Product References
Pyrimidine de novo synthesis inhibition selectively blocks effector but not memory T cell development.
Nature immunology
Scherer S,Oberle SG,Kanev K,Gerullis AK,Wu M,de Almeida GP,Puleston DJ,Baixauli F,Aly L,Greco A,Nizharadze T,Becker NB,Hoesslin MV,Donhauser LV,Berner J,Chu T,McNamara HA,Esencan Z,Roelli P,Wurmser C,Kleiter I,Vehreschild MJGT,Mayer CA,Knolle P,Klingenspor M,Fumagalli V,Iannacone M,Prlic M,Korn T,Pearce EL,Höfer T,Schulz AM,Zehn D
12-0454-82 was used in Flow cytometry/Cell sorting to show memory T cell precursors are resistant to pyrimidine starvation.
Wed Mar 01 00:00:00 EST 2023
Stem cell architecture drives myelodysplastic syndrome progression and predicts response to venetoclax-based therapy.
Nature medicine
Ganan-Gomez I,Yang H,Ma F,Montalban-Bravo G,Thongon N,Marchica V,Richard-Carpentier G,Chien K,Manyam G,Wang F,Alfonso A,Chen S,Class C,Kanagal-Shamanna R,Ingram JP,Ogoti Y,Rose A,Loghavi S,Lockyer P,Cambo B,Muftuoglu M,Schneider S,Adema V,McLellan M,Garza J,Marchesini M,Giuliani N,Pellegrini M,Wang J,Walker J,Li Z,Takahashi K,Leverson JD,Bueso-Ramos C,Andreeff M,Clise-Dwyer K,Garcia-Manero G,Colla S
12-0454-82 was used in Flow Cytometry to study the biological mechanisms that drive hypomethylating agent therapy failure at the stem-cell level to uncover vulnerabilities in the disease and halt its evolution.
Tue Mar 01 00:00:00 EST 2022
Impaired Proteolysis of Noncanonical RAS Proteins Drives Clonal Hematopoietic Transformation.
Cancer discovery
Chen S,Vedula RS,Cuevas-Navarro A,Lu B,Hogg SJ,Wang E,Benbarche S,Knorr K,Kim WJ,Stanley RF,Cho H,Erickson C,Singer M,Cui D,Tittley S,Durham BH,Pavletich TS,Fiala E,Walsh MF,Inoue D,Monette S,Taylor J,Rosen N,McCormick F,Lindsley RC,Castel P,Abdel-Wahab O
12-0454-82 was used in Flow cytometry/Cell sorting to reveal proteolysis of non-canonical RAS proteins as novel regulators of HSC self-renewal, define the function of RIT1 and LZTR1 mutations in leukemia, and identify means to overcome drug resistance due to LZTR1 downregulation.
Wed Oct 05 00:00:00 EDT 2022
Polypyrimidine tract binding protein 1 regulates the activation of mouse CD8 T cells.
European journal of immunology
D'Angeli V,Monzón-Casanova E,Matheson LS,Gizlenci Ö,Petkau G,Gooding C,Berrens RV,Smith CWJ,Turner M
12-0454-82 was used in Flow cytometry/Cell sorting to reveal a crucial role for PTBP1 in regulating CD8 T-cell activation.
Fri Jul 01 00:00:00 EDT 2022
Synthetic introns enable splicing factor mutation-dependent targeting of cancer cells.
Nature biotechnology
North K,Benbarche S,Liu B,Pangallo J,Chen S,Stahl M,Bewersdorf JP,Stanley RF,Erickson C,Cho H,Pineda JMB,Thomas JD,Polaski JT,Belleville AE,Gabel AM,Udy DB,Humbert O,Kiem HP,Abdel-Wahab O,Bradley RK
12-0454-82 was used in Flow cytometry/Cell sorting to demonstrate a method to drive splicing factor mutation-dependent gene expression to selectively eliminate tumor cells.
Fri Jul 01 00:00:00 EDT 2022
Smc3 dosage regulates B cell transit through germinal centers and restricts their malignant transformation.
Nature immunology
Rivas MA,Meydan C,Chin CR,Challman MF,Kim D,Bhinder B,Kloetgen A,Viny AD,Teater MR,McNally DR,Doane AS,Béguelin W,Fernández MTC,Shen H,Wang X,Levine RL,Chen Z,Tsirigos A,Elemento O,Mason CE,Melnick AM
Published figure using CD45.2 monoclonal antibody (Product # 12-0454-82) in Flow Cytometry
Mon Feb 01 00:00:00 EST 2021
Niche-specific MHC II and PD-L1 regulate CD4+CD8αα+ intraepithelial lymphocyte differentiation.
The Journal of experimental medicine
Moon S,Park Y,Hyeon S,Kim YM,Kim JH,Kim H,Park S,Lee KJ,Koo BK,Ha SJ,Lee SW
Published figure using CD45.2 monoclonal antibody (Product # 12-0454-82) in Flow Cytometry
Mon Apr 05 00:00:00 EDT 2021
Brd4 modulates diet-induced obesity via PPARγ-dependent Gdf3 expression in adipose tissue macrophages.
JCI insight
Hu X,Dong X,Li G,Chen Y,Chen J,He X,Sun H,Kim DH,Kemper JK,Chen LF
Published figure using CD45.2 monoclonal antibody (Product # 12-0454-82) in Flow Cytometry
Thu Apr 08 00:00:00 EDT 2021
Differentiation of fetal hematopoietic stem cells requires ARID4B to restrict autocrine KITLG/KIT-Src signaling.
Cell reports
Young IC,Wu B,Andricovich J,Chuang ST,Li R,Tzatsos A,Wu RC,Wu MY
Published figure using CD45.2 monoclonal antibody (Product # 12-0454-82) in Flow Cytometry
Tue Nov 23 00:00:00 EST 2021
Erythritol Ameliorates Small Intestinal Inflammation Induced by High-Fat Diets and Improves Glucose Tolerance.
International journal of molecular sciences
Kawano R,Okamura T,Hashimoto Y,Majima S,Senmaru T,Ushigome E,Asano M,Yamazaki M,Takakuwa H,Sasano R,Nakanishi N,Hamaguchi M,Fukui M
Published figure using CD45.2 monoclonal antibody (Product # 12-0454-82) in Flow Cytometry
Mon May 24 00:00:00 EDT 2021
Expansion of an Unusual Virtual Memory CD8+ Subpopulation Bearing Vα3.2 TCR in Themis-Deficient Mice.
Frontiers in immunology
Prasad M,Wojciech L,Brzostek J,Hu J,Chua YL,Tung DWH,Yap J,Rybakin V,Gascoigne NRJ
Published figure using CD45.2 monoclonal antibody (Product # 12-0454-82) in Flow Cytometry
Thu Sep 23 00:00:00 EDT 2021
The subunits of IL-12, originating from two distinct cells, can functionally synergize to protect against pathogen dissemination in vivo.
Cell reports
Gerber AN,Abdi K,Singh NJ
Published figure using CD45.2 monoclonal antibody (Product # 12-0454-82) in Flow Cytometry
Tue Oct 12 00:00:00 EDT 2021
A Therapeutic Strategy for Preferential Targeting of TET2 Mutant and TET-dioxygenase Deficient Cells in Myeloid Neoplasms.
Blood cancer discovery
Guan Y,Tiwari AD,Phillips JG,Hasipek M,Grabowski DR,Pagliuca S,Gopal P,Kerr CM,Adema V,Radivoyevitch T,Parker Y,Lindner DJ,Meggendorfer M,Abazeed M,Sekeres MA,Mian OY,Haferlach T,Maciejewski JP,Jha BK
12-0454 was used in Flow cytometry/Cell sorting to suggest that TET inhibitors may constitute a new class of targeted agents in TET2 mutant neoplasia.
