 00:00:00 EDT 2012

Aryl Hydrocarbon Receptor-Mediated Perturbations in Gene Expression during Early Stages of CD4(+) T-cell Differentiation.

Frontiers in immunology

Rohlman D,Pham D,Yu Z,Steppan LB,Kerkvliet NI

12-0041 was used in Flow cytometry/Cell sorting to characterise the influence of 2,3,7,8-tetrachlorodibenzo-p-dioxin-activated aryl hydrocarbon receptor on gene expression during CD4+ T-cell differentiation.

Thu Aug 23 00:00:00 EDT 2012

Soluble MOG35-55/I-A(b) dimers ameliorate experimental autoimmune encephalomyelitis by reducing encephalitogenic T cells.

PloS one

Gong Y,Wang Z,Liang Z,Duan H,Ouyang L,Yu Q,Xu Z,Shen G,Weng X,Wu X

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Fri Jul 19 00:00:00 EDT 2013

Human papillomavirus immunization is associated with increased expression of different innate immune regulatory receptors.

Clinical and vaccine immunology : CVI

Colmenares V,Noyola DE,Monsiváis-Urenda A,Salgado-Bustamante M,Estrada-Capetillo L,González-Amaro R,Baranda L

12-0041 was used in Flow cytometry/Cell sorting to study how HPV immunisation alters innate immune receptor function as part of its protective effect.

Sun Jul 01 00:00:00 EDT 2012

Deleterious effect of the IL-23/IL-17A axis and γδT cells on left ventricular remodeling after myocardial infarction.

Journal of the American Heart Association

Yan X,Shichita T,Katsumata Y,Matsuhashi T,Ito H,Ito K,Anzai A,Endo J,Tamura Y,Kimura K,Fujita J,Shinmura K,Shen W,Yoshimura A,Fukuda K,Sano M

12-0041 was used in Flow cytometry/Cell sorting to explore potential immune pathways involved in left ventricular remodelling as possible preventative therapeutic options.

Mon Oct 01 00:00:00 EDT 2012

Impact of enzymatic tissue disintegration on the level of surface molecule expression and immune cell function.

European journal of microbiology & immunology

Autengruber A,Gereke M,Hansen G,Hennig C,Bruder D

12-0041 was used in Flow cytometry/Cell sorting to indicate that enzymatic tissue disintegration can have profound effects on the expression of a variety of cell-surface molecules.

Fri Jun 01 00:00:00 EDT 2012

RelA and RelB transcription factors in distinct thymocyte populations control lymphotoxin-dependent interleukin-17 production in γδ T cells.

Immunity

Powolny-Budnicka I,Riemann M,Tänzer S,Schmid RM,Hehlgans T,Weih F

12-0041 was used in Flow cytometry/Cell sorting to investigate the contribution of NF-κB to IL-17 production by T cells, showing that RelA and RelB in distinct thymocyte populations control lymphotoxin-dependent IL-17 production.

Fri Mar 25 00:00:00 EDT 2011

Foxp3⁺ regulatory T cells exert asymmetric control over murine helper responses by inducing Th2 cell apoptosis.

Blood

Tian L,Altin JA,Makaroff LE,Franckaert D,Cook MC,Goodnow CC,Dooley J,Liston A

12-0041 was used in Flow cytometry/Cell sorting to demonstrate that Th2-driven diseases may be more responsive to regulatory T-cell manipulation.

Thu Aug 18 00:00:00 EDT 2011

Effects of Pre-conditioning Dose on the Immune Kinetics and Cytokine Production in the Leukocytes Infiltrating GVHD Tissues after MHC-matched Transplantation.

Immune network

Choi JH,Yoon H,Min CK,Choi EY

12-0041 was used in Flow cytometry/Cell sorting to analyse chimerism formation and immune kinetics of leukocytes during graft-versus-host disease.

Tue Feb 01 00:00:00 EST 2011

T cell factor 1 regulates thymocyte survival via a RORγt-dependent pathway.

Journal of immunology (Baltimore, Md. : 1950)

Wang R,Xie H,Huang Z,Ma J,Fang X,Ding Y,Sun Z

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Thu Dec 01 00:00:00 EST 2011

Angiopoietin 2 stimulates TIE2-expressing monocytes to suppress T cell activation and to promote regulatory T cell expansion.

