Invitrogen

CD4 Monoclonal Antibody (OKT4 (OKT-4)), FITC, eBioscience™

Advanced Verification

This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.

30 Published Figures

45 References

View all (606) CD4 antibodies

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CD4 Antibody (11-0048-80) in Flow

Staining of human peripheral blood mononuclear cells with CD45 Pacific Blue, CD3 APC, CD8 PerCP and CD4 FITC. As expected based on known relative expression patterns, CD4 clone OKT4 (OKT-4) stains a subset of lymphocytes (pink) and monocytes (orange), but not granulocytes (blue).

CD4 Antibody in Immunocytochemistry, Flow Cytometry (ICC/IF, Flow)

CD4 Antibody in Immunocytochemistry (ICC/IF)

CD4 Antibody in Immunohistochemistry (IHC)

Product Image Gallery

CD4 Antibody — Staining of human peripheral blood mononuclear cells with CD45 Pacific Blue, CD3 APC, CD8 PerCP and CD4 FITC. As expected based on known relative expression patterns, CD4 clone OKT4 (OKT-4) stains a subset of lymphocytes (pink) and monocytes (orange), but not granulocytes (blue). {RE}

Product Details

11-0048-80

Applications

Tested Dilution

Publications

Western Blot (WB)

View 1 publication 1 publication

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Flow Cytometry (Flow)

0.5 µg/test

View 42 publications 42 publications

Product Specifications

Species Reactivity

Human

Published species

Hamster, Human, Mouse

Host/Isotype

Mouse / IgG2b, kappa

Recommended Isotype Control

Mouse IgG2b kappa Isotype Control (eBMG2b), FITC, eBioscience™

Class

Monoclonal

Type

Antibody

Clone

OKT4 (OKT-4)

Conjugate

FITC FITC FITC

Excitation/Emission Max

498/517 nm View spectra

Form

Liquid

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.2

Contains

0.09% sodium azide

Storage conditions

4° C, store in dark, DO NOT FREEZE!

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_657744

Product Specific Information

Description: The OKT4 monoclonal antibody reacts with human CD4, a 59 kDa cell surface glycoprotein expressed by the majority of thymocytes, a subpopulation of mature T cells (T-helper cells) and in low levels on monocytes. CD4 is a receptor for the human immunodeficiency virus (HIV). The OKT4 antibody recognizes a different epitope than the RPA-T4 monoclonal antibody, and these antibodies do not cross-block binding to each other's respective epitopes.

Applications Reported: This OKT4 (OKT-4) antibody has been reported for use in flow cytometric analysis.

Applications Tested: This OKT4 (OKT-4) antibody has been tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at less than or equal to 0.5 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

Excitation: 488 nm; Emission: 520 nm; Laser: Blue Laser.

Filtration: 0.2 µm post-manufacturing filtered.

Target Information

The CD4 antigen is involved in the recognition of MHC class II molecules and is a co-receptor for HIV. CD4 is primarily expressed in a subset of T-lymphocytes, also referred to as T helper cells, but may also be expressed by other cells in the immune system, such as monocytes, macrophages, and dendritic cells. At the tissue level, CD4 expression may be detected in thymus, lymph nodes, tonsils, and spleen, and also in specific regions of the brain, gut, and other non-lymphoid tissues. CD4 functions to initiate or augment the early phase of T-cell activation through its association with the T-cell receptor complex and protein tyrosine kinase, Lck. It may also function as an important mediator of direct neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcripts have been identified in this gene [RefSeq, July 2017].

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Product References

Distinct SARS-CoV-2 specific NLRP3 and IL-1β responses in T cells of aging patients during acute COVID-19 infection.

Frontiers in immunology

Mahalingam SS,Jayaraman S,Arunkumar A,Dudley HM,Anthony DD,Shive CL,Jacobson JM,Pandiyan P

Published figure using CD4 monoclonal antibody (Product # 11-0048-80) in Flow Cytometry

Thu Oct 12 00:00:00 EDT 2023

Estrogen Protects against Renal Ischemia-Reperfusion Injury by Regulating Th17/Treg Cell Immune Balance.