Mon Mar 01 00:00:00 EST 2021
Molecular Mechanisms Underpinning the Circulation and Cellular Uptake of Mycobacterium ulcerans Toxin Mycolactone.
Frontiers in pharmacology
Tello Rubio B,Bugault F,Baudon B,Raynal B,Brûlé S,Morel JD,Saint-Auret S,Blanchard N,Demangel C,Guenin-Macé L
12-0454-82 was used in Flow cytometry/Cell sorting to fully characterize mycolactone's behavior in solution and to determine the role of different serum lipid carriers in mycolactone bioavailability.
Tue Oct 05 00:00:00 EDT 2021
Ddb1 Is Essential for the Expansion of CD4+ Helper T Cells by Regulating Cell Cycle Progression and Cell Death.
Frontiers in immunology
Yang L,Chen W,Li L,Xiao Y,Fan S,Zhang Q,Xia T,Li M,Hong Y,Zhao T,Li Q,Liu WH,Xiao N
Published figure using CD45.2 monoclonal antibody (Product # 12-0454-82) in Flow Cytometry
Mon Dec 20 00:00:00 EST 2021
Abraxane-induced bone marrow CD11b+ myeloid cell depletion in tumor-bearing mice is visualized by μPET-CT with 64Cu-labeled anti-CD11b and prevented by anti-CSF-1.
Theranostics
Cao Q,Huang Q,Wang YA,Li C
Published figure using CD45.2 monoclonal antibody (Product # 12-0454-82) in Flow Cytometry
Fri Jul 23 00:00:00 EDT 2021
Inflammasome activation leads to cDC1-independent cross-priming of CD8 T cells by epithelial cell-derived antigen.
eLife
Deets KA,Nichols Doyle R,Rauch I,Vance RE
12-0454-82 was used in Flow cytometry/Cell sorting to investigate whether inflammasomes provide sufficient signals to activate adaptive immunity.
Thu Dec 23 00:00:00 EST 2021
Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion.
Cancer cell
Su R,Dong L,Li Y,Gao M,Han L,Wunderlich M,Deng X,Li H,Huang Y,Gao L,Li C,Zhao Z,Robinson S,Tan B,Qing Y,Qin X,Prince E,Xie J,Qin H,Li W,Shen C,Sun J,Kulkarni P,Weng H,Huang H,Chen Z,Zhang B,Wu X,Olsen MJ,Müschen M,Marcucci G,Salgia R,Li L,Fathi AT,Li Z,Mulloy JC,Wei M,Horne D,Chen J
12-0454-82 was used in Flow Cytometry to demonstrate if fat mass and obesity-associated protein plays critical roles in cancer stem cell self-renewal and immune evasion.
Mon Jul 13 00:00:00 EDT 2020
RNA Demethylase ALKBH5 Selectively Promotes Tumorigenesis and Cancer Stem Cell Self-Renewal in Acute Myeloid Leukemia.
Cell stem cell
Shen C,Sheng Y,Zhu AC,Robinson S,Jiang X,Dong L,Chen H,Su R,Yin Z,Li W,Deng X,Chen Y,Hu YC,Weng H,Huang H,Prince E,Cogle CR,Sun M,Zhang B,Chen CW,Marcucci G,He C,Qian Z,Chen J
12-0454-82 was used in Flow Cytometry to reveal crucial functions of ALKBH5 in leukemogenesis and LSC/LIC self-renewal/maintenance and highlight the therapeutic potential of targeting the ALKBH5/m6A axis.
Thu Jul 02 00:00:00 EDT 2020
Multi-layered Spatial Transcriptomics Identify Secretory Factors Promoting Human Hematopoietic Stem Cell Development.
Cell stem cell
Crosse EI,Gordon-Keylock S,Rybtsov S,Binagui-Casas A,Felchle H,Nnadi NC,Kirschner K,Chandra T,Tamagno S,Webb DJ,Rossi F,Anderson RA,Medvinsky A
12-0454 was used in Flow cytometry/Cell sorting to identify secreted signals underlying human HSC development, combining spatial transcriptomics analysis of dorsoventral polarized signaling in the aorta with gene expression profiling of sorted cell populations and single cells.
Thu Nov 05 00:00:00 EST 2020
Deregulated Notch and Wnt signaling activates early-stage myeloid regeneration pathways in leukemia.
The Journal of experimental medicine
Kang YA,Pietras EM,Passegué E
Published figure using CD45.2 monoclonal antibody (Product # 12-0454-82) in Flow Cytometry
Mon Mar 02 00:00:00 EST 2020
Snai2 Maintains Bone Marrow Niche Cells by Repressing Osteopontin Expression.
Developmental cell
Wei Q,Nakahara F,Asada N,Zhang D,Gao X,Xu C,Alfieri A,Brodin NP,Zimmerman SE,Mar JC,Guha C,Guo W,Frenette PS
12-0454-82 was used in Immunohistochemistry to conclude that SNAI2 is a critical regulator of the transcriptional network maintaining MSPCs by the suppression of osteopontin expression.
Mon Jun 08 00:00:00 EDT 2020
Proenkephalin+ regulatory T cells expanded by ultraviolet B exposure maintain skin homeostasis with a healing function.
Proceedings of the National Academy of Sciences of the United States of America
Shime H,Odanaka M,Tsuiji M,Matoba T,Imai M,Yasumizu Y,Uraki R,Minohara K,Watanabe M,Bonito AJ,Fukuyama H,Ohkura N,Sakaguchi S,Morita A,Yamazaki S
Published figure using CD45.2 monoclonal antibody (Product # 12-0454-82) in Flow Cytometry
Tue Aug 25 00:00:00 EDT 2020
Mast Cells Occupy Stable Clonal Territories in Adult Steady-State Skin.
The Journal of investigative dermatology
Weitzmann A,Naumann R,Dudeck A,Zerjatke T,Gerbaulet A,Roers A
12-0454 was used in Flow cytometry/Cell sorting to conclude that during a limited window early in development, definitive MC precursors efficiently enter the skin, expand, and self-maintain, occupying stable territories.
Tue Dec 01 00:00:00 EST 2020
Interleukin 35 Delays Hindlimb Ischemia-Induced Angiogenesis Through Regulating ROS-Extracellular Matrix but Spares Later Regenerative Angiogenesis.
Frontiers in immunology
Fu H,Sun Y,Shao Y,Saredy J,Cueto R,Liu L,Drummer C,Johnson C,Xu K,Lu Y,Li X,Meng S,Xue ER,Tan J,Jhala NC,Yu D,Zhou Y,Bayless KJ,Yu J,Rogers TJ,Hu W,Snyder NW,Sun J,Qin X,Jiang X,Wang H,Yang X
Published figure using CD45.2 monoclonal antibody (Product # 12-0454-82) in Flow Cytometry
Fri Jul 09 00:00:00 EDT 2021
Deletion of immune evasion genes provides an effective vaccine design for tumor-associated herpesviruses.
NPJ vaccines
Brar G,Farhat NA,Sukhina A,Lam AK,Kim YH,Hsu T,Tong L,Lin WW,Ware CF,Blackman MA,Sun R,Wu TT
12-0454 was used in Flow cytometry/Cell sorting to provide a framework for effective vaccination against cancer-associated herpesviruses through the elimination of latency and key immune evasion mechanisms from the pathogen.
Thu Nov 05 00:00:00 EST 2020
The frequency of follicular T helper cells differs in acute and chronic neuroinflammation.
