Product References
Smc3 dosage regulates B cell transit through germinal centers and restricts their malignant transformation.
Nature immunology
Rivas MA,Meydan C,Chin CR,Challman MF,Kim D,Bhinder B,Kloetgen A,Viny AD,Teater MR,McNally DR,Doane AS,Béguelin W,Fernández MTC,Shen H,Wang X,Levine RL,Chen Z,Tsirigos A,Elemento O,Mason CE,Melnick AM
Published figure using CD45.2 monoclonal antibody (Product # 14-0454-82) in Flow Cytometry
Mon Feb 01 00:00:00 EST 2021
Niche-specific MHC II and PD-L1 regulate CD4+CD8αα+ intraepithelial lymphocyte differentiation.
The Journal of experimental medicine
Moon S,Park Y,Hyeon S,Kim YM,Kim JH,Kim H,Park S,Lee KJ,Koo BK,Ha SJ,Lee SW
Published figure using CD45.2 monoclonal antibody (Product # 14-0454-82) in Flow Cytometry
Mon Apr 05 00:00:00 EDT 2021
Aggravation of hepatic ischemia‑reperfusion injury with increased inflammatory cell infiltration is associated with the TGF‑β/Smad3 signaling pathway.
Molecular medicine reports
Li H,Shen X,Tong Y,Ji T,Feng Y,Tang Y,Mai R,Ye J,Que T,Luo X
14-0454-82 was used in Immunohistochemistry to investigate the role of the TGF‚β/Smad3 signaling pathway on hepatic injury induced by ischemia‚reperfusion in vivo.
Sun Aug 01 00:00:00 EDT 2021
Aggravation of hepatic ischemia‑reperfusion injury with increased inflammatory cell infiltration is associated with the TGF‑β/Smad3 signaling pathway.
Molecular medicine reports
Li H,Shen X,Tong Y,Ji T,Feng Y,Tang Y,Mai R,Ye J,Que T,Luo X
14-0454-82 was used in Immunohistochemistry to investigate the role of the TGF‚β/Smad3 signaling pathway on hepatic injury induced by ischemia‚reperfusion in vivo.
Sun Aug 01 00:00:00 EDT 2021
Brd4 modulates diet-induced obesity via PPARγ-dependent Gdf3 expression in adipose tissue macrophages.
JCI insight
Hu X,Dong X,Li G,Chen Y,Chen J,He X,Sun H,Kim DH,Kemper JK,Chen LF
Published figure using CD45.2 monoclonal antibody (Product # 14-0454-82) in Flow Cytometry
Thu Apr 08 00:00:00 EDT 2021
Differentiation of fetal hematopoietic stem cells requires ARID4B to restrict autocrine KITLG/KIT-Src signaling.
Cell reports
Young IC,Wu B,Andricovich J,Chuang ST,Li R,Tzatsos A,Wu RC,Wu MY
Published figure using CD45.2 monoclonal antibody (Product # 14-0454-82) in Flow Cytometry
Tue Nov 23 00:00:00 EST 2021
Erythritol Ameliorates Small Intestinal Inflammation Induced by High-Fat Diets and Improves Glucose Tolerance.
International journal of molecular sciences
Kawano R,Okamura T,Hashimoto Y,Majima S,Senmaru T,Ushigome E,Asano M,Yamazaki M,Takakuwa H,Sasano R,Nakanishi N,Hamaguchi M,Fukui M
Published figure using CD45.2 monoclonal antibody (Product # 14-0454-82) in Flow Cytometry
Mon May 24 00:00:00 EDT 2021
Expansion of an Unusual Virtual Memory CD8+ Subpopulation Bearing Vα3.2 TCR in Themis-Deficient Mice.
Frontiers in immunology
Prasad M,Wojciech L,Brzostek J,Hu J,Chua YL,Tung DWH,Yap J,Rybakin V,Gascoigne NRJ
Published figure using CD45.2 monoclonal antibody (Product # 14-0454-82) in Flow Cytometry
Thu Sep 23 00:00:00 EDT 2021
The subunits of IL-12, originating from two distinct cells, can functionally synergize to protect against pathogen dissemination in vivo.
Cell reports
Gerber AN,Abdi K,Singh NJ
Published figure using CD45.2 monoclonal antibody (Product # 14-0454-82) in Flow Cytometry
Tue Oct 12 00:00:00 EDT 2021
Ddb1 Is Essential for the Expansion of CD4+ Helper T Cells by Regulating Cell Cycle Progression and Cell Death.
Frontiers in immunology
Yang L,Chen W,Li L,Xiao Y,Fan S,Zhang Q,Xia T,Li M,Hong Y,Zhao T,Li Q,Liu WH,Xiao N
Published figure using CD45.2 monoclonal antibody (Product # 14-0454-82) in Flow Cytometry
Mon Dec 20 00:00:00 EST 2021
Abraxane-induced bone marrow CD11b+ myeloid cell depletion in tumor-bearing mice is visualized by μPET-CT with 64Cu-labeled anti-CD11b and prevented by anti-CSF-1.
Theranostics
Cao Q,Huang Q,Wang YA,Li C
Published figure using CD45.2 monoclonal antibody (Product # 14-0454-82) in Flow Cytometry
Fri Jul 23 00:00:00 EDT 2021
Kidney tissue hypoxia dictates T cell-mediated injury in murine lupus nephritis.
Science translational medicine
Chen PM,Wilson PC,Shyer JA,Veselits M,Steach HR,Cui C,Moeckel G,Clark MR,Craft J
14-0454-82 was used in Functional assay to elucidate the mechanisms of immune cell adaptation to kidney tissue and subsequent damage in murine lupus nephritis.
Wed Apr 08 00:00:00 EDT 2020
Deregulated Notch and Wnt signaling activates early-stage myeloid regeneration pathways in leukemia.
The Journal of experimental medicine
Kang YA,Pietras EM,Passegué E
Published figure using CD45.2 monoclonal antibody (Product # 14-0454-82) in Flow Cytometry
Mon Mar 02 00:00:00 EST 2020
Proenkephalin+ regulatory T cells expanded by ultraviolet B exposure maintain skin homeostasis with a healing function.
Proceedings of the National Academy of Sciences of the United States of America
Shime H,Odanaka M,Tsuiji M,Matoba T,Imai M,Yasumizu Y,Uraki R,Minohara K,Watanabe M,Bonito AJ,Fukuyama H,Ohkura N,Sakaguchi S,Morita A,Yamazaki S
Published figure using CD45.2 monoclonal antibody (Product # 14-0454-82) in Flow Cytometry
Tue Aug 25 00:00:00 EDT 2020
Proenkephalin+ regulatory T cells expanded by ultraviolet B exposure maintain skin homeostasis with a healing function.
Proceedings of the National Academy of Sciences of the United States of America
Shime H,Odanaka M,Tsuiji M,Matoba T,Imai M,Yasumizu Y,Uraki R,Minohara K,Watanabe M,Bonito AJ,Fukuyama H,Ohkura N,Sakaguchi S,Morita A,Yamazaki S
Published figure using CD45.2 monoclonal antibody (Product # 14-0454-82) in Flow Cytometry
Tue Aug 25 00:00:00 EDT 2020
Interleukin 35 Delays Hindlimb Ischemia-Induced Angiogenesis Through Regulating ROS-Extracellular Matrix but Spares Later Regenerative Angiogenesis.
Frontiers in immunology
Fu H,Sun Y,Shao Y,Saredy J,Cueto R,Liu L,Drummer C,Johnson C,Xu K,Lu Y,Li X,Meng S,Xue ER,Tan J,Jhala NC,Yu D,Zhou Y,Bayless KJ,Yu J,Rogers TJ,Hu W,Snyder NW,Sun J,Qin X,Jiang X,Wang H,Yang X
Published figure using CD45.2 monoclonal antibody (Product # 14-0454-82) in Flow Cytometry
Fri Jul 09 00:00:00 EDT 2021
The frequency of follicular T helper cells differs in acute and chronic neuroinflammation.
