Product References
Hematopoietic Cell Autonomous Disruption of Hematopoiesis in a Germline Loss-of-function Mouse Model of RUNX1-FPD.
HemaSphere
Ernst MPT,Pronk E,van Dijk C,van Strien PMH,van Tienhoven TVD,Wevers MJW,Sanders MA,Bindels EMJ,Speck NA,Raaijmakers MHGP
17-0454-82 was used in Flow cytometry/Cell sorting to study mice harboring a germline hypomorphic mutation of one Runx1 allele with a loss-of-function mutation in the other Runx1 allele (Runx1 L148A/- mice), which display many hematologic characteristics found in human RUNX1-FPD patients.
Wed Feb 01 00:00:00 EST 2023
Pyrimidine de novo synthesis inhibition selectively blocks effector but not memory T cell development.
Nature immunology
Scherer S,Oberle SG,Kanev K,Gerullis AK,Wu M,de Almeida GP,Puleston DJ,Baixauli F,Aly L,Greco A,Nizharadze T,Becker NB,Hoesslin MV,Donhauser LV,Berner J,Chu T,McNamara HA,Esencan Z,Roelli P,Wurmser C,Kleiter I,Vehreschild MJGT,Mayer CA,Knolle P,Klingenspor M,Fumagalli V,Iannacone M,Prlic M,Korn T,Pearce EL,Höfer T,Schulz AM,Zehn D
17-0454-82 was used in Flow cytometry/Cell sorting to show memory T cell precursors are resistant to pyrimidine starvation.
Wed Mar 01 00:00:00 EST 2023
Type 1 piliated uropathogenic Escherichia coli hijack the host immune response by binding to CD14.
eLife
Tomasek K,Leithner A,Glatzova I,Lukesch MS,Guet CC,Sixt M
17-0454-82 was used in flow cytometry to identify CD14, the major co-receptor for lipopolysaccharide detection, on mouse dendritic cells (DCs) as a binding partner of FimH, the protein located at the tip of the type 1 pilus of Escherichia coli.
Tue Jul 26 00:00:00 EDT 2022
Increased alveolar epithelial TRAF6 via autophagy-dependent TRIM37 degradation mediates particulate matter-induced lung metastasis.
Autophagy
Liu J,Li S,Fei X,Nan X,Shen Y,Xiu H,Cormier SA,Lu C,Guo C,Wang S,Cai Z,Wang P
17-0454-82 was used in Flow cytometry/Cell sorting to demonstrate the central role of PM-induced neutrophil recruitment in promoting lung cancer metastasis.
Sun May 01 00:00:00 EDT 2022
Pak2-mediated phosphorylation promotes RORγt ubiquitination and inhibits colonic inflammation.
Cell reports
Kathania M,Kumar R,Lenou ET,Basrur V,Theiss AL,Chernoff J,Venuprasad K
17-0454-82 was used in Flow cytometry/Cell sorting to uncover a mechanism by which the activity of RORγt is regulated that can be exploited therapeutically.
Tue Sep 13 00:00:00 EDT 2022
Smc3 dosage regulates B cell transit through germinal centers and restricts their malignant transformation.
Nature immunology
Rivas MA,Meydan C,Chin CR,Challman MF,Kim D,Bhinder B,Kloetgen A,Viny AD,Teater MR,McNally DR,Doane AS,Béguelin W,Fernández MTC,Shen H,Wang X,Levine RL,Chen Z,Tsirigos A,Elemento O,Mason CE,Melnick AM
Published figure using CD45.2 monoclonal antibody (Product # 17-0454-82) in Flow Cytometry
Mon Feb 01 00:00:00 EST 2021
Niche-specific MHC II and PD-L1 regulate CD4+CD8αα+ intraepithelial lymphocyte differentiation.
The Journal of experimental medicine
Moon S,Park Y,Hyeon S,Kim YM,Kim JH,Kim H,Park S,Lee KJ,Koo BK,Ha SJ,Lee SW
Published figure using CD45.2 monoclonal antibody (Product # 17-0454-82) in Flow Cytometry
Mon Apr 05 00:00:00 EDT 2021
Adoptive Transfer of Group 3-Like Innate Lymphoid Cells Restores Mouse Colon Resistance to Colonization of a Gamma Interferon-Susceptible Chlamydia muridarum Mutant.
Infection and immunity
He Y,Xu H,Song C,Koprivsek JJ,Arulanandam B,Yang H,Tao L,Zhong G
17-0454-82 was used in Flow Cytometry to demonstrate that ILC3s are sufficient for regulating chlamydial colonization, laying a foundation for further revealing the mechanisms by which an obligate intracellular bacterium activates colonic ILC3s.
Tue Jan 19 00:00:00 EST 2021
Brd4 modulates diet-induced obesity via PPARγ-dependent Gdf3 expression in adipose tissue macrophages.
JCI insight
Hu X,Dong X,Li G,Chen Y,Chen J,He X,Sun H,Kim DH,Kemper JK,Chen LF
Published figure using CD45.2 monoclonal antibody (Product # 17-0454-82) in Flow Cytometry
Thu Apr 08 00:00:00 EDT 2021
Differentiation of fetal hematopoietic stem cells requires ARID4B to restrict autocrine KITLG/KIT-Src signaling.
Cell reports
Young IC,Wu B,Andricovich J,Chuang ST,Li R,Tzatsos A,Wu RC,Wu MY
Published figure using CD45.2 monoclonal antibody (Product # 17-0454-82) in Flow Cytometry
Tue Nov 23 00:00:00 EST 2021
Erythritol Ameliorates Small Intestinal Inflammation Induced by High-Fat Diets and Improves Glucose Tolerance.
International journal of molecular sciences
Kawano R,Okamura T,Hashimoto Y,Majima S,Senmaru T,Ushigome E,Asano M,Yamazaki M,Takakuwa H,Sasano R,Nakanishi N,Hamaguchi M,Fukui M
Published figure using CD45.2 monoclonal antibody (Product # 17-0454-82) in Flow Cytometry
Mon May 24 00:00:00 EDT 2021
Expansion of an Unusual Virtual Memory CD8+ Subpopulation Bearing Vα3.2 TCR in Themis-Deficient Mice.
Frontiers in immunology
Prasad M,Wojciech L,Brzostek J,Hu J,Chua YL,Tung DWH,Yap J,Rybakin V,Gascoigne NRJ
Published figure using CD45.2 monoclonal antibody (Product # 17-0454-82) in Flow Cytometry
Thu Sep 23 00:00:00 EDT 2021
The subunits of IL-12, originating from two distinct cells, can functionally synergize to protect against pathogen dissemination in vivo.
Cell reports
Gerber AN,Abdi K,Singh NJ
Published figure using CD45.2 monoclonal antibody (Product # 17-0454-82) in Flow Cytometry
Tue Oct 12 00:00:00 EDT 2021
Ddb1 Is Essential for the Expansion of CD4+ Helper T Cells by Regulating Cell Cycle Progression and Cell Death.
Frontiers in immunology
Yang L,Chen W,Li L,Xiao Y,Fan S,Zhang Q,Xia T,Li M,Hong Y,Zhao T,Li Q,Liu WH,Xiao N
Published figure using CD45.2 monoclonal antibody (Product # 17-0454-82) in Flow Cytometry
Mon Dec 20 00:00:00 EST 2021
Abraxane-induced bone marrow CD11b+ myeloid cell depletion in tumor-bearing mice is visualized by μPET-CT with 64Cu-labeled anti-CD11b and prevented by anti-CSF-1.
Theranostics
Cao Q,Huang Q,Wang YA,Li C
Published figure using CD45.2 monoclonal antibody (Product # 17-0454-82) in Flow Cytometry
Fri Jul 23 00:00:00 EDT 2021
Inflammasome activation leads to cDC1-independent cross-priming of CD8 T cells by epithelial cell-derived antigen.
eLife
Deets KA,Nichols Doyle R,Rauch I,Vance RE
17-0454-82 was used in Flow cytometry/Cell sorting to investigate whether inflammasomes provide sufficient signals to activate adaptive immunity.
