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Thermo Fisher Scientific offers the most comprehensive miRNA collections available!
Learn more about our individual pre-designed mirVana Mimics & Inhibitors
If you’re ready to start screening with a pre-defined collection or want to request a custom library, request a quote now!
| Catalog # | pre-defined collections for human and mouse miRNA | nmol/well | # of miRNA |
|---|---|---|---|
| 4464074 | mirVana miRNA Mimics, Human v 21 - 384 or 96-Well Plates | 0.25 nmol | 2565 |
| 4464092 | mirVana miRNA Inhibitors, Human v 21 - 384 or 96-Well Plates | 0.25 nmol | 2565 |
| 4464075 | mirVana miRNA Mimics, Human v 21 - 384 or 96-Well Plates | 1 nmol | 2565 |
| 4464093 | mirVana miRNA Inhibitors, Human v 21 - 384 or 96-Well Plates | 1 nmol | 2565 |
| 4464074 | mirVana miRNA Mimics, Mouse v 21 - 384 or 96-Well Plates | 0.25 nmol | 1900 |
| 4464092 | mirVana miRNA Inhibitors, Mouse v 21 - 384 or 96-Well Plates | 0.25 nmol | 1900 |
| 4464075 | mirVana miRNA Mimics, Mouse v 21 - 384 or 96-Well Plates | 1 nmol | 1900 |
| 4464093 | mirVana miRNA Inhibitors, Mouse v 21 - 384 or 96-Well Plates | 1 nmol | 1900 |
In addition to our pre-defined genome-wide libraries, mirVana mimics and inhibitors are available as custom collections.
| Product lines for custom library fulfillment | Quantity per well |
|---|---|
| mirVana miRNA mimics–human, mouse, or rat, miRBase v22 | 0.25 or 1.0 nmol/well |
| mirVana miRNA inhibitors–human, mouse, or rat, miRBase v22 | 0.25 or 1.0 nmol/well |
The following selected peer-reviewed citations demonstrate the utility of mirVana mimic and inhibitor libraries in high-throughput screening applications to assess microRNA involvement in biological pathways such as those of development and growth, metabolic pathways and diseases, and cancer progression.
Lopes, IR et al. (2019) Shedding light on microRNA function via microscopy-based screening Methods 152: 55-64.
This comprehensive overview of miRNA mimic and inhibitor screening provides a detailed case study of the identification of miRNAs that control infection by the bacterial pathogen Samonella. It includes methodologies that are readily adaptable for screens to address a wide variety of biological questions.
Takagawa Y, et al. (2020) miR-1293, a Candidate for miRNA-Based Cancer Therapeutics, Simultaneously Targets BRD4 and the DNA Repair Pathway Molecular Therapy 28(6): 1494-1505.
A genome-wide human mirVana miRNA mimic screen carried out in 10 cancer cell lines uncovered three tumor-suppressive microRNAs which target the gene BRD4, suggesting potential candidate for miRNA-based cancer therapeutics.
Meyer H-J, et al. (2017) Identification of a novel miRNA that increases transient protein expression in combination with valproic acid Biotechnology Progress 33(4): 1139-1145.
A custom collection of 875 mirVana mimics was screened to successfully identify two human miRNAs that increase recombinant protein titers for the purpose of large molecule therapeutic development.
Pal AS, et al. (2020) Identification of microRNAs that promote erlotinib resistance in non-small cell lung cancer Biochemical Pharmacology.https://doi.org/10.1016/j.bcp.2020.114154
Multiple microRNAs that drive EGFR-inhibitor resistance were identified in this genome-wide screen using mirVana miRNAs, uncovering a model for how miRNA dysregulation may contribute to drug resistance.
Ensure effective delivery, detection, and interpretation of your miRNA modulation experiments
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If you have any questions on miRNA products or ordering, please contact us at RNAiSupport@thermofisher.com
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