Scientific reports
Baniahmad A,Birkner K,Görg J,Loos J,Zipp F,Wasser B,Bittner S
Published figure using CD45.2 monoclonal antibody (Product # 14-0454-82) in Flow Cytometry
Tue Nov 24 00:00:00 EST 2020
Mitochondrial Oxidative Phosphorylation Regulates the Fate Decision between Pathogenic Th17 and Regulatory T Cells.
Cell reports
Shin B,Benavides GA,Geng J,Koralov SB,Hu H,Darley-Usmar VM,Harrington LE
14-0454 was used in Flow cytometry/Cell sorting to study the role of mitochondrial oxidative phosphorylation in pathogenic Th17 differentiation.
Tue Feb 11 00:00:00 EST 2020
Long-term ex vivo haematopoietic-stem-cell expansion allows nonconditioned transplantation.
Nature
Wilkinson AC,Ishida R,Kikuchi M,Sudo K,Morita M,Crisostomo RV,Yamamoto R,Loh KM,Nakamura Y,Watanabe M,Nakauchi H,Yamazaki S
Published figure using CD45.2 monoclonal antibody (Product # 14-0454-82) in Flow Cytometry
Mon Jul 01 00:00:00 EDT 2019
Commensal Microbiota Promote Lung Cancer Development via γδ T Cells.
Cell
Jin C,Lagoudas GK,Zhao C,Bullman S,Bhutkar A,Hu B,Ameh S,Sandel D,Liang XS,Mazzilli S,Whary MT,Meyerson M,Germain R,Blainey PC,Fox JG,Jacks T
14-0454-82 was used in Flow Cytometry to link local microbiota-immune crosstalk to lung tumor development and thereby define key cellular and molecular mediators that may serve as effective targets in lung cancer intervention.
Thu Feb 21 00:00:00 EST 2019
TBKBP1 and TBK1 form a growth factor signalling axis mediating immunosuppression and tumourigenesis.
Nature cell biology
Zhu L,Li Y,Xie X,Zhou X,Gu M,Jie Z,Ko CJ,Gao T,Hernandez BE,Cheng X,Sun SC
14-0454 was used in Flow cytometry/Cell sorting to suggest a PKCθ-TBKBP1-TBK1 growth factor signalling axis that mediates both tumour growth and immunosuppression.
Sun Dec 01 00:00:00 EST 2019
Bone marrow dendritic cells regulate hematopoietic stem/progenitor cell trafficking.
The Journal of clinical investigation
Zhang J,Supakorndej T,Krambs JR,Rao M,Abou-Ezzi G,Ye RY,Li S,Trinkaus K,Link DC
14-0454-82 was used in Flow Cytometry to show that HSPC mobilization after cDC ablation is attenuated in mice lacking CXCR2 expression.
Tue Apr 30 00:00:00 EDT 2019
Inducible IL-7 Hyperexpression Influences Lymphocyte Homeostasis and Function and Increases Allograft Rejection.
Frontiers in immunology
Schreiber M,Weigelt M,Karasinsky A,Anastassiadis K,Schallenberg S,Petzold C,Bonifacio E,Kretschmer K,Hommel A
14-0454 was used in Flow cytometry/Cell sorting to show that transient hyperexpression of IL-7 can impair immune regulation, through disturbances in lymphocyte development pathways, and decrease graft survival time, even under immunosuppression.
Mon Sep 14 00:00:00 EDT 2020
Critical role of post-transcriptional regulation for IFN-γ in tumor-infiltrating T cells.
Oncoimmunology
Salerno F,Guislain A,Freen-Van Heeren JJ,Nicolet BP,Young HA,Wolkers MC
14-0454 was used in Flow cytometry/Cell sorting to conclude that post-transcriptional mechanisms could be modulated to potentiate effective T cell therapies in cancer.
Tue Jan 12 00:00:00 EST 2021
Irg1 expression in myeloid cells prevents immunopathology during M. tuberculosis infection.
The Journal of experimental medicine
Nair S,Huynh JP,Lampropoulou V,Loginicheva E,Esaulova E,Gounder AP,Boon ACM,Schwarzkopf EA,Bradstreet TR,Edelson BT,Artyomov MN,Stallings CL,Diamond MS
14-0454-82 was used in Flow Cytometry to study the role of Immune responsive gene 1 in the modulation of inflammation during Mycobacterium tuberculosis infection.
Mon Apr 02 00:00:00 EDT 2018
IL-7-dependent maintenance of ILC3s is required for normal entry of lymphocytes into lymph nodes.
The Journal of experimental medicine
Yang J,Cornelissen F,Papazian N,Reijmers RM,Llorian M,Cupedo T,Coles M,Seddon B
14-0454 was used in Flow cytometry/Cell sorting to investigate whether continued IL-7 expression was required for the maintenance of fully developed, adult lymph nodes.
Mon Apr 02 00:00:00 EDT 2018
Langerin+ DCs regulate innate IL-17 production in the oral mucosa during Candida albicans-mediated infection.
PLoS pathogens
Sparber F,Dolowschiak T,Mertens S,Lauener L,Clausen BE,Joller N,Stoitzner P,Tussiwand R,LeibundGut-Landmann S
14-0454-82 was used in Flow Cytometry to study innate IL-17 dependent antifungal immunity in the oral mucosa.
Tue May 01 00:00:00 EDT 2018
The H3K4 methyltransferase Setd1b is essential for hematopoietic stem and progenitor cell homeostasis in mice.
eLife
Schmidt K,Zhang Q,Tasdogan A,Petzold A,Dahl A,Arneth BM,Slany R,Fehling HJ,Kranz A,Stewart AF,Anastassiadis K
Published figure using CD45.2 monoclonal antibody (Product # 14-0454-82) in Flow Cytometry
Tue Jun 19 00:00:00 EDT 2018
Differential requirement of kindlin-3 for T cell progenitor homing to the non-vascularized and vascularized thymus.
eLife
Moretti FA,Klapproth S,Ruppert R,Margraf A,Weber J,Pick R,Scheiermann C,Sperandio M,Fässler R,Moser M
Published figure using CD45.2 monoclonal antibody (Product # 14-0454-82) in Flow Cytometry
Thu Sep 06 00:00:00 EDT 2018
Elimination of intravascular thrombi prevents early mortality and reduces gliosis in hyper-inflammatory experimental cerebral malaria.
Journal of neuroinflammation
Wilson KD,Ochoa LF,Solomon OD,Pal R,Cardona SM,Carpio VH,Keiser PH,Cardona AE,Vargas G,Stephens R
Published figure using CD45.2 monoclonal antibody (Product # 14-0454-82) in Immunofluorescence
Mon Jun 04 00:00:00 EDT 2018
Fludarabine as a cost-effective adjuvant to enhance engraftment of human normal and malignant hematopoiesis in immunodeficient mice.
Scientific reports
Pievani A,Michelozzi IM,Rambaldi B,Granata V,Corsi A,Dazzi F,Biondi A,Serafini M
14-0454 was used in Flow cytometry/Cell sorting to present a novel and affordable model for engraftment of human normal and malignant hematopoiesis in immunodeficient mice.
Thu Jun 14 00:00:00 EDT 2018
LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells.
Genome biology
Grigoryan A,Guidi N,Senger K,Liehr T,Soller K,Marka G,Vollmer A,Markaki Y,Leonhardt H,Buske C,Lipka DB,Plass C,Zheng Y,Mulaw MA,Geiger H,Florian MC
14-0454 was used in Flow cytometry/Cell sorting to show that not all histone modifications display a polar localization and that a reduction in H4K16ac amount and loss of epipolarity are specific to aged HSCs.
Wed Nov 07 00:00:00 EST 2018
Reduction of MHC-I expression limits T-lymphocyte-mediated killing of Cancer-initiating cells.
BMC cancer
Morrison BJ,Steel JC,Morris JC
14-0454 was used in Flow cytometry/Cell sorting to suggest that the attenuated expression of MHC-I molecules by CICs represents a potential strategy of CICs to escape immune recognition, and that the development of successful immunotherapy strategies targeting CICs may decrease their resistance to T cell-mediated immune detection by enhancing CIC MHC-I expression.
Thu Apr 26 00:00:00 EDT 2018
Myeloid progenitor cluster formation drives emergency and leukaemic myelopoiesis.
