Product References
The Pregnane X Receptor and Indole-3-Propionic Acid Shape the Intestinal Mesenchyme to Restrain Inflammation and Fibrosis.
Cellular and molecular gastroenterology and hepatology
Flannigan KL,Nieves KM,Szczepanski HE,Serra A,Lee JW,Alston LA,Ramay H,Mani S,Hirota SA
11-5321-82 was used in Flow Cytometry to highlight a role for IPA and its interactions with the PXR in regulating the mesenchyme and the development of inflammation and fibrosis, suggesting microbiota metabolites may be a vital determinant in the progression of fibrotic complications in IBD.
Thu Feb 23 00:00:00 EST 2023
MAIT cells activate dendritic cells to promote TFH cell differentiation and induce humoral immunity.
Cell reports
Pankhurst TE,Buick KH,Lange JL,Marshall AJ,Button KR,Palmer OR,Farrand KJ,Montgomerie I,Bird TW,Mason NC,Kuang J,Compton BJ,Comoletti D,Salio M,Cerundolo V,Quiñones-Mateu ME,Painter GF,Hermans IF,Connor LM
11-5321-82 was used in Flow cytometry/Cell sorting to show that mucosal-associated invariant T cells are promising vaccine targets that can be utilized as cellular adjuvants in mucosal vaccines.
Tue Apr 25 00:00:00 EDT 2023
QUAS-R: An SLC1A5-mediated glutamine uptake assay with single-cell resolution reveals metabolic heterogeneity with immune populations.
Cell reports
Pelgrom LR,Davis GM,O'Shaughnessy S,Wezenberg EJM,Van Kasteren SI,Finlay DK,Sinclair LV
11-5321-82 was used in Flow cytometry/Cell sorting to provide an easy sensitive single-cell assay to assess which cells support their function via SLC1A5-mediated uptake.
Tue Aug 29 00:00:00 EDT 2023
Listeria delivers tetanus toxoid protein to pancreatic tumors and induces cancer cell death in mice.
Science translational medicine
Selvanesan BC,Chandra D,Quispe-Tintaya W,Jahangir A,Patel A,Meena K,Alves Da Silva RA,Friedman M,Gabor L,Khouri O,Libutti SK,Yuan Z,Li J,Siddiqui S,Beck A,Tesfa L,Koba W,Chuy J,McAuliffe JC,Jafari R,Entenberg D,Wang Y,Condeelis J,DesMarais V,Balachandran V,Zhang X,Lin K,Gravekamp C
11-5321-82 was used in Immunohistochemistry (Paraffin) to suggest that Listeria-delivered recall antigens could be an alternative to neoantigen-mediated cancer immunotherapy.
Wed Mar 23 00:00:00 EDT 2022
Lysosomal acid lipase, CSF1R, and PD-L1 determine functions of CD11c+ myeloid-derived suppressor cells.
JCI insight
Zhao T,Liu S,Ding X,Johnson EM,Hanna NH,Singh K,Sen CK,Wan J,Du H,Yan C
11-5321-82 was used in Flow cytometry/Cell sorting to investigate if CD11c+ cells switched their functions to immune suppression and tumor growth stimulation through CSF1R/PD-L1 upregulation and metabolic reprogramming.
Thu Sep 08 00:00:00 EDT 2022
Tet2 deficiency drives liver microbiome dysbiosis triggering Tc1 cell autoimmune hepatitis.
Cell host & microbe
Pandey SP,Bender MJ,McPherson AC,Phelps CM,Sanchez LM,Rana M,Hedden L,Sangani KA,Chen L,Shapira JH,Siller M,Goel C,Verdú EF,Jabri B,Chang A,Chandran UR,Mullett SJ,Wendell SG,Singhi AD,Tilstra JS,Pierre JF,Arteel GE,Hinterleitner R,Meisel M
11-5321-82 was used in Flow cytometry/Cell sorting to demonstrate that I3A is required for L. reuteri-induced Tc1 cell differentiation in vitro and AIH-like pathology in vivo, both of which are restrained by Tet2 within CD8 T cells.
Wed Jul 13 00:00:00 EDT 2022
PI3K Signaling in Dendritic Cells Aggravates DSS-Induced Colitis.
Frontiers in immunology
Kuttke M,Hromadová D,Yildirim C,Brunner JS,Vogel A,Paar H,Peters S,Weber M,Hofmann M,Kerndl M,Kieler M,Datler H,Musiejovsky L,Salzmann M,Lang M,Soukup K,Halfmann A,Sharif O,Schabbauer G
11-5321-82 was used in Flow cytometry/Cell sorting to show that the PI3K signaling pathway in dendritic cells contributes to disease pathology by promoting IL-6 mediated Th1 responses.
Mon May 09 00:00:00 EDT 2022
Deletion of Lactate Dehydrogenase-A Impairs Oncogene-Induced Mouse Hepatocellular Carcinoma Development.
Cellular and molecular gastroenterology and hepatology
Serra M,Di Matteo M,Serneels J,Pal R,Cafarello ST,Lanza M,Sanchez-Martin C,Evert M,Castegna A,Calvisi DF,Mazzone M,Columbano A
11-5321-82 was used in Flow cytometry/Cell sorting to investigate whether lactate dehydrogenase-A genetic ablation interferes with metabolic reprogramming and hepatocellular carcinoma development in the mouse.
Mon Aug 29 00:00:00 EDT 2022
Endogenous retroviruses promote homeostatic and inflammatory responses to the microbiota.
Cell
Lima-Junior DS,Krishnamurthy SR,Bouladoux N,Collins N,Han SJ,Chen EY,Constantinides MG,Link VM,Lim AI,Enamorado M,Cataisson C,Gil L,Rao I,Farley TK,Koroleva G,Attig J,Yuspa SH,Fischbach MA,Kassiotis G,Belkaid Y
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Flow Cytometry
Thu Jul 08 00:00:00 EDT 2021
Regionally diverse astrocyte subtypes and their heterogeneous response to EAE.
Glia
Borggrewe M,Grit C,Vainchtein ID,Brouwer N,Wesseling EM,Laman JD,Eggen BJL,Kooistra SM,Boddeke EWGM
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Immunohistochemistry
Sat May 01 00:00:00 EDT 2021
CD11b Deficiency Exacerbates Methicillin-Resistant Staphylococcus aureus-Induced Sepsis by Upregulating Inflammatory Responses of Macrophages.
Immune network
Sim H,Jeong D,Kim HI,Pak S,Thapa B,Kwon HJ,Lee K
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Flow Cytometry
Thu Apr 01 00:00:00 EDT 2021
CD11b Deficiency Exacerbates Methicillin-Resistant Staphylococcus aureus-Induced Sepsis by Upregulating Inflammatory Responses of Macrophages.
Immune network
Sim H,Jeong D,Kim HI,Pak S,Thapa B,Kwon HJ,Lee K
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Flow Cytometry
Thu Apr 01 00:00:00 EDT 2021
Prostaglandin E2 serves a dual role in regulating the migration of dendritic cells.
International journal of molecular medicine
Diao G,Huang J,Zheng X,Sun X,Tian M,Han J,Guo J
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Flow Cytometry
Fri Jan 01 00:00:00 EST 2021
Wip1 regulates the immunomodulatory effects of murine mesenchymal stem cells in type 1 diabetes mellitus via targeting IFN-α/BST2.
Cell death discovery
Zhou N,Liu W,Zhang W,Liu Y,Li X,Wang Y,Zheng R,Zhang Y
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Flow Cytometry
Fri Oct 29 00:00:00 EDT 2021
Topical arginase inhibition decreases growth of cutaneous squamous cell carcinoma.
Scientific reports
Mittal A,Wang M,Vidyarthi A,Yanez D,Pizzurro G,Thakral D,Tracy E,Colegio OR
11-5321-82 was used in Flow Cytometry to demonstrate the therapeutic potential of transcutaneous arginase inhibition in cutaneous squamous cell carcinomas (cSCC).
Mon May 24 00:00:00 EDT 2021
Topical arginase inhibition decreases growth of cutaneous squamous cell carcinoma.
Scientific reports
Mittal A,Wang M,Vidyarthi A,Yanez D,Pizzurro G,Thakral D,Tracy E,Colegio OR
11-5321-82 was used in Flow Cytometry to demonstrate the therapeutic potential of transcutaneous arginase inhibition in cutaneous squamous cell carcinomas (cSCC).
Mon May 24 00:00:00 EDT 2021
Targeting Phosphatidylserine Enhances the Anti-tumor Response to Tumor-Directed Radiation Therapy in a Preclinical Model of Melanoma.
Cell reports
Budhu S,Giese R,Gupta A,Fitzgerald K,Zappasodi R,Schad S,Hirschhorn D,Campesato LF,De Henau O,Gigoux M,Liu C,Mazo G,Deng L,Barker CA,Wolchok JD,Merghoub T
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Flow Cytometry
Tue Jan 12 00:00:00 EST 2021
Transgene distribution and immune response after ultrasound delivery of rAAV9 and PHP.B to the brain in a mouse model of amyloidosis.
Molecular therapy. Methods & clinical development
Kofoed RH,Heinen S,Silburt J,Dubey S,Dibia CL,Maes M,Simpson EM,Hynynen K,Aubert I
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Immunocytochemistry
Fri Dec 10 00:00:00 EST 2021
Intestinal CD11b+ B Cells Ameliorate Colitis by Secreting Immunoglobulin A.
Frontiers in immunology
Fu Y,Wang Z,Yu B,Lin Y,Huang E,Liu R,Zhao C,Lu M,Xu W,Liu H,Liu Y,Wang L,Chu Y
11-5321-82 was used in Flow Cytometry to demonstrate that CD11b+ B cells are essential intestinal suppressive immune cells and the primary source of intestinal IgA, which plays an indispensable role in maintaining intestinal homeostasis.
Fri Jan 07 00:00:00 EST 2022
Modulation of lactate-lysosome axis in dendritic cells by clotrimazole potentiates antitumor immunity.
Journal for immunotherapy of cancer
Wang Z,Xu F,Hu J,Zhang H,Cui L,Lu W,He W,Wang X,Li M,Zhang H,Xiong W,Xie C,Liu Y,Zhou P,Liu J,Huang P,Qin XF,Xia X
11-5321-82 was used in Flow Cytometry to show that clotrimazole could trigger DC activation via the lactate-lysosome axis to promote antigen cross-presentation and could be used as a potential combination therapy approach to improving the therapeutic efficacy of anti-PD1 immunotherapy.
Sat May 01 00:00:00 EDT 2021
Smek1 deficiency exacerbates experimental autoimmune encephalomyelitis by activating proinflammatory microglia and suppressing the IDO1-AhR pathway.
Journal of neuroinflammation
Duan RN,Yang CL,Du T,Liu A,Wang AR,Sun WJ,Li X,Li JX,Yan CZ,Liu QJ
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Flow Cytometry
Mon Jun 28 00:00:00 EDT 2021
Potential role of senescent macrophages in radiation-induced pulmonary fibrosis.
Cell death & disease
Su L,Dong Y,Wang Y,Wang Y,Guan B,Lu Y,Wu J,Wang X,Li D,Meng A,Fan F
11-5321-82 was used in Flow Cytometry to provide important evidence that senescent macrophages might be the target for prevention and treatment of RIPF.
Sat May 22 00:00:00 EDT 2021
Frequent amplification of HDAC genes and efficacy of HDAC inhibitor chidamide and PD-1 blockade combination in soft tissue sarcoma.
Journal for immunotherapy of cancer
Que Y,Zhang XL,Liu ZX,Zhao JJ,Pan QZ,Wen XZ,Xiao W,Xu BS,Hong DC,Guo TH,Shen LJ,Fan WJ,Chen HY,Weng DS,Xu HR,Zhou PH,Zhang YZ,Niu XH,Zhang X
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Flow Cytometry
Mon Feb 01 00:00:00 EST 2021
Early activation of the cardiac CX3CL1/CX3CR1 axis delays β-adrenergic-induced heart failure.
Scientific reports
Flamant M,Mougenot N,Balse E,Le Fèvre L,Atassi F,Gautier EL,Le Goff W,Keck M,Nadaud S,Combadière C,Boissonnas A,Pavoine C
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Flow Cytometry
Thu Sep 09 00:00:00 EDT 2021
Expanded renal lymphatics improve recovery following kidney injury.
Physiological reports
Baranwal G,Creed HA,Black LM,Auger A,Quach AM,Vegiraju R,Eckenrode HE,Agarwal A,Rutkowski JM
11-5321-82 was used in Flow cytometry/Cell sorting to demonstrate that increased lymphatic density prior to injury alters the injury recovery response and affords protection from CKD progression.
Mon Nov 01 00:00:00 EDT 2021
PP2Cδ Controls the Differentiation and Function of Dendritic Cells Through Regulating the NSD2/mTORC2/ACLY Pathway.
Frontiers in immunology
Lv N,Jin S,Liang Z,Wu X,Kang Y,Su L,Dong Y,Wang B,Ma T,Shi L
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Flow Cytometry
Mon Feb 28 00:00:00 EST 2022
Inflammasome activation leads to cDC1-independent cross-priming of CD8 T cells by epithelial cell-derived antigen.
eLife
Deets KA,Nichols Doyle R,Rauch I,Vance RE
11-5321-82 was used in Flow cytometry/Cell sorting to investigate whether inflammasomes provide sufficient signals to activate adaptive immunity.
Thu Dec 23 00:00:00 EST 2021
Depletion of Retinal Dopaminergic Activity in a Mouse Model of Rod Dysfunction Exacerbates Experimental Autoimmune Uveoretinitis: A Role for the Gateway Reflex.
International journal of molecular sciences
Stofkova A,Zloh M,Andreanska D,Fiserova I,Kubovciak J,Hejda J,Kutilek P,Murakami M
11-5321-82 was used in Flow cytometry/Cell sorting to hypothesize that rod photoreceptor dysfunction causes remodeling of retinal neural activity, which influences the blood-retinal barrier and the development of retinal inflammation.
