Product References
Dlk1 maintains adult mice long-term HSCs by activating Notch signaling to restrict mitochondrial metabolism.
Experimental hematology & oncology
Huang D,Han Y,Tang T,Yang L,Jiang P,Qian W,Zhang Z,Qian X,Zeng X,Qian P
47-0454-82 was used in Flow cytometry/Cell sorting to demonstrate that Dlk1 is essential for maintaining HSC homeostasis, which is realized by governing Notch signalling and restricting mitochondrial metabolic activity.
Wed Jan 18 00:00:00 EST 2023
CD4+ T cell calibration of antigen-presenting cells optimizes antiviral CD8+ T cell immunity.
Nature immunology
Gressier E,Schulte-Schrepping J,Petrov L,Brumhard S,Stubbemann P,Hiller A,Obermayer B,Spitzer J,Kostevc T,Whitney PG,Bachem A,Odainic A,van de Sandt C,Nguyen THO,Ashhurst T,Wilson K,Oates CVL,Gearing LJ,Meischel T,Hochheiser K,Greyer M,Clarke M,Kreutzenbeck M,Gabriel SS,Kastenmüller W,Kurts C,Londrigan SL,Kallies A,Kedzierska K,Hertzog PJ,Latz E,Chen YE,Radford KJ,Chopin M,Schroeder J,Kurth F,Gebhardt T,Sander LE,Sawitzki B,Schultze JL,Schmidt SV,Bedoui S
47-0454-82 was used in Flow cytometry/Cell sorting to describe gradual interferon-α/interferon-β (IFNα/β)-induced transcriptional adaptations that endow APCs with the capacity to rapidly activate the transcriptional regulators p65, IRF1 and FOS after CD4+ T cell-mediated CD40 stimulation.
Thu Jun 01 00:00:00 EDT 2023
Inactivation of p53 provides a competitive advantage to del(5q) myelodysplastic syndrome hematopoietic stem cells during inflammation.
Haematologica
Muto T,Walker CS,Agarwal P,Vick E,Sampson A,Choi K,Niederkorn M,Ishikawa C,Hueneman K,Varney M,Starczynowski DT
47-0454-82 was used in Flow cytometry/Cell sorting to investigate the effects of inflammation on hematopoietic stem and progenitor cells (HSPC) in the context of myelodysplastic syndromes (MDS), particularly the del(5q) subtype.
Sun Oct 01 00:00:00 EDT 2023
Meis1 establishes the pre-hemogenic endothelial state prior to Runx1 expression.
Nature communications
Coulombe P,Cole G,Fentiman A,Parker JDK,Yung E,Bilenky M,Degefie L,Lac P,Ling MYM,Tam D,Humphries RK,Karsan A
47-0454-82 was used in Flow Cytometry to identify the transcription factor Meis1 as an essential regulator of hemogenic cell specification in the embryo prior to Runx1 expression.
Thu Jul 27 00:00:00 EDT 2023
RIPK3 controls MAIT cell accumulation during development but not during infection.
Cell death & disease
Patton T,Zhao Z,Lim XY,Eddy E,Wang H,Nelson AG,Ennis B,Eckle SBG,Souter MNT,Pediongco TJ,Koay HF,Zhang JG,Djajawi TM,Louis C,Lalaoui N,Jacquelot N,Lew AM,Pellicci DG,McCluskey J,Zhan Y,Chen Z,Lawlor KE,Corbett AJ
47-0454-82 was used in Flow cytometry/Cell sorting to suggest that, distinct from conventional T cells, the accumulation of MAIT cells is restrained by RIPK3 signalling, likely prior to thymic egress, in a manner independent of canonical apoptotic and necroptotic cell death pathways.
Sat Feb 11 00:00:00 EST 2023
Tetraspanin CD82 restrains phagocyte migration but supports macrophage activation.
iScience
McGowan ENS,Wong O,Jones E,Nguyen J,Wee J,Demaria MC,Deliyanti D,Johnson CJ,Hickey MJ,McConville MJ,Wilkinson-Berka JL,Wright MD,Binger KJ
47-0454-82 was used in Flow cytometry/Cell sorting to reveal an important role for CD82 in restraining phagocyte infiltration and mediating their differentiation in response to stimulatory cues.
Fri Jul 15 00:00:00 EDT 2022
cDC1 coordinate innate and adaptive responses in the omentum required for T cell priming and memory.