Journal of immunology (Baltimore, Md. : 1950)

Coffelt SB,Chen YY,Muthana M,Welford AF,Tal AO,Scholz A,Plate KH,Reiss Y,Murdoch C,De Palma M,Lewis CE

12-0041 was used in Immunofluorescence to suggest that ANGPT2-stimulated TIE2-expressing monocytes/macrophages represent a novel, potent immunosuppressive force in tumours.

Fri Apr 01 00:00:00 EDT 2011

Angiopoietin 2 stimulates TIE2-expressing monocytes to suppress T cell activation and to promote regulatory T cell expansion.

Journal of immunology (Baltimore, Md. : 1950)

Coffelt SB,Chen YY,Muthana M,Welford AF,Tal AO,Scholz A,Plate KH,Reiss Y,Murdoch C,De Palma M,Lewis CE

12-0041 was used in Immunofluorescence to suggest that ANGPT2-stimulated TIE2-expressing monocytes/macrophages represent a novel, potent immunosuppressive force in tumours.

Fri Apr 01 00:00:00 EDT 2011

IL-23-dependent and -independent enhancement pathways of IL-17A production by lactic acid.

International immunology

Yabu M,Shime H,Hara H,Saito T,Matsumoto M,Seya T,Akazawa T,Inoue N

12-0041 was used in Flow cytometry/Cell sorting to show lactic acid functions as an inflammatory mediator that activates IL-23-dependent and -independent pathways to promote chronic inflammation in tumour microenvironments.

Sat Jan 01 00:00:00 EST 2011

A single mid-gestation exposure to TCDD yields a postnatal autoimmune signature, differing by sex, in early geriatric C57BL/6 mice.

Toxicology

Mustafa A,Holladay SD,Witonsky S,Sponenberg DP,Karpuzoglu E,Gogal RM

12-0041 was used in Flow cytometry/Cell sorting to investigate the effect of prenatal TCDD on the postnatal autoimmune status of C57BL/6 mice.

Sun Dec 18 00:00:00 EST 2011

Requirements for prolongation of allograft survival with regulatory T cell infusion in lymphosufficient hosts.

The Journal of surgical research

Brennan TV,Tang Q,Liu FC,Hoang V,Bi M,Bluestone JA,Kang SM

12-0041 was used in Flow cytometry/Cell sorting to evaluate whether Tregs with a defined allospecificity are more effective than polyclonal Tregs at suppressing allograft rejection.

Fri Jul 01 00:00:00 EDT 2011

CD8 T-cell activation in mice injected with a plasmid DNA vaccine encoding AMA-1 of the reemerging Korean Plasmodium vivax.

The Korean journal of parasitology

Kim HJ,Jung BK,Lee JJ,Pyo KH,Kim TY,Choi BI,Kim TW,Hisaeda H,Himeno K,Shin EH,Chai JY

12-0041 was used in Flow cytometry/Cell sorting to study the cellular immunogenicity of a plasmid DNA vaccine - encoding AMA-1 of Plasmodium vivax - to mice.

Tue Mar 01 00:00:00 EST 2011

IL-1β promotes TGF-β1 and IL-2 dependent Foxp3 expression in regulatory T cells.

PloS one

Ganesh BB,Bhattacharya P,Gopisetty A,Sheng J,Vasu C,Prabhakar BS

12-0041 was used in Flow cytometry/Cell sorting to investigate the differential effects of IL-12 and IL-1β on Foxp3 expression in T cells, showing that IL-1β promotes TGF-β1- and IL-2-dependent Foxp3 expression in Tregs.

Tue Nov 15 00:00:00 EST 2011

T regulatory cells maintain intestinal homeostasis by suppressing γδ T cells.

Immunity

Park SG,Mathur R,Long M,Hosh N,Hao L,Hayden MS,Ghosh S

12-0041 was used in Flow cytometry/Cell sorting to explore the regulatory processes maintaining a tolerogenic attitude towards enteric commensal bacteria.

Wed Nov 24 00:00:00 EST 2010

Structure of the AML1-ETO NHR3-PKA(RIIα) complex and its contribution to AML1-ETO activity.

Journal of molecular biology

Corpora T,Roudaia L,Oo ZM,Chen W,Manuylova E,Cai X,Chen MJ,Cierpicki T,Speck NA,Bushweller JH

12-0041 was used in Flow cytometry/Cell sorting to elucidate the structure and function of the AML1-ETO NHR3-PKA(RIIα) complex.