Nature
Hérault A,Binnewies M,Leong S,Calero-Nieto FJ,Zhang SY,Kang YA,Wang X,Pietras EM,Chu SH,Barry-Holson K,Armstrong S,Göttgens B,Passegué E
Published figure using CD45.2 monoclonal antibody (Product # 14-0454-82) in Immunofluorescence
Thu Apr 06 00:00:00 EDT 2017
The transcription factor Runx3 guards cytotoxic CD8+ effector T cells against deviation towards follicular helper T cell lineage.
Nature immunology
Shan Q,Zeng Z,Xing S,Li F,Hartwig SM,Gullicksrud JA,Kurup SP,Van Braeckel-Budimir N,Su Y,Martin MD,Varga SM,Taniuchi I,Harty JT,Peng W,Badovinac VP,Xue HH
14-0454-82 was used in Flow Cytometry to show that Runx3-mediated Tcf7 repression coordinately enforced acquisition of cytotoxic functions and protected the cytotoxic lineage integrity by preventing TFH-lineage deviation.
Tue Aug 01 00:00:00 EDT 2017
Membrane-organizing protein moesin controls Treg differentiation and antitumor immunity via TGF-β signaling.
The Journal of clinical investigation
Ansa-Addo EA,Zhang Y,Yang Y,Hussey GS,Howley BV,Salem M,Riesenberg B,Sun S,Rockey DC,Karvar S,Howe PH,Liu B,Li Z
14-0454 was used in Flow cytometry/Cell sorting to investigate whether moesin plays a role during the generation of TGF-β-induced Tregs, showing that it controls Treg differentiation and antitumor immunity.
Mon Apr 03 00:00:00 EDT 2017
Egr2 and 3 control adaptive immune responses by temporally uncoupling expansion from T cell differentiation.
The Journal of experimental medicine
Miao T,Symonds ALJ,Singh R,Symonds JD,Ogbe A,Omodho B,Zhu B,Li S,Wang P
Published figure using CD45.2 monoclonal antibody (Product # 14-0454-82) in Flow Cytometry
Mon Jun 05 00:00:00 EDT 2017
Mast cells acquire MHCII from dendritic cells during skin inflammation.
The Journal of experimental medicine
Dudeck J,Medyukhina A,Fröbel J,Svensson CM,Kotrba J,Gerlach M,Gradtke AC,Schröder B,Speier S,Figge MT,Dudeck A
14-0454 was used in Flow cytometry/Cell sorting to identify an innate intercellular communication arming resident mast cells with key dendritic cell(DC) functions that might contribute to the acute defence potential during critical periods of migration-based DC absence.
Mon Dec 04 00:00:00 EST 2017
Dissection of SAP-dependent and SAP-independent SLAM family signaling in NKT cell development and humoral immunity.
The Journal of experimental medicine
Chen S,Cai C,Li Z,Liu G,Wang Y,Blonska M,Li D,Du J,Lin X,Yang M,Dong Z
14-0454-82 was used in Flow Cytometry to examine NKT cell development and humoral immunity in mice completely deficient in SFR.
Wed Feb 01 00:00:00 EST 2017
Polymicrobial sepsis impairs bystander recruitment of effector cells to infected skin despite optimal sensing and alarming function of skin resident memory CD8 T cells.
PLoS pathogens
Danahy DB,Anthony SM,Jensen IJ,Hartwig SM,Shan Q,Xue HH,Harty JT,Griffith TS,Badovinac VP
14-0454-82 was used in Flow Cytometry to directly examine the impact of sepsis on tissue resident memory CD8+ T cells in mice.
Fri Sep 01 00:00:00 EDT 2017
IL-1β and IL-23 Promote Extrathymic Commitment of CD27+CD122- γδ T Cells to γδT17 Cells.
Journal of immunology (Baltimore, Md. : 1950)
Muschaweckh A,Petermann F,Korn T
14-0454 was used in Flow cytometry/Cell sorting to study the mechanisms by which the peripheral pool of γδ T cells retain a considerable degree of plasticity.
Sun Oct 15 00:00:00 EDT 2017
Recipient bone marrow assimilates the myeloid/lymphoid reconstitution of distinct fetal hematopoietic stem cells.
Oncotarget
Guo XL,Chu L,Ke F,Mu LL,Li Z,Cai JJ,Li HF,Hong DL
Published figure using CD45.2 monoclonal antibody (Product # 14-0454-82) in Flow Cytometry
Tue Dec 12 00:00:00 EST 2017
Pneumocystis-Driven Inducible Bronchus-Associated Lymphoid Tissue Formation Requires Th2 and Th17 Immunity.
Cell reports
Eddens T,Elsegeiny W,Garcia-Hernadez ML,Castillo P,Trevejo-Nunez G,Serody K,Campfield BT,Khader SA,Chen K,Rangel-Moreno J,Kolls JK
Published figure using CD45.2 monoclonal antibody (Product # 14-0454-82) in Flow Cytometry
Tue Mar 28 00:00:00 EDT 2017
Intratumoral modulation of the inducible co-stimulator ICOS by recombinant oncolytic virus promotes systemic anti-tumour immunity.
Nature communications
Zamarin D,Holmgaard RB,Ricca J,Plitt T,Palese P,Sharma P,Merghoub T,Wolchok JD,Allison JP
Published figure using CD45.2 monoclonal antibody (Product # 14-0454-82) in Flow Cytometry
Mon Feb 13 00:00:00 EST 2017
WASH maintains NKp46+ ILC3 cells by promoting AHR expression.
Nature communications
Xia P,Liu J,Wang S,Ye B,Du Y,Xiong Z,Han ZG,Tong L,Fan Z
14-0454 was used in Flow cytometry/Cell sorting to study how WASH-mediated AHR expression has a critical function in the maintenance of NKp46(+) ILC3s.
Wed Jun 07 00:00:00 EDT 2017
Host-Protozoan Interactions Protect from Mucosal Infections through Activation of the Inflammasome.
Cell
Chudnovskiy A,Mortha A,Kana V,Kennard A,Ramirez JD,Rahman A,Remark R,Mogno I,Ng R,Gnjatic S,Amir ED,Solovyov A,Greenbaum B,Clemente J,Faith J,Belkaid Y,Grigg ME,Merad M
Published figure using CD45.2 monoclonal antibody (Product # 14-0454-82) in Flow Cytometry
Thu Oct 06 00:00:00 EDT 2016
The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity.
Cell
Damgaard RB,Walker JA,Marco-Casanova P,Morgan NV,Titheradge HL,Elliott PR,McHale D,Maher ER,McKenzie ANJ,Komander D
Published figure using CD45.2 monoclonal antibody (Product # 14-0454-82) in Flow Cytometry
Thu Aug 25 00:00:00 EDT 2016
Tcf1 and Lef1 transcription factors establish CD8(+) T cell identity through intrinsic HDAC activity.
Nature immunology
Xing S,Li F,Zeng Z,Zhao Y,Yu S,Shan Q,Li Y,Phillips FC,Maina PK,Qi HH,Liu C,Zhu J,Pope RM,Musselman CA,Zeng C,Peng W,Xue HH
14-0454 was used in Flow cytometry/Cell sorting to reveal that sequence-specific transcription factors can utilise intrinsic HDAC activity to guard cell identity by repressing lineage-inappropriate genes.
Wed Jun 01 00:00:00 EDT 2016
Experimentally-induced anti-myeloperoxidase vasculitis does not require properdin, MASP-2 or bone marrow-derived C5.
The Journal of pathology
Freeley SJ,Popat RJ,Parmar K,Kolev M,Hunt BJ,Stover CM,Schwaeble W,Kemper C,Robson MG
14-0454 was used in Flow cytometry/Cell sorting to discover that properdin, bone marrow-derived C5 the lectin pathway are not initiators of complement activation.
Thu Sep 01 00:00:00 EDT 2016
IL-10+ Innate-like B Cells Are Part of the Skin Immune System and Require α4β1 Integrin To Migrate between the Peritoneum and Inflamed Skin.