Thu Dec 23 00:00:00 EST 2021
Calibration of cell-intrinsic interleukin-2 response thresholds guides design of a regulatory T cell biased agonist.
eLife
Glassman CR,Su L,Majri-Morrison SS,Winkelmann H,Mo F,Li P,Pérez-Cruz M,Ho PP,Koliesnik I,Nagy N,Hnizdilova T,Picton LK,Kovar M,Bollyky P,Steinman L,Meyer E,Piehler J,Leonard WJ,Garcia KC
17-0454 was used in Flow cytometry/Cell sorting to show that cytokine partial agonists can be used to calibrate intrinsic differences in response thresholds across responding cell types to narrow pleiotropic actions, which may be generalizable to other cytokine and growth factor systems.
Tue May 18 00:00:00 EDT 2021
Niche-Selective Inhibition of Pathogenic Th17 Cells by Targeting Metabolic Redundancy.
Cell
Wu L,Hollinshead KER,Hao Y,Au C,Kroehling L,Ng C,Lin WY,Li D,Silva HM,Shin J,Lafaille JJ,Possemato R,Pacold ME,Papagiannakopoulos T,Kimmelman AC,Satija R,Littman DR
17-0454-82 was used in Flow Cytometry to suggest that inhibiting glycolysis by targeting Gpi1 could be an effective therapeutic strategy with minimum toxicity for Th17-mediated autoimmune diseases, and, more generally, that metabolic redundancies can be exploited for selective targeting of disease processes.
Thu Aug 06 00:00:00 EDT 2020
Targeting 7-Dehydrocholesterol Reductase Integrates Cholesterol Metabolism and IRF3 Activation to Eliminate Infection.
Immunity
Xiao J,Li W,Zheng X,Qi L,Wang H,Zhang C,Wan X,Zheng Y,Zhong R,Zhou X,Lu Y,Li Z,Qiu Y,Liu C,Zhang F,Zhang Y,Xu X,Yang Z,Chen H,Zhai Q,Wei B,Wang H
17-0454-82 was used in Flow Cytometry to propose that the DHCR7 inhibitors and 7-DHC are potential therapeutics against emerging or highly pathogenic viruses.
Tue Jan 14 00:00:00 EST 2020
RNA Demethylase ALKBH5 Selectively Promotes Tumorigenesis and Cancer Stem Cell Self-Renewal in Acute Myeloid Leukemia.
Cell stem cell
Shen C,Sheng Y,Zhu AC,Robinson S,Jiang X,Dong L,Chen H,Su R,Yin Z,Li W,Deng X,Chen Y,Hu YC,Weng H,Huang H,Prince E,Cogle CR,Sun M,Zhang B,Chen CW,Marcucci G,He C,Qian Z,Chen J
17-0454-82 was used in Flow Cytometry to reveal crucial functions of ALKBH5 in leukemogenesis and LSC/LIC self-renewal/maintenance and highlight the therapeutic potential of targeting the ALKBH5/m6A axis.
Thu Jul 02 00:00:00 EDT 2020
Deregulated Notch and Wnt signaling activates early-stage myeloid regeneration pathways in leukemia.
The Journal of experimental medicine
Kang YA,Pietras EM,Passegué E
Published figure using CD45.2 monoclonal antibody (Product # 17-0454-82) in Flow Cytometry
Mon Mar 02 00:00:00 EST 2020
Proenkephalin+ regulatory T cells expanded by ultraviolet B exposure maintain skin homeostasis with a healing function.
Proceedings of the National Academy of Sciences of the United States of America
Shime H,Odanaka M,Tsuiji M,Matoba T,Imai M,Yasumizu Y,Uraki R,Minohara K,Watanabe M,Bonito AJ,Fukuyama H,Ohkura N,Sakaguchi S,Morita A,Yamazaki S
Published figure using CD45.2 monoclonal antibody (Product # 17-0454-82) in Flow Cytometry
Tue Aug 25 00:00:00 EDT 2020
Immune modulating effects of additional supplementation of estradiol combined with testosterone in murine testosterone-deficient NAFLD model.
American journal of physiology. Gastrointestinal and liver physiology
Okamura T,Hamaguchi M,Bamba R,Nakajima H,Yoshimura Y,Kimura T,Nishida K,Hashimoto Y,Fukuda T,Senmaru T,Fukui M
17-0454-82 was used in Flow cytometry/Cell sorting to suggest that a combination of estrogen and testosterone may be clinically relevant for the treatment of NAFLD in patients with male menopause.
Mon Jun 01 00:00:00 EDT 2020
Interleukin 35 Delays Hindlimb Ischemia-Induced Angiogenesis Through Regulating ROS-Extracellular Matrix but Spares Later Regenerative Angiogenesis.
Frontiers in immunology
Fu H,Sun Y,Shao Y,Saredy J,Cueto R,Liu L,Drummer C,Johnson C,Xu K,Lu Y,Li X,Meng S,Xue ER,Tan J,Jhala NC,Yu D,Zhou Y,Bayless KJ,Yu J,Rogers TJ,Hu W,Snyder NW,Sun J,Qin X,Jiang X,Wang H,Yang X
Published figure using CD45.2 monoclonal antibody (Product # 17-0454-82) in Flow Cytometry
Fri Jul 09 00:00:00 EDT 2021
The frequency of follicular T helper cells differs in acute and chronic neuroinflammation.
Scientific reports
Baniahmad A,Birkner K,Görg J,Loos J,Zipp F,Wasser B,Bittner S
Published figure using CD45.2 monoclonal antibody (Product # 17-0454-82) in Flow Cytometry
Tue Nov 24 00:00:00 EST 2020
PTPN2 Deficiency Enhances Programmed T Cell Expansion and Survival Capacity of Activated T Cells.
Cell reports
Flosbach M,Oberle SG,Scherer S,Zecha J,von Hoesslin M,Wiede F,Chennupati V,Cullen JG,List M,Pauling JK,Baumbach J,Kuster B,Tiganis T,Zehn D
17-0454 was used in Flow cytometry/Cell sorting to show the therapeutic potential of targeting PTPN2 in T cell-based therapies to augment the number and survival capacity of antigen-specific T cells.
Tue Jul 28 00:00:00 EDT 2020
Inflammation-Induced Lactate Leads to Rapid Loss of Hepatic Tissue-Resident NK Cells.
Cell reports
Dodard G,Tata A,Erick TK,Jaime D,Miah SMS,Quatrini L,Escalière B,Ugolini S,Vivier E,Brossay L
17-0454 was used in Flow cytometry/Cell sorting to characterize the kinetics and immune response of each of the hepatic NK cell populations to viral challenge and other stimuli.
Tue Jul 07 00:00:00 EDT 2020
Long-term ex vivo haematopoietic-stem-cell expansion allows nonconditioned transplantation.
Nature
Wilkinson AC,Ishida R,Kikuchi M,Sudo K,Morita M,Crisostomo RV,Yamamoto R,Loh KM,Nakamura Y,Watanabe M,Nakauchi H,Yamazaki S
Published figure using CD45.2 monoclonal antibody (Product # 17-0454-82) in Flow Cytometry
Mon Jul 01 00:00:00 EDT 2019
Transcriptional Basis of Mouse and Human Dendritic Cell Heterogeneity.
Cell
Brown CC,Gudjonson H,Pritykin Y,Deep D,Lavallée VP,Mendoza A,Fromme R,Mazutis L,Ariyan C,Leslie C,Pe'er D,Rudensky AY
17-0454 was used in Flow cytometry/Cell sorting to identify two principal cDC2 lineages defined by distinct developmental pathways and transcriptional regulators, including T-bet and RORγt, two key transcription factors known to define innate and adaptive lymphocyte subsets.