Scientific reports
Baniahmad A,Birkner K,Görg J,Loos J,Zipp F,Wasser B,Bittner S
Published figure using CD45.2 monoclonal antibody (Product # 12-0454-82) in Flow Cytometry
Tue Nov 24 00:00:00 EST 2020
Programming Multifaceted Pulmonary T Cell Immunity by Combination Adjuvants.
Cell reports. Medicine
Marinaik CB,Kingstad-Bakke B,Lee W,Hatta M,Sonsalla M,Larsen A,Neldner B,Gasper DJ,Kedl RM,Kawaoka Y,Suresh M
12-0454 was used in Flow cytometry/Cell sorting to provide further insights into vaccine-induced multifaceted mucosal T cell immunity with implications in the development of vaccines against respiratorypathogens, including influenza virus and SARS-CoV-2.
Tue Sep 22 00:00:00 EDT 2020
Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages.
Nature metabolism
Covarrubias AJ,Kale A,Perrone R,Lopez-Dominguez JA,Pisco AO,Kasler HG,Schmidt MS,Heckenbach I,Kwok R,Wiley CD,Wong HS,Gibbs E,Iyer SS,Basisty N,Wu Q,Kim IJ,Silva E,Vitangcol K,Shin KO,Lee YM,Riley R,Ben-Sahra I,Ott M,Schilling B,Scheibye-Knudsen M,Ishihara K,Quake SR,Newman J,Brenner C,Campisi J,Verdin E
12-0454 was used in Flow cytometry/Cell sorting to uncover a new causal link among resident tissue macrophages, cellular senescence and tissue NAD decline during ageing and offer novel therapeutic opportunities to maintain NAD levels during ageing.
Sun Nov 01 00:00:00 EDT 2020
Id1 and Id3 Maintain Steady-State Hematopoiesis by Promoting Sinusoidal Endothelial Cell Survival and Regeneration.
Cell reports
Gadomski S,Singh SK,Singh S,Sarkar T,Klarmann KD,Berenschot M,Seaman S,Jakubison B,Gudmundsson KO,Lockett S,Keller JR
12-0454 was used in Flow cytometry/Cell sorting to investigate the effects of loss of ld genes on adult endothelial cell.
Tue Apr 28 00:00:00 EDT 2020
Long-term ex vivo haematopoietic-stem-cell expansion allows nonconditioned transplantation.
Nature
Wilkinson AC,Ishida R,Kikuchi M,Sudo K,Morita M,Crisostomo RV,Yamamoto R,Loh KM,Nakamura Y,Watanabe M,Nakauchi H,Yamazaki S
Published figure using CD45.2 monoclonal antibody (Product # 12-0454-82) in Flow Cytometry
Mon Jul 01 00:00:00 EDT 2019
Coordinated alterations in RNA splicing and epigenetic regulation drive leukaemogenesis.
Nature
Yoshimi A,Lin KT,Wiseman DH,Rahman MA,Pastore A,Wang B,Lee SC,Micol JB,Zhang XJ,de Botton S,Penard-Lacronique V,Stein EM,Cho H,Miles RE,Inoue D,Albrecht TR,Somervaille TCP,Batta K,Amaral F,Simeoni F,Wilks DP,Cargo C,Intlekofer AM,Levine RL,Dvinge H,Bradley RK,Wagner EJ,Krainer AR,Abdel-Wahab O
12-0454 was used in Flow cytometry/Cell sorting to study the mutations in IDH2 and SRSF2 that together promote leukaemogenesis through coordinated effects on the epigenome and RNA splicing.
Tue Oct 01 00:00:00 EDT 2019
CD8+ T cells induce cachexia during chronic viral infection.
Nature immunology
Baazim H,Schweiger M,Moschinger M,Xu H,Scherer T,Popa A,Gallage S,Ali A,Khamina K,Kosack L,Vilagos B,Smyth M,Lercher A,Friske J,Merkler D,Aderem A,Helbich TH,Heikenwälder M,Lang PA,Zechner R,Bergthaler A
12-0454-82 was used in Flow Cytometry to identify the role for CD8+ T cells in infection-associated cachexia.
Sat Jun 01 00:00:00 EDT 2019
Methods for Evaluating the Role of c-Fos and Dusp1 in Oncogene Dependence.
Journal of visualized experiments : JoVE
Kesarwani M,Kincaid Z,Azam M
12-0454 was used in Flow cytometry/Cell sorting to provide methods for target validation using in vitro and in vivo mouse models.
Mon Jan 07 00:00:00 EST 2019
Methods for Evaluating the Role of c-Fos and Dusp1 in Oncogene Dependence.
Journal of visualized experiments : JoVE
Kesarwani M,Kincaid Z,Azam M
12-0454 was used in Flow cytometry/Cell sorting to provide methods for target validation using in vitro and in vivo mouse models.
Mon Jan 07 00:00:00 EST 2019
CD38-NAD+Axis Regulates Immunotherapeutic Anti-Tumor T Cell Response.
Cell metabolism
Chatterjee S,Daenthanasanmak A,Chakraborty P,Wyatt MW,Dhar P,Selvam SP,Fu J,Zhang J,Nguyen H,Kang I,Toth K,Al-Homrani M,Husain M,Beeson G,Ball L,Helke K,Husain S,Garrett-Mayer E,Hardiman G,Mehrotra M,Nishimura MI,Beeson CC,Bupp MG,Wu J,Ogretmen B,Paulos CM,Rathmell J,Yu XZ,Mehrotra S
12-0454 was used in Flow cytometry/Cell sorting to establish ex vivo culture conditions to generate hybrid Th1/17 cells, which persist long-term in vivo while maintaining effector function.
Tue Jan 09 00:00:00 EST 2018
c-Maf controls immune responses by regulating disease-specific gene networks and repressing IL-2 in CD4+ T cells.
Nature immunology
Gabryšová L,Alvarez-Martinez M,Luisier R,Cox LS,Sodenkamp J,Hosking C,Pérez-Mazliah D,Whicher C,Kannan Y,Potempa K,Wu X,Bhaw L,Wende H,Sieweke MH,Elgar G,Wilson M,Briscoe J,Metzis V,Langhorne J,Luscombe NM,O'Garra A
12-0454 was used in Flow cytometry/Cell sorting to study the role of c-Maf as a regulator of the expression of cytokine-encoding genes.
Tue May 01 00:00:00 EDT 2018
Neutrophil and Macrophage Cell Surface Colony-Stimulating Factor 1 Shed by ADAM17 Drives Mouse Macrophage Proliferation in Acute and Chronic Inflammation.
Molecular and cellular biology
Tang J,Frey JM,Wilson CL,Moncada-Pazos A,Levet C,Freeman M,Rosenfeld ME,Stanley ER,Raines EW,Bornfeldt KE
12-0454 was used in Flow cytometry/Cell sorting to identify a significant defect in macrophage proliferation in mice lacking leukocyte transmembrane protease, ADAM17.
Sat Sep 01 00:00:00 EDT 2018
The H3K4 methyltransferase Setd1b is essential for hematopoietic stem and progenitor cell homeostasis in mice.
eLife
Schmidt K,Zhang Q,Tasdogan A,Petzold A,Dahl A,Arneth BM,Slany R,Fehling HJ,Kranz A,Stewart AF,Anastassiadis K
Published figure using CD45.2 monoclonal antibody (Product # 12-0454-82) in Flow Cytometry
Tue Jun 19 00:00:00 EDT 2018
Differential requirement of kindlin-3 for T cell progenitor homing to the non-vascularized and vascularized thymus.
eLife
Moretti FA,Klapproth S,Ruppert R,Margraf A,Weber J,Pick R,Scheiermann C,Sperandio M,Fässler R,Moser M
Published figure using CD45.2 monoclonal antibody (Product # 12-0454-82) in Flow Cytometry
Thu Sep 06 00:00:00 EDT 2018
IL-6 receptor blockade corrects defects of XIAP-deficient regulatory T cells.