Science immunology
Christian DA,Adams TA,Shallberg LA,Phan AT,Smith TE,Abraha M,Perry J,Ruthel G,Clark JT,Pritchard GH,Aronson LR,Gossa S,McGavern DB,Kedl RM,Hunter CA
47-0454-82 was used in Flow Cytometry to investigate how conventional type 1 dendritic cells (cDC1s) in the peritoneal cavity's omentum coordinate innate responses to microbial challenge and provide secondary signals required for CD8+ T cell expansion and memory formation, particularly after intraperitoneal immunization with Toxoplasma gondii.
Fri Sep 30 00:00:00 EDT 2022
PI3K Signaling in Dendritic Cells Aggravates DSS-Induced Colitis.
Frontiers in immunology
Kuttke M,Hromadová D,Yildirim C,Brunner JS,Vogel A,Paar H,Peters S,Weber M,Hofmann M,Kerndl M,Kieler M,Datler H,Musiejovsky L,Salzmann M,Lang M,Soukup K,Halfmann A,Sharif O,Schabbauer G
47-0454-82 was used in Flow cytometry/Cell sorting to show that the PI3K signaling pathway in dendritic cells contributes to disease pathology by promoting IL-6 mediated Th1 responses.
Mon May 09 00:00:00 EDT 2022
JAK1 signaling in dendritic cells promotes peripheral tolerance in autoimmunity through PD-L1-mediated regulatory T cell induction.
Cell reports
Vogel A,Martin K,Soukup K,Halfmann A,Kerndl M,Brunner JS,Hofmann M,Oberbichler L,Korosec A,Kuttke M,Datler H,Kieler M,Musiejovsky L,Dohnal A,Sharif O,Schabbauer G
47-0454-82 was used in Flow Cytometry to conclude that DC-intrinsic JAK1 promotes peripheral tolerance, suggesting potential unwarranted DC-mediated effects of Jakinibs in autoimmune diseases.
Tue Feb 22 00:00:00 EST 2022
TRAF6 functions as a tumor suppressor in myeloid malignancies by directly targeting MYC oncogenic activity.
Cell stem cell
Muto T,Guillamot M,Yeung J,Fang J,Bennett J,Nadorp B,Lasry A,Redondo LZ,Choi K,Gong Y,Walker CS,Hueneman K,Bolanos LC,Barreyro L,Lee LH,Greis KD,Vasyliev N,Khodadadi-Jamayran A,Nudler E,Lujambio A,Lowe SW,Aifantis I,Starczynowski DT
47-0454-82 was used in Flow cytometry/Cell sorting to identify signaling states that cooperate with pre-leukemic cells and, notably, the study aimed to uncover the role of the ubiquitin ligase TRAF6 in preventing the transition from a pre-leukemic stage to overt myeloid leukemia by regulating MYC through ubiquitination and acetylation mechanisms.
Thu Feb 03 00:00:00 EST 2022
Environmental enteric dysfunction induces regulatory T cells that inhibit local CD4+ T cell responses and impair oral vaccine efficacy.
Immunity
Bhattacharjee A,Burr AHP,Overacre-Delgoffe AE,Tometich JT,Yang D,Huckestein BR,Linehan JL,Spencer SP,Hall JA,Harrison OJ,Morais da Fonseca D,Norton EB,Belkaid Y,Hand TW
47-0454-82 was used in Flow Cytometry to provide insight into the poor efficacy of oral vaccines in EED and highlight how RORγT+FOXP3+ Treg cells can regulate intestinal immunity while leaving systemic responses intact.
Tue Aug 10 00:00:00 EDT 2021
HectD1 controls hematopoietic stem cell regeneration by coordinating ribosome assembly and protein synthesis.
Cell stem cell
Lv K,Gong C,Antony C,Han X,Ren JG,Donaghy R,Cheng Y,Pellegrino S,Warren AJ,Paralkar VR,Tong W
47-0454-82 was used in Flow cytometry/Cell sorting to reveal a role of the E3 ubiquitin ligase HectD1 in regulating HSC function via ribosome assembly and protein translation.
Thu Jul 01 00:00:00 EDT 2021
NLRP3 regulates alveolar bone loss in ligature-induced periodontitis by promoting osteoclastic differentiation.
Cell proliferation
Chen Y,Yang Q,Lv C,Chen Y,Zhao W,Li W,Chen H,Wang H,Sun W,Yuan H
47-0454-82 was used in Flow Cytometry to reveal that NLRP3 regulates alveolar bone loss in ligature-induced periodontitis by promoting osteoclastic differentiation.