Fri Dec 31 00:00:00 EST 2021
Epinephrine Production in Th17 Cells and Experimental Autoimmune Encephalitis.
Frontiers in immunology
Yang P,Tian H,Zou YR,Chambon P,Ichinose H,Honig G,Diamond B,Kim SJ
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Flow Cytometry
Mon Jul 05 00:00:00 EDT 2021
A Novel Thienopyrimidine Analog, TPH104, Mediates Immunogenic Cell Death in Triple-Negative Breast Cancer Cells.
Cancers
Tukaramrao DB,Malla S,Saraiya S,Hanely RA,Ray A,Kumari S,Raman D,Tiwari AK
11-5321-82 was used in Flow Cytometry to report a novel chemotherapeutic compound - TPH104 - capable of inducing immunogenic cell death in a triple-negative breast cancer (TNBC) cell line.
Sun Apr 18 00:00:00 EDT 2021
Systemic Inflammation Accelerates Changes in Microglial and Synaptic Markers in an Experimental Model of Chronic Neurodegeneration.
Frontiers in neuroscience
Chouhan JK,Püntener U,Booth SG,Teeling JL
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Immunohistochemistry
Sat Jan 22 00:00:00 EST 2022
Inflammatory Type 2 cDCs Acquire Features of cDC1s and Macrophages to Orchestrate Immunity to Respiratory Virus Infection.
Immunity
Bosteels C,Neyt K,Vanheerswynghels M,van Helden MJ,Sichien D,Debeuf N,De Prijck S,Bosteels V,Vandamme N,Martens L,Saeys Y,Louagie E,Lesage M,Williams DL,Tang SC,Mayer JU,Ronchese F,Scott CL,Hammad H,Guilliams M,Lambrecht BN
11-5321 was used in Flow cytometry/Cell sorting to show that monocyte-derived inflammatory DCs’’ are a mixture of monocyte-derived MCs that have little migratory and APC potential and bona fide pre-cDCderived, CD26-expressing inf-cDC2s that depend on Flt3L but not on GM-CSF.
Tue Jun 16 00:00:00 EDT 2020
Inflammatory Signals Induce AT2 Cell-Derived Damage-Associated Transient Progenitors that Mediate Alveolar Regeneration.
Cell stem cell
Choi J,Park JE,Tsagkogeorga G,Yanagita M,Koo BK,Han N,Lee JH
11-5321 was used in Flow cytometry/Cell sorting to map the trajectories of alveolar-lineage cells during injury repair and lung regeneration by single-cell RNA sequencing in combination with in vivo lineage tracing and organoid models.
Thu Sep 03 00:00:00 EDT 2020
Sensing of endogenous nucleic acids by ZBP1 induces keratinocyte necroptosis and skin inflammation.
The Journal of experimental medicine
Devos M,Tanghe G,Gilbert B,Dierick E,Verheirstraeten M,Nemegeer J,de Reuver R,Lefebvre S,De Munck J,Rehwinkel J,Vandenabeele P,Declercq W,Maelfait J
11-5321 was used in Flow cytometry/Cell sorting to show that sensing of endogenous nucleic acids by ZBP1 is critical in driving skin pathology characterised by antiviral and IL-17 immune responses.
Mon Jul 06 00:00:00 EDT 2020
Glufosinate constrains synchronous and metachronous metastasis by promoting anti-tumor macrophages.
EMBO molecular medicine
Menga A,Serra M,Todisco S,Riera-Domingo C,Ammarah U,Ehling M,Palmieri EM,Di Noia MA,Gissi R,Favia M,Pierri CL,Porporato PE,Castegna A,Mazzone M
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Flow Cytometry
Wed Oct 07 00:00:00 EDT 2020
Local and Systemic Immune Dysregulation Alters Glioma Growth in Hyperglycemic Mice.
Clinical cancer research : an official journal of the American Association for Cancer Research
Zhang IY,Zhou H,Liu H,Zhang L,Gao H,Liu S,Song Y,Alizadeh D,Yin HH,Pillai R,Badie B
11-5321 was used in Flow cytometry/Cell sorting to compare the growth of two phenotypically diverse syngeneic glioma models as a Control and diabetic mice.
Mon Jun 01 00:00:00 EDT 2020
Exosomes derived from microglia exposed to elevated pressure amplify the neuroinflammatory response in retinal cells.
Glia
Aires ID,Ribeiro-Rodrigues T,Boia R,Catarino S,Girão H,Ambrósio AF,Santiago AR
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Immunocytochemistry
Tue Dec 01 00:00:00 EST 2020
Astrocytes promote a protective immune response to brain Toxoplasma gondii infection via IL-33-ST2 signaling.
PLoS pathogens
Still KM,Batista SJ,O'Brien CA,Oyesola OO,Früh SP,Webb LM,Smirnov I,Kovacs MA,Cowan MN,Hayes NW,Thompson JA,Tait Wojno ED,Harris TH
11-5321 was used in Flow cytometry/Cell sorting to show that IL-33 is expressed by oligodendrocytes and astrocytes during T. gondii infection, is released locally into the cerebrospinal fluid of T. gondii-infected animals, and is required for control of infection.
Thu Oct 01 00:00:00 EDT 2020
Effect of mesenchymal stem cell-derived exosomes on the induction of mouse tolerogenic dendritic cells.
Journal of cellular physiology
Shahir M,Mahmoud Hashemi S,Asadirad A,Varahram M,Kazempour-Dizaji M,Folkerts G,Garssen J,Adcock I,Mortaz E
11-5321 was used in Flow cytometry/Cell sorting to investigate the effects of mesenchymal stem cell-derived exosomes and to understand their role in modulating the mouse tolergenic dendritic cell immune responses.
Thu Oct 01 00:00:00 EDT 2020
E6‑regulated overproduction of prostaglandin E2 may inhibit migration of dendritic cells in human papillomavirus 16‑positive cervical lesions.
International journal of oncology
Huang J,Diao G,Zhang Q,Chen Y,Han J,Guo J
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Flow Cytometry
Wed Apr 01 00:00:00 EDT 2020
Immunodominant AH1 Antigen-Deficient Necroptotic, but Not Apoptotic, Murine Cancer Cells Induce Antitumor Protection.
Journal of immunology (Baltimore, Md. : 1950)
Aaes TL,Verschuere H,Kaczmarek A,Heyndrickx L,Wiernicki B,Delrue I,De Craene B,Taminau J,Delvaeye T,Bertrand MJM,Declercq W,Berx G,Krysko DV,Adjemian S,Vandenabeele P
11-5321 was used in Flow cytometry/Cell sorting to highlight necroptosis as a possible preferred ICD form over apoptosis in the treatment of cancer.
Sat Feb 15 00:00:00 EST 2020
IFN-β signalling regulates RAW 264.7 macrophage activation, cytokine production, and killing activity.
Innate immunity
Karimi Y,Giles EC,Vahedi F,Chew MV,Nham T,Loukov D,Lee AJ,Bowdish DM,Ashkar AA
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Flow Cytometry
Wed Apr 01 00:00:00 EDT 2020
Dietary Glucose Consumption Promotes RALDH Activity in Small Intestinal CD103+CD11b+ Dendritic Cells.
Frontiers in immunology
Ko HJ,Hong SW,Verma R,Jung J,Lee M,Kim N,Kim D,Surh CD,Kim KS,Rudra D,Im SH
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Flow Cytometry
Mon Apr 19 00:00:00 EDT 2021
GDF3 Protects Mice against Sepsis-Induced Cardiac Dysfunction and Mortality by Suppression of Macrophage Pro-Inflammatory Phenotype.
Cells
Wang L,Li Y,Wang X,Wang P,Essandoh K,Cui S,Huang W,Mu X,Liu Z,Wang Y,Peng T,Fan GC
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Flow Cytometry
Fri Jan 03 00:00:00 EST 2020
Diversity in medullary thymic epithelial cells controls the activity and availability of iNKT cells.
Nature communications
Lucas B,White AJ,Cosway EJ,Parnell SM,James KD,Jones ND,Ohigashi I,Takahama Y,Jenkinson WE,Anderson G
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Flow Cytometry
Mon May 04 00:00:00 EDT 2020
Smooth muscle-derived progenitor cell myofibroblast differentiation through KLF4 downregulation promotes arterial remodeling and fibrosis.
JCI insight
Lu S,Jolly AJ,Strand KA,Dubner AM,Mutryn MF,Moulton KS,Nemenoff RA,Majesky MW,Weiser-Evans MC
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Flow Cytometry
Thu Dec 03 00:00:00 EST 2020
Hyaluronan Degradation by Cemip Regulates Host Defense against Staphylococcus aureus Skin Infection.
Cell reports
Dokoshi T,Zhang LJ,Li F,Nakatsuji T,Butcher A,Yoshida H,Shimoda M,Okada Y,Gallo RL
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Flow Cytometry
Tue Jan 07 00:00:00 EST 2020
Ly6cLo non-classical monocytes promote resolution of rhesus rotavirus-mediated perinatal hepatic inflammation.
Scientific reports
Alkhani A,Levy CS,Tsui M,Rosenberg KA,Polovina K,Mattis AN,Mack M,Van Dyken S,Wang BM,Maher JJ,Nijagal A
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Flow Cytometry
Tue Apr 28 00:00:00 EDT 2020
MiR-103 protects from recurrent spontaneous abortion via inhibiting STAT1 mediated M1 macrophage polarization.
International journal of biological sciences
Zhu X,Liu H,Zhang Z,Wei R,Zhou X,Wang Z,Zhao L,Guo Q,Zhang Y,Chu C,Wang L,Li X
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Flow Cytometry
Fri Nov 12 00:00:00 EST 2021
Cancer cell-intrinsic expression of MHC II in lung cancer cell lines is actively restricted by MEK/ERK signaling and epigenetic mechanisms.
Journal for immunotherapy of cancer
Neuwelt AJ,Kimball AK,Johnson AM,Arnold BW,Bullock BL,Kaspar RE,Kleczko EK,Kwak JW,Wu MH,Heasley LE,Doebele RC,Li HY,Nemenoff RA,Clambey ET
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Flow Cytometry
Wed Apr 01 00:00:00 EDT 2020
Immunomodulatory Effects of Recombinant Mycobacterium smegmatis Expressing Antigen-85B Epitopes in Infected J774A.1 Murine Macrophages.
Pathogens (Basel, Switzerland)
Kadir NA,Acosta A,Sarmiento ME,Norazmi MN
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Flow Cytometry
Sun Nov 29 00:00:00 EST 2020
Artificial Mini Dendritic Cells Boost T Cell-Based Immunotherapy for Ovarian Cancer.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Cheng S,Xu C,Jin Y,Li Y,Zhong C,Ma J,Yang J,Zhang N,Li Y,Wang C,Yang Z,Wang Y
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Flow Cytometry
Wed Apr 01 00:00:00 EDT 2020
Optimized Protocol for Isolation of Small Extracellular Vesicles from Human and Murine Lymphoid Tissues.
International journal of molecular sciences
Bordas M,Genard G,Ohl S,Nessling M,Richter K,Roider T,Dietrich S,Maaß KK,Seiffert M
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Flow Cytometry
Tue Aug 04 00:00:00 EDT 2020
Skeletal muscle healing by M1-like macrophages produced by transient expression of exogenous GM-CSF.
Stem cell research & therapy
Martins L,Gallo CC,Honda TSB,Alves PT,Stilhano RS,Rosa DS,Koh TJ,Han SW
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Flow Cytometry
Fri Nov 06 00:00:00 EST 2020
Blockade of the AHR restricts a Treg-macrophage suppressive axis induced by L-Kynurenine.
Nature communications
Campesato LF,Budhu S,Tchaicha J,Weng CH,Gigoux M,Cohen IJ,Redmond D,Mangarin L,Pourpe S,Liu C,Zappasodi R,Zamarin D,Cavanaugh J,Castro AC,Manfredi MG,McGovern K,Merghoub T,Wolchok JD
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Flow Cytometry
Tue Aug 11 00:00:00 EDT 2020
Immunotherapeutic Blockade of CD47 Inhibitory Signaling Enhances Innate and Adaptive Immune Responses to Viral Infection.
Cell reports
Cham LB,Torrez Dulgeroff LB,Tal MC,Adomati T,Li F,Bhat H,Huang A,Lang PA,Moreno ME,Rivera JM,Galkina SA,Kosikova G,Stoddart CA,McCune JM,Myers LM,Weissman IL,Lang KS,Hasenkrug KJ
11-5321 was used in Flow cytometry/Cell sorting to indicate that CD47 blockade not only enhances the function of innate immune cells but also links to adaptive immune responses through improved APC function.
Tue Apr 14 00:00:00 EDT 2020
Dendritic Cells and Microglia Have Non-redundant Functions in the Inflamed Brain with Protective Effects of Type 1 cDCs.
Cell reports
Gallizioli M,Miró-Mur F,Otxoa-de-Amezaga A,Cugota R,Salas-Perdomo A,Justicia C,Brait VH,Ruiz-Jaén F,Arbaizar-Rovirosa M,Pedragosa J,Bonfill-Teixidor E,Gelderblom M,Magnus T,Cano E,Del Fresno C,Sancho D,Planas AM
11-5321 was used in Flow cytometry/Cell sorting to reveal aspects of the dynamics and functions of brain DCs in the regulation of inflammation and immunity.
Tue Oct 20 00:00:00 EDT 2020
Lactobacillus reuteri 5454 and Bifidobacterium animalis ssp. lactis 5764 improve colitis while differentially impacting dendritic cells maturation and antimicrobial responses.
