Product References
Pyrimidine de novo synthesis inhibition selectively blocks effector but not memory T cell development.
Nature immunology
Scherer S,Oberle SG,Kanev K,Gerullis AK,Wu M,de Almeida GP,Puleston DJ,Baixauli F,Aly L,Greco A,Nizharadze T,Becker NB,Hoesslin MV,Donhauser LV,Berner J,Chu T,McNamara HA,Esencan Z,Roelli P,Wurmser C,Kleiter I,Vehreschild MJGT,Mayer CA,Knolle P,Klingenspor M,Fumagalli V,Iannacone M,Prlic M,Korn T,Pearce EL,Höfer T,Schulz AM,Zehn D
45-0454-82 was used in Flow cytometry/Cell sorting to show memory T cell precursors are resistant to pyrimidine starvation.
Wed Mar 01 00:00:00 EST 2023
Identification of fibroblast progenitors in the developing mouse thymus.
Development (Cambridge, England)
Ferreirinha P,Pinheiro RGR,Landry JJM,Alves NL
45-0454-82 was used in Flow cytometry/Cell sorting to identify CD140αβ+GP38+SCA-1- as a source of fibroblast progenitors and define SCA-1 as a marker for developmental stages of thymic fibroblast differentiation.
Sun May 15 00:00:00 EDT 2022
Diverging regulation of Bach2 protein and RNA expression determine cell fate in early B cell response.
Cell reports
Hu Q,Xu T,Zhang M,Zhang H,Liu Y,Li HB,Chen C,Zheng J,Zhang Z,Li F,Shen N,Zhang W,Melnick A,Huang C
45-0454-82 was used in Flow cytometry/Cell sorting to reveal that differential dynamics of Bach2 protein and transcripts in activated B cells control their cell-fate outcomes and imprint the fates of their descendant effector cells.
Tue Jul 05 00:00:00 EDT 2022
Sphingosine 1-Phosphate Receptor 4 Promotes Nonalcoholic Steatohepatitis by Activating NLRP3 Inflammasome.
Cellular and molecular gastroenterology and hepatology
Hong CH,Ko MS,Kim JH,Cho H,Lee CH,Yoon JE,Yun JY,Baek IJ,Jang JE,Lee SE,Cho YK,Baek JY,Oh SJ,Lee BY,Lim JS,Lee J,Hartig SM,Conde de la Rosa L,Garcia-Ruiz C,Lee KU,Fernández-Checa JC,Choi JW,Kim S,Koh EH
45-0454-82 was used in Flow Cytometry to show that S1PR4 may be a new therapeutic target for NASH that mediates the activation of NLRP3 inflammasome in hepatic macrophages.
Mon Apr 04 00:00:00 EDT 2022
Loss of T cell tolerance in the skin following immunopathology is linked to failed restoration of the dermal niche by recruited macrophages.
Cell reports
West HC,Davies J,Henderson S,Adegun OK,Ward S,Ferrer IR,Tye CA,Vallejo AF,Jardine L,Collin M,Polak ME,Bennett CL
45-0454-82 was used in Flow cytometry/Cell sorting to demonstrate that pathology initiates dermis-specific macrophage differentiation and show that aGVHD-primed macrophages continue to dominate the dermal compartment at the relative expense of quiescent MHCIIint cells.
Tue May 17 00:00:00 EDT 2022
Transcriptomic analysis of CFTR-impaired endothelial cells reveals a pro-inflammatory phenotype.
The European respiratory journal
Declercq M,de Zeeuw P,Conchinha NV,Geldhof V,Ramalho AS,García-Caballero M,Brepoels K,Ensinck M,Carlon MS,Bird MJ,Vinckier S,Proesmans M,Vermeulen F,Dupont L,Ghesquière B,Dewerchin M,Carmeliet P,Cassiman D,Treps L,Eelen G,Witters P
45-0454-82 was used in Flow Cytometry to suggest that ECs are no innocent bystanders in CF pathology, but rather may contribute to the exaggerated inflammatory phenotype, raising the question whether normalisation of vascular inflammation might be a novel therapeutic strategy to ameliorate the disease severity of CF.