Thu Oct 31 00:00:00 EDT 2019
CD8+ T cells induce cachexia during chronic viral infection.
Nature immunology
Baazim H,Schweiger M,Moschinger M,Xu H,Scherer T,Popa A,Gallage S,Ali A,Khamina K,Kosack L,Vilagos B,Smyth M,Lercher A,Friske J,Merkler D,Aderem A,Helbich TH,Heikenwälder M,Lang PA,Zechner R,Bergthaler A
17-0454-82 was used in Flow Cytometry to identify the role for CD8+ T cells in infection-associated cachexia.
Sat Jun 01 00:00:00 EDT 2019
Qa-1-Restricted CD8+ T Cells Can Compensate for the Absence of Conventional T Cells during Viral Infection.
Cell reports
Anderson CK,Reilly EC,Lee AY,Brossay L
17-0454 was used in Flow cytometry/Cell sorting to study compensatory mechanisms in immune responses to viruses when classical T cell immunity has been evaded.
Tue Apr 09 00:00:00 EDT 2019
SCGN deficiency results in colitis susceptibility.
eLife
Sifuentes-Dominguez LF,Li H,Llano E,Liu Z,Singla A,Patel AS,Kathania M,Khoury A,Norris N,Rios JJ,Starokadomskyy P,Park JY,Gopal P,Liu Q,Tan S,Chan L,Ross T,Harrison S,Venuprasad K,Baker LA,Jia D,Burstein E
17-0454-82 was used in Flow cytometry/Cell sorting to report the identification of an ultra rare missense variant (NM_006998.3:c.230G > A;p.Arg77His) in the SCGN gene causing Mendelian early-onset ulcerative colitis.
Wed Oct 30 00:00:00 EDT 2019
The Liver-Stage Plasmodium Infection Is a Critical Checkpoint for Development of Experimental Cerebral Malaria.
Frontiers in immunology
Sato Y,Ries S,Stenzel W,Fillatreau S,Matuschewski K
17-0454 was used in Flow cytometry/Cell sorting to reveal the essential role of early host interactions in the liver that may dampen the subsequent pro-inflammatory immune responses and influence the occurrence of ECM, highlighting a novel checkpoint in this fatal pathology.
Mon Nov 16 00:00:00 EST 2020
PPM1D Mutations Drive Clonal Hematopoiesis in Response to Cytotoxic Chemotherapy.
Cell stem cell
Hsu JI,Dayaram T,Tovy A,De Braekeleer E,Jeong M,Wang F,Zhang J,Heffernan TP,Gera S,Kovacs JJ,Marszalek JR,Bristow C,Yan Y,Garcia-Manero G,Kantarjian H,Vassiliou G,Futreal PA,Donehower LA,Takahashi K,Goodell MA
17-0454 was used in Flow cytometry/Cell sorting to establish the clinical relevance of PPM1D mutations in clonal haematopoiesis and the importance of studying mutation-treatment interactions.
Thu Nov 01 00:00:00 EDT 2018
Effector CD4 T cells with progenitor potential mediate chronic intestinal inflammation.
The Journal of experimental medicine
Shin B,Kress RL,Kramer PA,Darley-Usmar VM,Bellis SL,Harrington LE
17-0454 was used in Flow cytometry/Cell sorting to indicate that the chronicity of T cell-mediated inflammation is perpetuated by specific effector CD4 T cells with stem-like properties.
Mon Jul 02 00:00:00 EDT 2018
Defining the epigenetic status of blood cells using a cyanine-based fluorescent probe for PRMT1.
Blood advances
Su H,Sun CW,Liu SM,He X,Hu H,Pawlik KM,Townes TM,Han X,Klug CA,Henary M,Chen Y,Li L,Zheng YG,Zhao X
17-0454 was used in Flow cytometry/Cell sorting to characterise the epigenetic status of blood cells using a cyanine-based fluorescent probe for PRMT1.
Tue Nov 13 00:00:00 EST 2018
The antitumor effects of entinostat in ovarian cancer require adaptive immunity.
Cancer
Smith HJ,McCaw TR,Londono AI,Katre AA,Meza-Perez S,Yang ES,Forero A,Buchsbaum DJ,Randall TD,Straughn JM,Norian LA,Arend RC
17-0454-82 was used in Flow Cytometry to evaluate whether entinostat treatment and resultant MHCII expression would enhance beneficial immune responses and impair tumor growth in mice with ovarian cancer.
Sat Dec 15 00:00:00 EST 2018
Rejection of immunogenic tumor clones is limited by clonal fraction.
eLife
Gejman RS,Chang AY,Jones HF,DiKun K,Hakimi AA,Schietinger A,Scheinberg DA
Published figure using CD45.2 monoclonal antibody (Product # 17-0454-82) in Flow Cytometry
Fri Nov 30 00:00:00 EST 2018
The H3K4 methyltransferase Setd1b is essential for hematopoietic stem and progenitor cell homeostasis in mice.
eLife
Schmidt K,Zhang Q,Tasdogan A,Petzold A,Dahl A,Arneth BM,Slany R,Fehling HJ,Kranz A,Stewart AF,Anastassiadis K
Published figure using CD45.2 monoclonal antibody (Product # 17-0454-82) in Flow Cytometry
Tue Jun 19 00:00:00 EDT 2018
Differential requirement of kindlin-3 for T cell progenitor homing to the non-vascularized and vascularized thymus.
eLife
Moretti FA,Klapproth S,Ruppert R,Margraf A,Weber J,Pick R,Scheiermann C,Sperandio M,Fässler R,Moser M
Published figure using CD45.2 monoclonal antibody (Product # 17-0454-82) in Flow Cytometry
Thu Sep 06 00:00:00 EDT 2018
Spred1 Safeguards Hematopoietic Homeostasis against Diet-Induced Systemic Stress.
Cell stem cell
Tadokoro Y,Hoshii T,Yamazaki S,Eto K,Ema H,Kobayashi M,Ueno M,Ohta K,Arai Y,Hara E,Harada K,Oshima M,Oshima H,Arai F,Yoshimura A,Nakauchi H,Hirao A
17-0454-82 was used in Flow Cytometry to demonstrate the involvement of diet-induced stress on hematopoietic stem cell self-renewal.
Thu May 03 00:00:00 EDT 2018
The creatine kinase pathway is a metabolic vulnerability in EVI1-positive acute myeloid leukemia.
Nature medicine
Fenouille N,Bassil CF,Ben-Sahra I,Benajiba L,Alexe G,Ramos A,Pikman Y,Conway AS,Burgess MR,Li Q,Luciano F,Auberger P,Galinsky I,DeAngelo DJ,Stone RM,Zhang Y,Perkins AS,Shannon K,Hemann MT,Puissant A,Stegmaier K
17-0454 was used in Flow cytometry/Cell sorting to investigate the effect of MECOM on cellular metabolism.
Wed Mar 01 00:00:00 EST 2017
Store-Operated Ca2+ Entry Controls Clonal Expansion of T Cells through Metabolic Reprogramming.
Immunity
Vaeth M,Maus M,Klein-Hessling S,Freinkman E,Yang J,Eckstein M,Cameron S,Turvey SE,Serfling E,Berberich-Siebelt F,Possemato R,Feske S
17-0454 was used in Flow cytometry/Cell sorting to study the regulation of cell cycle entry in quiescent T cells by store-operated Ca2+ entry and calcineurin.
Tue Oct 17 00:00:00 EDT 2017
Egr2 and 3 control adaptive immune responses by temporally uncoupling expansion from T cell differentiation.
The Journal of experimental medicine
Miao T,Symonds ALJ,Singh R,Symonds JD,Ogbe A,Omodho B,Zhu B,Li S,Wang P
Published figure using CD45.2 monoclonal antibody (Product # 17-0454-82) in Flow Cytometry
Mon Jun 05 00:00:00 EDT 2017
Eros is a novel transmembrane protein that controls the phagocyte respiratory burst and is essential for innate immunity.