Mon Feb 01 00:00:00 EST 2021
Redundant cytokine requirement for intestinal microbiota-induced Th17 cell differentiation in draining lymph nodes.
Cell reports
Sano T,Kageyama T,Fang V,Kedmi R,Martinez CS,Talbot J,Chen A,Cabrera I,Gorshko O,Kurakake R,Yang Y,Ng C,Schwab SR,Littman DR
47-0454-82 was used in Flow Cytometry to show that intestine-draining mesenteric lymph nodes (MLNs), not intestine proper, are the dominant site of SFB-induced intestinal Th17 cell differentiation.
Tue Aug 24 00:00:00 EDT 2021
DA-DRD5 signaling controls colitis by regulating colonic M1/M2 macrophage polarization.
Cell death & disease
Liu L,Wu Y,Wang B,Jiang Y,Lin L,Li X,Yang S
47-0454 was used in Flow cytometry/Cell sorting to provide demonstration of DA-DRD5 signaling in colonic macrophages controlling the development of colitis by regulating M1/M2 macrophage polarization.
Mon May 17 00:00:00 EDT 2021
Calibration of cell-intrinsic interleukin-2 response thresholds guides design of a regulatory T cell biased agonist.
eLife
Glassman CR,Su L,Majri-Morrison SS,Winkelmann H,Mo F,Li P,Pérez-Cruz M,Ho PP,Koliesnik I,Nagy N,Hnizdilova T,Picton LK,Kovar M,Bollyky P,Steinman L,Meyer E,Piehler J,Leonard WJ,Garcia KC
47-0454 was used in Flow cytometry/Cell sorting to show that cytokine partial agonists can be used to calibrate intrinsic differences in response thresholds across responding cell types to narrow pleiotropic actions, which may be generalizable to other cytokine and growth factor systems.
Tue May 18 00:00:00 EDT 2021
Serum Amyloid A Proteins Induce Pathogenic Th17 Cells and Promote Inflammatory Disease.
Cell
Lee JY,Hall JA,Kroehling L,Wu L,Najar T,Nguyen HH,Lin WY,Yeung ST,Silva HM,Li D,Hine A,Loke P,Hudesman D,Martin JC,Kenigsberg E,Merad M,Khanna KM,Littman DR
47-0454 was used in Flow cytometry/Cell sorting to suggest that serum amyloid A proteins direct a pathogenic pro-inflammatory Th17 cell differentiation program and promote Th17-mediated inflammatory diseases.
Thu Jan 09 00:00:00 EST 2020
The Intermucosal Connection between the Mouth and Gut in Commensal Pathobiont-Driven Colitis.
Cell
Kitamoto S,Nagao-Kitamoto H,Jiao Y,Gillilland MG,Hayashi A,Imai J,Sugihara K,Miyoshi M,Brazil JC,Kuffa P,Hill BD,Rizvi SM,Wen F,Bishu S,Inohara N,Eaton KA,Nusrat A,Lei YL,Giannobile WV,Kamada N
47-0454-82 was used in Flow Cytometry to conclude that oral inflammation, such as periodontitis, exacerbates gut inflammation by supplying the gut with both colitogenic pathobionts and pathogenic T cells.
Thu Jul 23 00:00:00 EDT 2020
Adaptive response to inflammation contributes to sustained myelopoiesis and confers a competitive advantage in myelodysplastic syndrome HSCs.
Nature immunology
Muto T,Walker CS,Choi K,Hueneman K,Smith MA,Gul Z,Garcia-Manero G,Ma A,Zheng Y,Starczynowski DT
47-0454 was used in Flow cytometry/Cell sorting to show that chronic inflammation is a determinant for the competitive advantage of myelodysplastic syndrome (MDS) hematopoietic stem and progenitor cells (HSPCs) and for disease progression.
Fri May 01 00:00:00 EDT 2020
Transplantation tolerance modifies donor-specific B cell fate to suppress de novo alloreactive B cells.
The Journal of clinical investigation
Khiew SH,Jain D,Chen J,Yang J,Yin D,Young JS,Dent A,Sciammas R,Alegre ML,Chong AS
47-0454 was used in Flow cytometry/Cell sorting to showed that alloreactive B cells were not deleted but rapidly lost their ability to differentiate into germinal center B cells and secrete donor-specific antibodies., by using a murine model of heart tolerance.