Disease markers

Zhang Y,Chang Y,Han Z,Ma K,Zeng X,Li L

Published figure using CD4 monoclonal antibody (Product # 11-0048-80) in Flow Cytometry

Tue Oct 18 00:00:00 EDT 2022

Plasma Extracellular Vesicle Subtypes May be Useful as Potential Biomarkers of Immune Activation in People With HIV.

Pathogens & immunity

Bazié WW,Boucher J,Vitry J,Goyer B,Routy JP,Tremblay C,Trottier S,Jenabian MA,Provost P,Alary M,Gilbert C

Published figure using CD4 monoclonal antibody (Product # 11-0048-80) in Flow Cytometry

Sat Apr 23 00:00:00 EDT 2022

Targeting Phosphatidylserine Enhances the Anti-tumor Response to Tumor-Directed Radiation Therapy in a Preclinical Model of Melanoma.

Cell reports

Budhu S,Giese R,Gupta A,Fitzgerald K,Zappasodi R,Schad S,Hirschhorn D,Campesato LF,De Henau O,Gigoux M,Liu C,Mazo G,Deng L,Barker CA,Wolchok JD,Merghoub T

Published figure using CD4 monoclonal antibody (Product # 11-0048-80) in Flow Cytometry

Tue Jan 12 00:00:00 EST 2021

Immunophenotype of Gastric Tumors Unveils a Pleiotropic Role of Regulatory T Cells in Tumor Development.

Cancers

Rocha S,Basto AP,Ijsselsteijn ME,Teles SP,Azevedo MM,Gonçalves G,Gullo I,Almeida GM,Maqueda JJ,Oliveira MI,Carneiro F,Barata JT,Graça L,de Miranda NFCC,Carvalho J,Oliveira C

11-0048-80 was used in Flow Cytometry to explore the impact of regulatory T cell (Tregs) in gastric cancers (GCs) with distinct histology, and whether Tregs can directly influence tumor cell behavior and GC development.

Sat Jan 23 00:00:00 EST 2021

Small-molecule antagonist of VLA-4 (GW559090) attenuated neuro-inflammation by targeting Th17 cell trafficking across the blood-retinal barrier in experimental autoimmune uveitis.

Journal of neuroinflammation

Chen YH,Eskandarpour M,Zhang X,Galatowicz G,Greenwood J,Lightman S,Calder V

Published figure using CD4 monoclonal antibody (Product # 11-0048-80) in Flow Cytometry

Thu Feb 18 00:00:00 EST 2021

A Cross-Reactive Small Protein Binding Domain Provides a Model to Study Off-Tumor CAR-T Cell Toxicity.

Molecular therapy oncolytics

Hammill JA,Kwiecien JM,Dvorkin-Gheva A,Lau VWC,Baker C,Wu Y,Bezverbnaya K,Aarts C,Heslen CW,Denisova GF,Derocher H,Milne K,Nelson BH,Bramson JL

Published figure using CD4 monoclonal antibody (Product # 11-0048-80) in Flow Cytometry

Fri Jun 26 00:00:00 EDT 2020

The Potential of Nanobody-Targeted Photodynamic Therapy to Trigger Immune Responses.

Cancers

Beltrán Hernández I,Angelier ML,Del Buono D'Ondes T,Di Maggio A,Yu Y,Oliveira S

Published figure using CD4 monoclonal antibody (Product # 11-0048-80) in Flow Cytometry

Wed Apr 15 00:00:00 EDT 2020

Expression of CD20 after viral reactivation renders HIV-reservoir cells susceptible to Rituximab.

Nature communications

Serra-Peinado C,Grau-Expósito J,Luque-Ballesteros L,Astorga-Gamaza A,Navarro J,Gallego-Rodriguez J,Martin M,Curran A,Burgos J,Ribera E,Raventós B,Willekens R,Torrella A,Planas B,Badía R,Garcia F,Castellví J,Genescà M,Falcó V,Buzon MJ

Published figure using CD4 monoclonal antibody (Product # 11-0048-80) in Flow Cytometry

Fri Aug 16 00:00:00 EDT 2019

Accumulation of T-helper 22 cells, interleukin-22 and myeloid-derived suppressor cells promotes gastric cancer progression in elderly patients.