The Journal of experimental medicine
Thomas DC,Clare S,Sowerby JM,Pardo M,Juss JK,Goulding DA,van der Weyden L,Storisteanu D,Prakash A,Espéli M,Flint S,Lee JC,Hoenderdos K,Kane L,Harcourt K,Mukhopadhyay S,Umrania Y,Antrobus R,Nathan JA,Adams DJ,Bateman A,Choudhary JS,Lyons PA,Condliffe AM,Chilvers ER,Dougan G,Smith KG
17-0454 was used in Flow cytometry/Cell sorting to describe the key role of the previously uncharacterised protein Eros in host defence.
Mon Apr 03 00:00:00 EDT 2017
Human umbilical cord blood-borne fibroblasts contain marrow niche precursors that form a bone/marrow organoid in vivo.
Development (Cambridge, England)
Pievani A,Sacchetti B,Corsi A,Rambaldi B,Donsante S,Scagliotti V,Vergani P,Remoli C,Biondi A,Robey PG,Riminucci M,Serafini M
17-0454 was used in Flow cytometry/Cell sorting to show that human umbilical cord blood-borne fibroblasts are able to recapitulate the conditions by which the bone marrow microenvironment is formed and establish complete hematopoietic stem cell niches.
Wed Mar 15 00:00:00 EDT 2017
The soluble cytoplasmic tail of CD45 (ct-CD45) in human plasma contributes to keep T cells in a quiescent state.
European journal of immunology
Puck A,Hopf S,Modak M,Majdic O,Cejka P,Blüml S,Schmetterer K,Arnold-Schrauf C,Gerwien JG,Frederiksen KS,Thell E,Leitner J,Steinberger P,Aigner R,Seyerl-Jiresch M,Zlabinger GJ,Stöckl J
17-0454 was used in Flow cytometry/Cell sorting to demonstrate that ct-CD45 is present in human plasma and sets the threshold of T-cell activation.
Sun Jan 01 00:00:00 EST 2017
Recipient bone marrow assimilates the myeloid/lymphoid reconstitution of distinct fetal hematopoietic stem cells.
Oncotarget
Guo XL,Chu L,Ke F,Mu LL,Li Z,Cai JJ,Li HF,Hong DL
Published figure using CD45.2 monoclonal antibody (Product # 17-0454-82) in Flow Cytometry
Tue Dec 12 00:00:00 EST 2017
Pneumocystis-Driven Inducible Bronchus-Associated Lymphoid Tissue Formation Requires Th2 and Th17 Immunity.
Cell reports
Eddens T,Elsegeiny W,Garcia-Hernadez ML,Castillo P,Trevejo-Nunez G,Serody K,Campfield BT,Khader SA,Chen K,Rangel-Moreno J,Kolls JK
Published figure using CD45.2 monoclonal antibody (Product # 17-0454-82) in Flow Cytometry
Tue Mar 28 00:00:00 EDT 2017
Intratumoral modulation of the inducible co-stimulator ICOS by recombinant oncolytic virus promotes systemic anti-tumour immunity.
Nature communications
Zamarin D,Holmgaard RB,Ricca J,Plitt T,Palese P,Sharma P,Merghoub T,Wolchok JD,Allison JP
Published figure using CD45.2 monoclonal antibody (Product # 17-0454-82) in Flow Cytometry
Mon Feb 13 00:00:00 EST 2017
The chronically inflamed central nervous system provides niches for long-lived plasma cells.
Acta neuropathologica communications
Pollok K,Mothes R,Ulbricht C,Liebheit A,Gerken JD,Uhlmann S,Paul F,Niesner R,Radbruch H,Hauser AE
17-0454 was used in Flow cytometry/Cell sorting to investigate to what extent long-lived plasma cells are present in autoimmune central nervous system inflammation.
Sat Nov 25 00:00:00 EST 2017
STIM1 promotes migration, phagosomal maturation and antigen cross-presentation in dendritic cells.
Nature communications
Nunes-Hasler P,Maschalidi S,Lippens C,Castelbou C,Bouvet S,Guido D,Bermont F,Bassoy EY,Page N,Merkler D,Hugues S,Martinvalet D,Manoury B,Demaurex N
17-0454 was used in Flow cytometry/Cell sorting to show that ablation of the store-operated-Ca2+-entry regulator STIM1 in mouse myeloid cells impairs cross-presentation and dendritic cell migration in vivo and in vitro.
Fri Nov 24 00:00:00 EST 2017
Host-Protozoan Interactions Protect from Mucosal Infections through Activation of the Inflammasome.
Cell
Chudnovskiy A,Mortha A,Kana V,Kennard A,Ramirez JD,Rahman A,Remark R,Mogno I,Ng R,Gnjatic S,Amir ED,Solovyov A,Greenbaum B,Clemente J,Faith J,Belkaid Y,Grigg ME,Merad M
Published figure using CD45.2 monoclonal antibody (Product # 17-0454-82) in Flow Cytometry
Thu Oct 06 00:00:00 EDT 2016
The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity.
Cell
Damgaard RB,Walker JA,Marco-Casanova P,Morgan NV,Titheradge HL,Elliott PR,McHale D,Maher ER,McKenzie ANJ,Komander D
Published figure using CD45.2 monoclonal antibody (Product # 17-0454-82) in Flow Cytometry
Thu Aug 25 00:00:00 EDT 2016
The composition of the microbiota modulates allograft rejection.
The Journal of clinical investigation
Lei YM,Chen L,Wang Y,Stefka AT,Molinero LL,Theriault B,Aquino-Michaels K,Sivan AS,Nagler CR,Gajewski TF,Chong AS,Bartman C,Alegre ML
17-0454 was used in Flow cytometry/Cell sorting to test the influence of host and donor microbiota on skin transplant rejection.
Fri Jul 01 00:00:00 EDT 2016
CXCR4 identifies transitional bone marrow premonocytes that replenish the mature monocyte pool for peripheral responses.
The Journal of experimental medicine
Chong SZ,Evrard M,Devi S,Chen J,Lim JY,See P,Zhang Y,Adrover JM,Lee B,Tan L,Li JL,Liong KH,Phua C,Balachander A,Boey A,Liebl D,Tan SM,Chan JK,Balabanian K,Harris JE,Bianchini M,Weber C,Duchene J,Lum J,Poidinger M,Chen Q,Rénia L,Wang CI,Larbi A,Randolph GJ,Weninger W,Looney MR,Krummel MF,Biswas SK,Ginhoux F,Hidalgo A,Bachelerie F,Ng LG
17-0454 was used in Flow cytometry/Cell sorting to demonstrate the multifaceted role of CXCR4 in defining BM monocyte heterogeneity and in regulating their function in peripheral tissues.
Mon Oct 17 00:00:00 EDT 2016
Dendritic cell sphingosine-1-phosphate lyase regulates thymic egress.
The Journal of experimental medicine
Zamora-Pineda J,Kumar A,Suh JH,Zhang M,Saba JD
17-0454 was used in Flow cytometry/Cell sorting to investigate the role of dendritic cell sphingosine-1-phosphate lyase in thymic egress.
Mon Nov 14 00:00:00 EST 2016
Lung epithelium and myeloid cells cooperate to clear acute pneumococcal infection.
Mucosal immunology
Dudek M,Puttur F,Arnold-Schrauf C,Kühl AA,Holzmann B,Henriques-Normark B,Berod L,Sparwasser T
17-0454 was used in Flow cytometry/Cell sorting to investigate the extent to which MyD88 signaling is required to control S. pneumoniae infection, showing that lung epithelium and myeloid cells cooperate to clear infection.
Thu Sep 01 00:00:00 EDT 2016
Murine iPSC-Derived Macrophages as a Tool for Disease Modeling of Hereditary Pulmonary Alveolar Proteinosis due to Csf2rb Deficiency.