Fri Sep 24 00:00:00 EDT 2010

Potent antitumor effects of combined therapy with a telomerase-specific, replication-competent adenovirus (OBP-301) and IL-2 in a mouse model of renal cell carcinoma.

Cancer gene therapy

Huang P,Kaku H,Chen J,Kashiwakura Y,Saika T,Nasu Y,Urata Y,Fujiwara T,Watanabe M,Kumon H

12-0041 was used in Flow cytometry/Cell sorting to assess the effectiveness of a combined virus-interleukin therapy against carcinoma.

Thu Jul 01 00:00:00 EDT 2010

Stress-induced glucocorticoids at the earliest stages of herpes simplex virus-1 infection suppress subsequent antiviral immunity, implicating impaired dendritic cell function.

Journal of immunology (Baltimore, Md. : 1950)

Elftman MD,Hunzeker JT,Mellinger JC,Bonneau RH,Norbury CC,Truckenmiller ME

12-0041 was used in Flow cytometry/Cell sorting to investigate the specific mechanism for psychological stress-induced suppression of immune responses.

Mon Feb 15 00:00:00 EST 2010

Critical protective role for MCP-1 in pneumonic Burkholderia mallei infection.

Journal of immunology (Baltimore, Md. : 1950)

Goodyear A,Jones A,Troyer R,Bielefeldt-Ohmann H,Dow S

12-0041 was used in Flow cytometry/Cell sorting to assess the role of MCP-1 in immunity to acute pneumonia caused by gram-negative bacteria.

Mon Feb 01 00:00:00 EST 2010

Transient role of CD4+CD25+ regulatory T cells in mycobacterial infection in mice.

International immunology

Ozeki Y,Sugawara I,Udagawa T,Aoki T,Osada-Oka M,Tateishi Y,Hisaeda H,Nishiuchi Y,Harada N,Kobayashi K,Matsumoto S

12-0041 was used in Flow cytometry/Cell sorting to investigate the role of CD4(+)CD25(+) Treg cells in mycobacterial infection.

Mon Mar 01 00:00:00 EST 2010

Interleukin-6 contributes to age-related alteration of cytokine production by macrophages.

Mediators of inflammation

Gomez CR,Karavitis J,Palmer JL,Faunce DE,Ramirez L,Nomellini V,Kovacs EJ

12-0041 was used in Flow cytometry/Cell sorting to demonstrate in vitro that Interleukin-6 regulates age-related defects in splenic macrophages through alteration of proinflammatory cytokines.

Thu Nov 04 00:00:00 EDT 2010

Thymic alterations in GM2 gangliosidoses model mice.

PloS one

Kanzaki S,Yamaguchi A,Yamaguchi K,Kojima Y,Suzuki K,Koumitsu N,Nagashima Y,Nagahama K,Ehara M,Hirayasu Y,Ryo A,Aoki I,Yamanaka S

12-0041 was used in Flow cytometry/Cell sorting to study the Hexb(-/-) mouse model of Sandhoff disease, showing alterations to the thymus, potentially due to FcRγ.

Tue Aug 10 00:00:00 EDT 2010

Lymphotoxin beta receptor signaling promotes tertiary lymphoid organogenesis in the aorta adventitia of aged ApoE-/- mice.

The Journal of experimental medicine

Gräbner R,Lötzer K,Döpping S,Hildner M,Radke D,Beer M,Spanbroek R,Lippert B,Reardon CA,Getz GS,Fu YX,Hehlgans T,Mebius RE,van der Wall M,Kruspe D,Englert C,Lovas A,Hu D,Randolph GJ,Weih F,Habenicht AJ

12-0041 was used in Flow cytometry/Cell sorting to investigate how the LTbetaR pathway has a major role in shaping the immunological characteristics and overall integrity of the arterial wall.

Fri Jan 16 00:00:00 EST 2009

Gasp, a Grb2-associating protein, is critical for positive selection of thymocytes.

Proceedings of the National Academy of Sciences of the United States of America

Patrick MS,Oda H,Hayakawa K,Sato Y,Eshima K,Kirikae T,Iemura S,Shirai M,Abe T,Natsume T,Sasazuki T,Suzuki H

12-0041 was used in Flow cytometry/Cell sorting to investigate the molecular mechanisms involved in selection of T cells in the thymus.

Tue Sep 22 00:00:00 EDT 2009

Lack of TNFR2 expression by CD4(+) T cells exacerbates experimental colitis.