Scientific reports
Hrdý J,Alard J,Couturier-Maillard A,Boulard O,Boutillier D,Delacre M,Lapadatescu C,Cesaro A,Blanc P,Pot B,Ryffel B,Chamaillard M,Grangette C
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Flow Cytometry
Tue Mar 24 00:00:00 EDT 2020
Comparative Analysis of Age-Related Changes in Lacrimal Glands and Meibomian Glands of a C57BL/6 Male Mouse Model.
International journal of molecular sciences
Yoon CH,Ryu JS,Hwang HS,Kim MK
11-5321 was used in Flow cytometry/Cell sorting to suggest that age-dependent DED in C57BL/6 mice is related to inflammation of the LGs, the development of MG atrophy, and oxidative stress in both glands.
Thu Jun 11 00:00:00 EDT 2020
Nuclear imaging-guided PD-L1 blockade therapy increases effectiveness of cancer immunotherapy.
Journal for immunotherapy of cancer
Gao H,Wu Y,Shi J,Zhang X,Liu T,Hu B,Jia B,Wan Y,Liu Z,Wang F
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Flow Cytometry
Sun Nov 01 00:00:00 EDT 2020
Analysis of Myeloid Cells in Mouse Tissues with Flow Cytometry.
STAR protocols
Liu Z,Gu Y,Shin A,Zhang S,Ginhoux F
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Flow Cytometry
Fri Jun 19 00:00:00 EDT 2020
RON Expression Mediates Lipopolysaccharide-Mediated Dendritic Cell Maturation via March-I.
Frontiers in cellular and infection microbiology
Huang L,Fang X,Zhang X,Wu W,Yao H,Fang Q
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Immunoprecipitation
Sun Apr 02 00:00:00 EDT 2023
The Innate Immune Response to Infection Induces Erythropoietin-Dependent Replenishment of the Dendritic Cell Compartment.
Frontiers in immunology
Einwächter H,Heiseke A,Schlitzer A,Gasteiger G,Adler H,Voehringer D,Manz MG,Ruzsics Z,Dölken L,Koszinowski UH,Sparwasser T,Reindl W,Jordan S
11-5321-82 was used in Flow Cytometry to investigate the molecular and cellular mechanisms of inflammation-induced dendritic cell generation.
Mon Apr 19 00:00:00 EDT 2021
CDK4/6 inhibition promotes immune infiltration in ovarian cancer and synergizes with PD-1 blockade in a B cell-dependent manner.
Theranostics
Zhang QF,Li J,Jiang K,Wang R,Ge JL,Yang H,Liu SJ,Jia LT,Wang L,Chen BL
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Flow Cytometry
Tue Jun 01 00:00:00 EDT 2021
Tregitopes regulate the tolerogenic immune response and decrease the foetal death rate in abortion-prone mouse matings.
Scientific reports
Kedzierska AE,Lorek D,Slawek A,Chelmonska-Soyta A
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Flow Cytometry
Mon Jun 29 00:00:00 EDT 2020
Polyanhydride Nanoparticles Induce Low Inflammatory Dendritic Cell Activation Resulting in CD8+ T Cell Memory and Delayed Tumor Progression.
International journal of nanomedicine
Darling R,Senapati S,Christiansen J,Liu L,Ramer-Tait AE,Narasimhan B,Wannemuehler M
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Flow Cytometry
Mon Dec 07 00:00:00 EST 2020
The Chemoattractant Receptor Ebi2 Drives Intranodal Naive CD4+ T Cell Peripheralization to Promote Effective Adaptive Immunity.
Immunity
Baptista AP,Gola A,Huang Y,Milanez-Almeida P,Torabi-Parizi P,Urban JF,Shapiro VS,Gerner MY,Germain RN
11-5321 was used in Flow cytometry/Cell sorting to demonstrate evolutionary selection for distinct niches within the LN that promote cellular responses, emphasizing the critical link between fine-grained tissue organization and host defense.
Tue May 21 00:00:00 EDT 2019
A Macrophage-Pericyte Axis Directs Tissue Restoration via Amphiregulin-Induced Transforming Growth Factor Beta Activation.
Immunity
Minutti CM,Modak RV,Macdonald F,Li F,Smyth DJ,Dorward DA,Blair N,Husovsky C,Muir A,Giampazolias E,Dobie R,Maizels RM,Kendall TJ,Griggs DW,Kopf M,Henderson NC,Zaiss DM
11-5321-82 was used in Flow Cytometry to identify macrophages as a critical source of Amphiregulin, revealing a direct effector mechanism by which these cells contribute to tissue restoration after acute injury.
Tue Mar 19 00:00:00 EDT 2019
Stellate Cells, Hepatocytes, and Endothelial Cells Imprint the Kupffer Cell Identity on Monocytes Colonizing the Liver Macrophage Niche.
Immunity
Bonnardel J,T'Jonck W,Gaublomme D,Browaeys R,Scott CL,Martens L,Vanneste B,De Prijck S,Nedospasov SA,Kremer A,Van Hamme E,Borghgraef P,Toussaint W,De Bleser P,Mannaerts I,Beschin A,van Grunsven LA,Lambrecht BN,Taghon T,Lippens S,Elewaut D,Saeys Y,Guilliams M
11-5321-82 was used in Flow Cytometry to show that the Kupffer cell niche is composed of stellate cells, hepatocytes, and endothelial cells that together imprint the liver-specific macrophage identity.
Tue Oct 15 00:00:00 EDT 2019
cGAS/STING axis mediates a topoisomerase II inhibitor-induced tumor immunogenicity.
The Journal of clinical investigation
Wang Z,Chen J,Hu J,Zhang H,Xu F,He W,Wang X,Li M,Lu W,Zeng G,Zhou P,Huang P,Chen S,Li W,Xia LP,Xia X
11-5321 was used in Flow cytometry/Cell sorting to show that teniposide could trigger tumor immunogenicity and enable a potential chemoimmunotherapeutic approach to potentiating the therapeutic efficacy of anti-PD1 immunotherapy.
Tue Aug 13 00:00:00 EDT 2019
cGAS/STING axis mediates a topoisomerase II inhibitor-induced tumor immunogenicity.
The Journal of clinical investigation
Wang Z,Chen J,Hu J,Zhang H,Xu F,He W,Wang X,Li M,Lu W,Zeng G,Zhou P,Huang P,Chen S,Li W,Xia LP,Xia X
11-5321 was used in Flow cytometry/Cell sorting to show that teniposide could trigger tumor immunogenicity and enable a potential chemoimmunotherapeutic approach to potentiating the therapeutic efficacy of anti-PD1 immunotherapy.
Tue Aug 13 00:00:00 EDT 2019
Epigenetically modulated FOXM1 suppresses dendritic cell maturation in pancreatic cancer and colon cancer.
Molecular oncology
Zhou Z,Chen H,Xie R,Wang H,Li S,Xu Q,Xu N,Cheng Q,Qian Y,Huang R,Shao Z,Xiang M
11-5321 was used in Flow cytometry/Cell sorting to show that upregulation of FOXM1 by H3K79me2 in pancreatic cancer and colon cancer significantly inhibits maturation phenotypes and function of bone marrow dendritic cells (BMDCs) through the Wnt5a signaling pathway, and thus provide novel insights into FOXM1-based antitumor immunotherapy.
Mon Apr 01 00:00:00 EDT 2019
Critical Adverse Impact of IL-6 in Acute Pneumovirus Infection.
Journal of immunology (Baltimore, Md. : 1950)
Percopo CM,Ma M,Brenner TA,Krumholz JO,Break TJ,Laky K,Rosenberg HF
11-5321 was used in Flow cytometry/Cell sorting to examine the role of the pleiotropic cytokine IL-6 in acute infection with pneumonia virus of mice.
Fri Feb 01 00:00:00 EST 2019
Bilateral Effect of the Unilateral Corneal Nerve Cut on Both Ocular Surface and Lacrimal Gland.
Investigative ophthalmology & visual science
Lee HK,Kim KW,Ryu JS,Jeong HJ,Lee SM,Kim MK
11-5321 was used in Flow cytometry/Cell sorting to demonstrate that a unilateral cut of the corneal nerve results in activation of immune cells on the ocular surface and dysregulation of lacrimal secretion bilaterally through the bidirectional neuronal signals.
Wed Jan 02 00:00:00 EST 2019
Antiallodynic Effects of Cannabinoid Receptor 2 (CB2R) Agonists on Retrovirus Infection-Induced Neuropathic Pain.
Pain research & management
Sheng WS,Chauhan P,Hu S,Prasad S,Lokensgard JR
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Flow Cytometry
Mon Dec 16 00:00:00 EST 2019
Antitumor and immunomodulatory effects of a novel multitarget inhibitor, CS2164, in mouse hepatocellular carcinoma models.
Anti-cancer drugs
Zhou Y,Fu C,Kong Y,Pan D,Wang Y,Huang S,Li Z,Ning Z,Lu X,Shan S,Xin L
11-5321 was used in Flow cytometry/Cell sorting to investigate the antitumor and immunomodulatory effects of CS2164.
Tue Oct 01 00:00:00 EDT 2019
Intravitreal injection of adenosine A2A receptor antagonist reduces neuroinflammation, vascular leakage and cell death in the retina of diabetic mice.
Scientific reports
Aires ID,Madeira MH,Boia R,Rodrigues-Neves AC,Martins JM,Ambrósio AF,Santiago AR
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Immunohistochemistry
Wed Nov 20 00:00:00 EST 2019
MDM2 inhibitor APG-115 synergizes with PD-1 blockade through enhancing antitumor immunity in the tumor microenvironment.
Journal for immunotherapy of cancer
Fang DD,Tang Q,Kong Y,Wang Q,Gu J,Fang X,Zou P,Rong T,Wang J,Yang D,Zhai Y
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Flow Cytometry
Thu Nov 28 00:00:00 EST 2019
Sequential Sensing by TLR2 and Mincle Directs Immature Myeloid Cells to Protect against Invasive Group A Streptococcal Infection in Mice.
Cell reports
Matsumura T,Ikebe T,Arikawa K,Hosokawa M,Aiko M,Iguchi A,Togashi I,Kai S,Ohara S,Ohara N,Ohnishi M,Watanabe H,Kobayashi K,Takeyama H,Yamasaki S,Takahashi Y,Ato M
11-5321-82 was used in Flow Cytometry to show IFN-γ-producing immature myeloid cells can provide protection to mice in invasive group A Streptococcus infection.
Tue Apr 09 00:00:00 EDT 2019
ImmGen report: sexual dimorphism in the immune system transcriptome.
Nature communications
Gal-Oz ST,Maier B,Yoshida H,Seddu K,Elbaz N,Czysz C,Zuk O,Stranger BE,Ner-Gaon H,Shay T
11-5321 was used in Flow cytometry/Cell sorting to show transcriptional sexual dimorphism in macrophages.
Fri Sep 20 00:00:00 EDT 2019
Initiation of Antiviral B Cell Immunity Relies on Innate Signals from Spatially Positioned NKT Cells.
Cell
Gaya M,Barral P,Burbage M,Aggarwal S,Montaner B,Warren Navia A,Aid M,Tsui C,Maldonado P,Nair U,Ghneim K,Fallon PG,Sekaly RP,Barouch DH,Shalek AK,Bruckbauer A,Strid J,Batista FD
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Flow Cytometry
Thu Jan 25 00:00:00 EST 2018
NK Cells Stimulate Recruitment of cDC1 into the Tumor Microenvironment Promoting Cancer Immune Control.
Cell
Böttcher JP,Bonavita E,Chakravarty P,Blees H,Cabeza-Cabrerizo M,Sammicheli S,Rogers NC,Sahai E,Zelenay S,Reis e Sousa C
11-5321 was used in Flow cytometry/Cell sorting to reveal a cellular and molecular checkpoint for intratumoral cDC1 recruitment that is targeted by tumour-derived PGE2for immune evasion.
Thu Feb 22 00:00:00 EST 2018
Macrophage-specific MHCII expression is regulated by a remote Ciita enhancer controlled by NFAT5.
The Journal of experimental medicine
Buxadé M,Huerga Encabo H,Riera-Borrull M,Quintana-Gallardo L,López-Cotarelo P,Tellechea M,Martínez-Martínez S,Redondo JM,Martín-Caballero J,Flores JM,Bosch E,Rodríguez-Fernández JL,Aramburu J,López-Rodríguez C
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Flow Cytometry
Mon Nov 05 00:00:00 EST 2018
De Novo Fatty Acid Synthesis During Mycobacterial Infection Is a Prerequisite for the Function of Highly Proliferative T Cells, But Not for Dendritic Cells or Macrophages.
Frontiers in immunology
Stüve P,Minarrieta L,Erdmann H,Arnold-Schrauf C,Swallow M,Guderian M,Krull F,Hölscher A,Ghorbani P,Behrends J,Abraham WR,Hölscher C,Sparwasser TD,Berod L
11-5321-82 was used in Flow Cytometry to reveal that acetyl-CoA carboxylase 1-dependent fatty acid synthesis is a crucial mechanism in T cells, but not dendritic cells or macrophages, to fight against mycobacterial infection.
Wed Apr 10 00:00:00 EDT 2019
Functional antagonism of sphingosine-1-phosphate receptor 1 prevents cuprizone-induced demyelination.
Glia
Kim S,Bielawski J,Yang H,Kong Y,Zhou B,Li J
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Immunohistochemistry
Thu Mar 01 00:00:00 EST 2018
Functional antagonism of sphingosine-1-phosphate receptor 1 prevents cuprizone-induced demyelination.
Glia
Kim S,Bielawski J,Yang H,Kong Y,Zhou B,Li J
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Immunohistochemistry
Thu Mar 01 00:00:00 EST 2018
Murine CMV induces type 1 IFN that impairs differentiation of MDSCs critical for transplantation tolerance.