Journal of immunology (Baltimore, Md. : 1950)
Geherin SA,Gómez D,Glabman RA,Ruthel G,Hamann A,Debes GF
14-0454 was used in Flow cytometry/Cell sorting to investigate innate-like B cells within the skin.
Tue Mar 15 00:00:00 EDT 2016
Blood Stem Cell Activity Is Arrested by Th1-Mediated Injury Preventing Engraftment following Nonmyeloablative Conditioning.
Journal of immunology (Baltimore, Md. : 1950)
Müller AM,Florek M,Kohrt HE,Küpper NJ,Filatenkov A,Linderman JA,Hadeiba H,Negrin RS,Shizuru JA
14-0454 was used in Flow cytometry/Cell sorting to shed new light on the effects of CD4+ T cells on HSC biology.
Tue Nov 15 00:00:00 EST 2016
Murine iPSC-Derived Macrophages as a Tool for Disease Modeling of Hereditary Pulmonary Alveolar Proteinosis due to Csf2rb Deficiency.
Stem cell reports
Mucci A,Kunkiel J,Suzuki T,Brennig S,Glage S,Kühnel MP,Ackermann M,Happle C,Kuhn A,Schambach A,Trapnell BC,Hansen G,Moritz T,Lachmann N
Published figure using CD45.2 monoclonal antibody (Product # 14-0454-82) in Flow Cytometry
Tue Aug 09 00:00:00 EDT 2016
LTβR controls thymic portal endothelial cells for haematopoietic progenitor cell homing and T-cell regeneration.
Nature communications
Shi Y,Wu W,Chai Q,Li Q,Hou Y,Xia H,Ren B,Xu H,Guo X,Jin C,Lv M,Wang Z,Fu YX,Zhu M
Published figure using CD45.2 monoclonal antibody (Product # 14-0454-82) in Immunofluorescence
Fri Aug 05 00:00:00 EDT 2016
Coagulation induced by C3aR-dependent NETosis drives protumorigenic neutrophils during small intestinal tumorigenesis.
Nature communications
Guglietta S,Chiavelli A,Zagato E,Krieg C,Gandini S,Ravenda PS,Bazolli B,Lu B,Penna G,Rescigno M
14-0454 was used in Flow cytometry/Cell sorting to provide a mechanistic explanation for the tumour-promoting effects of hypercoagulation.
Mon Mar 21 00:00:00 EDT 2016
Tumor Progression Locus 2 (Tpl2) Activates the Mammalian Target of Rapamycin (mTOR) Pathway, Inhibits Forkhead Box P3 (FoxP3) Expression, and Limits Regulatory T Cell (Treg) Immunosuppressive Functions.
The Journal of biological chemistry
Li X,Acuff NV,Peeks AR,Kirkland R,Wyatt KD,Nagy T,Watford WT
14-0454-82 was used in Flow Cytometry to demonstrate that the serine/threonine kinase tumour progression locus 2 constrains the development of inducible regulatory T cells.
Fri Aug 05 00:00:00 EDT 2016
Role of TP53 mutations in the origin and evolution of therapy-related acute myeloid leukaemia.
Nature
Wong TN,Ramsingh G,Young AL,Miller CA,Touma W,Welch JS,Lamprecht TL,Shen D,Hundal J,Fulton RS,Heath S,Baty JD,Klco JM,Ding L,Mardis ER,Westervelt P,DiPersio JF,Walter MJ,Graubert TA,Ley TJ,Druley T,Link DC,Wilson RK
14-0454 was used in Flow cytometry/Cell sorting to investigate how prior exposure to cytotoxic therapy influences leukemogenesis and TP53 mutations in t-AML/t-MDS patients.
Thu Feb 26 00:00:00 EST 2015
T-box Transcription Factors Combine with the Cytokines TGF-β and IL-15 to Control Tissue-Resident Memory T Cell Fate.
Immunity
Mackay LK,Wynne-Jones E,Freestone D,Pellicci DG,Mielke LA,Newman DM,Braun A,Masson F,Kallies A,Belz GT,Carbone FR
14-0454 was used in Flow cytometry/Cell sorting to indicate that the T-box TFs control the two cytokines, TGF-β and IL-15, which are pivotal for CD8(+)CD103(+) Trm cell development and survival.
Tue Dec 15 00:00:00 EST 2015
Selective Treg reconstitution during lymphopenia normalizes DC costimulation and prevents graft-versus-host disease.
The Journal of clinical investigation
Bolton HA,Zhu E,Terry AM,Guy TV,Koh WP,Tan SY,Power CA,Bertolino P,Lahl K,Sparwasser T,Shklovskaya E,Fazekas de St Groth B
14-0454 was used in Flow cytometry/Cell sorting to indicate that achieving optimal recovery from lymphopenia should aim to improve early Treg reconstitution to increase the relative number of Tregs to DCs inhibiting spontaneous oligoclonal T cell proliferation.
Tue Sep 01 00:00:00 EDT 2015
Bcl11b is essential for group 2 innate lymphoid cell development.
The Journal of experimental medicine
Walker JA,Oliphant CJ,Englezakis A,Yu Y,Clare S,Rodewald HR,Belz G,Liu P,Fallon PG,McKenzie AN
14-0454 was used in Flow cytometry/Cell sorting to study the role of Bcl11b in the differentiation of group 2 innate lymphoid cells.
Mon Jun 01 00:00:00 EDT 2015
Transcriptional repressor ZEB2 promotes terminal differentiation of CD8+ effector and memory T cell populations during infection.
The Journal of experimental medicine
Omilusik KD,Best JA,Yu B,Goossens S,Weidemann A,Nguyen JV,Seuntjens E,Stryjewska A,Zweier C,Roychoudhuri R,Gattinoni L,Bird LM,Higashi Y,Kondoh H,Huylebroeck D,Haigh J,Goldrath AW
14-0454-82 was used in Flow Cytometry to study the upregulation of ZEB2 by activated T cells, specifically in the KLRG1(hi) effector CD8(+) T cell subset.
Mon Nov 16 00:00:00 EST 2015
TREM-2 promotes macrophage survival and lung disease after respiratory viral infection.
The Journal of experimental medicine
Wu K,Byers DE,Jin X,Agapov E,Alexander-Brett J,Patel AC,Cella M,Gilfilan S,Colonna M,Kober DL,Brett TJ,Holtzman MJ
14-0454 was used in Flow cytometry/Cell sorting to define the link between viral infection and type 2 immune response in chronic respiratory disease, showing that expression of TREM2 in macrophages is required, particularly soluble TREM2, which prevents apoptosis of macrophages and leads to chronic inflammatory disease.
Mon May 04 00:00:00 EDT 2015
Atypical chemokine receptor 1 deficiency reduces atherogenesis in ApoE-knockout mice.
Cardiovascular research
Wan W,Liu Q,Lionakis MS,Marino AP,Anderson SA,Swamydas M,Murphy PM
Published figure using CD45.2 monoclonal antibody (Product # 14-0454-82) in Flow Cytometry
Mon Jun 01 00:00:00 EDT 2015
Transfer of myelin-reactive th17 cells impairs endogenous remyelination in the central nervous system of cuprizone-fed mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Baxi EG,DeBruin J,Tosi DM,Grishkan IV,Smith MD,Kirby LA,Strasburger HJ,Fairchild AN,Calabresi PA,Gocke AR
14-0454 was used in Flow cytometry/Cell sorting to reveal an important role for T-cells and peripheral monocytes in impairing endogenous remyelination in vivo.
Wed Jun 03 00:00:00 EDT 2015
The atypical chemokine receptor ACKR2 suppresses Th17 responses to protein autoantigens.
Immunology and cell biology
Hansell CA,MacLellan LM,Oldham RS,Doonan J,Chapple KJ,Anderson EJ,Linington C,McInnes IB,Nibbs RJ,Goodyear CS
14-0454 was used in Flow cytometry/Cell sorting to investigate the role of ACKR2 in autoimmunity, showing that it suppresses Th17 responses to protein autoantigens.
Sun Feb 01 00:00:00 EST 2015
Dendritic Cell-Based Vaccines that Utilize Myeloid Rather than Plasmacytoid Cells Offer a Superior Survival Advantage in Malignant Glioma.