Oncology letters

Chen X,Wang Y,Wang J,Wen J,Jia X,Wang X,Zhang H

Published figure using CD4 monoclonal antibody (Product # 11-0048-80) in Flow Cytometry

Sun Jul 01 00:00:00 EDT 2018

IL-6 receptor blockade corrects defects of XIAP-deficient regulatory T cells.

Nature communications

Hsieh WC,Hsu TS,Chang YJ,Lai MZ

Published figure using CD4 monoclonal antibody (Product # 11-0048-80) in Flow Cytometry

Wed Jan 31 00:00:00 EST 2018

Complement receptor CD46 co-stimulates optimal human CD8⁺ T cell effector function via fatty acid metabolism.

Nature communications

Arbore G,West EE,Rahman J,Le Friec G,Niyonzima N,Pirooznia M,Tunc I,Pavlidis P,Powell N,Li Y,Liu P,Servais A,Couzi L,Fremeaux-Bacchi V,Placais L,Ferraro A,Walsh PR,Kavanagh D,Afzali B,Lavender P,Lachmann HJ,Kemper C

Published figure using CD4 monoclonal antibody (Product # 11-0048-80) in Flow Cytometry

Wed Oct 10 00:00:00 EDT 2018

Ex vivo culture of human atherosclerotic plaques: A model to study immune cells in atherogenesis.

Atherosclerosis

Lebedeva A,Vorobyeva D,Vagida M,Ivanova O,Felker E,Fitzgerald W,Danilova N,Gontarenko V,Shpektor A,Vasilieva E,Margolis L

Published figure using CD4 monoclonal antibody (Product # 11-0048-80) in Flow Cytometry

Fri Dec 01 00:00:00 EST 2017

Hormonal vitamin D up-regulates tissue-specific PD-L1 and PD-L2 surface glycoprotein expression in humans but not mice.

The Journal of biological chemistry

Dimitrov V,Bouttier M,Boukhaled G,Salehi-Tabar R,Avramescu RG,Memari B,Hasaj B,Lukacs GL,Krawczyk CM,White JH

Published figure using CD4 monoclonal antibody (Product # 11-0048-80) in Flow Cytometry

Fri Dec 15 00:00:00 EST 2017

Single-cell profiling reveals GPCR heterogeneity and functional patterning during neuroinflammation.

JCI insight

Tischner D,Grimm M,Kaur H,Staudenraus D,Carvalho J,Looso M,Günther S,Wanke F,Moos S,Siller N,Breuer J,Schwab N,Zipp F,Waisman A,Kurschus FC,Offermanns S,Wettschureck N

Published figure using CD4 monoclonal antibody (Product # 11-0048-80) in Flow Cytometry

Thu Aug 03 00:00:00 EDT 2017

Targeted Disruption of TCF12 Reveals HEB as Essential in Human Mesodermal Specification and Hematopoiesis.

Stem cell reports

Li Y,Brauer PM,Singh J,Xhiku S,Yoganathan K,Zúñiga-Pflücker JC,Anderson MK

Published figure using CD4 monoclonal antibody (Product # 11-0048-80) in Flow Cytometry

Tue Sep 12 00:00:00 EDT 2017

CD3xPDL1 bi-specific T cell engager (BiTE) simultaneously activates T cells and NKT cells, kills PDL1⁺ tumor cells, and extends the survival of tumor-bearing humanized mice.

Oncotarget

Horn LA,Ciavattone NG,Atkinson R,Woldergerima N,Wolf J,Clements VK,Sinha P,Poudel M,Ostrand-Rosenberg S

11-0048 was used in Flow cytometry/Cell sorting to suggest that the CD3xPDL1 BiTE may be efficacious for patients with PDL1(+) solid tumors, in combination with other immunotherapies that do not specifically neutralize PD1 pathway-mediated immune suppression.

Tue Aug 29 00:00:00 EDT 2017

CD3xPDL1 bi-specific T cell engager (BiTE) simultaneously activates T cells and NKT cells, kills PDL1⁺ tumor cells, and extends the survival of tumor-bearing humanized mice.