Blood advances
Dangi A,Zhang L,Zhang X,Luo X
11-5321 was used in Flow cytometry/Cell sorting to provide a solid foundation for seeking effective therapies for promoting transplantation tolerance in settings of CMV infection.
Tue Mar 27 00:00:00 EDT 2018
RD5-mediated lack of PE_PGRS and PPE-MPTR export in BCG vaccine strains results in strong reduction of antigenic repertoire but little impact on protection.
PLoS pathogens
Ates LS,Sayes F,Frigui W,Ummels R,Damen MPM,Bottai D,Behr MA,van Heijst JWJ,Bitter W,Majlessi L,Brosch R
11-5321 was used in Flow cytometry/Cell sorting to show that a predicted total of 89 PE_PGRS/PPE-MPTR surface proteins are not exported by certain animal-adapted strains of the M. tuberculosis complex including M. bovis.
Fri Jun 01 00:00:00 EDT 2018
Age Influences Microglial Activation After Cuprizone-Induced Demyelination.
Frontiers in aging neuroscience
Klein B,Mrowetz H,Barker CM,Lange S,Rivera FJ,Aigner L
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Immunohistochemistry
Thu Oct 01 00:00:00 EDT 2020
Age Influences Microglial Activation After Cuprizone-Induced Demyelination.
Frontiers in aging neuroscience
Klein B,Mrowetz H,Barker CM,Lange S,Rivera FJ,Aigner L
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Immunohistochemistry
Thu Oct 01 00:00:00 EDT 2020
FACS isolation of live mouse eosinophils at high purity via a protocol that does not target Siglec F.
Journal of immunological methods
Geslewitz WE,Percopo CM,Rosenberg HF
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Flow Cytometry
Thu Mar 01 00:00:00 EST 2018
Myeloid apolipoprotein E controls dendritic cell antigen presentation and T cell activation.
Nature communications
Bonacina F,Coe D,Wang G,Longhi MP,Baragetti A,Moregola A,Garlaschelli K,Uboldi P,Pellegatta F,Grigore L,Da Dalt L,Annoni A,Gregori S,Xiao Q,Caruso D,Mitro N,Catapano AL,Marelli-Berg FM,Norata GD
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Flow Cytometry
Mon Aug 06 00:00:00 EDT 2018
CD4+ T cells are activated in regional lymph nodes and migrate to skin to initiate lymphedema.
Nature communications
García Nores GD,Ly CL,Cuzzone DA,Kataru RP,Hespe GE,Torrisi JS,Huang JJ,Gardenier JC,Savetsky IL,Nitti MD,Yu JZ,Rehal S,Mehrara BJ
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Flow Cytometry
Thu May 17 00:00:00 EDT 2018
Lin-CCR2+ hematopoietic stem and progenitor cells overcome resistance to PD-1 blockade.
Nature communications
Flores CT,Wildes TJ,Drake JA,Moore GL,Dean BD,Abraham RS,Mitchell DA
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Flow Cytometry
Wed Oct 17 00:00:00 EDT 2018
miR-21 Protects Against Ischemia/Reperfusion-Induced Acute Kidney Injury by Preventing Epithelial Cell Apoptosis and Inhibiting Dendritic Cell Maturation.
Frontiers in physiology
Song N,Zhang T,Xu X,Lu Z,Yu X,Fang Y,Hu J,Jia P,Teng J,Ding X
Fri Apr 08 00:00:00 EDT 2022
Murine Norovirus Infection Induces TH1 Inflammatory Responses to Dietary Antigens.
Cell host & microbe
Bouziat R,Biering SB,Kouame E,Sangani KA,Kang S,Ernest JD,Varma M,Brown JJ,Urbanek K,Dermody TS,Ng A,Hinterleitner R,Hwang S,Jabri B
11-5321-82 was used in Flow cytometry/Cell sorting to show that the acute CW3 strain of murine norovirus, but not the persistent CR6 strain, induces TH1 immunity to dietary antigen.
Wed Nov 14 00:00:00 EST 2018
BNIP3 modulates the interface between B16-F10 melanoma cells and immune cells.
Oncotarget
Romano E,Rufo N,Korf H,Mathieu C,Garg AD,Agostinis P
11-5321 was used in Flow cytometry/Cell sorting to evaluate the role played by BNIP3 in modulating the interface between B16-F10 melanoma cells and immune cells.
Tue Apr 03 00:00:00 EDT 2018
Nitric oxide dependent signaling via cyclic GMP in dendritic cells regulates migration and T-cell polarization.
Scientific reports
Gnipp S,Mergia E,Puschkarow M,Bufe A,Koesling D,Peters M
11-5321 was used in Flow cytometry/Cell sorting to show that activity of NO-GC1 in DCs is important for the magnitude and bias of the Th response in allergic airway disease most likely by counteracting intracellular cAMP.
Fri Jul 20 00:00:00 EDT 2018
Indoleamine 2 3-dioxygenase knockout limits angiotensin II-induced aneurysm in low density lipoprotein receptor-deficient mice fed with high fat diet.
PloS one
Metghalchi S,Vandestienne M,Haddad Y,Esposito B,Dairou J,Tedgui A,Mallat Z,Potteaux S,Taleb S
11-5321 was used in Flow cytometry/Cell sorting to show that the knockout of IDO prevented VSMC apoptosis in AngII -treated Ldlr-/- mice fed with HFD, suggesting a detrimental role of IDO in AAA formation and thus would be an important target for the treatment of aneurysm.
Fri Jun 22 00:00:00 EDT 2018
A prominent air pollutant, Indeno[1,2,3-cd]pyrene, enhances allergic lung inflammation via aryl hydrocarbon receptor.
Scientific reports
Wong TH,Lee CL,Su HH,Lee CL,Wu CC,Wang CC,Sheu CC,Lai RS,Leung SY,Lin CC,Wei YF,Wang CJ,Lin YC,Chen HL,Huang MS,Yen JH,Huang SK,Suen JL
11-5321 was used in Flow cytometry/Cell sorting to suggest that chronic exposure to environmental PAHs may pose a significant risk for asthma.
Mon Mar 26 00:00:00 EDT 2018
Antibody Tumor Targeting Is Enhanced by CD27 Agonists through Myeloid Recruitment.
Cancer cell
Turaj AH,Hussain K,Cox KL,Rose-Zerilli MJJ,Testa J,Dahal LN,Chan HTC,James S,Field VL,Carter MJ,Kim HJ,West JJ,Thomas LJ,He LZ,Keler T,Johnson PWM,Al-Shamkhani A,Thirdborough SM,Beers SA,Cragg MS,Glennie MJ,Lim SH
11-5321 was used in Flow cytometry/Cell sorting to demonstrate the therapeutic advantage of using an immunomodulatory mAb to regulate lymphoid cells, which then recruit and activate myeloid cells for enhanced killing of mAb-opsonized tumors.
Mon Dec 11 00:00:00 EST 2017
Cholesterol Accumulation in Dendritic Cells Links the Inflammasome to Acquired Immunity.
Cell metabolism
Westerterp M,Gautier EL,Ganda A,Molusky MM,Wang W,Fotakis P,Wang N,Randolph GJ,D'Agati VD,Yvan-Charvet L,Tall AR
11-5321 was used in Flow cytometry/Cell sorting to identify an essential role of DC cholesterol efflux pathways in maintaining immune tolerance.
Tue Jun 06 00:00:00 EDT 2017
A CCR4 antagonist reverses the tumor-promoting microenvironment of renal cancer.
The Journal of clinical investigation
Berlato C,Khan MN,Schioppa T,Thompson R,Maniati E,Montfort A,Jangani M,Canosa M,Kulbe H,Hagemann UB,Duncan AR,Fletcher L,Wilkinson RW,Powles T,Quezada SA,Balkwill FR
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Flow Cytometry
Wed Mar 01 00:00:00 EST 2017
Prolonged Deleterious Influences of Chemotherapeutic Agent CPT-11 on Resident Peritoneal Macrophages and B1 Cells.
Frontiers in immunology
Bai WJ,Li CG,Zhang CC,Xu LH,Zeng QZ,Hu B,Hong Z,He XH,Ouyang DY
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Flow Cytometry
Wed Nov 20 00:00:00 EST 2019
MicroRNA-21: A Positive Regulator for Optimal Production of Type I and Type III Interferon by Plasmacytoid Dendritic Cells.
Frontiers in immunology
Liu F,Liu C,Hu X,Shang Y,Wu L
11-5321 was used in Immunocytochemistry to elucidate the role of miR-21 as an essential positive regulator for the production of both IFN-α and IFN-λ by plasmacytoid dendritic cells and for promoting host defense against viral infection.
Wed Nov 20 00:00:00 EST 2019
MyD88 signaling in dendritic cells and the intestinal epithelium controls immunity against intestinal infection with C. rodentium.
PLoS pathogens
Friedrich C,Mamareli P,Thiemann S,Kruse F,Wang Z,Holzmann B,Strowig T,Sparwasser T,Lochner M
11-5321 was used in Flow cytometry/Cell sorting to suggest that MyD88 signaling in DC and IEC is both essential and sufficient to induce a full spectrum of host responses upon intestinal infection with C. rodentium.
Mon May 01 00:00:00 EDT 2017
Peripheral administration of the soluble TNF inhibitor XPro1595 modifies brain immune cell profiles, decreases beta-amyloid plaque load, and rescues impaired long-term potentiation in 5xFAD mice.
Neurobiology of disease
MacPherson KP,Sompol P,Kannarkat GT,Chang J,Sniffen L,Wildner ME,Norris CM,Tansey MG
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Flow Cytometry
Thu Jun 01 00:00:00 EDT 2017
Increased White Matter Inflammation in Aging- and Alzheimer's Disease Brain.
Frontiers in molecular neuroscience
Raj D,Yin Z,Breur M,Doorduin J,Holtman IR,Olah M,Mantingh-Otter IJ,Van Dam D,De Deyn PP,den Dunnen W,Eggen BJL,Amor S,Boddeke E
11-5321 was used in Flow cytometry/Cell sorting to indicate that microglia-induced neuroinflammation is predominant in the white matter of aging mice and humans as well as in EOAD brains.
Thu Oct 01 00:00:00 EDT 2020
Occludin Expression in Epidermal γδ T Cells in Response to Epidermal Stress Causes Them To Migrate into Draining Lymph Nodes.
Journal of immunology (Baltimore, Md. : 1950)
Saito T,Yano M,Ohki Y,Tomura M,Nakano N
11-5321-82 was used in Flow Cytometry to determine that activated γδ T cells expressed occludin and migrated into draining lymph nodes in an occludin-dependent manner.
Sat Jul 01 00:00:00 EDT 2017
Cyclic AMP-Elevating Capacity of Adenylate Cyclase Toxin-Hemolysin Is Sufficient for Lung Infection but Not for Full Virulence of Bordetella pertussis.
Infection and immunity
Skopova K,Tomalova B,Kanchev I,Rossmann P,Svedova M,Adkins I,Bibova I,Tomala J,Masin J,Guiso N,Osicka R,Sedlacek R,Kovar M,Sebo P
11-5321 was used in Flow cytometry/Cell sorting to construct the first B. pertussis mutant secreting a CyaA toxin having an intact capacity to deliver the AC enzyme into CD11b-expressing host phagocytes but impaired in formation of cell-permeabilizing pores and defective in cAMP elevation in CD11b- cells.
Thu Jun 01 00:00:00 EDT 2017
Discrimination of the heterogeneity of bone marrow‑derived dendritic cells.
Molecular medicine reports
Wang J,Dai X,Hsu C,Ming C,He Y,Zhang J,Wei L,Zhou P,Wang CY,Yang J,Gong N
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Flow Cytometry
Wed Nov 01 00:00:00 EDT 2017
Loss of IRF2BP2 in Microglia Increases Inflammation and Functional Deficits after Focal Ischemic Brain Injury.
Frontiers in cellular neuroscience
Cruz SA,Hari A,Qin Z,Couture P,Huang H,Lagace DC,Stewart AFR,Chen HH
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Flow Cytometry
Thu Mar 17 00:00:00 EDT 2022
Role of a novel immune modulating DDR2-expressing population in silica-induced pulmonary fibrosis.
PloS one
McDonald LT,Johnson SD,Russell DL,Young MRI,LaRue AC
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Flow Cytometry
Mon Sep 25 00:00:00 EDT 2017
Heavy Chain-Hyaluronan/Pentraxin 3 from Amniotic Membrane Suppresses Inflammation and Scarring in Murine Lacrimal Gland and Conjunctiva of Chronic Graft-versus-Host Disease.
Scientific reports
Ogawa Y,He H,Mukai S,Imada T,Nakamura S,Su CW,Mahabole M,Tseng SC,Tsubota K
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Immunofluorescence
Mon Feb 06 00:00:00 EST 2017
Location of tumor affects local and distant immune cell type and number.
Immunity, inflammation and disease
Hensel JA,Khattar V,Ashton R,Lee C,Siegal GP,Ponnazhagan S
11-5321 was used in Flow cytometry/Cell sorting to demonstrate that location of tumour, and not simply the tumour itself, has a definitive role in regulating immune effectors.
Wed Mar 01 00:00:00 EST 2017
Modulation of Innate Immunity by lignin-Carbohydrate, a Novel TLR4 Ligand, Results in Augmentation of Mucosal IgA and Systemic IgG Production.
International journal of molecular sciences
Tsuji R,Ikado K,Fujiwara D
11-5321 was used in Flow cytometry/Cell sorting to investigate immune-stimulatory activity of lignin-rich enzyme lignin in vivo.
Tue Dec 26 00:00:00 EST 2017
Composition of the Schistosoma mansoni worm secretome: Identification of immune modulatory Cyclophilin A.
PLoS neglected tropical diseases
Floudas A,Cluxton CD,Fahel J,Khan AR,Saunders SP,Amu S,Alcami A,Fallon PG
11-5321 was used in Flow cytometry/Cell sorting to demonstrate the unique protein composition of the S. mansoni male worm secretome and immunomodulatory activity of S. mansoni Cyclophilin A.