Wed Jul 01 00:00:00 EDT 2020
Critical role of WNK1 in MYC-dependent early mouse thymocyte development.
eLife
Köchl R,Vanes L,Llorian Sopena M,Chakravarty P,Hartweger H,Fountain K,White A,Cowan J,Anderson G,Tybulewicz VL
47-0454 was used in Flow cytometry/Cell sorting to ind that WNK1 is required for the transition of double negative (DN) thymocytes through the β-selection checkpoint and subsequent proliferation and differentiation into double positive (DP) thymocytes.
Wed Oct 14 00:00:00 EDT 2020
TNFAIP3 Plays a Role in Aging of the Hematopoietic System.
Frontiers in immunology
Smith MA,Culver-Cochran AE,Adelman ER,Rhyasen GW,Ma A,Figueroa ME,Starczynowski DT
47-0454-82 was used in Flow Cytometry to find that the expression of A20 is significantly reduced in aged hematopoietic stem and progenitor cells (HSPC) as compared to young HSPC.
Wed Apr 28 00:00:00 EDT 2021
Osteoprotegerin-dependent M cell self-regulation balances gut infection and immunity.
Nature communications
Kimura S,Nakamura Y,Kobayashi N,Shiroguchi K,Kawakami E,Mutoh M,Takahashi-Iwanaga H,Yamada T,Hisamoto M,Nakamura M,Udagawa N,Sato S,Kaisho T,Iwanaga T,Hase K
47-0454 was used in Flow cytometry/Cell sorting to identify that the balance between infectious risk and the ability to perform immunosurveillance at the mucosal surface is dependent on osteprotegerin-dependent self-regulation of M cell differentiation.
Mon Jan 13 00:00:00 EST 2020
Inflammation-Induced Lactate Leads to Rapid Loss of Hepatic Tissue-Resident NK Cells.
Cell reports
Dodard G,Tata A,Erick TK,Jaime D,Miah SMS,Quatrini L,Escalière B,Ugolini S,Vivier E,Brossay L
47-0454 was used in Flow cytometry/Cell sorting to characterize the kinetics and immune response of each of the hepatic NK cell populations to viral challenge and other stimuli.
Tue Jul 07 00:00:00 EDT 2020
The Bone Marrow Protects and Optimizes Immunological Memory during Dietary Restriction.
Cell
Collins N,Han SJ,Enamorado M,Link VM,Huang B,Moseman EA,Kishton RJ,Shannon JP,Dixit D,Schwab SR,Hickman HD,Restifo NP,McGavern DB,Schwartzberg PL,Belkaid Y
47-0454-82 was used in Flow Cytometry to show that memory T cells collapsed in secondary lymphoid organs in the context of dietary restriction (DR) but dramatically accumulated within the bone marrow (BM), where they adopted a state associated with energy conservation.
Thu Aug 22 00:00:00 EDT 2019
The chemokine receptor CCR7 is a promising target for rheumatoid arthritis therapy.
Cellular & molecular immunology
Moschovakis GL,Bubke A,Friedrichsen M,Ristenpart J,Back JW,Falk CS,Kremmer E,Förster R
47-0454-82 was used in Flow Cytometry to demonstrate that CCR7 signaling is essential for the induction of CIA and identify CCR7 as a potential therapeutic target in RA.
Tue Oct 01 00:00:00 EDT 2019
PTCy ameliorates GVHD by restoring regulatory and effector T-cell homeostasis in recipients with PD-1 blockade.
Blood advances
Ikegawa S,Meguri Y,Kondo T,Sugiura H,Sando Y,Nakamura M,Iwamoto M,Maeda Y,Matsuoka KI
47-0454-82 was used in Flow Cytometry to present that the influence of PD-1 blockade differed within T-cell subsets and caused unbalanced reconstitution of T-cell subsets, resulting in severe GVHD. PTCy successfully restored T-cell homeostasis and ameliorated GVHD induced by PD-1-/- donor T cells.
Tue Dec 10 00:00:00 EST 2019
ATP released by intestinal bacteria limits the generation of protective IgA against enteropathogens.
Nature communications
Proietti M,Perruzza L,Scribano D,Pellegrini G,D'Antuono R,Strati F,Raffaelli M,Gonzalez SF,Thelen M,Hardt WD,Slack E,Nicoletti M,Grassi F
47-0454 was used in Flow cytometry/Cell sorting to show that modulation of eATP in the small intestine can affect high-affinity IgA response against gut colonizing bacteria.