Oncotarget

Horn LA,Ciavattone NG,Atkinson R,Woldergerima N,Wolf J,Clements VK,Sinha P,Poudel M,Ostrand-Rosenberg S

Tue Aug 29 00:00:00 EDT 2017

PD-L1 expression and prognostic impact in glioblastoma.

Neuro-oncology

Nduom EK,Wei J,Yaghi NK,Huang N,Kong LY,Gabrusiewicz K,Ling X,Zhou S,Ivan C,Chen JQ,Burks JK,Fuller GN,Calin GA,Conrad CA,Creasy C,Ritthipichai K,Radvanyi L,Heimberger AB

Published figure using CD4 monoclonal antibody (Product # 11-0048-80) in Flow Cytometry

Mon Feb 01 00:00:00 EST 2016

Altered expression of miR-92a correlates with Th17 cell frequency in patients with primary biliary cirrhosis.

International journal of molecular medicine

Liang DY,Hou YQ,Luo LJ,Ao L

11-0048 was used in Flow cytometry/Cell sorting to study the altered expression of miR-92a and its impact on the frequency of Th17 cells in patients with primary biliary cirrhosis.

Fri Jul 01 00:00:00 EDT 2016

Tax and Semaphorin 4D Released from Lymphocytes Infected with Human Lymphotropic Virus Type 1 and Their Effect on Neurite Growth.

AIDS research and human retroviruses

Quintremil S,Alberti C,Rivera M,Medina F,Puente J,Cartier L,Ramírez E,Tanaka Y,Valenzuela MA

Published figure using CD4 monoclonal antibody (Product # 11-0048-80) in Flow Cytometry

Fri Jan 01 00:00:00 EST 2016

Tumor-derived exosomes regulate expression of immune function-related genes in human T cell subsets.

Scientific reports

Muller L,Mitsuhashi M,Simms P,Gooding WE,Whiteside TL

Published figure using CD4 monoclonal antibody (Product # 11-0048-80) in Flow Cytometry

Thu Feb 04 00:00:00 EST 2016

PSG9 Stimulates Increase in FoxP3+ Regulatory T-Cells through the TGF-β1 Pathway.

PloS one

Jones K,Ballesteros A,Mentink-Kane M,Warren J,Rattila S,Malech H,Kang E,Dveksler G

11-0048 was used in Flow cytometry/Cell sorting to investigate whether pregnancy-specific glycoprotein 9, a potential predictive biomarker of pre-eclampsia, plays an immunoregulatory role during pregnancy.

Wed Jul 26 00:00:00 EDT 2017

The Expression of Programmed Death-1 on CD4+ and CD8+ T Lymphocytes in Patients with Type 2 Diabetes and Severe Sepsis.

PloS one

Jia Y,Zhao Y,Li C,Shao R

11-0048 was used in Flow cytometry/Cell sorting to investigate the expression of Programmed death-1 on T lymphocytes in patients with type 2 diabetes mellitus and severe sepsis.

Mon Jul 24 00:00:00 EDT 2017

A Systematic Study of the Effect of Different Molecular Weights of Hyaluronic Acid on Mesenchymal Stromal Cell-Mediated Immunomodulation.

PloS one

Gómez-Aristizábal A,Kim KP,Viswanathan S

11-0048 was used in Flow cytometry/Cell sorting to investigate the combined mechanism of action of MSCs and hyaluronic acid.

Wed Jul 06 00:00:00 EDT 2016

Homeostatic regulation of T cell trafficking by a B cell-derived peptide is impaired in autoimmune and chronic inflammatory disease.

Nature medicine

Chimen M,McGettrick HM,Apta B,Kuravi SJ,Yates CM,Kennedy A,Odedra A,Alassiri M,Harrison M,Martin A,Barone F,Nayar S,Hitchcock JR,Cunningham AF,Raza K,Filer A,Copland DA,Dick AD,Robinson J,Kalia N,Walker LSK,Buckley CD,Nash GB,Narendran P,Rainger GE

11-0048 was used in Flow cytometry/Cell sorting to demonstrate that exogenous PEPITEM reduces T cell recruitment into inflamed tissues in multiple animal models of autoimmune, inflammatory diseases.