Sun Oct 01 00:00:00 EDT 2017
Pplase of Dermatophagoides farinae promotes ovalbumin-induced airway allergy by modulating the functions of dendritic cells in a mouse model.
Scientific reports
Wang H,Mo L,Xiao X,An S,Liu X,Ba J,Wu W,Ran P,Yang P,Liu Z
11-5321 was used in an ELISA assay to demonstrate that Pplase is not a dustmite allergen but can enhance allergic responses.
Mon Feb 27 00:00:00 EST 2017
Pplase of Dermatophagoides farinae promotes ovalbumin-induced airway allergy by modulating the functions of dendritic cells in a mouse model.
Scientific reports
Wang H,Mo L,Xiao X,An S,Liu X,Ba J,Wu W,Ran P,Yang P,Liu Z
11-5321 was used in an ELISA assay to demonstrate that Pplase is not a dustmite allergen but can enhance allergic responses.
Mon Feb 27 00:00:00 EST 2017
Boosting the hypoxic response in myeloid cells accelerates resolution of fibrosis and regeneration of the liver in mice.
Oncotarget
Kantari-Mimoun C,Krzywinska E,Castells M,Milien C,Klose R,Meinecke AK,Lemberger U,Mathivet T,Gojkovic M,Schrödter K,Österreicher C,Fandrey J,Rundqvist H,Stockmann C
11-5321 was used in Flow cytometry/Cell sorting to show that the resolution of fibrosis can be accelerated by deleting VHL, a negative regulator of HIFs and VEGF, specifically in myeloid cells in mice.
Tue Feb 28 00:00:00 EST 2017
Loss of HIF-1α in natural killer cells inhibits tumour growth by stimulating non-productive angiogenesis.
Nature communications
Krzywinska E,Kantari-Mimoun C,Kerdiles Y,Sobecki M,Isagawa T,Gotthardt D,Castells M,Haubold J,Millien C,Viel T,Tavitian B,Takeda N,Fandrey J,Vivier E,Sexl V,Stockmann C
11-5321 was used in Flow cytometry/Cell sorting to investigate the mechanisms by which loss of HIF1α in natural killer cells inhibits tumour growth.
Fri Nov 17 00:00:00 EST 2017
Identification of 14-dehydroergosterol as a novel anti-inflammatory compound inducing tolerogenic dendritic cells.
Scientific reports
Ano Y,Ikado K,Shindo K,Koizumi H,Fujiwara D
11-5321 was used in Flow cytometry/Cell sorting to investigate if 14-dehydroergosterol induces tolerogenic dendritic cells (DCs) to convert to a tolerogenic type.
Tue Oct 24 00:00:00 EDT 2017
Microglial brain region-dependent diversity and selective regional sensitivities to aging.
Nature neuroscience
Grabert K,Michoel T,Karavolos MH,Clohisey S,Baillie JK,Stevens MP,Freeman TC,Summers KM,McColl BW
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Flow Cytometry
Tue Mar 01 00:00:00 EST 2016
CCR7 and IRF4-dependent dendritic cells regulate lymphatic collecting vessel permeability.
The Journal of clinical investigation
Ivanov S,Scallan JP,Kim KW,Werth K,Johnson MW,Saunders BT,Wang PL,Kuan EL,Straub AC,Ouhachi M,Weinstein EG,Williams JW,Briseño C,Colonna M,Isakson BE,Gautier EL,Förster R,Davis MJ,Zinselmeyer BH,Randolph GJ
11-5321 was used in Flow cytometry/Cell sorting to investigate the molecular signals that affect lymphatic collecting vessel permeability.
Fri Apr 01 00:00:00 EDT 2016
Lymphatic vessels regulate immune microenvironments in human and murine melanoma.
The Journal of clinical investigation
Lund AW,Wagner M,Fankhauser M,Steinskog ES,Broggi MA,Spranger S,Gajewski TF,Alitalo K,Eikesdal HP,Wiig H,Swartz MA
11-5321 was used in Flow cytometry/Cell sorting to suggest that the establishment of tumour-associated inflammation and immunity critically depends on lymphatic vessel remodelling and drainage.
Thu Sep 01 00:00:00 EDT 2016
Lung epithelium and myeloid cells cooperate to clear acute pneumococcal infection.
Mucosal immunology
Dudek M,Puttur F,Arnold-Schrauf C,Kühl AA,Holzmann B,Henriques-Normark B,Berod L,Sparwasser T
11-5321 was used in Flow cytometry/Cell sorting to investigate the extent to which MyD88 signaling is required to control S. pneumoniae infection, showing that lung epithelium and myeloid cells cooperate to clear infection.
Thu Sep 01 00:00:00 EDT 2016
Interleukin-13 immune gene therapy prevents CNS inflammation and demyelination via alternative activation of microglia and macrophages.
Glia
Guglielmetti C,Le Blon D,Santermans E,Salas-Perdomo A,Daans J,De Vocht N,Shah D,Hoornaert C,Praet J,Peerlings J,Kara F,Bigot C,Mai Z,Goossens H,Hens N,Hendrix S,Verhoye M,Planas AM,Berneman Z,van der Linden A,Ponsaerts P
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Immunofluorescence
Thu Dec 01 00:00:00 EST 2016
Microglia are less pro-inflammatory than myeloid infiltrates in the hippocampus of mice exposed to status epilepticus.
Glia
Vinet J,Vainchtein ID,Spano C,Giordano C,Bordini D,Curia G,Dominici M,Boddeke HW,Eggen BJ,Biagini G
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Immunofluorescence
Mon Aug 01 00:00:00 EDT 2016
Opposite Effects of Coinjection and Distant Injection of Mesenchymal Stem Cells on Breast Tumor Cell Growth.
Stem cells translational medicine
Zheng H,Zou W,Shen J,Xu L,Wang S,Fu YX,Fan W
Thu Sep 01 00:00:00 EDT 2016
Recruited monocytes modulate malaria-induced lung injury through CD36-mediated clearance of sequestered infected erythrocytes.
Journal of leukocyte biology
Lagassé HA,Anidi IU,Craig JM,Limjunyawong N,Poupore AK,Mitzner W,Scott AL
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Flow Cytometry
Sun May 01 00:00:00 EDT 2016
Lymphatic endothelial lineage assemblage during corneal lymphangiogenesis.
Laboratory investigation; a journal of technical methods and pathology
Connor AL,Kelley PM,Tempero RM
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Immunofluorescence
Tue Mar 01 00:00:00 EST 2016
Resident T Cells Are Unable To Control Herpes Simplex Virus-1 Activity in the Brain Ependymal Region during Latency.
Journal of immunology (Baltimore, Md. : 1950)
Menendez CM,Jinkins JK,Carr DJ
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Flow Cytometry
Mon Aug 15 00:00:00 EDT 2016
Effects of ketanserin on experimental colitis in mice and macrophage function.
International journal of molecular medicine
Xiao J,Shao L,Shen J,Jiang W,Feng Y,Zheng P,Liu F
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Flow Cytometry
Tue Mar 01 00:00:00 EST 2016
Repulsive guidance molecule a blockade exerts the immunoregulatory function in DCs stimulated with ABP and LPS.
Human vaccines & immunotherapeutics
Xu X,Gao Y,Zhai Z,Zhang S,Shan F,Feng J
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Flow Cytometry
Tue Aug 02 00:00:00 EDT 2016
Thiol peroxiredoxin, a novel allergen from Bombyx mori, modulates functions of macrophages and dendritic cells.
American journal of translational research
Wang H,Hu W,Liang Z,Zeng L,Li J,Yan H,Yang P,Liu Z,Wang L
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Flow Cytometry
Thu Oct 01 00:00:00 EDT 2020
Allergy Enhances Neurogenesis and Modulates Microglial Activation in the Hippocampus.
Frontiers in cellular neuroscience
Klein B,Mrowetz H,Thalhamer J,Scheiblhofer S,Weiss R,Aigner L
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Immunofluorescence
Fri Jul 22 00:00:00 EDT 2016
Stroke sensitivity in the aged: sex chromosome complement vs. gonadal hormones.
Aging
McCullough LD,Mirza MA,Xu Y,Bentivegna K,Steffens EB,Ritzel R,Liu F
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Flow Cytometry
Fri Jul 01 00:00:00 EDT 2016
Epidermal RAF prevents allergic skin disease.
eLife
Raguz J,Jeric I,Niault T,Nowacka JD,Kuzet SE,Rupp C,Fischer I,Biggi S,Borsello T,Baccarini M
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Flow Cytometry
Tue Jul 19 00:00:00 EDT 2016
Intracerebral transplantation of interleukin 13-producing mesenchymal stem cells limits microgliosis, oligodendrocyte loss and demyelination in the cuprizone mouse model.
Journal of neuroinflammation
Le Blon D,Guglielmetti C,Hoornaert C,Quarta A,Daans J,Dooley D,Lemmens E,Praet J,De Vocht N,Reekmans K,Santermans E,Hens N,Goossens H,Verhoye M,Van der Linden A,Berneman Z,Hendrix S,Ponsaerts P
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Immunofluorescence
Wed Nov 09 00:00:00 EST 2016
Intracerebral transplantation of interleukin 13-producing mesenchymal stem cells limits microgliosis, oligodendrocyte loss and demyelination in the cuprizone mouse model.
Journal of neuroinflammation
Le Blon D,Guglielmetti C,Hoornaert C,Quarta A,Daans J,Dooley D,Lemmens E,Praet J,De Vocht N,Reekmans K,Santermans E,Hens N,Goossens H,Verhoye M,Van der Linden A,Berneman Z,Hendrix S,Ponsaerts P
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Immunofluorescence
Wed Nov 09 00:00:00 EST 2016
Internalization and presentation of myelin antigens by the brain endothelium guides antigen-specific T cell migration.
eLife
Lopes Pinheiro MA,Kamermans A,Garcia-Vallejo JJ,van Het Hof B,Wierts L,O'Toole T,Boeve D,Verstege M,van der Pol SM,van Kooyk Y,de Vries HE,Unger WW
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Flow Cytometry
Thu Jun 23 00:00:00 EDT 2016
Intravaginal Chlamydia trachomatis Challenge Infection Elicits TH1 and TH17 Immune Responses in Mice That Promote Pathogen Clearance and Genital Tract Damage.
PloS one
Vicetti Miguel RD,Quispe Calla NE,Pavelko SD,Cherpes TL
11-5321 was used in Flow cytometry/Cell sorting to determine if intravaginal infection with occulogenital Chlamydia trachomatis is a possible mouse model for Chlamydia infection in humans.
Fri Aug 04 00:00:00 EDT 2017
B cell-derived transforming growth factor-β1 expression limits the induction phase of autoimmune neuroinflammation.
Scientific reports
Bjarnadóttir K,Benkhoucha M,Merkler D,Weber MS,Payne NL,Bernard CCA,Molnarfi N,Lalive PH
11-5321-82 was used in Flow Cytometry to test the role for transforming growth factor-β1 expression in regulatory B cell function in autoimmune neuroinflammation.
Thu Oct 06 00:00:00 EDT 2016
Suppression of Antitumor Immune Responses by Human Papillomavirus through Epigenetic Downregulation of CXCL14.
mBio
Cicchini L,Westrich JA,Xu T,Vermeer DW,Berger JN,Clambey ET,Lee D,Song JI,Lambert PF,Greer RO,Lee JH,Pyeon D
11-5321 was used in Flow cytometry/Cell sorting to investigate the underlying mechanism of immune suppression induced by HPV oncoprotein E7, showing that there is epigenetic downregulation of CXCL14.
Tue May 03 00:00:00 EDT 2016
Vaccination with Necroptotic Cancer Cells Induces Efficient Anti-tumor Immunity.
Cell reports
Aaes TL,Kaczmarek A,Delvaeye T,De Craene B,De Koker S,Heyndrickx L,Delrue I,Taminau J,Wiernicki B,De Groote P,Garg AD,Leybaert L,Grooten J,Bertrand MJ,Agostinis P,Berx G,Declercq W,Vandenabeele P,Krysko DV
11-5321 was used in Flow cytometry/Cell sorting to show that necroptotic cancer cells release damage-associated molecular patterns and promote maturation of dendritic cells, the cross-priming of cytotoxic T cells, and the production of IFN-γ.
Tue Apr 12 00:00:00 EDT 2016
Differentiation/Purification Protocol for Retinal Pigment Epithelium from Mouse Induced Pluripotent Stem Cells as a Research Tool.
PloS one
Iwasaki Y,Sugita S,Mandai M,Yonemura S,Onishi A,Ito S,Mochizuki M,Ohno-Matsui K,Takahashi M
11-5321 was used in Flow cytometry/Cell sorting to establish a protocol for differentiation of retinal pigment epithelium with high purity from mouse induced pluripotent stem cells.
Tue Aug 01 00:00:00 EDT 2017
MHC-compatible bone marrow stromal/stem cells trigger fibrosis by activating host T cells in a scleroderma mouse model.
eLife
Ogawa Y,Morikawa S,Okano H,Mabuchi Y,Suzuki S,Yaguchi T,Sato Y,Mukai S,Yaguchi S,Inaba T,Okamoto S,Kawakami Y,Tsubota K,Matsuzaki Y,Shimmura S
11-5321 was used in Flow cytometry/Cell sorting to investigate the fibrosis in a scleroderma mouse model which is triggered by antigen mismatched bone marrow stromal/stem cells.
Tue Jan 26 00:00:00 EST 2016
Loss of the Ubiquitin-conjugating Enzyme UBE2W Results in Susceptibility to Early Postnatal Lethality and Defects in Skin, Immune, and Male Reproductive Systems.