Nature communications
Hsieh WC,Hsu TS,Chang YJ,Lai MZ
12-0454 was used in Flow cytometry/Cell sorting to demonstrate that immunosuppressive defects in XIAP-deficient regulatory T cells can be corrected by treatment with autologous induced Treg cells and IL-6 Receptor blockade.
Wed Jan 31 00:00:00 EST 2018
IL-6 receptor blockade corrects defects of XIAP-deficient regulatory T cells.
Nature communications
Hsieh WC,Hsu TS,Chang YJ,Lai MZ
12-0454 was used in Flow cytometry/Cell sorting to demonstrate that immunosuppressive defects in XIAP-deficient regulatory T cells can be corrected by treatment with autologous induced Treg cells and IL-6 Receptor blockade.
Wed Jan 31 00:00:00 EST 2018
Analysis of Runx1 Using Induced Gene Ablation Reveals Its Essential Role in Pre-liver HSC Development and Limitations of an In Vivo Approach.
Stem cell reports
Senserrich J,Batsivari A,Rybtsov S,Gordon-Keylock S,Souilhol C,Buchholz F,Hills D,Zhao S,Medvinsky A
12-0454 was used in Flow cytometry/Cell sorting to study tamoxifen-inducible Runx1 inactivation in vivo.
Tue Sep 11 00:00:00 EDT 2018
RhoA, Rac1, and Cdc42 differentially regulate αSMA and collagen I expression in mesenchymal stem cells.
The Journal of biological chemistry
Ge J,Burnier L,Adamopoulou M,Kwa MQ,Schaks M,Rottner K,Brakebusch C
12-0454 was used in Flow cytometry/Cell sorting to provide molecular insights into the role of Rho GTPases in TGFβ signalling and understanding of mesenchymal stem cells in fibriosis.
Fri Jun 15 00:00:00 EDT 2018
Epigenetic control of IL-23 expression in keratinocytes is important for chronic skin inflammation.
Nature communications
Li H,Yao Q,Mariscal AG,Wu X,Hülse J,Pedersen E,Helin K,Waisman A,Vinkel C,Thomsen SF,Avgustinova A,Benitah SA,Lovato P,Norsgaard H,Mortensen MS,Veng L,Rozell B,Brakebusch C
12-0454 was used in Flow cytometry/Cell sorting to show that keratinocyte-produced IL-23 is sufficient to cause a chronic skin inflammation with an IL-17 profile in mice.
Thu Apr 12 00:00:00 EDT 2018
TGF-β1 Negatively Regulates the Number and Function of Hematopoietic Stem Cells.
Stem cell reports
Wang X,Dong F,Zhang S,Yang W,Yu W,Wang Z,Zhang S,Wang J,Ma S,Wu P,Gao Y,Dong J,Tang F,Cheng T,Ema H
12-0454 was used in Flow cytometry/Cell sorting to examine the effect of transforming growth factor Β1 on haematopoietic stem cell function.
Tue Jul 10 00:00:00 EDT 2018
Epidermal Growth Factor Receptor Expression Licenses Type-2 Helper T Cells to Function in a T Cell Receptor-Independent Fashion.
Immunity
Minutti CM,Drube S,Blair N,Schwartz C,McCrae JC,McKenzie AN,Kamradt T,Mokry M,Coffer PJ,Sibilia M,Sijts AJ,Fallon PG,Maizels RM,Zaiss DM
12-0454 was used in Flow cytometry/Cell sorting to reveal a mechanism by which antigen presentation controls the innate effector function of Th2 cells at the site of inflammation.
Tue Oct 17 00:00:00 EDT 2017
Analyses of a Mutant Foxp3 Allele Reveal BATF as a Critical Transcription Factor in the Differentiation and Accumulation of Tissue Regulatory T Cells.
Immunity
Hayatsu N,Miyao T,Tachibana M,Murakami R,Kimura A,Kato T,Kawakami E,Endo TA,Setoguchi R,Watarai H,Nishikawa T,Yasuda T,Yoshida H,Hori S
12-0454 was used in Flow cytometry/Cell sorting to identify BATF as a regulator of tissue regulatory T cells and suggest that sequence-specific perturbations of Foxp3-DNA interactions can influence specific facets of Treg physiology and the immunopathologies.
Tue Aug 15 00:00:00 EDT 2017
Egr2 and 3 control adaptive immune responses by temporally uncoupling expansion from T cell differentiation.
The Journal of experimental medicine
Miao T,Symonds ALJ,Singh R,Symonds JD,Ogbe A,Omodho B,Zhu B,Li S,Wang P
Published figure using CD45.2 monoclonal antibody (Product # 12-0454-82) in Flow Cytometry
Mon Jun 05 00:00:00 EDT 2017
A molecular roadmap of the AGM region reveals BMPER as a novel regulator of HSC maturation.
The Journal of experimental medicine
McGarvey AC,Rybtsov S,Souilhol C,Tamagno S,Rice R,Hills D,Godwin D,Rice D,Tomlinson SR,Medvinsky A
12-0454 was used in Flow cytometry/Cell sorting to identify novel secreted regulators of haematopoietic stem cell maturation.
Mon Dec 04 00:00:00 EST 2017
Inhibiting Oxidative Phosphorylation In Vivo Restrains Th17 Effector Responses and Ameliorates Murine Colitis.
Journal of immunology (Baltimore, Md. : 1950)
Franchi L,Monteleone I,Hao LY,Spahr MA,Zhao W,Liu X,Demock K,Kulkarni A,Lesch CA,Sanchez B,Carter L,Marafini I,Hu X,Mashadova O,Yuan M,Asara JM,Singh H,Lyssiotis CA,Monteleone G,Opipari AW,Glick GD
12-0454 was used in Flow cytometry/Cell sorting to highlight the importance of analysing metabolism in effector lymphocytes within in vivo inflammatory contexts.
Sat Apr 01 00:00:00 EDT 2017
Recipient bone marrow assimilates the myeloid/lymphoid reconstitution of distinct fetal hematopoietic stem cells.
Oncotarget
Guo XL,Chu L,Ke F,Mu LL,Li Z,Cai JJ,Li HF,Hong DL
Tue Dec 12 00:00:00 EST 2017
Recipient bone marrow assimilates the myeloid/lymphoid reconstitution of distinct fetal hematopoietic stem cells.
Oncotarget
Guo XL,Chu L,Ke F,Mu LL,Li Z,Cai JJ,Li HF,Hong DL
Tue Dec 12 00:00:00 EST 2017
Pneumocystis-Driven Inducible Bronchus-Associated Lymphoid Tissue Formation Requires Th2 and Th17 Immunity.
Cell reports
Eddens T,Elsegeiny W,Garcia-Hernadez ML,Castillo P,Trevejo-Nunez G,Serody K,Campfield BT,Khader SA,Chen K,Rangel-Moreno J,Kolls JK
Published figure using CD45.2 monoclonal antibody (Product # 12-0454-82) in Flow Cytometry
Tue Mar 28 00:00:00 EDT 2017
Intratumoral modulation of the inducible co-stimulator ICOS by recombinant oncolytic virus promotes systemic anti-tumour immunity.
Nature communications
Zamarin D,Holmgaard RB,Ricca J,Plitt T,Palese P,Sharma P,Merghoub T,Wolchok JD,Allison JP
Published figure using CD45.2 monoclonal antibody (Product # 12-0454-82) in Flow Cytometry
Mon Feb 13 00:00:00 EST 2017
IL-7-dependent STAT1 activation limits homeostatic CD4+ T cell expansion.