Journal of immunology (Baltimore, Md. : 1950)
Dey M,Chang AL,Miska J,Wainwright DA,Ahmed AU,Balyasnikova IV,Pytel P,Han Y,Tobias A,Zhang L,Qiao J,Lesniak MS
14-0454 was used in Flow cytometry/Cell sorting to compare the ability of myeloid and plasmacytoid dendritic cells to generate effective antiglioma immunity.
Wed Jul 01 00:00:00 EDT 2015
OX40- and CD27-mediated costimulation synergizes with anti-PD-L1 blockade by forcing exhausted CD8+ T cells to exit quiescence.
Journal of immunology (Baltimore, Md. : 1950)
Buchan S,Manzo T,Flutter B,Rogel A,Edwards N,Zhang L,Sivakumaran S,Ghorashian S,Carpenter B,Bennett C,Freeman GJ,Sykes M,Croft M,Al-Shamkhani A,Chakraverty R
14-0454 was used in Flow cytometry/Cell sorting to study how CD27-mediated co-stimulation can synergise with co-inhibitory checkpoint blockade to switch off molecular programs for quiescence in exhausted T cell populations.
Thu Jan 01 00:00:00 EST 2015
PI3Kδ Regulates the Magnitude of CD8+ T Cell Responses after Challenge with Listeria monocytogenes.
Journal of immunology (Baltimore, Md. : 1950)
Pearce VQ,Bouabe H,MacQueen AR,Carbonaro V,Okkenhaug K
14-0454 was used in Flow cytometry/Cell sorting to investigate the effect of inhibition of the p110δ subunit of PI3Kδ on CD8(+) T cell responses to Listeria monocytogenes infection.
Thu Oct 01 00:00:00 EDT 2015
Axitinib increases the infiltration of immune cells and reduces the suppressive capacity of monocytic MDSCs in an intracranial mouse melanoma model.
Oncoimmunology
Du Four S,Maenhout SK,De Pierre K,Renmans D,Niclou SP,Thielemans K,Neyns B,Aerts JL
Published figure using CD45.2 monoclonal antibody (Product # 14-0454-82) in Flow Cytometry
Wed Apr 01 00:00:00 EDT 2015
Small-molecule inhibitors targeting INK4 protein p18(INK4C) enhance ex vivo expansion of haematopoietic stem cells.
Nature communications
Gao Y,Yang P,Shen H,Yu H,Song X,Zhang L,Zhang P,Cheng H,Xie Z,Hao S,Dong F,Ma S,Ji Q,Bartlow P,Ding Y,Wang L,Liu H,Li Y,Cheng H,Miao W,Yuan W,Yuan Y,Cheng T,Xie XQ
14-0454 was used in Flow cytometry/Cell sorting to investigate how putative small-molecule inhibitors for p18 protein are valuable for further dissecting the signalling pathways of stem cell self-renewal.
Wed Feb 18 00:00:00 EST 2015
CCR7-dependent trafficking of RORγ⁺ ILCs creates a unique microenvironment within mucosal draining lymph nodes.
Nature communications
Mackley EC,Houston S,Marriott CL,Halford EE,Lucas B,Cerovic V,Filbey KJ,Maizels RM,Hepworth MR,Sonnenberg GF,Milling S,Withers DR
14-0454 was used in Flow cytometry/Cell sorting to investigate whether group 3 innate lymphoid cells migrate from their mucosal and peripheral sites to local draining secondary lymphoid tissues.
Fri Jan 09 00:00:00 EST 2015
Bi-Allelic TCRα or β Recombination Enhances T Cell Development but Is Dispensable for Antigen Responses and Experimental Autoimmune Encephalomyelitis.
PloS one
Schuldt NJ,Auger JL,Hogquist KA,Binstadt BA
14-0454 was used in Flow cytometry/Cell sorting to investigate dual TCRβ expression in T cells.
Thu Jun 23 00:00:00 EDT 2016
Lis1 regulates asymmetric division in hematopoietic stem cells and in leukemia.
Nature genetics
Zimdahl B,Ito T,Blevins A,Bajaj J,Konuma T,Weeks J,Koechlein CS,Kwon HY,Arami O,Rizzieri D,Broome HE,Chuah C,Oehler VG,Sasik R,Hardiman G,Reya T
14-0454 was used in Flow cytometry/Cell sorting to show that Lis1 is critically required for the development of the haematopoietic system.
Sat Mar 01 00:00:00 EST 2014
Deficiency of melanoma differentiation-associated protein 5 results in exacerbated chronic postviral lung inflammation.
American journal of respiratory and critical care medicine
Kim WK,Jain D,Sánchez MD,Koziol-White CJ,Matthews K,Ge MQ,Haczku A,Panettieri RA,Frieman MB,López CB
14-0454 was used in Magnetic cell separation to establish the role of intracellular viral sensor protein melanoma differentiation-associated protein 5 in the development of chronic lung disease.
Sat Feb 15 00:00:00 EST 2014
In utero depletion of fetal hematopoietic stem cells improves engraftment after neonatal transplantation in mice.
Blood
Derderian SC,Togarrati PP,King C,Moradi PW,Reynaud D,Czechowicz A,Weissman IL,MacKenzie TC
14-0454 was used in Flow cytometry/Cell sorting to develop a successful foetal conditioning strategy associated with minimal toxicity.
Thu Aug 07 00:00:00 EDT 2014
Combined MEK and JAK inhibition abrogates murine myeloproliferative neoplasm.
The Journal of clinical investigation
Kong G,Wunderlich M,Yang D,Ranheim EA,Young KH,Wang J,Chang YI,Du J,Liu Y,Tey SR,Zhang X,Juckett M,Mattison R,Damnernsawad A,Zhang J,Mulloy JC,Zhang J
14-0454 was used in Flow cytometry/Cell sorting to investigate the effect of combined targeting of MEK/ERK and JAK/STAT signalling on the murine myeloproliferative neoplasm.
Sun Jun 01 00:00:00 EDT 2014
WASH is required for the differentiation commitment of hematopoietic stem cells in a c-Myc-dependent manner.
The Journal of experimental medicine
Xia P,Wang S,Huang G,Zhu P,Li M,Ye B,Du Y,Fan Z
Published figure using CD45.2 monoclonal antibody (Product # 14-0454-82) in Flow Cytometry
Mon Sep 22 00:00:00 EDT 2014
Progressive replacement of embryo-derived cardiac macrophages with age.
The Journal of experimental medicine
Molawi K,Wolf Y,Kandalla PK,Favret J,Hagemeyer N,Frenzel K,Pinto AR,Klapproth K,Henri S,Malissen B,Rodewald HR,Rosenthal NA,Bajenoff M,Prinz M,Jung S,Sieweke MH
14-0454 was used in Flow cytometry/Cell sorting to report that the embryo-derived population of cardiac macrophages is progressively substituted for monocyte-derived macrophages within the first weeks after birth.
Mon Oct 20 00:00:00 EDT 2014
CCL2/CCR2-dependent recruitment of functional antigen-presenting cells into tumors upon chemotherapy.
Cancer research
Ma Y,Mattarollo SR,Adjemian S,Yang H,Aymeric L,Hannani D,Portela Catani JP,Duret H,Teng MW,Kepp O,Wang Y,Sistigu A,Schultze JL,Stoll G,Galluzzi L,Zitvogel L,Smyth MJ,Kroemer G
14-0454 was used in Flow cytometry/Cell sorting to underscore the importance of the CCL2/CCR2 signaling axis for therapeutic anticancer immune responses as elicited by immunogenic chemotherapy.
Wed Jan 15 00:00:00 EST 2014
Distinct APC subtypes drive spatially segregated CD4+ and CD8+ T-cell effector activity during skin infection with HSV-1.
PLoS pathogens
Macleod BL,Bedoui S,Hor JL,Mueller SN,Russell TA,Hollett NA,Heath WR,Tscharke DC,Brooks AG,Gebhardt T
14-0454 was used in Flow cytometry/Cell sorting to study the regulation of T-cell effector function in situ at sites of pathogen replication.