Thu Apr 01 00:00:00 EDT 2021
Smc3 dosage regulates B cell transit through germinal centers and restricts their malignant transformation.
Nature immunology
Rivas MA,Meydan C,Chin CR,Challman MF,Kim D,Bhinder B,Kloetgen A,Viny AD,Teater MR,McNally DR,Doane AS,Béguelin W,Fernández MTC,Shen H,Wang X,Levine RL,Chen Z,Tsirigos A,Elemento O,Mason CE,Melnick AM
Published figure using CD45.2 monoclonal antibody (Product # 45-0454-82) in Flow Cytometry
Mon Feb 01 00:00:00 EST 2021
Niche-specific MHC II and PD-L1 regulate CD4+CD8αα+ intraepithelial lymphocyte differentiation.
The Journal of experimental medicine
Moon S,Park Y,Hyeon S,Kim YM,Kim JH,Kim H,Park S,Lee KJ,Koo BK,Ha SJ,Lee SW
Published figure using CD45.2 monoclonal antibody (Product # 45-0454-82) in Flow Cytometry
Mon Apr 05 00:00:00 EDT 2021
Multifaceted modes of action of the anticancer probiotic Enterococcus hirae.
Cell death and differentiation
Goubet AG,Wheeler R,Fluckiger A,Qu B,Lemaître F,Iribarren K,Mondragón L,Tidjani Alou M,Pizzato E,Durand S,Derosa L,Aprahamian F,Bossut N,Moya-Nilges M,Derrien D,Chen G,Leduc M,Joseph A,Pons N,Le Chatelier E,Segata N,Yonekura S,Iebba V,Kepp O,Raoult D,André F,Kroemer G,Boneca IG,Zitvogel L,Daillère R
45-0454-82 was used in Flow cytometry/Cell sorting to surmise that immunological, metabolic, epithelial, and microbial modes of action of the live E. hirae cooperate to circumvent primary resistance to therapy.
Thu Jul 01 00:00:00 EDT 2021
Ageing promotes early T follicular helper cell differentiation by modulating expression of RBPJ.
Aging cell
Webb LMC,Fra-Bido S,Innocentin S,Matheson LS,Attaf N,Bignon A,Novarino J,Fazilleau N,Linterman MA
45-0454-82 was used in Flow Cytometry to show increased formation of Tfh precursors (pre-Tfh) but no associated increase in germinal centre (GC)-Tfh cells in aged mice, suggesting age-driven promotion of only early Tfh cell differentiation.
Fri Jan 01 00:00:00 EST 2021
Brd4 modulates diet-induced obesity via PPARγ-dependent Gdf3 expression in adipose tissue macrophages.
JCI insight
Hu X,Dong X,Li G,Chen Y,Chen J,He X,Sun H,Kim DH,Kemper JK,Chen LF
Published figure using CD45.2 monoclonal antibody (Product # 45-0454-82) in Flow Cytometry
Thu Apr 08 00:00:00 EDT 2021
Differentiation of fetal hematopoietic stem cells requires ARID4B to restrict autocrine KITLG/KIT-Src signaling.
Cell reports
Young IC,Wu B,Andricovich J,Chuang ST,Li R,Tzatsos A,Wu RC,Wu MY
Published figure using CD45.2 monoclonal antibody (Product # 45-0454-82) in Flow Cytometry
Tue Nov 23 00:00:00 EST 2021
Erythritol Ameliorates Small Intestinal Inflammation Induced by High-Fat Diets and Improves Glucose Tolerance.
International journal of molecular sciences
Kawano R,Okamura T,Hashimoto Y,Majima S,Senmaru T,Ushigome E,Asano M,Yamazaki M,Takakuwa H,Sasano R,Nakanishi N,Hamaguchi M,Fukui M
Published figure using CD45.2 monoclonal antibody (Product # 45-0454-82) in Flow Cytometry
Mon May 24 00:00:00 EDT 2021
Expansion of an Unusual Virtual Memory CD8+ Subpopulation Bearing Vα3.2 TCR in Themis-Deficient Mice.