JCI insight
Le Saout C,Luckey MA,Villarino AV,Smith M,Hasley RB,Myers TG,Imamichi H,Park JH,O'Shea JJ,Lane HC,Catalfamo M
12-0454 was used in Flow cytometry/Cell sorting to propose a model in which T cells undergoing lymphopenia-induced proliferation upregulate STAT1 protein, switching on an alternate IL-7-dependent program.
Thu Nov 16 00:00:00 EST 2017
Mutant U2AF1-expressing cells are sensitive to pharmacological modulation of the spliceosome.
Nature communications
Shirai CL,White BS,Tripathi M,Tapia R,Ley JN,Ndonwi M,Kim S,Shao J,Carver A,Saez B,Fulton RS,Fronick C,O'Laughlin M,Lagisetti C,Webb TR,Graubert TA,Walter MJ
12-0454 was used in Flow cytometry/Cell sorting to suggest a potential for treating haematological cancers harbouring U2AF1 mutations with pre-mRNA splicing modulators like sudemycins.
Mon Jan 09 00:00:00 EST 2017
Host-Protozoan Interactions Protect from Mucosal Infections through Activation of the Inflammasome.
Cell
Chudnovskiy A,Mortha A,Kana V,Kennard A,Ramirez JD,Rahman A,Remark R,Mogno I,Ng R,Gnjatic S,Amir ED,Solovyov A,Greenbaum B,Clemente J,Faith J,Belkaid Y,Grigg ME,Merad M
Published figure using CD45.2 monoclonal antibody (Product # 12-0454-82) in Flow Cytometry
Thu Oct 06 00:00:00 EDT 2016
The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity.
Cell
Damgaard RB,Walker JA,Marco-Casanova P,Morgan NV,Titheradge HL,Elliott PR,McHale D,Maher ER,McKenzie ANJ,Komander D
Published figure using CD45.2 monoclonal antibody (Product # 12-0454-82) in Flow Cytometry
Thu Aug 25 00:00:00 EDT 2016
Developing HSCs become Notch independent by the end of maturation in the AGM region.
Blood
Souilhol C,Lendinez JG,Rybtsov S,Murphy F,Wilson H,Hills D,Batsivari A,Binagui-Casas A,McGarvey AC,MacDonald HR,Kageyama R,Siebel C,Zhao S,Medvinsky A
12-0454 was used in Flow cytometry/Cell sorting to investigate how Notch signalling regulates hematopoietic stem cell (HSC) formation in the embryo, showing that HSCs become Notch independent by the end of maturation in the aorta-gonad-mesonephros region.
Thu Sep 22 00:00:00 EDT 2016
CD8+ T cells drive autoimmune hematopoietic stem cell dysfunction and bone marrow failure.
Journal of autoimmunity
Gravano DM,Al-Kuhlani M,Davini D,Sanders PD,Manilay JO,Hoyer KK
12-0454 was used in Flow cytometry/Cell sorting to investigate whether CD8+ T cells play a non-redundant role in driving bone marrow failure.
Thu Dec 01 00:00:00 EST 2016
Recruited monocytes modulate malaria-induced lung injury through CD36-mediated clearance of sequestered infected erythrocytes.
Journal of leukocyte biology
Lagassé HA,Anidi IU,Craig JM,Limjunyawong N,Poupore AK,Mitzner W,Scott AL
Sun May 01 00:00:00 EDT 2016
Murine iPSC-Derived Macrophages as a Tool for Disease Modeling of Hereditary Pulmonary Alveolar Proteinosis due to Csf2rb Deficiency.
Stem cell reports
Mucci A,Kunkiel J,Suzuki T,Brennig S,Glage S,Kühnel MP,Ackermann M,Happle C,Kuhn A,Schambach A,Trapnell BC,Hansen G,Moritz T,Lachmann N
Published figure using CD45.2 monoclonal antibody (Product # 12-0454-82) in Flow Cytometry
Tue Aug 09 00:00:00 EDT 2016
CD19 CAR immune pressure induces B-precursor acute lymphoblastic leukaemia lineage switch exposing inherent leukaemic plasticity.
Nature communications
Jacoby E,Nguyen SM,Fountaine TJ,Welp K,Gryder B,Qin H,Yang Y,Chien CD,Seif AE,Lei H,Song YK,Khan J,Lee DW,Mackall CL,Gardner RA,Jensen MC,Shern JF,Fry TJ
12-0454 was used in Flow cytometry/Cell sorting to study how CD19 CAR immune pressure induces a B-precursor acute lymphoblastic leukaemia lineage switch.
Wed Jul 27 00:00:00 EDT 2016
Inductive interactions mediated by interplay of asymmetric signalling underlie development of adult haematopoietic stem cells.
Nature communications
Souilhol C,Gonneau C,Lendinez JG,Batsivari A,Rybtsov S,Wilson H,Morgado-Palacin L,Hills D,Taoudi S,Antonchuk J,Zhao S,Medvinsky A
12-0454 was used in Flow cytometry/Cell sorting to study how several signalling pathways interact to regulate the emergence of haematopoietic stem cells in the aorta.
Tue Mar 08 00:00:00 EST 2016
Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS.
Nature
Krönke J,Fink EC,Hollenbach PW,MacBeth KJ,Hurst SN,Udeshi ND,Chamberlain PP,Mani DR,Man HW,Gandhi AK,Svinkina T,Schneider RK,McConkey M,Järås M,Griffiths E,Wetzler M,Bullinger L,Cathers BE,Carr SA,Chopra R,Ebert BL
12-0454 was used in Flow cytometry/Cell sorting to demonstrate the ubiquitination dependent mechanism by which lenalidomide induces the degradation of casein kinase 1A1 in del(5q) myelodysplastic syndrome.
Thu Jul 09 00:00:00 EDT 2015
Atypical chemokine receptor 1 deficiency reduces atherogenesis in ApoE-knockout mice.
Cardiovascular research
Wan W,Liu Q,Lionakis MS,Marino AP,Anderson SA,Swamydas M,Murphy PM
Published figure using CD45.2 monoclonal antibody (Product # 12-0454-82) in Flow Cytometry
Mon Jun 01 00:00:00 EDT 2015
Axitinib increases the infiltration of immune cells and reduces the suppressive capacity of monocytic MDSCs in an intracranial mouse melanoma model.
Oncoimmunology
Du Four S,Maenhout SK,De Pierre K,Renmans D,Niclou SP,Thielemans K,Neyns B,Aerts JL
Published figure using CD45.2 monoclonal antibody (Product # 12-0454-82) in Flow Cytometry
Wed Apr 01 00:00:00 EDT 2015
Langerhans cell homeostasis and activation is altered in hyperplastic human papillomavirus type 16 E7 expressing epidermis.
PloS one
Abd Warif NM,Stoitzner P,Leggatt GR,Mattarollo SR,Frazer IH,Hibma MH
12-0454 was used in Flow cytometry/Cell sorting to demonstrate that the atypical activation of Langerhans cells by human papillomavirus may contribute to an immune suppressive microenvironment.
Thu Apr 14 00:00:00 EDT 2016
Megakaryocytes regulate hematopoietic stem cell quiescence through CXCL4 secretion.
Nature medicine
Bruns I,Lucas D,Pinho S,Ahmed J,Lambert MP,Kunisaki Y,Scheiermann C,Schiff L,Poncz M,Bergman A,Frenette PS
12-0454 was used in Flow cytometry/Cell sorting to indicate that a terminally differentiated cell type derived from HSCs contributes to the HSC niche, directly regulating HSC behavior.