Stem cell reports
Mucci A,Kunkiel J,Suzuki T,Brennig S,Glage S,Kühnel MP,Ackermann M,Happle C,Kuhn A,Schambach A,Trapnell BC,Hansen G,Moritz T,Lachmann N
Published figure using CD45.2 monoclonal antibody (Product # 17-0454-82) in Flow Cytometry
Tue Aug 09 00:00:00 EDT 2016
Single Targeted Exon Mutation Creates a True Congenic Mouse for Competitive Hematopoietic Stem Cell Transplantation: The C57BL/6-CD45.1(STEM) Mouse.
Stem cell reports
Mercier FE,Sykes DB,Scadden DT
17-0454 was used in Flow cytometry/Cell sorting to define the molecular regulators of hematopoietic stem and progenitor cells using a novel C57BL/6-CD45.1(STEM) mouse model.
Tue Jun 14 00:00:00 EDT 2016
Pivotal role for skin transendothelial radio-resistant anti-inflammatory macrophages in tissue repair.
eLife
Barreiro O,Cibrian D,Clemente C,Alvarez D,Moreno V,Valiente Í,Bernad A,Vestweber D,Arroyo AG,Martín P,von Andrian UH,Sánchez Madrid F
17-0454 was used in Flow cytometry/Cell sorting to describe a novel subset of murine dermal perivascular macrophages that extend protrusions across the endothelial junctions in steady-state and capture blood-borne macromolecules.
Wed Jun 15 00:00:00 EDT 2016
CCR7 Controls Thymus Recirculation, but Not Production and Emigration, of Foxp3(+) T Cells.
Cell reports
Cowan JE,McCarthy NI,Anderson G
17-0454 was used in Flow cytometry/Cell sorting to investigate CCR7 and Rag2pGFP levels during Treg development, showing that CCR7 controls thymus recirculation, but not production and emigration, of Foxp3(+) T cells.
Tue Feb 09 00:00:00 EST 2016
Local fibroblast proliferation but not influx is responsible for synovial hyperplasia in a murine model of rheumatoid arthritis.
Biochemical and biophysical research communications
Matsuo Y,Mizoguchi F,Saito T,Kawahata K,Ueha S,Matsushima K,Inagaki Y,Miyasaka N,Kohsaka H
17-0454-82 was used in Flow cytometry/Cell sorting to indicate that local fibroblast proliferation but not cellular influx is responsible for the synovial hyperplasia in CAIA.
Fri Feb 12 00:00:00 EST 2016
Aging of mice is associated with p16(Ink4a)- and β-galactosidase-positive macrophage accumulation that can be induced in young mice by senescent cells.
Aging
Hall BM,Balan V,Gleiberman AS,Strom E,Krasnov P,Virtuoso LP,Rydkina E,Vujcic S,Balan K,Gitlin I,Leonova K,Polinsky A,Chernova OB,Gudkov AV
17-0454 was used in Flow cytometry/Cell sorting to investigate the role of p16(Ink4a)/β-gal(pH6)-positive macrophages in aging, which previously was attributed solely to senescent cells.
Fri Jul 01 00:00:00 EDT 2016
Timing of CSF-1/CSF-1R signaling blockade is critical to improving responses to CTLA-4 based immunotherapy.
Oncoimmunology
Holmgaard RB,Brachfeld A,Gasmi B,Jones DR,Mattar M,Doman T,Murphy M,Schaer D,Wolchok JD,Merghoub T
Fri Jul 01 00:00:00 EDT 2016
Atypical chemokine receptor 1 deficiency reduces atherogenesis in ApoE-knockout mice.
Cardiovascular research
Wan W,Liu Q,Lionakis MS,Marino AP,Anderson SA,Swamydas M,Murphy PM
Published figure using CD45.2 monoclonal antibody (Product # 17-0454-82) in Flow Cytometry
Mon Jun 01 00:00:00 EDT 2015
Invariant NKT cells require autophagy to coordinate proliferation and survival signals during differentiation.
Journal of immunology (Baltimore, Md. : 1950)
Pei B,Zhao M,Miller BC,Véla JL,Bruinsma MW,Virgin HW,Kronenberg M
17-0454 was used in Flow cytometry/Cell sorting to examine the effect of a disrupting autophagy on the differentiation of iNKT cells, showing that they require autophagy to coordinate proliferation and survival.
Mon Jun 15 00:00:00 EDT 2015
Axitinib increases the infiltration of immune cells and reduces the suppressive capacity of monocytic MDSCs in an intracranial mouse melanoma model.
Oncoimmunology
Du Four S,Maenhout SK,De Pierre K,Renmans D,Niclou SP,Thielemans K,Neyns B,Aerts JL
Published figure using CD45.2 monoclonal antibody (Product # 17-0454-82) in Flow Cytometry
Wed Apr 01 00:00:00 EDT 2015
Identification and characterization of latency-associated peptide-expressing γδ T cells.
Nature communications
Rezende RM,da Cunha AP,Kuhn C,Rubino S,M'Hamdi H,Gabriely G,Vandeventer T,Liu S,Cialic R,Pinheiro-Rosa N,Oliveira RP,Gaublomme JT,Obholzer N,Kozubek J,Pochet N,Faria AMC,Weiner HL
17-0454 was used in Flow cytometry/Cell sorting to describe a subset of regulatory γδ T cells that express the latency-associated peptide, a membrane-bound TGF-β1.
Tue Dec 08 00:00:00 EST 2015
STAT4 controls GM-CSF production by both Th1 and Th17 cells during EAE.
Journal of neuroinflammation
McWilliams IL,Rajbhandari R,Nozell S,Benveniste E,Harrington LE
17-0454 was used in Flow cytometry/Cell sorting to establish the role of STAT4 in the regulation of cytokine production during experimental autoimmune encephalomyelitis pathogenesis.
Tue Jun 30 00:00:00 EDT 2015
Triplication of a 21q22 region contributes to B cell transformation through HMGN1 overexpression and loss of histone H3 Lys27 trimethylation.
Nature genetics
Lane AA,Chapuy B,Lin CY,Tivey T,Li H,Townsend EC,van Bodegom D,Day TA,Wu SC,Liu H,Yoda A,Alexe G,Schinzel AC,Sullivan TJ,Malinge S,Taylor JE,Stegmaier K,Jaffe JD,Bustin M,te Kronnie G,Izraeli S,Harris MH,Stevenson KE,Neuberg D,Silverman LB,Sallan SE,Bradner JE,Hahn WC,Crispino JD,Pellman D,Weinstock DM
17-0454 was used in Flow cytometry/Cell sorting to show that germline triplication of only 31 genes orthologous to human chromosome 21q22 confers mouse progenitor B cell self renew in vitro.
Sun Jun 01 00:00:00 EDT 2014
WASH is required for the differentiation commitment of hematopoietic stem cells in a c-Myc-dependent manner.
The Journal of experimental medicine
Xia P,Wang S,Huang G,Zhu P,Li M,Ye B,Du Y,Fan Z
Published figure using CD45.2 monoclonal antibody (Product # 17-0454-82) in Flow Cytometry
Mon Sep 22 00:00:00 EDT 2014
E and Id proteins influence invariant NKT cell sublineage differentiation and proliferation.
Journal of immunology (Baltimore, Md. : 1950)
D'Cruz LM,Stradner MH,Yang CY,Goldrath AW
17-0454 was used in Flow cytometry/Cell sorting to investigate the mechanism by which E and Id proteins control the development of invariant NKT sublineages after positive selection.
Sat Mar 01 00:00:00 EST 2014
Leukocyte population dynamics and detection of IL-9 as a major cytokine at the mouse fetal-maternal interface.
PloS one
Habbeddine M,Verbeke P,Karaz S,Bobé P,Kanellopoulos-Langevin C
Published figure using CD45.2 monoclonal antibody (Product # 17-0454-82) in Flow Cytometry
Wed Jun 10 00:00:00 EDT 2015
Osteocytes regulate primary lymphoid organs and fat metabolism.