Wed Jan 16 00:00:00 EST 2019
Qa-1-Restricted CD8+ T Cells Can Compensate for the Absence of Conventional T Cells during Viral Infection.
Cell reports
Anderson CK,Reilly EC,Lee AY,Brossay L
47-0454 was used in Flow cytometry/Cell sorting to study compensatory mechanisms in immune responses to viruses when classical T cell immunity has been evaded.
Tue Apr 09 00:00:00 EDT 2019
The Sympathetic Nervous System Mitigates CNS Autoimmunity via β2-Adrenergic Receptor Signaling in Immune Cells.
Cell reports
Araujo LP,Maricato JT,Guereschi MG,Takenaka MC,Nascimento VM,de Melo FM,Quintana FJ,Brum PC,Basso AS
47-0454-82 was used in Flow Cytometry to uncover a suppressive role for the SNS in CNS autoimmunity while they identify potential targets for therapeutic intervention.
Tue Sep 17 00:00:00 EDT 2019
Blimp1 Prevents Methylation of Foxp3 and Loss of Regulatory T Cell Identity at Sites of Inflammation.
Cell reports
Garg G,Muschaweckh A,Moreno H,Vasanthakumar A,Floess S,Lepennetier G,Oellinger R,Zhan Y,Regen T,Hiltensperger M,Peter C,Aly L,Knier B,Palam LR,Kapur R,Kaplan MH,Waisman A,Rad R,Schotta G,Huehn J,Kallies A,Korn T
47-0454 was used in Flow cytometry/Cell sorting to identify a Blimp1-dependent pathway that preserves Treg cell stability in inflamed non-lymphoid tissues.
Tue Feb 12 00:00:00 EST 2019
Fractalkine Modulates Microglia Metabolism in Brain Ischemia.
Frontiers in cellular neuroscience
Lauro C,Chece G,Monaco L,Antonangeli F,Peruzzi G,Rinaldo S,Paone A,Cutruzzolà F,Limatola C
47-0454 was used in Flow cytometry/Cell sorting to investigate the involvement of CX3CL1 in the modulation of microglia phenotype and the underlying neuroprotective effect on ischemia injury.
Wed Sep 30 00:00:00 EDT 2020
Critical Role for the Microbiota in CX3CR1+ Intestinal Mononuclear Phagocyte Regulation of Intestinal T Cell Responses.
Immunity
Kim M,Galan C,Hill AA,Wu WJ,Fehlner-Peach H,Song HW,Schady D,Bettini ML,Simpson KW,Longman RS,Littman DR,Diehl GE
47-0454 was used in Flow cytometry/Cell sorting to identify a cellular mechanism by which the microbiota limits intestinal inflammation and promotes tissue homeostasis.
Tue Jul 17 00:00:00 EDT 2018
Interleukin-17-Producing γδ T Cells Originate from SOX13+ Progenitors that Are Independent of γδTCR Signaling.
Immunity
Spidale NA,Sylvia K,Narayan K,Miu B,Frascoli M,Melichar HJ,Zhihao W,Kisielow J,Palin A,Serwold T,Love P,Kobayashi M,Yoshimoto M,Jain N,Kang J
47-0454-82 was used in Flow Cytometry to generate reporter mice for the Tγδ17 lineage-defining transcription factor SOX13 and identify fetal-origin, intrathymic Sox13+ progenitors.
Tue Nov 20 00:00:00 EST 2018
Gain-of-Function Mutation of Card14 Leads to Spontaneous Psoriasis-like Skin Inflammation through Enhanced Keratinocyte Response to IL-17A.
Immunity
Wang M,Zhang S,Zheng G,Huang J,Songyang Z,Zhao X,Lin X
47-0454 was used in Flow cytometry/Cell sorting to show CARMA2 serves as a key mediator of IL-17A signaling and its constitutive activation in keratinocytes leads to the onset of psoriasis.
Tue Jul 17 00:00:00 EDT 2018
IL1RAP potentiates multiple oncogenic signaling pathways in AML.
The Journal of experimental medicine
Mitchell K,Barreyro L,Todorova TI,Taylor SJ,Antony-Debré I,Narayanagari SR,Carvajal LA,Leite J,Piperdi Z,Pendurti G,Mantzaris I,Paietta E,Verma A,Gritsman K,Steidl U
47-0454 was used in Flow cytometry to show that targeting of interleukin-1 receptor accessory protein via RNA interference, genetic deletion, or antibodies inhibits acute myeloid leukaemia pathogenesis in vitro and in vivo.