Sat Nov 01 00:00:00 EDT 2014
WASH is required for the differentiation commitment of hematopoietic stem cells in a c-Myc-dependent manner.
The Journal of experimental medicine
Xia P,Wang S,Huang G,Zhu P,Li M,Ye B,Du Y,Fan Z
Published figure using CD45.2 monoclonal antibody (Product # 12-0454-82) in Flow Cytometry
Mon Sep 22 00:00:00 EDT 2014
12-Hydroxyheptadecatrienoic acid promotes epidermal wound healing by accelerating keratinocyte migration via the BLT2 receptor.
The Journal of experimental medicine
Liu M,Saeki K,Matsunobu T,Okuno T,Koga T,Sugimoto Y,Yokoyama C,Nakamizo S,Kabashima K,Narumiya S,Shimizu T,Yokomizo T
12-0454 was used in Flow cytometry/Cell sorting to demonstrate the potential use of BLT2 agonists as therapeutic agents to accelerate wound healing.
Mon Jun 02 00:00:00 EDT 2014
Chronic exposure to type-I IFN under lymphopenic conditions alters CD4 T cell homeostasis.
PLoS pathogens
Le Saout C,Hasley RB,Imamichi H,Tcheung L,Hu Z,Luckey MA,Park JH,Durum SK,Smith M,Rupert AW,Sneller MC,Lane HC,Catalfamo M
12-0454 was used in Flow cytometry/Cell sorting to define the mechanisms behind immune cell maintenance in HIV infected individuals.
Sat Mar 01 00:00:00 EST 2014
Differential requirement for CCR4 and CCR7 during the development of innate and adaptive αβT cells in the adult thymus.
Journal of immunology (Baltimore, Md. : 1950)
Cowan JE,McCarthy NI,Parnell SM,White AJ,Bacon A,Serge A,Irla M,Lane PJ,Jenkinson EJ,Jenkinson WE,Anderson G
12-0454 was used in Flow cytometry/Cell sorting to identify novel roles for CCR7 during intrathymic T cell development, highlighting its importance in enabling multiple αβT cell lineages to access the thymic medulla.
Fri Aug 01 00:00:00 EDT 2014
Administration of the resveratrol analogues isorhapontigenin and heyneanol-A protects mice hematopoietic cells against irradiation injuries.
BioMed research international
Wang H,Yang YL,Zhang H,Yan H,Wu XJ,Zhang CZ
12-0454 was used in Flow cytometry/Cell sorting to examine if isorhapontigenin and heyneanol-A, two analogues of resveratrol, could mitigate IR-induced BM suppression.
Mon Mar 30 00:00:00 EDT 2015
Leukocyte population dynamics and detection of IL-9 as a major cytokine at the mouse fetal-maternal interface.
PloS one
Habbeddine M,Verbeke P,Karaz S,Bobé P,Kanellopoulos-Langevin C
Published figure using CD45.2 monoclonal antibody (Product # 12-0454-82) in Flow Cytometry
Wed Jun 10 00:00:00 EDT 2015
Tracing the origin of the HSC hierarchy reveals an SCF-dependent, IL-3-independent CD43(-) embryonic precursor.
Stem cell reports
Rybtsov S,Batsivari A,Bilotkach K,Paruzina D,Senserrich J,Nerushev O,Medvinsky A
12-0454 was used in Flow cytometry/Cell sorting to further define the hierarchical organisation of the developing haematopoietic stem cell lineage.
Tue Sep 09 00:00:00 EDT 2014
Arteriolar niches maintain haematopoietic stem cell quiescence.
Nature
Kunisaki Y,Bruns I,Scheiermann C,Ahmed J,Pinho S,Zhang D,Mizoguchi T,Wei Q,Lucas D,Ito K,Mar JC,Bergman A,Frenette PS
12-0454 was used in Flow cytometry/Cell sorting to investigate the spatial localisation of quiescent haematopoietic stem cells in bone marrow, showing that arteriolar niches maintain quiescence.
Thu Oct 31 00:00:00 EDT 2013
Mutual expression of the transcription factors Runx3 and ThPOK regulates intestinal CD4⁺ T cell immunity.
Nature immunology
Reis BS,Rogoz A,Costa-Pinto FA,Taniuchi I,Mucida D
Published figure using CD45.2 monoclonal antibody (Product # 12-0454-82) in Flow Cytometry
Fri Mar 01 00:00:00 EST 2013
miR-126 and miR-126* repress recruitment of mesenchymal stem cells and inflammatory monocytes to inhibit breast cancer metastasis.
Nature cell biology
Zhang Y,Yang P,Sun T,Li D,Xu X,Rui Y,Li C,Chong M,Ibrahim T,Mercatali L,Amadori D,Lu X,Xie D,Li QJ,Wang XF
Published figure using CD45.2 monoclonal antibody (Product # 12-0454-82) in Flow Cytometry
Fri Mar 01 00:00:00 EST 2013
Mouse extraembryonic arterial vessels harbor precursors capable of maturing into definitive HSCs.
Blood
Gordon-Keylock S,Sobiesiak M,Rybtsov S,Moore K,Medvinsky A
12-0454 was used in Flow cytometry/Cell sorting to elucidate the hematopoietic stem cell initiating potential of cell clusters in mouse extraembryonic vessels.
Thu Oct 03 00:00:00 EDT 2013
Expression of the secondary granule proteins major basic protein 1 (MBP-1) and eosinophil peroxidase (EPX) is required for eosinophilopoiesis in mice.
Blood
Doyle AD,Jacobsen EA,Ochkur SI,McGarry MP,Shim KG,Nguyen DT,Protheroe C,Colbert D,Kloeber J,Neely J,Shim KP,Dyer KD,Rosenberg HF,Lee JJ,Lee NA
12-0454 was used in Flow cytometry/Cell sorting to investigate the contributions of the granule proteins MBP-1 and EPX to eosinophil activity using double knockout mice.
Thu Aug 01 00:00:00 EDT 2013
The thymic medulla is required for Foxp3+ regulatory but not conventional CD4+ thymocyte development.
The Journal of experimental medicine
Cowan JE,Parnell SM,Nakamura K,Caamano JH,Lane PJ,Jenkinson EJ,Jenkinson WE,Anderson G
12-0454 was used in Flow cytometry/Cell sorting to demonstrate a differential requirement for the thymic medulla in relation to CD4 conventional and Foxp3(+) thymocyte lineages.
Mon Apr 08 00:00:00 EDT 2013
Th17-cell plasticity in Helicobacter hepaticus-induced intestinal inflammation.
Mucosal immunology
Morrison PJ,Bending D,Fouser LA,Wright JF,Stockinger B,Cooke A,Kullberg MC
12-0454 was used in Flow cytometry/Cell sorting to uncover the immunoinflammatory contribution of Th1 and Th17 T cell subsets during murine Helicobacter hepaticus-induced typhlocolitis.
Fri Nov 01 00:00:00 EDT 2013
Direct effects of IL-4 on mast cells drive their intestinal expansion and increase susceptibility to anaphylaxis in a murine model of food allergy.
Mucosal immunology
Burton OT,Darling AR,Zhou JS,Noval-Rivas M,Jones TG,Gurish MF,Chatila TA,Oettgen HC
12-0454 was used in Flow cytometry/Cell sorting to demonstrate that IL-4-signaling is a key determinant of mast cell expansion in food allergy.
Mon Jul 01 00:00:00 EDT 2013
Arrayed lentiviral barcoding for quantification analysis of hematopoietic dynamics.
Stem cells (Dayton, Ohio)
Grosselin J,Sii-Felice K,Payen E,Chretien S,Tronik-Le Roux D,Leboulch P
Published figure using CD45.2 monoclonal antibody (Product # 12-0454-82) in Flow Cytometry
Tue Oct 01 00:00:00 EDT 2013
Clonally diverse T cell homeostasis is maintained by a common program of cell-cycle control.