Fri Aug 01 00:00:00 EDT 2014
In vivo functional mapping of the conserved protein domains within murine Themis1.
Immunology and cell biology
Zvezdova E,Lee J,El-Khoury D,Barr V,Akpan I,Samelson L,Love PE
14-0454 was used in Flow cytometry/Cell sorting to investigate the functional importance of different Themis1 domains.
Mon Sep 01 00:00:00 EDT 2014
Cutting edge: CD8+ recent thymic emigrants exhibit increased responses to low-affinity ligands and improved access to peripheral sites of inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Berkley AM,Fink PJ
14-0454-82 was used in Flow Cytometry to investigate if the maturation state of peripheral T cells impacts the response to bacterial infection due to intrinsic differences in TCR signaling.
Wed Oct 01 00:00:00 EDT 2014
Leukocyte population dynamics and detection of IL-9 as a major cytokine at the mouse fetal-maternal interface.
PloS one
Habbeddine M,Verbeke P,Karaz S,Bobé P,Kanellopoulos-Langevin C
Published figure using CD45.2 monoclonal antibody (Product # 14-0454-82) in Flow Cytometry
Wed Jun 10 00:00:00 EDT 2015
CXCR4 is dispensable for T cell egress from chronically inflamed skin via the afferent lymph.
PloS one
Geherin SA,Wilson RP,Jennrich S,Debes GF
14-0454 was used in Flow cytometry/Cell sorting to assess the role of CXCR4 for T cell egress from chronically inflamed skin.
Wed Jan 14 00:00:00 EST 2015
Interferon-γ induces expression of MHC class II on intestinal epithelial cells and protects mice from colitis.
PloS one
Thelemann C,Eren RO,Coutaz M,Brasseit J,Bouzourene H,Rosa M,Duval A,Lavanchy C,Mack V,Mueller C,Reith W,Acha-Orbea H
14-0454 was used in Flow cytometry/Cell sorting to investigate how epithelial MHCII expression is induced and how a deficiency in inducible epithelial MHCII expression alters susceptibility to colitis and the outcome of colon-specific immune responses.
Mon Dec 22 00:00:00 EST 2014
CD28 expression is required after T cell priming for helper T cell responses and protective immunity to infection.
eLife
Linterman MA,Denton AE,Divekar DP,Zvetkova I,Kane L,Ferreira C,Veldhoen M,Clare S,Dougan G,Espéli M,Smith KG
14-0454 was used in Flow cytometry/Cell sorting to determine the role for CD28 after T cell priming.
Mon Oct 27 00:00:00 EDT 2014
Mutual expression of the transcription factors Runx3 and ThPOK regulates intestinal CD4⁺ T cell immunity.
Nature immunology
Reis BS,Rogoz A,Costa-Pinto FA,Taniuchi I,Mucida D
Published figure using CD45.2 monoclonal antibody (Product # 14-0454-82) in Flow Cytometry
Fri Mar 01 00:00:00 EST 2013
The microRNA miR-155 controls CD8(+) T cell responses by regulating interferon signaling.
Nature immunology
Gracias DT,Stelekati E,Hope JL,Boesteanu AC,Doering TA,Norton J,Mueller YM,Fraietta JA,Wherry EJ,Turner M,Katsikis PD
14-0454 was used in Flow cytometry/Cell sorting to study the role of miR-155 in the regulation of CD8(+) T cell interferon responses to pathogens in vivo.
Sat Jun 01 00:00:00 EDT 2013
miR-126 and miR-126* repress recruitment of mesenchymal stem cells and inflammatory monocytes to inhibit breast cancer metastasis.
Nature cell biology
Zhang Y,Yang P,Sun T,Li D,Xu X,Rui Y,Li C,Chong M,Ibrahim T,Mercatali L,Amadori D,Lu X,Xie D,Li QJ,Wang XF
Published figure using CD45.2 monoclonal antibody (Product # 14-0454-82) in Flow Cytometry
Fri Mar 01 00:00:00 EST 2013
Nrf2 regulates haematopoietic stem cell function.
Nature cell biology
Tsai JJ,Dudakov JA,Takahashi K,Shieh JH,Velardi E,Holland AM,Singer NV,West ML,Smith OM,Young LF,Shono Y,Ghosh A,Hanash AM,Tran HT,Moore MA,van den Brink MR
14-0454 was used in Flow cytometry/Cell sorting to investigate the link between Nrf2 and CXCR4, thought to partially contribute to the maintenance of haematopoietic stem cell function.
Fri Mar 01 00:00:00 EST 2013
Immune response to RB1-regulated senescence limits radiation-induced osteosarcoma formation.
The Journal of clinical investigation
Kansara M,Leong HS,Lin DM,Popkiss S,Pang P,Garsed DW,Walkley CR,Cullinane C,Ellul J,Haynes NM,Hicks R,Kuijjer ML,Cleton-Jansen AM,Hinds PW,Smyth MJ,Thomas DM
14-0454 was used in Flow cytometry/Cell sorting to indicate that overcoming the immune response to senescence is a rate-limiting step in the formation of IR-induced osteosarcoma.
Sun Dec 01 00:00:00 EST 2013
Gata2 cis-element is required for hematopoietic stem cell generation in the mammalian embryo.
The Journal of experimental medicine
Gao X,Johnson KD,Chang YI,Boyer ME,Dewey CN,Zhang J,Bresnick EH
14-0454 was used in Flow cytometry/Cell sorting to investigate the role of Gata2 cis-element in generation of hematopoietic stem cells.
Mon Dec 16 00:00:00 EST 2013
Histone demethylase Lsd1 represses hematopoietic stem and progenitor cell signatures during blood cell maturation.
eLife
Kerenyi MA,Shao Z,Hsu YJ,Guo G,Luc S,O'Brien K,Fujiwara Y,Peng C,Nguyen M,Orkin SH
14-0454 was used in Flow cytometry/Cell sorting to study how Lsd1-mediated concurrent repression of enhancer and promoter activity of stem and progenitor cell genes is a pivotal epigenetic mechanism required for proper hematopoietic maturation.
Tue Jun 18 00:00:00 EDT 2013
Arrayed lentiviral barcoding for quantification analysis of hematopoietic dynamics.
Stem cells (Dayton, Ohio)
Grosselin J,Sii-Felice K,Payen E,Chretien S,Tronik-Le Roux D,Leboulch P
Published figure using CD45.2 monoclonal antibody (Product # 14-0454-82) in Flow Cytometry
Tue Oct 01 00:00:00 EDT 2013
Impaired neutrophil function in 24p3 null mice contributes to enhanced susceptibility to bacterial infections.
Journal of immunology (Baltimore, Md. : 1950)
Liu Z,Petersen R,Devireddy L
14-0454 was used in Flow cytometry/Cell sorting to show that lipocalin 24p3(-/-) mice are defective in immune function.
Wed May 01 00:00:00 EDT 2013
Syndecan-1, a cell surface proteoglycan, negatively regulates initial leukocyte recruitment to the brain across the choroid plexus in murine experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950)
Zhang X,Wu C,Song J,Götte M,Sorokin L
14-0454 was used in Flow cytometry/Cell sorting to investigate how the choroid plexus epithelium is a novel source of IL-6 in EAE and demonstrate that its expression negatively correlates with syndecan-1 expression at this site.
Fri Nov 01 00:00:00 EDT 2013
Bone marrow-induced Mef2c deficiency delays B-cell development and alters the expression of key B-cell regulatory proteins.
International immunology
Debnath I,Roundy KM,Pioli PD,Weis JJ,Weis JH
14-0454 was used in Flow cytometry/Cell sorting to evaluate the role of Mef2c in B-cell development.
Fri Feb 01 00:00:00 EST 2013
Bone marrow-induced Mef2c deficiency delays B-cell development and alters the expression of key B-cell regulatory proteins.
International immunology
Debnath I,Roundy KM,Pioli PD,Weis JJ,Weis JH
14-0454 was used in Flow cytometry/Cell sorting to evaluate the role of Mef2c in B-cell development.
Fri Feb 01 00:00:00 EST 2013
The cardioprotective protein apolipoprotein A1 promotes potent anti-tumorigenic effects.