Frontiers in immunology
Prasad M,Wojciech L,Brzostek J,Hu J,Chua YL,Tung DWH,Yap J,Rybakin V,Gascoigne NRJ
Published figure using CD45.2 monoclonal antibody (Product # 45-0454-82) in Flow Cytometry
Thu Sep 23 00:00:00 EDT 2021
The subunits of IL-12, originating from two distinct cells, can functionally synergize to protect against pathogen dissemination in vivo.
Cell reports
Gerber AN,Abdi K,Singh NJ
Published figure using CD45.2 monoclonal antibody (Product # 45-0454-82) in Flow Cytometry
Tue Oct 12 00:00:00 EDT 2021
Ddb1 Is Essential for the Expansion of CD4+ Helper T Cells by Regulating Cell Cycle Progression and Cell Death.
Frontiers in immunology
Yang L,Chen W,Li L,Xiao Y,Fan S,Zhang Q,Xia T,Li M,Hong Y,Zhao T,Li Q,Liu WH,Xiao N
Published figure using CD45.2 monoclonal antibody (Product # 45-0454-82) in Flow Cytometry
Mon Dec 20 00:00:00 EST 2021
Abraxane-induced bone marrow CD11b+ myeloid cell depletion in tumor-bearing mice is visualized by μPET-CT with 64Cu-labeled anti-CD11b and prevented by anti-CSF-1.
Theranostics
Cao Q,Huang Q,Wang YA,Li C
Published figure using CD45.2 monoclonal antibody (Product # 45-0454-82) in Flow Cytometry
Fri Jul 23 00:00:00 EDT 2021
Mitochondrial transcription factor A in RORγt+ lymphocytes regulate small intestine homeostasis and metabolism.
Nature communications
Fu Z,Dean JW,Xiong L,Dougherty MW,Oliff KN,Chen ZE,Jobin C,Garrett TJ,Zhou L
45-0454-82 was used in Flow Cytometry to show that IL-22, a cytokine produced by RORγt+ lymphocytes inhibits IL-13-induced tuft cell differentiation in vitro, and suppresses the tuft cell-type 2 immune circuit and small intestine lengthening in vivo, highlighting its key role in gut tissue remodeling.
Thu Jul 22 00:00:00 EDT 2021
Redundant cytokine requirement for intestinal microbiota-induced Th17 cell differentiation in draining lymph nodes.
Cell reports
Sano T,Kageyama T,Fang V,Kedmi R,Martinez CS,Talbot J,Chen A,Cabrera I,Gorshko O,Kurakake R,Yang Y,Ng C,Schwab SR,Littman DR
45-0454-82 was used in Flow Cytometry to show that intestine-draining mesenteric lymph nodes (MLNs), not intestine proper, are the dominant site of SFB-induced intestinal Th17 cell differentiation.
Tue Aug 24 00:00:00 EDT 2021
Inflammasome activation leads to cDC1-independent cross-priming of CD8 T cells by epithelial cell-derived antigen.
eLife
Deets KA,Nichols Doyle R,Rauch I,Vance RE
45-0454-82 was used in Flow cytometry/Cell sorting to investigate whether inflammasomes provide sufficient signals to activate adaptive immunity.
Thu Dec 23 00:00:00 EST 2021
Caspase-8-Dependent Inflammatory Responses Are Controlled by Its Adaptor, FADD, and Necroptosis.
Immunity
Tummers B,Mari L,Guy CS,Heckmann BL,Rodriguez DA,Rühl S,Moretti J,Crawford JC,Fitzgerald P,Kanneganti TD,Janke LJ,Pelletier S,Blander JM,Green DR
45-0454-82 was used in Flow Cytometry to suggest an in vivo role of the inflammatory RIPK1-caspase-8-FADD (FADDosome) complex and reveal a FADD-independent inflammatory role of caspase-8 that involves activation of an inflammasome.
Tue Jun 16 00:00:00 EDT 2020
Heterogenous Populations of Tissue-Resident CD8+ T Cells Are Generated in Response to Infection and Malignancy.
Immunity
Milner JJ,Toma C,He Z,Kurd NS,Nguyen QP,McDonald B,Quezada L,Widjaja CE,Witherden DA,Crowl JT,Shaw LA,Yeo GW,Chang JT,Omilusik KD,Goldrath AW
45-0454 was used in Flow cytometry/Cell sorting to identify discrete lineages of intestinal antigen-specific CD8+ T cells, including a Blimp1hiId3lo tissue-resident effector cell population most prominent in the early phase of acute viral and bacterial infections and a molecularly distinct Blimp1loId3hi tissue-resident memory population that subsequently accumulated at later infection time points.