Mon Jun 04 00:00:00 EDT 2018
Human cancer evolution in the context of a human immune system in mice.
Molecular oncology
Gammelgaard OL,Terp MG,Preiss B,Ditzel HJ
47-0454 was used in Flow cytometry/Cell sorting to suggest that HIS mice may provide a promising in vivo tumor model for evaluating immune modulatory anticancer therapies.
Mon Oct 01 00:00:00 EDT 2018
Improved in vitro and in vivo activity against CD303-expressing targets of the chimeric 122A2 antibody selected for specific glycosylation pattern.
mAbs
Fournier N,Jacque E,Fontayne A,Derache D,Dupont G,Verhaeghe L,Baptista L,Dehenne A,Dezetter AS,Terrier A,Longue A,Pochet-Beghin V,Beghin C,Chtourou S,de Romeuf C
47-0454 was used in Flow cytometry/Cell sorting to indicate that ch122A2 mAb could represent a promising cytotoxic mAb candidate for pathologies requiring a decrease in type I IFNs or pDCs.
Mon Aug 12 00:00:00 EDT 2019
Renal Sodium Gradient Orchestrates a Dynamic Antibacterial Defense Zone.
Cell
Berry MR,Mathews RJ,Ferdinand JR,Jing C,Loudon KW,Wlodek E,Dennison TW,Kuper C,Neuhofer W,Clatworthy MR
47-0454-82 was used in Flow Cytometry to reveal a critical accessory role for the homeostatic function of a vital organ in optimizing tissue defense.
Thu Aug 24 00:00:00 EDT 2017
Commensal Microbes and Hair Follicle Morphogenesis Coordinately Drive Treg Migration into Neonatal Skin.
Cell host & microbe
Scharschmidt TC,Vasquez KS,Pauli ML,Leitner EG,Chu K,Truong HA,Lowe MM,Sanchez Rodriguez R,Ali N,Laszik ZG,Sonnenburg JL,Millar SE,Rosenblum MD
47-0454 was used in Flow cytometry/Cell sorting to show that hair follicle (HF) development facilitates the accumulation of regulatory T cells in neonatal skin and that upon skin entry these cells localise to HFs.
Wed Apr 12 00:00:00 EDT 2017
Ubiquitination of hnRNPA1 by TRAF6 links chronic innate immune signaling with myelodysplasia.
Nature immunology
Fang J,Bolanos LC,Choi K,Liu X,Christie S,Akunuru S,Kumar R,Wang D,Chen X,Greis KD,Stoilov P,Filippi MD,Maciejewski JP,Garcia-Manero G,Weirauch MT,Salomonis N,Geiger H,Zheng Y,Starczynowski DT
47-0454 was used in Flow cytometry/Cell sorting to examine the significance of ubiquitin signalling in coordinating RNA processing by Toll-like receptor pathways during an immune response and in premalignant haematologic diseases.
Wed Feb 01 00:00:00 EST 2017
Lentiviral Vectors with Cellular Promoters Correct Anemia and Lethal Bone Marrow Failure in a Mouse Model for Diamond-Blackfan Anemia.
Molecular therapy : the journal of the American Society of Gene Therapy
Debnath S,Jaako P,Siva K,Rothe M,Chen J,Dahl M,Gaspar HB,Flygare J,Schambach A,Karlsson S
47-0454 was used in Flow cytometry/Cell sorting to assess the efficacy of the human elongation factor 1α short promoter with or without the locus control region of the Β-globin gene for treatment of ribosomal protein S19-deficient Diamond-Blackfan anaemia.
Wed Aug 02 00:00:00 EDT 2017
Engineered erythrocytes covalently linked to antigenic peptides can protect against autoimmune disease.
Proceedings of the National Academy of Sciences of the United States of America
Pishesha N,Bilate AM,Wibowo MC,Huang NJ,Li Z,Deshycka R,Bousbaine D,Li H,Patterson HC,Dougan SK,Maruyama T,Lodish HF,Ploegh HL
47045482 was used in flow cytometry to investigate the use of red blood cells expressing disease-associated autoantigenas a means of inducing antigen-specific tolerance
Tue Mar 21 00:00:00 EDT 2017
Loss of MAPK-activated protein kinase 2 enables potent dendritic cell-driven anti-tumour T cell response.