Cell metabolism
Sato M,Asada N,Kawano Y,Wakahashi K,Minagawa K,Kawano H,Sada A,Ikeda K,Matsui T,Katayama Y
17-0454 was used in Flow cytometry/Cell sorting to study the effects of osteocyte ablation on the homeostasis of remote organs in mice.
Tue Nov 05 00:00:00 EST 2013
Mutual expression of the transcription factors Runx3 and ThPOK regulates intestinal CD4⁺ T cell immunity.
Nature immunology
Reis BS,Rogoz A,Costa-Pinto FA,Taniuchi I,Mucida D
Published figure using CD45.2 monoclonal antibody (Product # 17-0454-82) in Flow Cytometry
Fri Mar 01 00:00:00 EST 2013
Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens.
Nature immunology
Satpathy AT,Briseño CG,Lee JS,Ng D,Manieri NA,Kc W,Wu X,Thomas SR,Lee WL,Turkoz M,McDonald KG,Meredith MM,Song C,Guidos CJ,Newberry RD,Ouyang W,Murphy TL,Stappenbeck TS,Gommerman JL,Nussenzweig MC,Colonna M,Kopan R,Murphy KM
17-0454 was used in Flow cytometry/Cell sorting to elucidate the cellular source of essential IL-23 production required for the mucosal response to attaching-and-effacing bacterial infection.
Sun Sep 01 00:00:00 EDT 2013
Expression and regulation of intergenic long noncoding RNAs during T cell development and differentiation.
Nature immunology
Hu G,Tang Q,Sharma S,Yu F,Escobar TM,Muljo SA,Zhu J,Zhao K
17-0454 was used in Flow cytometry/Cell sorting to identify essential components of a regulatory circuit important for the migration of TH2 cells.
Fri Nov 01 00:00:00 EDT 2013
miR-126 and miR-126* repress recruitment of mesenchymal stem cells and inflammatory monocytes to inhibit breast cancer metastasis.
Nature cell biology
Zhang Y,Yang P,Sun T,Li D,Xu X,Rui Y,Li C,Chong M,Ibrahim T,Mercatali L,Amadori D,Lu X,Xie D,Li QJ,Wang XF
Published figure using CD45.2 monoclonal antibody (Product # 17-0454-82) in Flow Cytometry
Fri Mar 01 00:00:00 EST 2013
Distinct functions of chemokine receptor axes in the atherogenic mobilization and recruitment of classical monocytes.
EMBO molecular medicine
Soehnlein O,Drechsler M,Döring Y,Lievens D,Hartwig H,Kemmerich K,Ortega-Gómez A,Mandl M,Vijayan S,Projahn D,Garlichs CD,Koenen RR,Hristov M,Lutgens E,Zernecke A,Weber C
17-0454 was used in Flow cytometry/Cell sorting to investigate the differential role of classical and non-classical leukocytes in atheroprogression under high-fat diet, showing that CXCL1 and CCR1/CCR5 are important in the mobilisation and recruitment of classical monocytes in atheroprogression.
Fri Mar 01 00:00:00 EST 2013
IL-21 restricts virus-driven Treg cell expansion in chronic LCMV infection.
PLoS pathogens
Schmitz I,Schneider C,Fröhlich A,Frebel H,Christ D,Leonard WJ,Sparwasser T,Oxenius A,Freigang S,Kopf M
17-0454 was used in Flow cytometry/Cell sorting to investigate the role of Foxp3+ regulatory T (Treg) cells during viral infections, showing that IL-21 restricts virus-driven Treg cell expansion in chronic LCMV infection.
Mon Dec 09 00:00:00 EST 2013
Efficiently stimulated adult microglia cross-prime naive CD8+ T cells injected in the brain.
European journal of immunology
Jarry U,Jeannin P,Pineau L,Donnou S,Delneste Y,Couez D
17-0454 was used in Flow cytometry/Cell sorting to study whether microglia are able to cross-present antigen to naive CD8(+) T cells within the brain microenvironment in vivo.
Wed May 01 00:00:00 EDT 2013
Arrayed lentiviral barcoding for quantification analysis of hematopoietic dynamics.
Stem cells (Dayton, Ohio)
Grosselin J,Sii-Felice K,Payen E,Chretien S,Tronik-Le Roux D,Leboulch P
Published figure using CD45.2 monoclonal antibody (Product # 17-0454-82) in Flow Cytometry
Tue Oct 01 00:00:00 EDT 2013
Heme oxygenase-1 expression protects the heart from acute injury caused by inducible Cre recombinase.
Laboratory investigation; a journal of technical methods and pathology
Hull TD,Bolisetty S,DeAlmeida AC,Litovsky SH,Prabhu SD,Agarwal A,George JF
17-0454 was used in Flow cytometry/Cell sorting to demonstrate that HO-1 induction prevents the depression of cardiac function imposed by Cre-induced cardiac toxicity.
Thu Aug 01 00:00:00 EDT 2013
Regulatory CD8+ T cells associated with erosion of immune surveillance in persistent virus infection suppress in vitro and have a reversible proliferative defect.
Journal of immunology (Baltimore, Md. : 1950)
Hu Z,Zhang W,Usherwood EJ
17-0454 was used in Flow cytometry/Cell sorting to investigate the generation, phenotype and function of IL-10 producing CD8+ T cells during persistent virus infection.
Mon Jul 01 00:00:00 EDT 2013
The cardioprotective protein apolipoprotein A1 promotes potent anti-tumorigenic effects.
The Journal of biological chemistry
Zamanian-Daryoush M,Lindner D,Tallant TC,Wang Z,Buffa J,Klipfell E,Parker Y,Hatala D,Parsons-Wingerter P,Rayman P,Yusufishaq MSS,Fisher EA,Smith JD,Finke J,DiDonato JA,Hazen SL
17-0454 was used in Flow cytometry/Cell sorting to show that apolipoprotein A1 potently suppresses tumour growth and metastasis.
Fri Jul 19 00:00:00 EDT 2013
G-CSF/anti-G-CSF antibody complexes drive the potent recovery and expansion of CD11b+Gr-1+ myeloid cells without compromising CD8+ T cell immune responses.
Journal of hematology & oncology
Rubinstein MP,Salem ML,Doedens AL,Moore CJ,Chiuzan C,Rivell GL,Cole DJ,Goldrath AW
17-0454 was used in Flow cytometry/Cell sorting to evaluate whether the biological activity of G-CSF can be improved by pre-association with anti-G-CSF monoclonal antibodies prior to injection.
Tue Oct 01 00:00:00 EDT 2013
Analyses of microglia effector function using CX3CR1-GFP knock-in mice.
Methods in molecular biology (Clifton, N.J.)
Garcia JA,Cardona SM,Cardona AE
17-0454 was used in Flow cytometry/Cell sorting to analyse the role of CX3CR1 in central nervous system inflammation in bone marrow radiation chimeric mice.
Thu Jan 30 00:00:00 EST 2014
Transcription factor RORα is critical for nuocyte development.
Nature immunology
Wong SH,Walker JA,Jolin HE,Drynan LF,Hams E,Camelo A,Barlow JL,Neill DR,Panova V,Koch U,Radtke F,Hardman CS,Hwang YY,Fallon PG,McKenzie AN
17-0454 was used in Flow cytometry/Cell sorting to study how nuocytes arose in the bone marrow and differentiated from common lymphoid progenitors, indicating they are a distinct, previously unknown member of the lymphoid lineage.
Sun Jan 22 00:00:00 EST 2012
Up-regulation of a HOXA-PBX3 homeobox-gene signature following down-regulation of miR-181 is associated with adverse prognosis in patients with cytogenetically abnormal AML.