European journal of immunology

Dayer Schneider J,Seibold I,Saxer-Sekulic N,Paredes BE,Saurer L,Mueller C

12-0041 was used in Flow cytometry/Cell sorting to assess the role of TNF receptor 2 signalling in the CD4(+) T-cell transfer model of colitis.

Wed Jul 01 00:00:00 EDT 2009

Human CD8+CXCR3+ T cells have the same function as murine CD8+CD122+ Treg.

European journal of immunology

Shi Z,Okuno Y,Rifa'i M,Endharti AT,Akane K,Isobe K,Suzuki H

12-0041-82 was used in Flow Cytometry to suggest that human CD8(+)CXCR3(+) T cells are the counterparts of murine CD8(+)CD122(+) Treg.

Sat Aug 01 00:00:00 EDT 2009

Infection with a helminth parasite attenuates autoimmunity through TGF-beta-mediated suppression of Th17 and Th1 responses.

Journal of immunology (Baltimore, Md. : 1950)

Walsh KP,Brady MT,Finlay CM,Boon L,Mills KH

12-0041 was used in Flow cytometry/Cell sorting to provide evidence that parasites can exert bystander immunosuppression of pathogenic T cells that mediate autoimmune diseases.

Sat Aug 01 00:00:00 EDT 2009

c-Myb is required for pro-B cell differentiation.

Journal of immunology (Baltimore, Md. : 1950)

Fahl SP,Crittenden RB,Allman D,Bender TP

12-0041 was used in Flow cytometry/Cell sorting to demonstrate that c-Myb is absolutely required for the survival and differentiation of CD19(+) B-lineage cells.

Sun Nov 01 00:00:00 EDT 2009

The adaptor molecule signaling lymphocytic activation molecule-associated protein (SAP) regulates IFN-gamma and IL-4 production in V alpha 14 transgenic NKT cells via effects on GATA-3 and T-bet expression.

Journal of immunology (Baltimore, Md. : 1950)

Cen O,Ueda A,Guzman L,Jain J,Bassiri H,Nichols KE,Stein PL

12-0041 was used in Flow cytometry/Cell sorting to study the mechanism by which signalling lymphocytic activation molecule-associated protein exerts control over natural killer T cell development and cytokine production.

Sun Feb 01 00:00:00 EST 2009

Langerin+ CD8alpha+ dendritic cells are critical for cross-priming and IL-12 production in response to systemic antigens.

Journal of immunology (Baltimore, Md. : 1950)

Farrand KJ,Dickgreber N,Stoitzner P,Ronchese F,Petersen TR,Hermans IF

12-0041 was used in Flow cytometry/Cell sorting to investigate the role of langerin(+)CD8alpha(+) dendritic cells in priming T cells, showing that they are critical for cross-priming and IL-12 production in response to systemic antigens.

Tue Dec 15 00:00:00 EST 2009

Absence of IFN-beta impairs antigen presentation capacity of splenic dendritic cells via down-regulation of heat shock protein 70.

Journal of immunology (Baltimore, Md. : 1950)

Zietara N,Łyszkiewicz M,Gekara N,Puchałka J,Dos Santos VA,Hunt CR,Pandita TK,Lienenklaus S,Weiss S

12-0041 was used in Flow cytometry/Cell sorting to investigate the role of low level production of IFN, showing that its absence impairs antigen presentation capacity of splenic dendritic cells.

Wed Jul 15 00:00:00 EDT 2009

GITR Blockade Facilitates Treg Mediated Allograft Survival.

Transplantation

Sonawane SB,Kim JI,Lee MK,Lee SH,Duff PE,Moore DJ,Lian MM,Deng S,Choi Y,Yeh H,Caton AJ,Markmann JF

12-0041 was used in Flow cytometry/Cell sorting to study how inflammation and other innate immune signals may activate antigen presenting cells to up-regulate GITR.

Fri Nov 27 00:00:00 EST 2009

Deletion of both the C3a and C5a receptors fails to protect against experimental autoimmune encephalomyelitis.

Neuroscience letters

Ramos TN,Wohler JE,Barnum SR

12-0041 was used in Flow cytometry/Cell sorting to demonstrate the delayed onset of experimental autoimmune encephalomyelitis but no attenuation of disease severity in C3aR/C5aR double knockout mice.