The Journal of biological chemistry
Wang B,Merillat SA,Vincent M,Huber AK,Basrur V,Mangelberger D,Zeng L,Elenitoba-Johnson K,Miller RA,Irani DN,Dlugosz AA,Schnell S,Scaglione KM,Paulson HL
11-5321 was used in Flow cytometry/Cell sorting to establish that UBE2W is an important protein for early postnatal survival and the normal functioning of multiple organ systems.
Fri Feb 05 00:00:00 EST 2016
Antigen presenting cell abnormalities in the Cln3(-/-) mouse model of juvenile neuronal ceroid lipofuscinosis.
Biochimica et biophysica acta
Hersrud SL,Kovács AD,Pearce DA
11-5321 was used in Flow cytometry/Cell sorting to show that CLN3 deficiency alters antigen presenting cells, which can contribute to the autoimmune response in juvenile neuronal ceroid lipofuscinosis.
Fri Jul 01 00:00:00 EDT 2016
Heme Oxygenase-1-Expressing Dendritic Cells Promote Foxp3+ Regulatory T Cell Differentiation and Induce Less Severe Airway Inflammation in Murine Models.
PloS one
Wong TH,Chen HA,Gau RJ,Yen JH,Suen JL
11-5321 was used in Flow cytometry/Cell sorting to study the role of heme oxygenase-1 in dendritic cell-mediated T cell differentiation.
Mon Jul 10 00:00:00 EDT 2017
Injectable, spontaneously assembling, inorganic scaffolds modulate immune cells in vivo and increase vaccine efficacy.
Nature biotechnology
Kim J,Li WA,Choi Y,Lewin SA,Verbeke CS,Dranoff G,Mooney DJ
11532182 was used in flow cytometry to investigate the application of intra-dermal mesoporous silica rods in immune modulation.
Thu Jan 01 00:00:00 EST 2015
Resolvin E1 inhibits dendritic cell migration in the skin and attenuates contact hypersensitivity responses.
The Journal of experimental medicine
Sawada Y,Honda T,Hanakawa S,Nakamizo S,Murata T,Ueharaguchi-Tanada Y,Ono S,Amano W,Nakajima S,Egawa G,Tanizaki H,Otsuka A,Kitoh A,Dainichi T,Ogawa N,Kobayashi Y,Yokomizo T,Arita M,Nakamura M,Miyachi Y,Kabashima K
11-5321 was used in Flow cytometry/Cell sorting to study the inhibition of dendritic cell migration in the skin and the attenuation of contact hypersensitivity responses via Resolvin E1.
Mon Oct 19 00:00:00 EDT 2015
KIM-1-/TIM-1-mediated phagocytosis links ATG5-/ULK1-dependent clearance of apoptotic cells to antigen presentation.
The EMBO journal
Brooks CR,Yeung MY,Brooks YS,Chen H,Ichimura T,Henderson JM,Bonventre JV
11-5321 was used in Flow cytometry/Cell sorting to investigate the role of KIM-1/TIM-1 in phagocytosis, showing that they link ATG5-/ULK1-dependent clearance of apoptotic cells to antigen presentation.
Thu Oct 01 00:00:00 EDT 2015
Adaptive Immune Regulation of Mammary Postnatal Organogenesis.
Developmental cell
Plaks V,Boldajipour B,Linnemann JR,Nguyen NH,Kersten K,Wolf Y,Casbon AJ,Kong N,van den Bijgaart RJ,Sheppard D,Melton AC,Krummel MF,Werb Z
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Flow Cytometry
Mon Sep 14 00:00:00 EDT 2015
Antitumor immunity triggered by melphalan is potentiated by melanoma cell surface-associated calreticulin.
Cancer research
Dudek-Perić AM,Ferreira GB,Muchowicz A,Wouters J,Prada N,Martin S,Kiviluoto S,Winiarska M,Boon L,Mathieu C,van den Oord J,Stas M,Gougeon ML,Golab J,Garg AD,Agostinis P
11-5321 was used in Flow cytometry/Cell sorting to illustrate how melphalan triggers inflammatory cell death that can be leveraged by immunomodulators.
Wed Apr 15 00:00:00 EDT 2015
Thrombin-processed Ecrg4 recruits myeloid cells and induces antitumorigenic inflammation.
Neuro-oncology
Lee J,Dang X,Borboa A,Coimbra R,Baird A,Eliceiri BP
11-5321 was used in Flow cytometry/Cell sorting to identify Ecrg4 as a paracrine factor that activates microglia and is chemotactic for monocytes, with potential as an antitumor therapeutic.
Fri May 01 00:00:00 EDT 2015
Benefits of Neuronal Preferential Systemic Gene Therapy for Neurotransmitter Deficiency.
Molecular therapy : the journal of the American Society of Gene Therapy
Lee NC,Muramatsu S,Chien YH,Liu WS,Wang WH,Cheng CH,Hu MK,Chen PW,Tzen KY,Byrne BJ,Hwu WL
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Immunohistochemistry
Thu Oct 01 00:00:00 EDT 2015
The late endosomal adaptor molecule p14 (LAMTOR2) regulates TGFβ1-mediated homeostasis of Langerhans cells.
The Journal of investigative dermatology
Sparber F,Tripp CH,Komenda K,Scheffler JM,Clausen BE,Huber LA,Romani N,Stoitzner P
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Flow Cytometry
Thu Jan 01 00:00:00 EST 2015
Novel mode of ISG15-mediated protection against influenza A virus and Sendai virus in mice.
Journal of virology
Morales DJ,Monte K,Sun L,Struckhoff JJ,Agapov E,Holtzman MJ,Stappenbeck TS,Lenschow DJ
11-5321 was used in Flow cytometry/Cell sorting to characterise the pathogenesis of influenza A virus and Sendai virus in ISG15(-/-) mice, showing that these mice are more susceptible to infection, and that ISG15 does not seem to directly inhibit virus replication or modulation of the acute immune response.
Thu Jan 01 00:00:00 EST 2015
A novel regulatory macrophage induced by a helminth molecule instructs IL-10 in CD4+ T cells and protects against mucosal inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Ziegler T,Rausch S,Steinfelder S,Klotz C,Hepworth MR,Kühl AA,Burda PC,Lucius R,Hartmann S
11-5321 was used in Flow cytometry/Cell sorting to investigate the mechanism by which the helminth immunomodulator AvCystatin induces a novel regulatory macrophage able to protect against allergic mucosal inflammation in mice.
Sun Feb 15 00:00:00 EST 2015
A genome-wide analysis identifies a notch-RBP-Jκ-IL-7Rα axis that controls IL-17-producing γδ T cell homeostasis in mice.
Journal of immunology (Baltimore, Md. : 1950)
Nakamura M,Shibata K,Hatano S,Sato T,Ohkawa Y,Yamada H,Ikuta K,Yoshikai Y
11-5321 was used in Flow cytometry/Cell sorting to investigate additional roles for the Notch axis in the homeostasis of γδ T cells.
Thu Jan 01 00:00:00 EST 2015
Reducing progression of experimental lupus nephritis via inhibition of the B7/CD28 signaling pathway.
Molecular medicine reports
Huang L,Kong Y,Wang J,Sun J,Shi Q,Qiu YH
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Flow Cytometry
Tue Sep 01 00:00:00 EDT 2015
Macrophages Contribute to the Spermatogonial Niche in the Adult Testis.
Cell reports
DeFalco T,Potter SJ,Williams AV,Waller B,Kan MJ,Capel B
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Immunofluorescence
Tue Aug 18 00:00:00 EDT 2015
Macrophages Contribute to the Spermatogonial Niche in the Adult Testis.
Cell reports
DeFalco T,Potter SJ,Williams AV,Waller B,Kan MJ,Capel B
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Immunofluorescence
Tue Aug 18 00:00:00 EDT 2015
Macrophages Contribute to the Spermatogonial Niche in the Adult Testis.
Cell reports
DeFalco T,Potter SJ,Williams AV,Waller B,Kan MJ,Capel B
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Immunofluorescence
Tue Aug 18 00:00:00 EDT 2015
Determining Leukocyte Origins Using Parabiosis in the PyMT Breast Tumor Model.
Bio-protocol
Franklin RA,Li MO
11-5321 was used in Flow cytometry/Cell sorting to describe the use of parabiosis to define cell ontogeny in a mouse model of breast cancer.
Thu Aug 20 00:00:00 EDT 2015
H9N2 influenza whole inactivated virus combined with polyethyleneimine strongly enhances mucosal and systemic immunity after intranasal immunization in mice.
Clinical and vaccine immunology : CVI
Qin T,Yin Y,Huang L,Yu Q,Yang Q
11-5321 was used in Flow cytometry/Cell sorting to investigate the immune activity of polyethyleneimine with H9N2 influenza whole inactivated virus, showing that it enhances mucosal and systemic immunity after intranasal immunization.
Wed Apr 01 00:00:00 EDT 2015
4T1 Murine Mammary Carcinoma Cells Enhance Macrophage-Mediated Innate Inflammatory Responses.
PloS one
Madera L,Greenshields A,Coombs MR,Hoskin DW
11-5321 was used in Flow cytometry/Cell sorting to investigate how cancers affect macrophage-dependent innate host defence, showing that they enhance macrophage-mediated innate inflammatory responses.
Tue May 03 00:00:00 EDT 2016
Lignin-rich enzyme lignin (LREL), a cellulase-treated lignin-carbohydrate derived from plants, activates myeloid dendritic cells via Toll-like receptor 4 (TLR4).
The Journal of biological chemistry
Tsuji R,Koizumi H,Aoki D,Watanabe Y,Sugihara Y,Matsushita Y,Fukushima K,Fujiwara D
11-5321 was used in Flow cytometry/Cell sorting to investigate the role of lignin-rich enzyme lignin in dendritic cells.
Fri Feb 13 00:00:00 EST 2015
Iron prevents the development of experimental cerebral malaria by attenuating CXCR3-mediated T cell chemotaxis.
PloS one
Van Den Ham KM,Shio MT,Rainone A,Fournier S,Krawczyk CM,Olivier M
11-5321 was used in Flow cytometry/Cell sorting to determine that the incidence of ECM was markedly reduced in mice treated with iron dextran.
Thu Jan 21 00:00:00 EST 2016
Sexually dimorphic outcomes and inflammatory responses in hypoxic-ischemic encephalopathy.
Journal of neuroinflammation
Mirza MA,Ritzel R,Xu Y,McCullough LD,Liu F
11-5321 was used in Flow cytometry/Cell sorting to determine HIE leads to an equivalent primary brain injury in male and female neonates that develops into sexually dimorphic outcomes in later life.
Fri Feb 20 00:00:00 EST 2015
E-cadherin expression in macrophages dampens their inflammatory responsiveness in vitro, but does not modulate M2-regulated pathologies in vivo.
Scientific reports
Van den Bossche J,Laoui D,Naessens T,Smits HH,Hokke CH,Stijlemans B,Grooten J,De Baetselier P,Van Ginderachter JA
11-5321 was used in Flow cytometry/Cell sorting to investigate the effect of overexpression of E-cadherin in macrophages, showing that it dampens their inflammatory responsiveness in vitro, but does not modulate M2-regulated pathologies.
Fri Jul 31 00:00:00 EDT 2015
Expression of the Receptor Tyrosine Kinase EphB2 on Dendritic Cells Is Modulated by Toll-Like Receptor Ligation but Is Not Required for T Cell Activation.
PloS one
Mimche PN,Brady LM,Keeton S,Fenne DS,King TP,Quicke KM,Hudson LE,Lamb TJ
11-5321 was used in Flow cytometry/Cell sorting to investigate the contribution of Ephrin B2 to dendritic cell responses.
Wed Jun 01 00:00:00 EDT 2016
Microfluidic squeezing for intracellular antigen loading in polyclonal B-cells as cellular vaccines.
Scientific reports
Szeto GL,Van Egeren D,Worku H,Sharei A,Alejandro B,Park C,Frew K,Brefo M,Mao S,Heimann M,Langer R,Jensen K,Irvine DJ
11-5321 was used in Flow cytometry/Cell sorting to demonstrate proof-of-concept for mechano-poration as an enabling technology for loading B-cells with antigens to prime specific CD8(+)T-cells.
Fri May 22 00:00:00 EDT 2015
High-fat-diet-mediated dysbiosis promotes intestinal carcinogenesis independently of obesity.
Nature
Schulz MD,Atay C,Heringer J,Romrig FK,Schwitalla S,Aydin B,Ziegler PK,Varga J,Reindl W,Pommerenke C,Salinas-Riester G,Böck A,Alpert C,Blaut M,Polson SC,Brandl L,Kirchner T,Greten FR,Polson SW,Arkan MC
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Flow Cytometry
Thu Oct 23 00:00:00 EDT 2014
Sessile alveolar macrophages communicate with alveolar epithelium to modulate immunity.
Nature
Westphalen K,Gusarova GA,Islam MN,Subramanian M,Cohen TS,Prince AS,Bhattacharya J
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Immunofluorescence
Thu Feb 27 00:00:00 EST 2014
Paneth cell extrusion and release of antimicrobial products is directly controlled by immune cell-derived IFN-γ.
The Journal of experimental medicine
Farin HF,Karthaus WR,Kujala P,Rakhshandehroo M,Schwank G,Vries RG,Kalkhoven E,Nieuwenhuis EE,Clevers H
11-5321 was used in Immunofluorescence to study the control of paneth cell degranulation in primary epithelial organoids in culture, showing that it is directly controlled by immune cell-derived IFN-γ.
Mon Jun 30 00:00:00 EDT 2014
Immunogenicity of undifferentiated and differentiated allogeneic mouse mesenchymal stem cells.
Journal of tissue engineering
Mukonoweshuro B,Brown CJ,Fisher J,Ingham E
11-5321 was used in Flow cytometry/Cell sorting to determine that although mesenchymal stem cells possess immunosuppressive properties, they may not be immunoprivileged.