Blood
Li Z,Huang H,Li Y,Jiang X,Chen P,Arnovitz S,Radmacher MD,Maharry K,Elkahloun A,Yang X,He C,He M,Zhang Z,Dohner K,Neilly MB,Price C,Lussier YA,Zhang Y,Larson RA,Le Beau MM,Caligiuri MA,Bullinger L,Valk PJ,Delwel R,Lowenberg B,Liu PP,Marcucci G,Bloomfield CD,Rowley JD,Chen J
17-0454 was used in Flow cytometry/Cell sorting to study the prognostic impact of the four members of the miR-181 family in patients with CA-AML.
Thu Mar 08 00:00:00 EST 2012
N-cadherin in osteolineage cells is not required for maintenance of hematopoietic stem cells.
Blood
Greenbaum AM,Revollo LD,Woloszynek JR,Civitelli R,Link DC
17-0454 was used in Flow cytometry/Cell sorting to investigate whether N-cadherin expression on osteoblast lineage cells regulates HSC function and quiescence, showing that it is not required.
Thu Jul 12 00:00:00 EDT 2012
Control of murine Ly6C(high) monocyte traffic and immunosuppressive activities by atypical chemokine receptor D6.
Blood
Savino B,Castor MG,Caronni N,Sarukhan A,Anselmo A,Buracchi C,Benvenuti F,Pinho V,Teixeira MM,Mantovani A,Locati M,Bonecchi R
17-0454 was used in Flow cytometry/Cell sorting to study how control of CCR2 ligands by D6 regulates the traffic of Ly6C(high) monocytes and controls their immunosuppressive potential.
Thu May 31 00:00:00 EDT 2012
Zbtb46 expression distinguishes classical dendritic cells and their committed progenitors from other immune lineages.
The Journal of experimental medicine
Satpathy AT,KC W,Albring JC,Edelson BT,Kretzer NM,Bhattacharya D,Murphy TL,Murphy KM
17-0454 was used in Flow cytometry/Cell sorting to identify Zbtb46 as a transcription factor selectively expressed by classical DCs and their committed progenitors.
Mon Jun 04 00:00:00 EDT 2012
The fractalkine receptor but not CCR2 is present on microglia from embryonic development throughout adulthood.
Journal of immunology (Baltimore, Md. : 1950)
Mizutani M,Pino PA,Saederup N,Charo IF,Ransohoff RM,Cardona AE
17-0454 was used in Flow cytometry/Cell sorting to study CX3CR1 and CCR2 transcription unit activation in reporter mice to infer how myeloid lineages differentiate during development.
Sun Jan 01 00:00:00 EST 2012
Prevention and mitigation of acute radiation syndrome in mice by synthetic lipopeptide agonists of Toll-like receptor 2 (TLR2).
PloS one
Shakhov AN,Singh VK,Bone F,Cheney A,Kononov Y,Krasnov P,Bratanova-Toshkova TK,Shakhova VV,Young J,Weil MM,Panoskaltsis-Mortari A,Orschell CM,Baker PS,Gudkov A,Feinstein E
17-0454 was used in Flow cytometry/Cell sorting to illustrate the strong potential of LP-based TLR2 agonists for anti-radiation prophylaxis and therapy in defence and medical scenarios.
Tue Aug 28 00:00:00 EDT 2012
CD8α(+) dendritic cells are an obligate cellular entry point for productive infection by Listeria monocytogenes.
Immunity
Edelson BT,Bradstreet TR,Hildner K,Carrero JA,Frederick KE,KC W,Belizaire R,Aoshi T,Schreiber RD,Miller MJ,Murphy TL,Unanue ER,Murphy KM
17-0454 was used in Flow cytometry/Cell sorting to elucidate the mechanism by which Listeria establishes productive infection in mice.
Fri Aug 26 00:00:00 EDT 2011
Prostaglandin E2 suppresses the differentiation of retinoic acid-producing dendritic cells in mice and humans.
The Journal of experimental medicine
Stock A,Booth S,Cerundolo V
17-0454 was used in Flow cytometry/Cell sorting to study how PGE2 stimulates the expression of the inducible cyclic AMP early repressor, which appears to directly inhibit RALDH expression in DCs.
Mon Apr 11 00:00:00 EDT 2011
DOCK8 deficiency impairs CD8 T cell survival and function in humans and mice.
The Journal of experimental medicine
Randall KL,Chan SS,Ma CS,Fung I,Mei Y,Yabas M,Tan A,Arkwright PD,Al Suwairi W,Lugo Reyes SO,Yamazaki-Nakashimada MA,Garcia-Cruz Mde L,Smart JM,Picard C,Okada S,Jouanguy E,Casanova JL,Lambe T,Cornall RJ,Russell S,Oliaro J,Tangye SG,Bertram EM,Goodnow CC
17-0454 was used in Flow cytometry/Cell sorting to study the role of DOCK8 in the survival and function of human and mouse CD8 T cells.
Mon Oct 24 00:00:00 EDT 2011
CD73-deficient mice have increased antitumor immunity and are resistant to experimental metastasis.
Cancer research
Stagg J,Divisekera U,Duret H,Sparwasser T,Teng MW,Darcy PK,Smyth MJ
17-0454 was used in Flow cytometry/Cell sorting to study CD73 gene-targeted mice to investigate the role of host-derived CD73 on antitumor immunity and tumor cell metastasis.
Fri Apr 15 00:00:00 EDT 2011
Distribution of lentiviral vector integration sites in mice following therapeutic gene transfer to treat β-thalassemia.
Molecular therapy : the journal of the American Society of Gene Therapy
Ronen K,Negre O,Roth S,Colomb C,Malani N,Denaro M,Brady T,Fusil F,Gillet-Legrand B,Hehir K,Beuzard Y,Leboulch P,Down JD,Payen E,Bushman FD
17-0454 was used in Flow cytometry/Cell sorting to study integration sites of a lentiviral vector encoding β-globin during treatment of β-thalassemia, showing that integration occurred multiple times and clonal populations with integration near growth-control genes were not enriched.
Fri Jul 01 00:00:00 EDT 2011
A role for IL-27 in limiting T regulatory cell populations.
Journal of immunology (Baltimore, Md. : 1950)
Wojno ED,Hosken N,Stumhofer JS,O'Hara AC,Mauldin E,Fang Q,Turka LA,Levin SD,Hunter CA
17-0454 was used in Flow cytometry/Cell sorting to show that mice that overexpress IL-27 had decreased Treg frequencies and developed spontaneous inflammation.
Fri Jul 01 00:00:00 EDT 2011
Vitamin A deficiency impairs vaccine-elicited gastrointestinal immunity.
Journal of immunology (Baltimore, Md. : 1950)
Kaufman DR,De Calisto J,Simmons NL,Cruz AN,Villablanca EJ,Mora JR,Barouch DH
17-0454 was used in Flow cytometry/Cell sorting to suggest that oral vitamin A supplementation may be important for optimizing the success of vaccines against HIV-1 and other mucosal pathogens in the developing world.
Mon Aug 15 00:00:00 EDT 2011
Restricted microbiota and absence of cognate TCR antigen leads to an unbalanced generation of Th17 cells.
Journal of immunology (Baltimore, Md. : 1950)
Lochner M,Bérard M,Sawa S,Hauer S,Gaboriau-Routhiau V,Fernandez TD,Snel J,Bousso P,Cerf-Bensussan N,Eberl G
17-0454 was used in Flow cytometry/Cell sorting to demonstrate that a complex microbiota and cognate antigen are required to generate a properly regulated set of Foxp3+RORγt+ T cells and Th17 cells.
Tue Feb 01 00:00:00 EST 2011
Batf3-dependent CD11b(low/-) peripheral dendritic cells are GM-CSF-independent and are not required for Th cell priming after subcutaneous immunization.
PloS one
Edelson BT,Bradstreet TR,KC W,Hildner K,Herzog JW,Sim J,Russell JH,Murphy TL,Unanue ER,Murphy KM
17-0454 was used in Flow cytometry/Cell sorting to compare development of peripheral tissue dendritic cells, and susceptibility to experimental autoimmune encephalitis in GM-CSF receptor deficient mice.