Thu Dec 31 00:00:00 EST 2009

Induction of antigen-specific immune tolerance by TGF-beta-induced CD4+Foxp3+ regulatory T cells.

International journal of clinical and experimental medicine

Fan H,Wang J,Zhou X,Liu Z,Zheng SG

12-0041 was used in Flow cytometry/Cell sorting to investigate the use of TGF-beta-induced Treg cells to protect MHC-mismatched organ grafts from rejection in a clinical setting.

Tue Aug 25 00:00:00 EDT 2009

MGL2 Dermal dendritic cells are sufficient to initiate contact hypersensitivity in vivo.

PloS one

Kumamoto Y,Denda-Nagai K,Aida S,Higashi N,Irimura T

12-0041 was used in Flow cytometry/Cell sorting to investigate the functional and phenotypic differences between Langerhans and dermal dendritic cells, showing that macrophage galactose-type C-type lectin (MGL) 2 is only expression in dermal dendritic cells, which are sufficient to initiate contact hypersensitivity in vivo.

Thu Aug 06 00:00:00 EDT 2009

Vaccine adjuvants alter TCR-based selection thresholds.

Immunity

Malherbe L,Mark L,Fazilleau N,McHeyzer-Williams LJ,McHeyzer-Williams MG

12-0041 was used in Flow cytometry/Cell sorting to demonstrate the capacity of adjuvants to modify antigen-specific helper T cell clonal composition.

Thu May 01 00:00:00 EDT 2008

Sequential phases in the development of Aire-expressing medullary thymic epithelial cells involve distinct cellular input.

European journal of immunology

White AJ,Withers DR,Parnell SM,Scott HS,Finke D,Lane PJ,Jenkinson EJ,Anderson G

12-0041 was used in Flow cytometry/Cell sorting to analyse the cellular and molecular requirements for the initial appearance of Aire+ medullary thymic epithelial cells in the embryonic thymus, in addition to their persistence in the adult thymus.

Tue Apr 01 00:00:00 EDT 2008

Loss of extracellular superoxide dismutase leads to acute lung damage in the presence of ambient air: a potential mechanism underlying adult respiratory distress syndrome.

The American journal of pathology

Gongora MC,Lob HE,Landmesser U,Guzik TJ,Martin WD,Ozumi K,Wall SM,Wilson DS,Murthy N,Gravanis M,Fukai T,Harrison DG

12-0041 was used in Flow cytometry/Cell sorting to study the role of acute SOD3 reduction in lung injury.

Wed Oct 01 00:00:00 EDT 2008

Pervasive and stochastic changes in the TCR repertoire of regulatory T-cell-deficient mice.

International immunology

Zheng L,Sharma R,Kung JT,Deshmukh US,Jarjour WN,Fu SM,Ju ST

12-0041 was used in Flow cytometry/Cell sorting to compare the T-cell receptor V beta gene family expression profile of normal and Treg-lacking mice.

Tue Apr 01 00:00:00 EDT 2008

Suppression of alkali burn-induced corneal neovascularization by dendritic cell vaccination targeting VEGF receptor 2.

Investigative ophthalmology & visual science

Mochimaru H,Usui T,Yaguchi T,Nagahama Y,Hasegawa G,Usui Y,Shimmura S,Tsubota K,Amano S,Kawakami Y,Ishida S

Thu May 01 00:00:00 EDT 2008

Lymphotoxin a-dependent and -independent signals regulate stromal organizer cell homeostasis during lymph node organogenesis.

Blood

White A,Carragher D,Parnell S,Msaki A,Perkins N,Lane P,Jenkinson E,Anderson G,Caamaño JH

12-0041 was used in Flow cytometry/Cell sorting to further investigate the mechanisms that regulate the development of stromal organiser cells.

Sat Sep 15 00:00:00 EDT 2007

miR-150, a microRNA expressed in mature B and T cells, blocks early B cell development when expressed prematurely.

Proceedings of the National Academy of Sciences of the United States of America

Zhou B,Wang S,Mayr C,Bartel DP,Lodish HF

12-0041 was used in Immunofluorescence to study how miR-150 can down-regulate mRNAs important for B cell function, and how it can block further B cell development when expressed prematurely.

Tue Apr 24 00:00:00 EDT 2007

Myocardial infarct-sparing effect of adenosine A2A receptor activation is due to its action on CD4+ T lymphocytes.