Fri May 09 00:00:00 EDT 2014
Roles of major histocompatibility complex class II in inducing protective immune responses to influenza vaccination.
Journal of virology
O E,Lee YT,Ko EJ,Kim KH,Lee YN,Song JM,Kwon YM,Kim MC,Perez DR,Kang SM
11-5321 was used in Flow cytometry/Cell sorting to reveal that MHC-II molecules play multiple roles in inducing protective immunity to influenza vaccination.
Tue Jul 01 00:00:00 EDT 2014
C/EBPβ expression is an independent predictor of overall survival in breast cancer patients by MHCII/CD4-dependent mechanism of metastasis formation.
Oncogenesis
Kurzejamska E,Johansson J,Jirström K,Prakash V,Ananthaseshan S,Boon L,Fuxe J,Religa P
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Immunohistochemistry
Mon Nov 03 00:00:00 EST 2014
Site-specific chemokine expression regulates central nervous system inflammation and determines clinical phenotype in autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950)
Stoolman JS,Duncker PC,Huber AK,Segal BM
11-5321 was used in Flow cytometry/Cell sorting to investigate the role of CXCL2 in atypical EAE, showing that site-specific chemokine expression regulates CNS inflammation and determines clinical phenotype.
Tue Jul 15 00:00:00 EDT 2014
IFN-γ-producing and IL-17-producing γδ T cells differentiate at distinct developmental stages in murine fetal thymus.
Journal of immunology (Baltimore, Md. : 1950)
Shibata K,Yamada H,Nakamura M,Hatano S,Katsuragi Y,Kominami R,Yoshikai Y
11-5321 was used in Flow cytometry/Cell sorting to compare the functions of γδ T cells derived from double-negative 2 and double-negative 3 cells in the murine fetal thymus.
Sat Mar 01 00:00:00 EST 2014
Tumor-promoting role of TGFβ1 signaling in ultraviolet B-induced skin carcinogenesis is associated with cutaneous inflammation and lymph node migration of dermal dendritic cells.
Carcinogenesis
Ravindran A,Mohammed J,Gunderson AJ,Cui X,Glick AB
11-5321 was used in Flow cytometry/Cell sorting to study how TGFβ1 signalling has a tumour-promoting role in UVB-induced skin carcinogenesis, which is mediated in part through its role in UVB-induced migration of dDC and cutaneous inflammation.
Tue Apr 01 00:00:00 EDT 2014
Nizatidine, a small molecular compound, enhances killed H5N1 vaccine cell-mediated responses and protects mice from lethal viral challenge.
Human vaccines & immunotherapeutics
Wang S,Wu B,Xue J,Wang M,Chen R,Wang B
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Flow Cytometry
Mon Jan 05 00:00:00 EST 2015
BCG vaccine mediated reduction in the MHC-II expression of macrophages and dendritic cells is reversed by activation of Toll-like receptors 7 and 9.
Cellular immunology
Bakhru P,Sirisaengtaksin N,Soudani E,Mukherjee S,Khan A,Jagannath C
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Flow Cytometry
Wed Jan 01 00:00:00 EST 2014
BCG vaccine mediated reduction in the MHC-II expression of macrophages and dendritic cells is reversed by activation of Toll-like receptors 7 and 9.
Cellular immunology
Bakhru P,Sirisaengtaksin N,Soudani E,Mukherjee S,Khan A,Jagannath C
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Flow Cytometry
Wed Jan 01 00:00:00 EST 2014
Amniotic fluid stem cells prevent follicle atresia and rescue fertility of mice with premature ovarian failure induced by chemotherapy.
PloS one
Xiao GY,Liu IH,Cheng CC,Chang CC,Lee YH,Cheng WT,Wu SC
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Flow Cytometry
Thu May 28 00:00:00 EDT 2015
Assessing the role of STAT3 in DC differentiation and autologous DC immunotherapy in mouse models of GBM.
PloS one
Assi H,Espinosa J,Suprise S,Sofroniew M,Doherty R,Zamler D,Lowenstein PR,Castro MG
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Flow Cytometry
Fri Jan 23 00:00:00 EST 2015
Assessing the role of STAT3 in DC differentiation and autologous DC immunotherapy in mouse models of GBM.
PloS one
Assi H,Espinosa J,Suprise S,Sofroniew M,Doherty R,Zamler D,Lowenstein PR,Castro MG
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Flow Cytometry
Fri Jan 23 00:00:00 EST 2015
Toll-like receptor agonist augments virus-like particle-mediated protection from Ebola virus with transient immune activation.
PloS one
Martins KA,Steffens JT,van Tongeren SA,Wells JB,Bergeron AA,Dickson SP,Dye JM,Salazar AM,Bavari S
11-5321 was used in Flow cytometry/Cell sorting to explore the impact of a stabilised dsRNA mimic, polyICLC, on Ebola virus-like particle vaccination of C57BL/6 mice and Hartley guinea pigs.
Tue Jan 20 00:00:00 EST 2015
Phospholipase cε, an effector of ras and rap small GTPases, is required for airway inflammatory response in a mouse model of bronchial asthma.
PloS one
Nagano T,Edamatsu H,Kobayashi K,Takenaka N,Yamamoto M,Sasaki N,Nishimura Y,Kataoka T
11-5321 was used in Flow cytometry/Cell sorting to demonstrate that PLCε is important in bronchial asthma pathogenesis through upregulating inflammatory cytokine production by bronchial epithelial cells.
Wed Jun 10 00:00:00 EDT 2015
The alarmin Mrp8/14 as regulator of the adaptive immune response during allergic contact dermatitis.
The EMBO journal
Petersen B,Wolf M,Austermann J,van Lent P,Foell D,Ahlmann M,Kupas V,Loser K,Sorg C,Roth J,Vogl T
11-5321 was used in Flow cytometry/Cell sorting to study the role of TLR-4 ligand Mrp8/14 in inflammation and adaptive immunity.
Wed Jan 09 00:00:00 EST 2013
Lipidoid Nanoparticles Containing PD-L1 siRNA Delivered In Vivo Enter Kupffer Cells and Enhance NK and CD8(+) T Cell-mediated Hepatic Antiviral Immunity.
Molecular therapy. Nucleic acids
Dolina JS,Sung SS,Novobrantseva TI,Nguyen TM,Hahn YS
11-5321 was used in Flow cytometry/Cell sorting to demonstrate that PD-L1 knockdown on KCs is central in determining the outcome of liver viral infections, and they represent a new class of gene therapy.
Tue Feb 19 00:00:00 EST 2013
TGFβ1 overexpression by keratinocytes alters skin dendritic cell homeostasis and enhances contact hypersensitivity.
The Journal of investigative dermatology
Mohammed J,Gunderson AJ,Khong HH,Koubek RD,Udey MC,Glick AB
11-5321 was used in Immunofluorescence to highlight a role for keratinocyte-derived TGFβ1 in dendritic cell trafficking and in the initiation of skin inflammation.
Tue Jan 01 00:00:00 EST 2013
Irf8-regulated genomic responses drive pathological inflammation during cerebral malaria.
PLoS pathogens
Berghout J,Langlais D,Radovanovic I,Tam M,MacMicking JD,Stevenson MM,Gros P
11-5321 was used in Flow cytometry/Cell sorting to show that inactivation of Irf8 confers protection against the development of cerebral malaria.
Tue Feb 18 00:00:00 EST 2014
NK cells are necessary for recovery of corneal CD11c+ dendritic cells after epithelial abrasion injury.
Journal of leukocyte biology
Gao Y,Li Z,Hassan N,Mehta P,Burns AR,Tang X,Smith CW
11-5321 was used in Immunofluorescence to investigate the mechanisms controlling CD11c(+) MHCII(+) DCs during corneal epithelial wound healing.
Thu Aug 01 00:00:00 EDT 2013
Aeroallergen challenge promotes dendritic cell proliferation in the airways.
Journal of immunology (Baltimore, Md. : 1950)
Veres TZ,Voedisch S,Spies E,Valtonen J,Prenzler F,Braun A
11-5321 was used in Flow cytometry/Cell sorting to study dendritic cell proliferation in the airways of mice in the steady state and after local aeroallergen provocation.
Fri Feb 01 00:00:00 EST 2013
Skin thymic stromal lymphopoietin initiates Th2 responses through an orchestrated immune cascade.
Nature communications
Leyva-Castillo JM,Hener P,Michea P,Karasuyama H,Chan S,Soumelis V,Li M
11-5321 was used in Flow cytometry/Cell sorting to investigate the mechanisms by which thymic stromal lymphopoietin leads to Th2 initiation, showing that it occurs through an orchestrated immune cascade.
Tue Oct 07 00:00:00 EDT 2014
In vivo knockdown of TAK1 accelerates bone marrow proliferation/differentiation and induces systemic inflammation.
PloS one
Vink PM,Smout WM,Driessen-Engels LJ,de Bruin AM,Delsing D,Krajnc-Franken MA,Jansen AJ,Rovers EF,van Puijenbroek AA,Kaptein A,Nolte MA,Garritsen A,van Eenennaam H
11-5321 was used in Flow cytometry/Cell sorting to study the function of TAK1 protein in the adult immune system.
Fri Sep 06 00:00:00 EDT 2013
NK cells impede glioblastoma virotherapy through NKp30 and NKp46 natural cytotoxicity receptors.
Nature medicine
Alvarez-Breckenridge CA,Yu J,Price R,Wojton J,Pradarelli J,Mao H,Wei M,Wang Y,He S,Hardcastle J,Fernandez SA,Kaur B,Lawler SE,Vivier E,Mandelboim O,Moretta A,Caligiuri MA,Chiocca EA
11-5321 was used in Flow cytometry/Cell sorting to demonstrate that glioblastoma virotherapy is limited partially by an antiviral NK cell response involving specific NCRs, uncovering new potential targets to enhance cancer virotherapy.
Sat Dec 01 00:00:00 EST 2012
Endothelial cells provide an instructive niche for the differentiation and functional polarization of M2-like macrophages.
Blood
He H,Xu J,Warren CM,Duan D,Li X,Wu L,Iruela-Arispe ML
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Flow Cytometry
Thu Oct 11 00:00:00 EDT 2012
Harnessing oncolytic virus-mediated antitumor immunity in an infected cell vaccine.
Molecular therapy : the journal of the American Society of Gene Therapy
Lemay CG,Rintoul JL,Kus A,Paterson JM,Garcia V,Falls TJ,Ferreira L,Bridle BW,Conrad DP,Tang VA,Diallo JS,Arulanandam R,Le Boeuf F,Garson K,Vanderhyden BC,Stojdl DF,Lichty BD,Atkins HL,Parato KA,Bell JC,Auer RC
11-5321 was used in Flow cytometry/Cell sorting to develop a novel OV-infected cell treatment for a robust antitumour T-cell response effective against a broader range of tumours.
Sat Sep 01 00:00:00 EDT 2012
Unexpected role for MHC II-peptide complexes in shaping CD8 T-cell expansion and differentiation in vivo.
Proceedings of the National Academy of Sciences of the United States of America
Do JS,Valujskikh A,Vignali DA,Fairchild RL,Min B
11-5321 was used in Flow cytometry/Cell sorting to reveal a previously undefined MHC II-dependent regulation that tunes CD8 T-cell reactivity.
Tue Jul 31 00:00:00 EDT 2012
Chemokine receptor Ccr1 drives neutrophil-mediated kidney immunopathology and mortality in invasive candidiasis.
PLoS pathogens
Lionakis MS,Fischer BG,Lim JK,Swamydas M,Wan W,Richard Lee CC,Cohen JI,Scheinberg P,Gao JL,Murphy PM
11-5321 was used in Flow cytometry/Cell sorting to show that mice lacking the chemokine receptor Ccr1 have improved renal function and survival without affecting the tissue fungal burden.
Mon Dec 17 00:00:00 EST 2012
A20 (Tnfaip3) deficiency in myeloid cells protects against influenza A virus infection.
PLoS pathogens
Maelfait J,Roose K,Bogaert P,Sze M,Saelens X,Pasparakis M,Carpentier I,van Loo G,Beyaert R
11-5321 was used in Flow cytometry/Cell sorting to examine the role of the ubiquitin-editing protein A20 in the innate immune responses to IAV and other viruses.
Mon Jul 09 00:00:00 EDT 2012
Inhibition of TLR ligand- and interferon gamma-induced murine microglial activation by Panax notoginseng.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology
Beamer CA,Shepherd DM
11-5321 was used in Flow cytometry/Cell sorting to investigate the effects of Panax notoginseng on TLR ligand-and IFNγ-induced activation in N9 and EOC20 microglial cells lines.
Fri Jun 01 00:00:00 EDT 2012
Eosinophil contamination of thioglycollate-elicited peritoneal macrophage cultures skews the functional readouts of in vitro assays.
Journal of leukocyte biology
Misharin AV,Saber R,Perlman H
11-5321 was used in Flow cytometry/Cell sorting to examine the presence of other cell types in freshly isolated and cultured thioglycollate-elicited peritoneal cells.
Wed Aug 01 00:00:00 EDT 2012
Plasma membrane proteomes of differentially matured dendritic cells identified by LC-MS/MS combined with iTRAQ labelling.
Journal of proteomics
Ferret-Bernard S,Castro-Borges W,Dowle AA,Sanin DE,Cook PC,Turner JD,MacDonald AS,Thomas JR,Mountford AP
11-5321 was used in Flow cytometry/Cell sorting to investigate the molecular events and proteome changes which occur when immature dendritic cells generate Th2-type responses.
Wed Jan 04 00:00:00 EST 2012
Changes in lamina propria dendritic cells on the oral administration of exogenous protein antigens during weaning.