Journal of immunology (Baltimore, Md. : 1950)
Hogan T,Shuvaev A,Commenges D,Yates A,Callard R,Thiebaut R,Seddon B
12-0454 was used in Flow cytometry/Cell sorting to analyse the heterogenous proliferative response of T cell clones to lymphopenia using in vivo and mathematical models.
Mon Apr 15 00:00:00 EDT 2013
A non-redundant function of cyclin E1 in hematopoietic stem cells.
Cell cycle (Georgetown, Tex.)
Campaner S,Viale A,De Fazio S,Doni M,De Franco F,D'Artista L,Sardella D,Pelicci PG,Amati B
12-0454 was used in Flow cytometry/Cell sorting to support a role for cyclin E1 in controlling the exit from quiescence in hematopoietic stem cells.
Sun Dec 01 00:00:00 EST 2013
Inhibiting TGFβ1 has a protective effect on mouse bone marrow suppression following ionizing radiation exposure in vitro.
Journal of radiation research
Zhang H,Wang YA,Meng A,Yan H,Wang X,Niu J,Li J,Wang H
12-0454 was used in Flow cytometry/Cell sorting to examine if the TGF1 inhibitor, SB431542, can mitigate ionizing radiation-induced bone marrow suppression, showing that inhibition has a protective effect.
Mon Jul 01 00:00:00 EDT 2013
The cardioprotective protein apolipoprotein A1 promotes potent anti-tumorigenic effects.
The Journal of biological chemistry
Zamanian-Daryoush M,Lindner D,Tallant TC,Wang Z,Buffa J,Klipfell E,Parker Y,Hatala D,Parsons-Wingerter P,Rayman P,Yusufishaq MSS,Fisher EA,Smith JD,Finke J,DiDonato JA,Hazen SL
Published figure using CD45.2 monoclonal antibody (Product # 12-0454-82) in Flow Cytometry
Fri Jul 19 00:00:00 EDT 2013
Highly self-reactive naive CD4 T cells are prone to differentiate into regulatory T cells.
Nature communications
Martin B,Auffray C,Delpoux A,Pommier A,Durand A,Charvet C,Yakonowsky P,de Boysson H,Bonilla N,Audemard A,Sparwasser T,Salomon BL,Malissen B,Lucas B
12-0454 was used in Flow cytometry/Cell sorting to show that naive CD4 T cells with the highest avidity for self are prone to differentiate into regulatory T cells.
Thu Feb 27 00:00:00 EST 2014
Plasmacytoid dendritic cells transport peripheral antigens to the thymus to promote central tolerance.
Immunity
Hadeiba H,Lahl K,Edalati A,Oderup C,Habtezion A,Pachynski R,Nguyen L,Ghodsi A,Adler S,Butcher EC
12-0454 was used in Flow cytometry/Cell sorting to explore the mechanisms underlying the contribution to immune tolerance conducted by peripheral dendritic cells.
Fri Mar 23 00:00:00 EDT 2012
NF-Y is necessary for hematopoietic stem cell proliferation and survival.
Blood
Bungartz G,Land H,Scadden DT,Emerson SG
12-0454 was used in Flow cytometry/Cell sorting to show that the trimeric transcription factor NF-Y is critical for the survival of cycling, but not quiescent hematopoietic stem cells.
Thu Feb 09 00:00:00 EST 2012
The location of splenic NKT cells favours their rapid activation by blood-borne antigen.
The EMBO journal
Barral P,Sánchez-Niño MD,van Rooijen N,Cerundolo V,Batista FD
12-0454 was used in Flow cytometry/Cell sorting to study the distribution and dynamics of natural killer T cells within the spleen.
Wed May 16 00:00:00 EDT 2012
Direct reduction of antigen receptor expression in polyclonal B cell populations developing in vivo results in light chain receptor editing.
Journal of immunology (Baltimore, Md. : 1950)
Shen S,Manser T
12-0454 was used in Flow cytometry/Cell sorting to test the role of BCR expression plays in receptor editing in an polyclonal, in vivo population of B cells.
Sun Jan 01 00:00:00 EST 2012
Interleukin-15 treatment induces weight loss independent of lymphocytes.
PloS one
Barra NG,Chew MV,Reid S,Ashkar AA
12-0454 was used in Flow cytometry/Cell sorting to determine if lymphocytes, particularly natural killer cells, play a role in Interleukin-15 mediated weight loss.
Tue Nov 27 00:00:00 EST 2012
In vivo inhibition of c-MYC in myeloid cells impairs tumor-associated macrophage maturation and pro-tumoral activities.
PloS one
Pello OM,Chèvre R,Laoui D,De Juan A,Lolo F,Andrés-Manzano MJ,Serrano M,Van Ginderachter JA,Andrés V
12-0454-82 was used in Flow cytometry/Cell sorting to identify c-Myc as a positive regulator of the pro-tumoral program of tumour-associated macrophages, suggesting a potential target for anti-cancer therapy.
Mon Feb 25 00:00:00 EST 2013
Autocrine IL-2 is required for secondary population expansion of CD8(+) memory T cells.
Nature immunology
Feau S,Arens R,Togher S,Schoenberger SP
12-0454 was used in Flow cytometry/Cell sorting to investigate the role of CD4(+) T cells in priming CD8(+) memory T cells, showing that autocrine IL-2 is required for secondary population expansion.
Sun Jul 31 00:00:00 EDT 2011
Hierarchical organization and early hematopoietic specification of the developing HSC lineage in the AGM region.
The Journal of experimental medicine
Rybtsov S,Sobiesiak M,Taoudi S,Souilhol C,Senserrich J,Liakhovitskaia A,Ivanovs A,Frampton J,Zhao S,Medvinsky A
12-0454 was used in Flow cytometry/Cell sorting to show that pre-HSCs are broadly distributed through the wall of the dorsal aorta, and propose a simple model for HSC development in the AGM region.
Mon Jun 06 00:00:00 EDT 2011
Bile retinoids imprint intestinal CD103+ dendritic cells with the ability to generate gut-tropic T cells.
Mucosal immunology
Jaensson-Gyllenbäck E,Kotarsky K,Zapata F,Persson EK,Gundersen TE,Blomhoff R,Agace WW
12-0454 was used in Flow cytometry/Cell sorting to demonstrate that imprinting of CD103(+) DCs is itself critically dependent on vitamin A and occurs locally within the small intestine (SI).
Fri Jul 01 00:00:00 EDT 2011
Cellular competition independent of BAFF/B lymphocyte stimulator results in low frequency of an autoreactive clonotype in mature polyclonal B cell compartments.
Journal of immunology (Baltimore, Md. : 1950)
Nikbakht N,Migone TS,Ward CP,Manser T
12-0454 was used in Flow cytometry/Cell sorting to investigate the role of the peripheral B cell pro-survival cytokine BAFF/BLyS in the regulation of immunological tolerance and autoreactive cells.
Fri Jul 01 00:00:00 EDT 2011
Helios is associated with CD4 T cells differentiating to T helper 2 and follicular helper T cells in vivo independently of Foxp3 expression.
PloS one
Serre K,Bénézech C,Desanti G,Bobat S,Toellner KM,Bird R,Chan S,Kastner P,Cunningham AF,Maclennan IC,Mohr E
12-0454 was used in Flow cytometry/Cell sorting to reveal the selective upregulation of Helios during Th2 and TFh responses to alum-protein vaccines.
Mon Oct 17 00:00:00 EDT 2011
Distribution of primed T cells and antigen-loaded antigen presenting cells following intranasal immunization in mice.