Scientific reports
Soukup K,Halfmann A,Dillinger B,Poyer F,Martin K,Blauensteiner B,Kauer M,Kuttke M,Schabbauer G,Dohnal AM
47-0454 was used in Flow cytometry/Cell sorting to suggest that MAPK-activated protein kinase 2 deletion leads to an expansion of stimulatory CD103+ dendritic cells, mounting a potent CD8+ T cell anti-tumour response in mice.
Mon Sep 18 00:00:00 EDT 2017
Group A Streptococcus intranasal infection promotes CNS infiltration by streptococcal-specific Th17 cells.
The Journal of clinical investigation
Dileepan T,Smith ED,Knowland D,Hsu M,Platt M,Bittner-Eddy P,Cohen B,Southern P,Latimer E,Harley E,Agalliu D,Cleary PP
47-0454 was used in Flow cytometry/Cell sorting to elucidate the immunopathological contribution of Group A streptococci (GAS)-specific CD4+ T cells in the induced neuropathology following infection with GAS.
Fri Jan 01 00:00:00 EST 2016
Regenerative Potential of Mesenchymal Stromal Cells: Age-Related Changes.
Stem cells international
Bruna F,Contador D,Conget P,Erranz B,Sossa CL,Arango-Rodríguez ML
47-0454 was used in Flow cytometry/Cell sorting to suggest, the treatment with adult''s BM-MSCs or their acd-MSCs in cutaneous wound promotes a better tissue repair/regeneration.
Wed Jun 01 00:00:00 EDT 2016
Pivotal role for skin transendothelial radio-resistant anti-inflammatory macrophages in tissue repair.
eLife
Barreiro O,Cibrian D,Clemente C,Alvarez D,Moreno V,Valiente Í,Bernad A,Vestweber D,Arroyo AG,Martín P,von Andrian UH,Sánchez Madrid F
47-0454 was used in Flow cytometry/Cell sorting to describe a novel subset of murine dermal perivascular macrophages that extend protrusions across the endothelial junctions in steady-state and capture blood-borne macromolecules.
Wed Jun 15 00:00:00 EDT 2016
BAFF activation of the ERK5 MAP kinase pathway regulates B cell survival.
The Journal of experimental medicine
Jacque E,Schweighoffer E,Tybulewicz VL,Ley SC
47-0454 was used in Flow cytometry/Cell sorting to reveal a potentially critical role for the MEK5-ERK5 MAP kinase signalling pathway in BAFF-induced mature B cell survival and homeostatic maintenance of B2 cell numbers.
Mon Jun 01 00:00:00 EDT 2015
A Threshold Level of Intratumor CD8+ T-cell PD1 Expression Dictates Therapeutic Response to Anti-PD1.
Cancer research
Ngiow SF,Young A,Jacquelot N,Yamazaki T,Enot D,Zitvogel L,Smyth MJ
47-0454 was used in Flow cytometry/Cell sorting to provide a framework to interrogate intra-tumour CD8(+) T-cell PD1 and immune PDL1 levels and response in human cancer.
Tue Sep 15 00:00:00 EDT 2015
Leptin receptor signaling in T cells is required for Th17 differentiation.
Journal of immunology (Baltimore, Md. : 1950)
Reis BS,Lee K,Fanok MH,Mascaraque C,Amoury M,Cohn LB,Rogoz A,Dallner OS,Moraes-Vieira PM,Domingos AI,Mucida D
47-0454 was used in Flow cytometry/Cell sorting to show that leptin receptor signalling in T cells is required for Th17 differentiation.
Mon Jun 01 00:00:00 EDT 2015
Targeting Antigen to Clec9A Primes Follicular Th Cell Memory Responses Capable of Robust Recall.
Journal of immunology (Baltimore, Md. : 1950)
Kato Y,Zaid A,Davey GM,Mueller SN,Nutt SL,Zotos D,Tarlinton DM,Shortman K,Lahoud MH,Heath WR,Caminschi I
47-0454 was used in Flow cytometry/Cell sorting to examine how Clec9A targeting promotes the development of follicular Th cells.
Sat Aug 01 00:00:00 EDT 2015
A 3-D enteroid-based model to study T-cell and epithelial cell interaction.
Journal of immunological methods
Rogoz A,Reis BS,Karssemeijer RA,Mucida D
47-0454 was used in Flow cytometry/Cell sorting to describe a novel method for studying specific pathways in intestinal epithelial cell or immune cell compartments.