Cytotechnology
Ohue R,Nakamoto M,Kitabatake N,Tani F
11-5321 was used in Flow cytometry/Cell sorting to suggest that the behavior of tolerogenic PDCA-1(+) DCs may change at weaning with the removal of the immunoprotective components of maternal milk.
Tue May 01 00:00:00 EDT 2012
Isolation and characterization of novel murine epiphysis derived mesenchymal stem cells.
PloS one
Cheng CC,Lian WS,Hsiao FS,Liu IH,Lin SP,Lee YH,Chang CC,Xiao GY,Huang HY,Cheng CF,Cheng WT,Wu SC
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Flow Cytometry
Fri Sep 07 00:00:00 EDT 2012
Preferential colonization of metastases by oncolytic vaccinia virus strain GLV-1h68 in a human PC-3 prostate cancer model in nude mice.
PloS one
Donat U,Weibel S,Hess M,Stritzker J,Härtl B,Sturm JB,Chen NG,Gentschev I,Szalay AA
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Immunofluorescence
Tue May 07 00:00:00 EDT 2013
Prostaglandin E2 suppresses the differentiation of retinoic acid-producing dendritic cells in mice and humans.
The Journal of experimental medicine
Stock A,Booth S,Cerundolo V
11-5321 was used in Flow cytometry/Cell sorting to study how PGE2 stimulates the expression of the inducible cyclic AMP early repressor, which appears to directly inhibit RALDH expression in DCs.
Mon Apr 11 00:00:00 EDT 2011
Organ-specific innate immune responses in a mouse model of invasive candidiasis.
Journal of innate immunity
Lionakis MS,Lim JK,Lee CC,Murphy PM
11-5321 was used in Flow cytometry/Cell sorting to provide the first detailed analysis of leukocyte subsets accumulating in different target organs during invasive candidiasis.
Fri Jun 17 00:00:00 EDT 2011
Innate immune activation by the viral PAMP poly I:C potentiates pulmonary graft-versus-host disease after allogeneic hematopoietic cell transplant.
Transplant immunology
Kinnier CV,Martinu T,Gowdy KM,Nugent JL,Kelly FL,Palmer SM
11-5321 was used in Flow cytometry/Cell sorting to suggest a novel pathway in which the innate antiviral response to a single viral PAMP can potentiate pulmonary GVHD after allogeneic HCT.
Sat Jan 15 00:00:00 EST 2011
Distribution of primed T cells and antigen-loaded antigen presenting cells following intranasal immunization in mice.
PloS one
Ciabattini A,Pettini E,Fiorino F,Prota G,Pozzi G,Medaglini D
11-5321 was used in Flow cytometry/Cell sorting to elucidate the trafficking of antigen-specific primed T cells to non-draining peripheral and mucosa-associated lymph nodes following nasal immunisation.
Fri Apr 29 00:00:00 EDT 2011
Unraveling molecular signatures of immunostimulatory adjuvants in the female genital tract through systems biology.
PloS one
Lindqvist M,Nookaew I,Brinkenberg I,Samuelson E,Thörn K,Nielsen J,Harandi AM
11-5321 was used in Flow cytometry/Cell sorting to identify molecular signatures that can be used as biomarkers for mucosal adjuvant potency.
Fri Dec 09 00:00:00 EST 2011
In vivo requirement for Atg5 in antigen presentation by dendritic cells.
Immunity
Lee HK,Mattei LM,Steinberg BE,Alberts P,Lee YH,Chervonsky A,Mizushima N,Grinstein S,Iwasaki A
11-5321 was used in Flow cytometry/Cell sorting to investigate how dendritic cells utilise autophagic machinery to optimally present extracellular microbial antigens for MHC II molecules.
Fri Feb 26 00:00:00 EST 2010
Ig gene-like molecule CD31 plays a nonredundant role in the regulation of T-cell immunity and tolerance.
Proceedings of the National Academy of Sciences of the United States of America
Ma L,Mauro C,Cornish GH,Chai JG,Coe D,Fu H,Patton D,Okkenhaug K,Franzoso G,Dyson J,Nourshargh S,Marelli-Berg FM
11-5321 was used in Magnetic cell separation to investigate the contribution of CD31 to T-cell responses, showing that it plays a nonredundant role in the regulation of T-cell immunity and tolerance.
Tue Nov 09 00:00:00 EST 2010
T-cell polarization depends on concentration of the danger signal used to activate dendritic cells.
Immunology and cell biology
Peters M,Dudziak K,Stiehm M,Bufe A
11-5321 was used in Flow cytometry/Cell sorting to show that presentation of allergen by DCs generated with GMCSF is not sufficient to lead to induction of allergic immune response.
Thu Jul 01 00:00:00 EDT 2010
Fine-scale staging of T cell lineage commitment in adult mouse thymus.
Journal of immunology (Baltimore, Md. : 1950)
Yui MA,Feng N,Rothenberg EV
11-5321 was used in Flow cytometry/Cell sorting to determine the gene regulatory changes that accompany commitment in adult wild-type double-negative adult thymocytes.
Thu Jul 01 00:00:00 EDT 2010
Group V secretory phospholipase A2 reveals its role in house dust mite-induced allergic pulmonary inflammation by regulation of dendritic cell function.
Journal of immunology (Baltimore, Md. : 1950)
Giannattasio G,Fujioka D,Xing W,Katz HR,Boyce JA,Balestrieri B
11-5321 was used in Flow cytometry/Cell sorting to demonstrate the role of group V secretory phospholipase A(2) in antigen presenting cells following infection with the house dust mite, Dermatophagoides farinae.
Fri Oct 01 00:00:00 EDT 2010
Enhanced response to mouse thyroid-stimulating hormone (TSH) receptor immunization in TSH receptor-knockout mice.
Endocrinology
Nakahara M,Mitsutake N,Sakamoto H,Chen CR,Rapoport B,McLachlan SM,Nagayama Y
11-5321 was used in Flow cytometry/Cell sorting to study the autoimmune response of thyroid-stimulating hormone receptor (TSHR) knockout mice to immunisation with TSHR.
Sun Aug 01 00:00:00 EDT 2010
Inhibition of B-cell activation by retinal pigment epithelium.
Investigative ophthalmology & visual science
Sugita S,Horie S,Yamada Y,Mochizuki M
11-5321 was used in Flow cytometry/Cell sorting to determine whether retinal pigment epithelial (RPE) cells can inhibit B-cell activation in vitro, showing that B-cell proliferation was suppressed.
Mon Nov 01 00:00:00 EDT 2010
DKK1 mediated inhibition of Wnt signaling in postnatal mice leads to loss of TEC progenitors and thymic degeneration.
PloS one
Osada M,Jardine L,Misir R,Andl T,Millar SE,Pezzano M
11-5321 was used in Flow cytometry/Cell sorting to demonstrate that canonical Wnt signaling within TECs is required for the maintenance of epithelial microenvironments in the postnatal thymus.
Mon Feb 08 00:00:00 EST 2010
Cell-cell cooperation at the T helper cell/mast cell immunological synapse.
Blood
Gaudenzio N,Espagnolle N,Mars LT,Liblau R,Valitutti S,Espinosa E
11-5321 was used in Flow cytometry/Cell sorting to investigate whether cognate interactions between mast cells and class II-restricted CD4(+) T cells occur.
Thu Dec 03 00:00:00 EST 2009
Lymphocytes in the peritoneum home to the omentum and are activated by resident dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Carlow DA,Gold MR,Ziltener HJ
11-5321 was used in Flow cytometry/Cell sorting to show that B and T lymphocytes counterflow from the peritoneal cavity to the omentum in mice where they are activated by resident dendritic cells.
Wed Jul 15 00:00:00 EDT 2009
4-1BB functions as a survival factor in dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Choi BK,Kim YH,Kwon PM,Lee SC,Kang SW,Kim MS,Lee MJ,Kwon BS
11-5321 was used in Flow cytometry/Cell sorting to investigate the function of CD137 on dendritic cells, showing that it functions as a survival factor.
Wed Apr 01 00:00:00 EDT 2009
Mycobacterium bovis BCG decreases MHC-II expression in vivo on murine lung macrophages and dendritic cells during aerosol infection.
Cellular immunology
Pecora ND,Fulton SA,Reba SM,Drage MG,Simmons DP,Urankar-Nagy NJ,Boom WH,Harding CV
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Flow Cytometry
Fri Jan 02 00:00:00 EST 2009
The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance.
Immunity
Akiyama T,Shimo Y,Yanai H,Qin J,Ohshima D,Maruyama Y,Asaumi Y,Kitazawa J,Takayanagi H,Penninger JM,Matsumoto M,Nitta T,Takahama Y,Inoue J
11-5321 was used in Flow cytometry/Cell sorting to investigate signals underlying the development of medullary thymic epithelial cells.
Fri Sep 19 00:00:00 EDT 2008
Identification of regulatory functions for 4-1BB and 4-1BBL in myelopoiesis and the development of dendritic cells.
Nature immunology
Lee SW,Park Y,So T,Kwon BS,Cheroutre H,Mittler RS,Croft M
11-5321 was used in Flow cytometry/Cell sorting to show that the costimulatory molecule 4-1BB, and also its ligand 4-1BBL, is able to limit myelopoiesis and dendritic cell development.
Fri Aug 01 00:00:00 EDT 2008
Region-specific expression of immunoregulatory proteins on microglia in the healthy CNS.
Glia
de Haas AH,Boddeke HW,Biber K
11-5321 was used in Flow cytometry/Cell sorting to evaluate the existence of distinct microglia phenotypes in various regions of the healthy, adult mouse central nervous system.
Sun Jun 01 00:00:00 EDT 2008
Down-regulation of dendritic cell signaling pathways by Leishmania amazonensis amastigotes.
Molecular immunology
Xin L,Li K,Soong L
11-5321 was used in Flow cytometry/Cell sorting to suggest that La parasites, especially in their intracellular forms, have evolved unique strategies to actively down-regulate early innate signalling events.
Tue Jul 01 00:00:00 EDT 2008
Recruitment and in situ renewal regulate rapid accumulation of CD11c+ cells in the lung following intranasal superantigen challenge.
International archives of allergy and immunology
Muralimohan G,Rossi RJ,Vella AT
11-5321 was used in Flow cytometry/Cell sorting to investigate how staphylococcal enterotoxins regulate innate immune cells, showing that it leads to rapid accumulation of CD11c+ cells in the lung following superantigen challenge.
Tue Sep 09 00:00:00 EDT 2008
CD11b facilitates the development of peripheral tolerance by suppressing Th17 differentiation.
The Journal of experimental medicine
Ehirchiou D,Xiong Y,Xu G,Chen W,Shi Y,Zhang L
11-5321 was used in Flow cytometry/Cell sorting to investigate the role of APCs in mediating immune suppression and T cell activation.
Mon Jul 09 00:00:00 EDT 2007
The tetraspanin CD9 mediates lateral association of MHC class II molecules on the dendritic cell surface.
Proceedings of the National Academy of Sciences of the United States of America
Unternaehrer JJ,Chow A,Pypaert M,Inaba K,Mellman I
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Western Blot
Tue Jan 02 00:00:00 EST 2007
CD83 influences cell-surface MHC class II expression on B cells and other antigen-presenting cells.
International immunology
Kuwano Y,Prazma CM,Yazawa N,Watanabe R,Ishiura N,Kumanogoh A,Okochi H,Tamaki K,Fujimoto M,Tedder TF
11-5321 was used in Flow cytometry/Cell sorting to investigate the role of CD83 in B cells and antigen-presenting cells.
Wed Aug 01 00:00:00 EDT 2007
Production of monoclonal antibodies that recognize the extracellular domain of mouse langerin/CD207.
Journal of immunological methods
Cheong C,Idoyaga J,Do Y,Pack M,Park SH,Lee H,Kang YS,Choi JH,Kim JY,Bonito A,Inaba K,Yamazaki S,Steinman RM,Park CG
11-5321-82 was used in Flow Cytometry to show that new IgG anti-CD207 mAbs should be useful for further research on LCs and dendritic cells including an evaluation of the consequences of antigen delivery within anti-CD207 mAbs in vivo.
Tue Jul 31 00:00:00 EDT 2007
Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.
The Journal of clinical investigation
Idzko M,Hammad H,van Nimwegen M,Kool M,Müller T,Soullié T,Willart MA,Hijdra D,Hoogsteden HC,Lambrecht BN
11-5321 was used in Flow cytometry/Cell sorting to demonstrate the therapeutic potential of the sphingosine 1-phosphate receptor agonist, FTY720, as an antiasthmatic drug in a murine asthma model.
Wed Nov 01 00:00:00 EST 2006
Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.
The Journal of clinical investigation
Idzko M,Hammad H,van Nimwegen M,Kool M,Müller T,Soullié T,Willart MA,Hijdra D,Hoogsteden HC,Lambrecht BN
11-5321 was used in Flow cytometry/Cell sorting to demonstrate the therapeutic potential of the sphingosine 1-phosphate receptor agonist, FTY720, as an antiasthmatic drug in a murine asthma model.
Wed Nov 01 00:00:00 EST 2006
Light chain editing generates polyreactive antibodies in chronic graft-versus-host reaction.
The Journal of experimental medicine
Witsch EJ,Cao H,Fukuyama H,Weigert M
11-5321 was used in Flow cytometry/Cell sorting to investigate the structure, specificity, and origin of the induced autoantibodies in chronic graft-versus-host disease, showing that light chain editing generates polyreactive antibodies.
Mon Jul 10 00:00:00 EDT 2006
Infiltration of inflammatory cells plays an important role in matrix metalloproteinase expression and activation in the heart during sepsis.
The American journal of pathology
Cuenca J,Martín-Sanz P,Alvarez-Barrientos AM,Boscá L,Goren N
Published figure using MHC Class II (I-A/I-E) monoclonal antibody (Product # 11-5321-82) in Immunohistochemistry
Wed Nov 01 00:00:00 EST 2006