Circulation

Yang Z,Day YJ,Toufektsian MC,Xu Y,Ramos SI,Marshall MA,French BA,Linden J

Tue Nov 07 00:00:00 EST 2006

In vivo ablation of CD11c-positive dendritic cells increases susceptibility to herpes simplex virus type 1 infection and diminishes NK and T-cell responses.

Journal of virology

Kassim SH,Rajasagi NK,Zhao X,Chervenak R,Jennings SR

12-0041 was used in Flow cytometry/Cell sorting to investigate the role of different dendritic cell subsets in response to herpes simplex virus type 1 infection in mice.

Sat Apr 01 00:00:00 EST 2006

Essential roles of CD8+CD122+ regulatory T cells in the maintenance of T cell homeostasis.

The Journal of experimental medicine

Rifa'i M,Kawamoto Y,Nakashima I,Suzuki H

12-0041 was used in Flow cytometry/Cell sorting to investigate the effect of transfer of CD8+CD122+ cells into CD122-deficient neonates, showing that CD8+CD122+ regulatory T cells are essential for T cell homeostasis.

Mon Nov 01 00:00:00 EST 2004

Involvement of p38 mitogen-activated protein kinase in different stages of thymocyte development.

Blood

Hsu SC,Wu CC,Han J,Lai MZ

12-0041 was used in Western Blotting to demonstrate that, in addition to early thymocyte development, p38 is involved in positive selection.

Sat Feb 01 00:00:00 EST 2003

Runx3 and Runx1 are required for CD8 T cell development during thymopoiesis.

Proceedings of the National Academy of Sciences of the United States of America

Woolf E,Xiao C,Fainaru O,Lotem J,Rosen D,Negreanu V,Bernstein Y,Goldenberg D,Brenner O,Berke G,Levanon D,Groner Y

Published figure using CD4 monoclonal antibody (Product # 12-0041-82) in Flow Cytometry

Tue Jun 24 00:00:00 EDT 2003

Increased p300 expression inhibits glucocorticoid receptor-T-cell receptor antagonism but does not affect thymocyte positive selection.

Molecular and cellular biology

Yu CT,Feng MH,Shih HM,Lai MZ

12-0041 was used in Western Blotting to determine the effects of increased p300 expression on GR-TCR crosstalk between thymocytes.

Mon Jul 01 00:00:00 EDT 2002

Increased p300 expression inhibits glucocorticoid receptor-T-cell receptor antagonism but does not affect thymocyte positive selection.

Molecular and cellular biology

Yu CT,Feng MH,Shih HM,Lai MZ

12-0041 was used in Western Blotting to determine the effects of increased p300 expression on GR-TCR crosstalk between thymocytes.

Mon Jul 01 00:00:00 EDT 2002

Increased p300 expression inhibits glucocorticoid receptor-T-cell receptor antagonism but does not affect thymocyte positive selection.

Molecular and cellular biology

Yu CT,Feng MH,Shih HM,Lai MZ

12-0041 was used in Western Blotting to determine the effects of increased p300 expression on GR-TCR crosstalk between thymocytes.

Mon Jul 01 00:00:00 EDT 2002

Bioinformatics

Protein Aliases: CD4; CD4 antigen p55; cd4a; fCD4; Leu-3; T-cell differentiation antigen L3T4; T-cell surface antigen T4/Leu-3; T-cell surface glycoprotein CD4; T-cell surface glycoprotein CD4 precursor (T-cell surface antigen T4/Leu-3) (T-cell differentiation antigen L3T4)

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Gene Aliases: Cd4; L3T4; Ly-4

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UniProt ID: (Mouse) P06332

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Entrez Gene ID: (Mouse) 12504

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Function(s)

glycoprotein binding protein binding zinc ion binding coreceptor activity enzyme binding protein kinase binding protein homodimerization activity

Process(es)

cytokine production immune system process induction by virus of host cell-cell fusion immune response cell adhesion cell surface receptor signaling pathway T cell differentiation maintenance of protein location in cell T cell activation T cell selection protein palmitoleylation positive regulation of protein kinase activity positive regulation of peptidyl-tyrosine phosphorylation defense response to Gram-negative bacterium positive regulation of calcium-mediated signaling regulation of T cell activation positive regulation of T cell activation

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CD4 Monoclonal Antibody (GK1.5), PE, eBioscience™

CD4 Antibody (12-0041-82) in Flow

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12-0041-82

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