Thu Mar 15 00:00:00 EDT 2012
One naive T cell, multiple fates in CD8+ T cell differentiation.
The Journal of experimental medicine
Gerlach C,van Heijst JW,Swart E,Sie D,Armstrong N,Kerkhoven RM,Zehn D,Bevan MJ,Schepers K,Schumacher TN
17-0454 was used in Flow cytometry/Cell sorting to assess the potential for development of single naive T cells into different subsets.
Mon Jun 07 00:00:00 EDT 2010
Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8alpha+ conventional dendritic cells.
The Journal of experimental medicine
Edelson BT,KC W,Juang R,Kohyama M,Benoit LA,Klekotka PA,Moon C,Albring JC,Ise W,Michael DG,Bhattacharya D,Stappenbeck TS,Holtzman MJ,Sung SS,Murphy TL,Hildner K,Murphy KM
17-0454 was used in Flow cytometry/Cell sorting to study the relationship between nonlymphoid CD103-expressing dendritic cells (DCs) and other DC subsets.
Mon Apr 12 00:00:00 EDT 2010
Runx1 isoforms show differential expression patterns during hematopoietic development but have similar functional effects in adult hematopoietic stem cells.
Experimental hematology
Challen GA,Goodell MA
17-0454 was used in Flow cytometry/Cell sorting to study how Runx1 isoforms hold similar functions in adult hematopoietic stem cells, but show differential expression patterns during hematopoietic development.
Sat May 01 00:00:00 EDT 2010
miR-33-mediated downregulation of p53 controls hematopoietic stem cell self-renewal.
Cell cycle (Georgetown, Tex.)
Herrera-Merchan A,Cerrato C,Luengo G,Dominguez O,Piris MA,Serrano M,Gonzalez S
17-0454 was used in Immunocytochemistry to define the role of miR-33 in controlling HSC self-renewal through p53.
Sun Aug 15 00:00:00 EDT 2010
Commitment to the regulatory T cell lineage requires CARMA1 in the thymus but not in the periphery.
PLoS biology
Barnes MJ,Krebs P,Harris N,Eidenschenk C,Gonzalez-Quintial R,Arnold CN,Crozat K,Sovath S,Moresco EM,Theofilopoulos AN,Beutler B,Hoebe K
17-0454 was used in Flow cytometry/Cell sorting to investigate methods to distinguish between Tregs of thymic or peripheral origin, showing that commitment requires CARMA1 in the thymus but not in the periphery.
Tue Mar 03 00:00:00 EST 2009
In vivo expansion of activated naive CD8+ T cells and NK cells driven by complexes of IL-2 and anti-IL-2 monoclonal antibody as novel approach of cancer immunotherapy.
Journal of immunology (Baltimore, Md. : 1950)
Tomala J,Chmelova H,Mrkvan T,Rihova B,Kovar M
17-0454 was used in Flow cytometry/Cell sorting to investigate the potential for replacement of IL-2 by IL-2 immunocomplexes for cancer therapy.
Thu Oct 15 00:00:00 EDT 2009
Wiskott-Aldrich syndrome protein is required for homeostasis and function of invariant NKT cells.
Journal of immunology (Baltimore, Md. : 1950)
Astrakhan A,Ochs HD,Rawlings DJ
17-0454 was used in Flow cytometry/Cell sorting to investigate the role for WASp within the iNKT lineage.
Mon Jun 15 00:00:00 EDT 2009
CD4+CD25+ regulatory T cells suppress mast cell degranulation and allergic responses through OX40-OX40L interaction.
Immunity
Gri G,Piconese S,Frossi B,Manfroi V,Merluzzi S,Tripodo C,Viola A,Odom S,Rivera J,Colombo MP,Pucillo CE
17-0454 was used in Flow cytometry/Cell sorting to explore whether Treg cells influence the immediate hypersensitivity response of mast cells.
Fri Nov 14 00:00:00 EST 2008
IL-7 and IL-15 differentially regulate CD8+ T-cell subsets during contraction of the immune response.
Blood
Rubinstein MP,Lind NA,Purton JF,Filippou P,Best JA,McGhee PA,Surh CD,Goldrath AW
17-0454 was used in Flow cytometry/Cell sorting to study IL-7 and IL-15 regulation of CD8+ T-cell subsets during contraction of the immune response.
Sat Nov 01 00:00:00 EDT 2008
In vivo equilibrium of proinflammatory IL-17+ and regulatory IL-10+ Foxp3+ RORgamma t+ T cells.
The Journal of experimental medicine
Lochner M,Peduto L,Cherrier M,Sawa S,Langa F,Varona R,Riethmacher D,Si-Tahar M,Di Santo JP,Eberl G
17-0454 was used in Flow cytometry/Cell sorting to study how potentially antagonistic pro-inflammatory IL-17-producing and regulatory Foxp3(+) RORgamma t(+) T cells coexist and are tightly controlled.
Mon Jun 09 00:00:00 EDT 2008
CXCL9, but not CXCL10, promotes CXCR3-dependent immune-mediated kidney disease.
Journal of the American Society of Nephrology : JASN
Menke J,Zeller GC,Kikawada E,Means TK,Huang XR,Lan HY,Lu B,Farber J,Luster AD,Kelley VR
17-0454 was used in Flow cytometry/Cell sorting to identify additional therapeutic chemokine targets for immune-mediated nephritis.
Sun Jun 01 00:00:00 EDT 2008
Role for MyD88 signaling in murine gammaherpesvirus 68 latency.
Journal of virology
Gargano LM,Moser JM,Speck SH
17-0454 was used in Flow cytometry/Cell sorting to investigate the role of toll-like receptor signalling in the establishment and maintenance of murine gammaherpesvirus 68 latency in vivo, showing that MyD88 is important for the establishment of latency.
Tue Apr 01 00:00:00 EDT 2008
miR-150, a microRNA expressed in mature B and T cells, blocks early B cell development when expressed prematurely.
Proceedings of the National Academy of Sciences of the United States of America
Zhou B,Wang S,Mayr C,Bartel DP,Lodish HF
17-0454 was used in Immunofluorescence to study how miR-150 can down-regulate mRNAs important for B cell function, and how it can block further B cell development when expressed prematurely.
Tue Apr 24 00:00:00 EDT 2007
miR-150, a microRNA expressed in mature B and T cells, blocks early B cell development when expressed prematurely.
Proceedings of the National Academy of Sciences of the United States of America
Zhou B,Wang S,Mayr C,Bartel DP,Lodish HF
17-0454 was used in Immunofluorescence to study how miR-150 can down-regulate mRNAs important for B cell function, and how it can block further B cell development when expressed prematurely.
Tue Apr 24 00:00:00 EDT 2007
MOZ is essential for maintenance of hematopoietic stem cells.
Genes & development
Katsumoto T,Aikawa Y,Iwama A,Ueda S,Ichikawa H,Ochiya T,Kitabayashi I
17-0454 was used in Flow cytometry/Cell sorting to show that monocytic leukemia zinc-finger protein is required for maintenance of hematopoietic stem cells.
Mon May 15 00:00:00 EDT 2006
Direct stimulation of T cells by membrane vesicles from antigen-presenting cells.
Proceedings of the National Academy of Sciences of the United States of America
Kovar M,Boyman O,Shen X,Hwang I,Kohler R,Sprent J
17-0454 was used in Flow cytometry/Cell sorting to study how dissociated cell membrane fragments from a DC line can be used as an effective substitute for viable DC.
Tue Aug 01 00:00:00 EDT 2006
Intrinsic lymphotoxin-beta receptor requirement for homeostasis of lymphoid tissue dendritic cells.
Immunity
Kabashima K,Banks TA,Ansel KM,Lu TT,Ware CF,Cyster JG
17-0454 was used in Flow cytometry/Cell sorting to demonstrate the importance of lymphotoxin receptor signalling in maintaining CD8- dendritic cell populations and development.
Fri Apr 01 00:00:00 EST 2005