Fri May 01 00:00:00 EDT 2015

Low B and T lymphocyte attenuator expression on CD4+ T cells in the early stage of sepsis is associated with the severity and mortality of septic patients: a prospective cohort study.

Critical care (London, England)

Shao R,Li CS,Fang Y,Zhao L,Hang C

11-0048 was used in Flow cytometry/Cell sorting to investigate B and T lymphocyte attenuator expression on CD4(+) T cells in healthy controls and septic patients.

Fri Aug 28 00:00:00 EDT 2015

The HIV-1 gp120 CD4-bound conformation is preferentially targeted by antibody-dependent cellular cytotoxicity-mediating antibodies in sera from HIV-1-infected individuals.

Journal of virology

Veillette M,Coutu M,Richard J,Batraville LA,Dagher O,Bernard N,Tremblay C,Kaufmann DE,Roger M,Finzi A

Published figure using CD4 monoclonal antibody (Product # 11-0048-80) in Flow Cytometry

Thu Jan 01 00:00:00 EST 2015

Skewed T-helper (Th)1/2- and Th17/T regulatory‑cell balances in patients with renal cell carcinoma.

Molecular medicine reports

Li L,Yang C,Zhao Z,Xu B,Zheng M,Zhang C,Min Z,Guo J,Rong R

11-0048 was used in Flow cytometry/Cell sorting to demonstrate that the balance of Th1 and Th2 cells is skewed towards the Th2 profile in the peripheral blood of patients with RCC.

Sun Feb 01 00:00:00 EST 2015

Aging and cytomegalovirus infection differentially and jointly affect distinct circulating T cell subsets in humans.

Journal of immunology (Baltimore, Md. : 1950)

Wertheimer AM,Bennett MS,Park B,Uhrlaub JL,Martinez C,Pulko V,Currier NL,Nikolich-Žugich D,Kaye J,Nikolich-Žugich J

Published figure using CD4 monoclonal antibody (Product # 11-0048-80) in Flow Cytometry

Sat Mar 01 00:00:00 EST 2014

Calcium signaling via Orai1 is essential for induction of the nuclear orphan receptor pathway to drive Th17 differentiation.

Journal of immunology (Baltimore, Md. : 1950)

Kim KD,Srikanth S,Tan YV,Yee MK,Jew M,Damoiseaux R,Jung ME,Shimizu S,An DS,Ribalet B,Waschek JA,Gwack Y

11-0048 was used in Flow cytometry/Cell sorting to identify a novel class of small molecules that inhibit Ca(2+) release-activated Ca(2+) channel activity.

Wed Jan 01 00:00:00 EST 2014

An increased abundance of tumor-infiltrating regulatory T cells is correlated with the progression and prognosis of pancreatic ductal adenocarcinoma.

PloS one

Tang Y,Xu X,Guo S,Zhang C,Tang Y,Tian Y,Ni B,Lu B,Wang H

11-0048 was used in Flow cytometry/Cell sorting to reveal Tregs may promote PDA progression by inhibiting the antitumour immunity of CD8+ T cells at local intratumoural sites.

Tue Jan 06 00:00:00 EST 2015

An increased abundance of tumor-infiltrating regulatory T cells is correlated with the progression and prognosis of pancreatic ductal adenocarcinoma.

PloS one

Tang Y,Xu X,Guo S,Zhang C,Tang Y,Tian Y,Ni B,Lu B,Wang H

11-0048 was used in Flow cytometry/Cell sorting to reveal Tregs may promote PDA progression by inhibiting the antitumour immunity of CD8+ T cells at local intratumoural sites.

Tue Jan 06 00:00:00 EST 2015

Azithromycin suppresses CD4(+) T-cell activation by direct modulation of mTOR activity.

Scientific reports

Ratzinger F,Haslacher H,Poeppl W,Hoermann G,Kovarik JJ,Jutz S,Steinberger P,Burgmann H,Pickl WF,Schmetterer KG

11-0048 was used in Flow cytometry/Cell sorting to evaluate the in vitro effects of the antibiotics azithromycin and clarithromycin on the activation of CD4(+) T cells.

Thu Dec 11 00:00:00 EST 2014

Association of a NOD2 gene polymorphism and T-helper 17 cells with presumed ocular toxoplasmosis.