PloS one
Ciabattini A,Pettini E,Fiorino F,Prota G,Pozzi G,Medaglini D
12-0454 was used in Flow cytometry/Cell sorting to elucidate the trafficking of antigen-specific primed T cells to non-draining peripheral and mucosa-associated lymph nodes following nasal immunisation.
Fri Apr 29 00:00:00 EDT 2011
Initial clonal expansion of germinal center B cells takes place at the perimeter of follicles.
Immunity
Coffey F,Alabyev B,Manser T
12-0454 was used in Immunofluorescence on frozen tissues to study the proliferation, differentiation, and microenvironmental locale in populations of pre-germinal centre B cells responding to antigen.
Fri Apr 17 00:00:00 EDT 2009
Initial clonal expansion of germinal center B cells takes place at the perimeter of follicles.
Immunity
Coffey F,Alabyev B,Manser T
12-0454 was used in Immunofluorescence on frozen tissues to study the proliferation, differentiation, and microenvironmental locale in populations of pre-germinal centre B cells responding to antigen.
Fri Apr 17 00:00:00 EDT 2009
MT1-MMP and RECK are involved in human CD34+ progenitor cell retention, egress, and mobilization.
The Journal of clinical investigation
Vagima Y,Avigdor A,Goichberg P,Shivtiel S,Tesio M,Kalinkovich A,Golan K,Dar A,Kollet O,Petit I,Perl O,Rosenthal E,Resnick I,Hardan I,Gellman YN,Naor D,Nagler A,Lapidot T
12-0454 was used in Flow cytometry/Cell sorting to study the mechanisms governing haematopoietic progenitor cell mobilisation.
Sun Mar 01 00:00:00 EST 2009
Signal transduction inhibition of APCs diminishes th17 and Th1 responses in experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950)
Skarica M,Wang T,McCadden E,Kardian D,Calabresi PA,Small D,Whartenby KA
12-0454 was used in Flow cytometry/Cell sorting to show that targeted inhibition of DCs in EAE-infected mice leads to a decrease in CNS infiltration of pathogenic Ag-specific T cells.
Wed Apr 01 00:00:00 EDT 2009
The lupus susceptibility locus Sle1 breaches peripheral B cell tolerance at the antibody-forming cell and germinal center checkpoints.
Journal of immunology (Baltimore, Md. : 1950)
Vuyyuru R,Mohan C,Manser T,Rahman ZS
12-0454 was used in Magnetic cell separation to show that Sle1 perturbs the action of peripheral tolerance checkpoints operative on antinuclear Ag B cells in both the AFC and GC pathways in a cell autonomous fashion.
Sun Nov 01 00:00:00 EDT 2009
The survival of memory CD4+ T cells within the gut lamina propria requires OX40 and CD30 signals.
Journal of immunology (Baltimore, Md. : 1950)
Withers DR,Jaensson E,Gaspal F,McConnell FM,Eksteen B,Anderson G,Agace WW,Lane PJL
12-0454 was used in Flow cytometry/Cell sorting to investigate how signals through CD30 and OX40 may be required for the survival of CD4+ T cells within the gut lamina propria.
Thu Oct 15 00:00:00 EDT 2009
Follicular shuttling of marginal zone B cells facilitates antigen transport.
Nature immunology
Cinamon G,Zachariah MA,Lam OM,Foss FW,Cyster JG
12-0454 was used in Flow cytometry/Cell sorting to investigate the mechanism of capture and follicular delivery of blood-borne antigens in the splenic marginal zone, showing that it is mediated by follicular shuttling of B cells.
Tue Jan 01 00:00:00 EST 2008
IL-7 and IL-15 differentially regulate CD8+ T-cell subsets during contraction of the immune response.
Blood
Rubinstein MP,Lind NA,Purton JF,Filippou P,Best JA,McGhee PA,Surh CD,Goldrath AW
12-0454 was used in Flow cytometry/Cell sorting to study IL-7 and IL-15 regulation of CD8+ T-cell subsets during contraction of the immune response.
Sat Nov 01 00:00:00 EDT 2008
CXCL9, but not CXCL10, promotes CXCR3-dependent immune-mediated kidney disease.
Journal of the American Society of Nephrology : JASN
Menke J,Zeller GC,Kikawada E,Means TK,Huang XR,Lan HY,Lu B,Farber J,Luster AD,Kelley VR
12-0454 was used in Flow cytometry/Cell sorting to identify additional therapeutic chemokine targets for immune-mediated nephritis.
Sun Jun 01 00:00:00 EDT 2008
Retinoic acid receptor signaling levels and antigen dose regulate gut homing receptor expression on CD8+ T cells.
Mucosal immunology
Svensson M,Johansson-Lindbom B,Zapata F,Jaensson E,Austenaa LM,Blomhoff R,Agace WW
12-0454 was used in Flow cytometry/Cell sorting to demonstrate that both splenic and mesenteric lymph node DCs enhance retinoic acid receptor signaling in CD8(+) T-cells.
Tue Jan 01 00:00:00 EST 2008
Donor deficiency of decay-accelerating factor accelerates murine T cell-mediated cardiac allograft rejection.
Journal of immunology (Baltimore, Md. : 1950)
Pavlov V,Raedler H,Yuan S,Leisman S,Kwan WH,Lalli PN,Medof ME,Heeger PS
12-0454 was used in Flow cytometry/Cell sorting to reveal that donor DAF expression regulates the strength of the direct alloreactive CD8(+) T cell response.
Wed Oct 01 00:00:00 EDT 2008
Quantum dots for tracking dendritic cells and priming an immune response in vitro and in vivo.
PloS one
Sen D,Deerinck TJ,Ellisman MH,Parker I,Cahalan MD
12-0454 was used in Flow cytometry/Cell sorting to investigate the potential of QDs for imaging of DCs and as a particle-based antigen-delivery system.
Mon Sep 29 00:00:00 EDT 2008
Presenilins regulate alphabeta T cell development by modulating TCR signaling.
The Journal of experimental medicine
Laky K,Fowlkes BJ
12-0454 was used in Flow cytometry/Cell sorting to suggest a model in which PS-dependent Notch signalling influences positive selection and the development of alphabeta T cells by modifying TCR signal transduction.
Mon Sep 03 00:00:00 EDT 2007
Immature hematopoietic cells display selective requirements for adhesion- and degranulation-promoting adaptor protein in development and homeostatsis.
European journal of immunology
Dluzniewska J,Zou L,Harmon IR,Ellingson MT,Peterson EJ
12-0454-82 was used in Flow Cytometry to highlight the dynamic regulation of ADAP during T cell maturation and document expression patterns that suggest a possible role for ADAP in development of non-T hematopoietic lineages.
Thu Nov 01 00:00:00 EDT 2007
Functional specialization of gut CD103+ dendritic cells in the regulation of tissue-selective T cell homing.
The Journal of experimental medicine
Johansson-Lindbom B,Svensson M,Pabst O,Palmqvist C,Marquez G,Förster R,Agace WW
12-0454 was used in Flow cytometry/Cell sorting to demonstrate a unique function for lamina propria-derived CD103(+) mesenteric lymph node dendritic cells in the generation of gut-tropic effector T cells.
Mon Oct 17 00:00:00 EDT 2005
Obesity is associated with macrophage accumulation in adipose tissue.
The Journal of clinical investigation
Weisberg SP,McCann D,Desai M,Rosenbaum M,Leibel RL,Ferrante AW
12-0454 was used in Flow cytometry/Cell sorting to demonstrate adipose tissue macrophages participate in inflammatory pathways that are activated in obese individuals..
Mon Dec 01 00:00:00 EST 2003