Mon Jun 01 00:00:00 EDT 2015
The miR-126-VEGFR2 axis controls the innate response to pathogen-associated nucleic acids.
Nature immunology
Agudo J,Ruzo A,Tung N,Salmon H,Leboeuf M,Hashimoto D,Becker C,Garrett-Sinha LA,Baccarini A,Merad M,Brown BD
47-0454 was used in Flow cytometry/Cell sorting to identify the miR-126-VEGFR2 axis as an important regulator of the innate response that operates through multiscale control of pDCs.
Wed Jan 01 00:00:00 EST 2014
Collective nitric oxide production provides tissue-wide immunity during Leishmania infection.
The Journal of clinical investigation
Olekhnovitch R,Ryffel B,Müller AJ,Bousso P
47-0454 was used in Flow cytometry/Cell sorting to investigate the contribution of cell-intrinsic and cell-extrinsic nitric oxide activity on the control of Leishmania major infection.
Tue Apr 01 00:00:00 EDT 2014
Parasite fate and involvement of infected cells in the induction of CD4+ and CD8+ T cell responses to Toxoplasma gondii.
PLoS pathogens
Dupont CD,Christian DA,Selleck EM,Pepper M,Leney-Greene M,Harms Pritchard G,Koshy AA,Wagage S,Reuter MA,Sibley LD,Betts MR,Hunter CA
47-0454 was used in Flow cytometry/Cell sorting to identify a critical role for actively infected host cells in initiating T. gondii-specific CD4+ and CD8+ T cell responses.
Tue Apr 01 00:00:00 EDT 2014
Recruitment of bone marrow-derived cells to periodontal tissue defects.
Frontiers in cell and developmental biology
Kimura Y,Komaki M,Iwasaki K,Sata M,Izumi Y,Morita I
47-0454 was used in Flow cytometry/Cell sorting to study the recruitment of bone marrow-derived cells to periodontal tissue defects.
Mon Nov 03 00:00:00 EST 2014
Foxp3 expression in macrophages associated with RENCA tumors in mice.
PloS one
Devaud C,Yong CS,John LB,Westwood JA,Duong CP,House CM,Denoyer D,Li J,Darcy PK,Kershaw MH
47-0454 was used in Flow cytometry/Cell sorting to study how tumour-associated macrophages could express Foxp3.
Mon Nov 16 00:00:00 EST 2015
Absence of signaling into CD4⁺ cells via C3aR and C5aR enables autoinductive TGF-β1 signaling and induction of Foxp3⁺ regulatory T cells.
Nature immunology
Strainic MG,Shevach EM,An F,Lin F,Medof ME
47-0454 was used in Flow cytometry/Cell sorting to demonstrate that a lack of signalling can convert CD4(+) cells to Foxp3(+) iT(reg) cells, amongst other effects.
Fri Feb 01 00:00:00 EST 2013
Host immunity contributes to the anti-melanoma activity of BRAF inhibitors.
The Journal of clinical investigation
Knight DA,Ngiow SF,Li M,Parmenter T,Mok S,Cass A,Haynes NM,Kinross K,Yagita H,Koya RC,Graeber TG,Ribas A,McArthur GA,Smyth MJ
47-0454 was used in Flow cytometry/Cell sorting to investigate the contribution of host immunity to the anti-melanoma activity of BRAF inhibitors.
Fri Mar 01 00:00:00 EST 2013
A role for IL-27 in limiting T regulatory cell populations.
Journal of immunology (Baltimore, Md. : 1950)
Wojno ED,Hosken N,Stumhofer JS,O'Hara AC,Mauldin E,Fang Q,Turka LA,Levin SD,Hunter CA
47-0454 was used in Flow cytometry/Cell sorting to show that mice that overexpress IL-27 had decreased Treg frequencies and developed spontaneous inflammation.
Fri Jul 01 00:00:00 EDT 2011
Targeting of B and T lymphocyte associated (BTLA) prevents graft-versus-host disease without global immunosuppression.
The Journal of experimental medicine
Albring JC,Sandau MM,Rapaport AS,Edelson BT,Satpathy A,Mashayekhi M,Lathrop SK,Hsieh CS,Stelljes M,Colonna M,Murphy TL,Murphy KM
47-0454 was used in Flow cytometry/Cell sorting to show that administration of a nondepleting, monoclonal antibody permanently prevented graft-versus-host-disease when administered at the time of the transplant.
Mon Nov 22 00:00:00 EST 2010