The Journal of biological chemistry
Zamanian-Daryoush M,Lindner D,Tallant TC,Wang Z,Buffa J,Klipfell E,Parker Y,Hatala D,Parsons-Wingerter P,Rayman P,Yusufishaq MSS,Fisher EA,Smith JD,Finke J,DiDonato JA,Hazen SL
Published figure using CD45.2 monoclonal antibody (Product # 14-0454-82) in Flow Cytometry
Fri Jul 19 00:00:00 EDT 2013
T-Bet and Eomes Regulate the Balance between the Effector/Central Memory T Cells versus Memory Stem Like T Cells.
PloS one
Li G,Yang Q,Zhu Y,Wang HR,Chen X,Zhang X,Lu B
14-0454 was used in Flow cytometry/Cell sorting to investigate the role of T-bet and Eomes in shaping the memory T cell pool.
Tue Oct 10 00:00:00 EDT 2017
Bone marrow and nonbone marrow Toll like receptor 4 regulate acute hepatic injury induced by endotoxemia.
PloS one
Hochhauser E,Avlas O,Fallach R,Bachmetov L,Zemel R,Pappo O,Shainberg A,Ben Ari Z
14-0454 was used in Flow cytometry/Cell sorting to suggest that the absence of the TLR4 gene plays a pivotal role in reducing hepatic lipopolysaccharide (LPS) induced injury.
Thu Jan 15 00:00:00 EST 2015
Low-affinity T cells are programmed to maintain normal primary responses but are impaired in their recall to low-affinity ligands.
Cell reports
Knudson KM,Goplen NP,Cunningham CA,Daniels MA,Teixeiro E
14-0454 was used in Flow cytometry/Cell sorting to demonstrate that distinct mechanisms drive effector/memory development in high- and low-affinity T-cells.
Thu Aug 15 00:00:00 EDT 2013
A self-help program for memory CD8+ T cells: positive feedback via CD40-CD40L signaling as a critical determinant of secondary expansion.
PloS one
Shugart JA,Bambina S,Alice AF,Montler R,Bahjat KS
14-0454 was used in Flow cytometry/Cell sorting to demonstrate that vaccination regimens differ in their dependence on CD40L-expressing CD8+ T cells for secondary expansion.
Tue Jan 07 00:00:00 EST 2014
The receptor Ly108 functions as a SAP adaptor-dependent on-off switch for T cell help to B cells and NKT cell development.
Immunity
Kageyama R,Cannons JL,Zhao F,Yusuf I,Lao C,Locci M,Schwartzberg PL,Crotty S
14-0454 was used in Flow cytometry/Cell sorting to investigate the mechanisms underlying the defects in humoural immunity present in humans and mice deficient in the adaptor protein, SAP.
Fri Jun 29 00:00:00 EDT 2012
Molecular definition of the identity and activation of natural killer cells.
Nature immunology
Bezman NA,Kim CC,Sun JC,Min-Oo G,Hendricks DW,Kamimura Y,Best JA,Goldrath AW,Lanier LL
14-0454 was used in Flow cytometry/Cell sorting to systematically define the transcriptome of mouse natural killer cells in several contexts.
Mon Oct 01 00:00:00 EDT 2012
TGF-β signaling to T cells inhibits autoimmunity during lymphopenia-driven proliferation.
Nature immunology
Zhang N,Bevan MJ
14-0454 was used in Flow cytometry/Cell sorting to propose that TGF-β signaling controls the self-reactivity of peripheral T cells but that in the absence of TGF-β signals, an added trigger such as lymphopenia is needed to drive overt autoimmune disease.
Sun May 27 00:00:00 EDT 2012
Kruppel-like factor 7 overexpression suppresses hematopoietic stem and progenitor cell function.
Blood
Schuettpelz LG,Gopalan PK,Giuste FO,Romine MP,van Os R,Link DC
14-0454 was used in Flow cytometry/Cell sorting to investigate the role of kruppel-like factor 7 in hematopoietic stem and progenitor cell function.
Thu Oct 11 00:00:00 EDT 2012
The bone marrow functions as the central site of proliferation for long-lived NK cells.
Journal of immunology (Baltimore, Md. : 1950)
van Helden MJ,de Graaf N,Boog CJ,Topham DJ,Zaiss DM,Sijts AJ
14-0454 was used in Flow cytometry/Cell sorting to investigate the dynamics of natural killer cell responses after intranasal respiratory virus infection in mice.
Sat Sep 01 00:00:00 EDT 2012
Population dynamics of naive and memory CD8 T cell responses after antigen stimulations in vivo.
Journal of immunology (Baltimore, Md. : 1950)
Martin MD,Condotta SA,Harty JT,Badovinac VP
14-0454 was used in Flow cytometry/Cell sorting to investigate cell-autonomous functional differences between naive and memory CD8 T cells.
Wed Feb 01 00:00:00 EST 2012
CCR2 defines a distinct population of NK cells and mediates their migration during influenza virus infection in mice.
PloS one
van Helden MJ,Zaiss DM,Sijts AJ
14-0454 was used in Flow cytometry/Cell sorting to determine the role of CCR2 in NK cell migration during intranasal influenza virus infection, showing that it defines a distinct population of NK cells and mediates their migration.
Mon Jun 10 00:00:00 EDT 2013
Delivery of progenitors to the thymus limits T-lineage reconstitution after bone marrow transplantation.
Blood
Zlotoff DA,Zhang SL,De Obaldia ME,Hess PR,Todd SP,Logan TD,Bhandoola A
14-0454 was used in Flow cytometry/Cell sorting to explain why T cells are among the last of the hematopoietic lineages to recover after bone marrow transplantation (BMT).
Thu Aug 18 00:00:00 EDT 2011
Maternal T cells limit engraftment after in utero hematopoietic cell transplantation in mice.
The Journal of clinical investigation
Nijagal A,Wegorzewska M,Jarvis E,Le T,Tang Q,MacKenzie TC
14-0454 was used in Flow cytometry/Cell sorting to investigate whether maternal cells trafficking into the fetus impose the barrier to effective in utero hematopoietic cell transplantation, showing that maternal T cells limit engraftment.
Tue Feb 01 00:00:00 EST 2011
Interleukin 37 expression protects mice from colitis.
Proceedings of the National Academy of Sciences of the United States of America
McNamee EN,Masterson JC,Jedlicka P,McManus M,Grenz A,Collins CB,Nold MF,Nold-Petry C,Bufler P,Dinarello CA,Rivera-Nieves J
14-0454 was used in Flow cytometry/Cell sorting to investigate how IL-37 emerged as a key modulator of intestinal inflammation.
Tue Oct 04 00:00:00 EDT 2011
The metalloprotease-disintegrin ADAM8 is essential for the development of experimental asthma.
American journal of respiratory and critical care medicine
Naus S,Blanchet MR,Gossens K,Zaph C,Bartsch JW,McNagny KM,Ziltener HJ
14-0454 was used in Flow cytometry/Cell sorting to determine that ADAM8 plays a crucial proinflammatory role in airway inflammation.
Tue Jun 15 00:00:00 EDT 2010
Muscle injury activates resident fibro/adipogenic progenitors that facilitate myogenesis.
Nature cell biology
Joe AW,Yi L,Natarajan A,Le Grand F,So L,Wang J,Rudnicki MA,Rossi FM
14-0454 was used in Flow cytometry/Cell sorting to study how FAPs expand upon damage to provide a transient source of pro-differentiation signals for proliferating myogenic progenitors.
Mon Feb 01 00:00:00 EST 2010
Three-dimensional cartography of hematopoietic clusters in the vasculature of whole mouse embryos.
Development (Cambridge, England)
Yokomizo T,Dzierzak E
14-0454 was used in Flow cytometry/Cell sorting to devise a method to make transparent whole mouse embryos for the observation of hematopoietic clusters.
Mon Nov 01 00:00:00 EDT 2010
Potent anti-tumor responses to immunization with dendritic cells loaded with tumor tissue and an NKT cell ligand.