The Journal of infectious diseases

Dutra MS,Béla SR,Peixoto-Rangel AL,Fakiola M,Cruz AG,Gazzinelli A,Quites HF,Bahia-Oliveira LM,Peixe RG,Campos WR,Higino-Rocha AC,Miller NE,Blackwell JM,Antonelli LR,Gazzinelli RT

11-0048 was used in Flow cytometry/Cell sorting to suggest that NOD2 influences the production of IL-17A by CD4 T lymphocytes and might contribute to the development of ocular toxoplasmosis.

Tue Jan 01 00:00:00 EST 2013

Memory T cells in latent Mycobacterium tuberculosis infection are directed against three antigenic islands and largely contained in a CXCR3+CCR6+ Th1 subset.

PLoS pathogens

Lindestam Arlehamn CS,Gerasimova A,Mele F,Henderson R,Swann J,Greenbaum JA,Kim Y,Sidney J,James EA,Taplitz R,McKinney DM,Kwok WW,Grey H,Sallusto F,Peters B,Sette A

11-0048 was used in Flow cytometry/Cell sorting to further define the immunological footprint of Mycobacterium tuberculosis CD4 T cell recognition.

Tue Jan 01 00:00:00 EST 2013

Role of gastric epithelial cell-derived transforming growth factor beta in reduced CD4+ T cell proliferation and development of regulatory T cells during Helicobacter pylori infection.

Infection and immunity

Beswick EJ,Pinchuk IV,Earley RB,Schmitt DA,Reyes VE

11-0048 was used in Flow cytometry/Cell sorting to show how TGF-β produced by gastric epithelial cells inhibits CD4+ T cell responses during H. pylori infection, suggesting a possible mechanism of persistence.

Fri Jul 01 00:00:00 EDT 2011

Common gamma chain cytokines promote rapid in vitro expansion of allo-specific human CD8+ suppressor T cells.

PloS one

Yu Y,Zitzner JR,Houlihan J,Herrera N,Xu L,Miller J,Mathew JM,Tambur AR,Luo X

11-0048 was used in Flow cytometry/Cell sorting to demonstrate the use of common γc cytokines in combination with donor APCs as a strategy for generation of donor-specific T cells for immunotherapy.

Mon Aug 27 00:00:00 EDT 2012

Assessment of seasonal influenza A virus-specific CD4 T-cell responses to 2009 pandemic H1N1 swine-origin influenza A virus.

Journal of virology

Ge X,Tan V,Bollyky PL,Standifer NE,James EA,Kwok WW

11-0048 was used in Flow cytometry/Cell sorting to investigate how, without protective antibody responses, individuals vaccinated against seasonal influenza A may still benefit from preexisting cross-reactive memory CD4 T cells reducing their susceptibility to S-OIV infection.

Thu Apr 01 00:00:00 EDT 2010

CD4-CCR5 interaction in intracellular compartments contributes to receptor expression at the cell surface.

Blood

Achour L,Scott MG,Shirvani H,Thuret A,Bismuth G,Labbé-Jullié C,Marullo S

Published figure using CD4 monoclonal antibody (Product # 11-0048-80) in Flow Cytometry

Thu Feb 26 00:00:00 EST 2009

CD4-CCR5 interaction in intracellular compartments contributes to receptor expression at the cell surface.

Blood

Achour L,Scott MG,Shirvani H,Thuret A,Bismuth G,Labbé-Jullié C,Marullo S

Published figure using CD4 monoclonal antibody (Product # 11-0048-80) in Flow Cytometry

Thu Feb 26 00:00:00 EST 2009

CD4-CCR5 interaction in intracellular compartments contributes to receptor expression at the cell surface.

Blood

Achour L,Scott MG,Shirvani H,Thuret A,Bismuth G,Labbé-Jullié C,Marullo S

Published figure using CD4 monoclonal antibody (Product # 11-0048-80) in Flow Cytometry

Thu Feb 26 00:00:00 EST 2009

CD4-CCR5 interaction in intracellular compartments contributes to receptor expression at the cell surface.