Immunology and cell biology
Petersen TR,Sika-Paotonu D,Knight DA,Dickgreber N,Farrand KJ,Ronchese F,Hermans IF
14-0454 was used in Flow cytometry/Cell sorting to investigate the impact of eliciting T-cell help from activated iNKT cells using alpha-galactosylceramide, showing potent anti-tumour response.
Thu Jul 01 00:00:00 EDT 2010
ATP-binding cassette transporter G1 negatively regulates thymocyte and peripheral lymphocyte proliferation.
Journal of immunology (Baltimore, Md. : 1950)
Armstrong AJ,Gebre AK,Parks JS,Hedrick CC
14-0454 was used in Flow cytometry/Cell sorting to demonstrate that ATP-binding cassette transporter G1 regulates cholesterol homeostasis in thymocytes and peripheral CD4 T cells.
Fri Jan 01 00:00:00 EST 2010
The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation.
Nature immunology
Koch MA,Tucker-Heard G,Perdue NR,Killebrew JR,Urdahl KB,Campbell DJ
14-0454 was used in Flow cytometry/Cell sorting to study how in a subset of CD4(+) T cells, the activities of the transcription factors Foxp3 and T-bet are overlaid.
Mon Jun 01 00:00:00 EDT 2009
AID constrains germinal center size by rendering B cells susceptible to apoptosis.
Blood
Zaheen A,Boulianne B,Parsa JY,Ramachandran S,Gommerman JL,Martin A
14-0454 was used in Flow cytometry/Cell sorting to report a link between AID-induced DNA damage and B-cell apoptosis that has implications for the development of B-cell disorders.
Thu Jul 16 00:00:00 EDT 2009
Identification of a myeloid committed progenitor as the cancer-initiating cell in acute promyelocytic leukemia.
Blood
Guibal FC,Alberich-Jorda M,Hirai H,Ebralidze A,Levantini E,Di Ruscio A,Zhang P,Santana-Lemos BA,Neuberg D,Wagers AJ,Rego EM,Tenen DG
14-0454 was used in Flow cytometry/Cell sorting to provide further understanding of the biology of APL by demonstrating that a committed transformed progenitor can propagate the disease.
Thu Dec 24 00:00:00 EST 2009
Highly purified Th17 cells from BDC2.5NOD mice convert into Th1-like cells in NOD/SCID recipient mice.
The Journal of clinical investigation
Bending D,De la Peña H,Veldhoen M,Phillips JM,Uyttenhove C,Stockinger B,Cooke A
14-0454 was used in Flow cytometry/Cell sorting to show that purified Th17 cells from BDC2.5NOD mice convert into Th1-like cells in NOD/SCID recipient mice, secrete IFN-γ and induce diabetes.
Sun Mar 01 00:00:00 EST 2009
Cytokine-dependent regulation of NADPH oxidase activity and the consequences for activated T cell homeostasis.
The Journal of experimental medicine
Purushothaman D,Sarin A
14-0454 was used in Flow cytometry/Cell sorting to reveal a likely role for NADPH oxidase in regulating adaptive, in addition to innate, immunity.
Mon Jul 06 00:00:00 EDT 2009
Sialoadhesin-positive macrophages bind regulatory T cells, negatively controlling their expansion and autoimmune disease progression.
Journal of immunology (Baltimore, Md. : 1950)
Wu C,Rauch U,Korpos E,Song J,Loser K,Crocker PR,Sorokin LM
14-0454 was used in Flow cytometry/Cell sorting to propose a new direct cell-cell interaction-based mechanism regulating the expansion of Tregs during autoimmune and inflammatory processes.
Fri May 15 00:00:00 EDT 2009
Dynamic imaging of T cell-parasite interactions in the brains of mice chronically infected with Toxoplasma gondii.
Journal of immunology (Baltimore, Md. : 1950)
Schaeffer M,Han SJ,Chtanova T,van Dooren GG,Herzmark P,Chen Y,Roysam B,Striepen B,Robey EA
14-0454 was used in Flow cytometry/Cell sorting to directly observe the dynamics of T cell-parasite interactions within living tissue and further understand immune responses to persistent pathogens in the brain.
Fri May 15 00:00:00 EDT 2009
CCR7 ligands are required for development of experimental autoimmune encephalomyelitis through generating IL-23-dependent Th17 cells.
Journal of immunology (Baltimore, Md. : 1950)
Kuwabara T,Ishikawa F,Yasuda T,Aritomi K,Nakano H,Tanaka Y,Okada Y,Lipp M,Kakiuchi T
14-0454 was used in Flow cytometry/Cell sorting to deduce the role of CCL19 and CCL21 in inducing experimental autoimmune encephalomyelitis.
Sat Aug 15 00:00:00 EDT 2009
The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues.
Nature immunology
Waskow C,Liu K,Darrasse-Jèze G,Guermonprez P,Ginhoux F,Merad M,Shengelia T,Yao K,Nussenzweig M
14-0454-82 was used in Immunohistochemistry to investigate the hematopoietic growth factors regulating dendritic development.
Sun Jun 01 00:00:00 EDT 2008
The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues.
Nature immunology
Waskow C,Liu K,Darrasse-Jèze G,Guermonprez P,Ginhoux F,Merad M,Shengelia T,Yao K,Nussenzweig M
14-0454-82 was used in Immunohistochemistry to investigate the hematopoietic growth factors regulating dendritic development.
Sun Jun 01 00:00:00 EDT 2008
CD40L+ CD4+ memory T cells migrate in a CD62P-dependent fashion into reactive lymph nodes and license dendritic cells for T cell priming.
The Journal of experimental medicine
Martín-Fontecha A,Baumjohann D,Guarda G,Reboldi A,Hons M,Lanzavecchia A,Sallusto F
14-0454 was used in Flow cytometry/Cell sorting to show that T(EM) cells can behave as endogenous adjuvants.
Mon Oct 27 00:00:00 EDT 2008
Regulatory role of B cells in a murine model of allergic airway disease.
Journal of immunology (Baltimore, Md. : 1950)
Singh A,Carson WF,Secor ER,Guernsey LA,Flavell RA,Clark RB,Thrall RS,Schramm CM
14-0454 was used in Flow cytometry/Cell sorting to investigate the role of B cells in the resolution of allergic airway disease and induction of local inhalational tolerance.
Sun Jun 01 00:00:00 EDT 2008
Elimination of antigen-presenting cells and autoreactive T cells by Fas contributes to prevention of autoimmunity.
Immunity
Stranges PB,Watson J,Cooper CJ,Choisy-Rossi CM,Stonebraker AC,Beighton RA,Hartig H,Sundberg JP,Servick S,Kaufmann G,Fink PJ,Chervonsky AV
14-0454 was used in Flow cytometry/Cell sorting to study the effects of tissue-specific Fas deletion in antigen-presenting cells or T cells on autoimmunity in mice.
Tue May 01 00:00:00 EDT 2007
Altering the distribution of Foxp3(+) regulatory T cells results in tissue-specific inflammatory disease.
The Journal of experimental medicine
Sather BD,Treuting P,Perdue N,Miazgowicz M,Fontenot JD,Rudensky AY,Campbell DJ
14-0454 was used in Flow cytometry/Cell sorting to investigate the factors which impact regulatory T cell homing receptor expression, tissue distribution and peripheral tolerance maintenance.
Mon Jun 11 00:00:00 EDT 2007
Msx2-interacting nuclear target protein (Mint) deficiency reveals negative regulation of early thymocyte differentiation by Notch/RBP-J signaling.
Proceedings of the National Academy of Sciences of the United States of America
Tsuji M,Shinkura R,Kuroda K,Yabe D,Honjo T
14-0454-82 was used in Flow Cytometry to o investigate where and how Notch regulates early T cell differentiation by using specific up-regulation of Notch signaling by Mint knockout.
Tue Jan 30 00:00:00 EST 2007
Plk1 regulates activation of the anaphase promoting complex by phosphorylating and triggering SCFbetaTrCP-dependent destruction of the APC Inhibitor Emi1.
Molecular biology of the cell
Hansen DV,Loktev AV,Ban KH,Jackson PK
Published figure using CD45.2 monoclonal antibody (Product # 14-0454-82) in Western Blot
Wed Dec 01 00:00:00 EST 2004