Blood

Achour L,Scott MG,Shirvani H,Thuret A,Bismuth G,Labbé-Jullié C,Marullo S

Published figure using CD4 monoclonal antibody (Product # 11-0048-80) in Flow Cytometry

Thu Feb 26 00:00:00 EST 2009

Naive CD4 t cell proliferation is controlled by mammalian target of rapamycin regulation of GRAIL expression.

Journal of immunology (Baltimore, Md. : 1950)

Lin JT,Lineberry NB,Kattah MG,Su LL,Utz PJ,Fathman CG,Wu L

11-0048 was used in Flow cytometry/Cell sorting to investigate the role of GRAIL in CD4 T cells, showing that proliferation is controlled by mTOR regulation of GRAIL expression.

Fri May 15 00:00:00 EDT 2009

T-cell responses to survivin in cancer patients undergoing radiation therapy.

Clinical cancer research : an official journal of the American Association for Cancer Research

Schaue D,Comin-Anduix B,Ribas A,Zhang L,Goodglick L,Sayre JW,Debucquoy A,Haustermans K,McBride WH

11-0048 was used in Flow cytometry/Cell sorting to show that radiation therapy may increase the likelihood of some cancer patients responding to immunotherapy.

Fri Aug 01 00:00:00 EDT 2008

TCR-induced downregulation of protein tyrosine phosphatase PEST augments secondary T cell responses.

Molecular immunology

Arimura Y,Vang T,Tautz L,Williams S,Mustelin T

11-0048 was used in Flow cytometry/Cell sorting to investigate how PTP-PEST is down-regulated following T cell activation, and how that can lead to reduced IL-2 secretion following TCR and CD28 stimulation.

Sun Jun 01 00:00:00 EDT 2008

T regulatory cell levels decrease in people infected with Schistosoma mansoni on effective treatment.

The American journal of tropical medicine and hygiene

Watanabe K,Mwinzi PN,Black CL,Muok EM,Karanja DM,Secor WE,Colley DG

11-0048 was used in Flow cytometry/Cell sorting to investigate the role of Tregs in Schistosoma mansoni infection, showing that Treg levels decrease in people on effective treatment.

Mon Oct 01 00:00:00 EDT 2007

Bioinformatics

Protein Aliases: CD4; CD4 antigen (p55); CD4 antigen p55; CD4 receptor; cd4a; fCD4; Leu-3; T-cell surface antigen T4/Leu-3; T-cell surface glycoprotein CD4

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Gene Aliases: CD4; CD4mut

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UniProt ID: (Human) P01730

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Entrez Gene ID: (Human) 920

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Function(s)

virus receptor activity glycoprotein binding receptor activity transmembrane signaling receptor activity extracellular matrix structural constituent protein binding zinc ion binding coreceptor activity immunoglobulin binding enzyme binding protein kinase binding MHC class II protein binding protein homodimerization activity protein tyrosine kinase binding

Process(es)

cytokine production adaptive immune response induction by virus of host cell-cell fusion immune response signal transduction cell surface receptor signaling pathway enzyme linked receptor protein signaling pathway transmembrane receptor protein tyrosine kinase signaling pathway positive regulation of calcium ion transport into cytosol fusion of virus membrane with host plasma membrane T cell differentiation entry into host cell T cell costimulation response to estradiol maintenance of protein location in cell response to vitamin D helper T cell enhancement of adaptive immune response positive regulation of T cell proliferation T cell selection positive regulation of interleukin-2 biosynthetic process positive regulation of protein kinase activity regulation of defense response to virus by virus positive regulation of peptidyl-tyrosine phosphorylation defense response to Gram-negative bacterium positive regulation of calcium-mediated signaling T cell receptor signaling pathway regulation of T cell activation

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CD4 Monoclonal Antibody (OKT4 (OKT-4)), FITC, eBioscience™

CD4 Antibody (11-0048-80) in Flow

Product Details

11-0048-80

Western Blot (WB)

Immunohistochemistry (IHC)

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Species Reactivity

Published species

Host/Isotype

Recommended Isotype Control

Class

Type

Clone

Conjugate

Excitation/Emission Max

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Product Specific Information

Target Information

How to use the Panel Builder

Bioinformatics

Performance Guarantee

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