Tue May 19 00:00:00 EDT 2020
Deregulated Notch and Wnt signaling activates early-stage myeloid regeneration pathways in leukemia.
The Journal of experimental medicine
Kang YA,Pietras EM,Passegué E
Published figure using CD45.2 monoclonal antibody (Product # 45-0454-82) in Flow Cytometry
Mon Mar 02 00:00:00 EST 2020
Snai2 Maintains Bone Marrow Niche Cells by Repressing Osteopontin Expression.
Developmental cell
Wei Q,Nakahara F,Asada N,Zhang D,Gao X,Xu C,Alfieri A,Brodin NP,Zimmerman SE,Mar JC,Guha C,Guo W,Frenette PS
45-0454-82 was used in Flow Cytometry to conclude that SNAI2 is a critical regulator of the transcriptional network maintaining MSPCs by the suppression of osteopontin expression.
Mon Jun 08 00:00:00 EDT 2020
Proenkephalin+ regulatory T cells expanded by ultraviolet B exposure maintain skin homeostasis with a healing function.
Proceedings of the National Academy of Sciences of the United States of America
Shime H,Odanaka M,Tsuiji M,Matoba T,Imai M,Yasumizu Y,Uraki R,Minohara K,Watanabe M,Bonito AJ,Fukuyama H,Ohkura N,Sakaguchi S,Morita A,Yamazaki S
Published figure using CD45.2 monoclonal antibody (Product # 45-0454-82) in Flow Cytometry
Tue Aug 25 00:00:00 EDT 2020
Interleukin 35 Delays Hindlimb Ischemia-Induced Angiogenesis Through Regulating ROS-Extracellular Matrix but Spares Later Regenerative Angiogenesis.
Frontiers in immunology
Fu H,Sun Y,Shao Y,Saredy J,Cueto R,Liu L,Drummer C,Johnson C,Xu K,Lu Y,Li X,Meng S,Xue ER,Tan J,Jhala NC,Yu D,Zhou Y,Bayless KJ,Yu J,Rogers TJ,Hu W,Snyder NW,Sun J,Qin X,Jiang X,Wang H,Yang X
Published figure using CD45.2 monoclonal antibody (Product # 45-0454-82) in Flow Cytometry
Fri Jul 09 00:00:00 EDT 2021
Metabolic profiling during malaria reveals the role of the aryl hydrocarbon receptor in regulating kidney injury.
eLife
Lissner MM,Cumnock K,Davis NM,Vilches-Moure JG,Basak P,Navarrete DJ,Allen JA,Schneider D
45-0454-80 was used in Flow Cytometry to detail the host immune and metabolic response during sickness and recovery in a mouse model of malaria.
Tue Oct 06 00:00:00 EDT 2020
The frequency of follicular T helper cells differs in acute and chronic neuroinflammation.
Scientific reports
Baniahmad A,Birkner K,Görg J,Loos J,Zipp F,Wasser B,Bittner S
Published figure using CD45.2 monoclonal antibody (Product # 45-0454-82) in Flow Cytometry
Tue Nov 24 00:00:00 EST 2020
Long-term ex vivo haematopoietic-stem-cell expansion allows nonconditioned transplantation.
Nature
Wilkinson AC,Ishida R,Kikuchi M,Sudo K,Morita M,Crisostomo RV,Yamamoto R,Loh KM,Nakamura Y,Watanabe M,Nakauchi H,Yamazaki S
Published figure using CD45.2 monoclonal antibody (Product # 45-0454-82) in Flow Cytometry
Mon Jul 01 00:00:00 EDT 2019
A Thpok-Directed Transcriptional Circuitry Promotes Bcl6 and Maf Expression to Orchestrate T Follicular Helper Differentiation.
Immunity
Vacchio MS,Ciucci T,Gao Y,Watanabe M,Balmaceno-Criss M,McGinty MT,Huang A,Xiao Q,McConkey C,Zhao Y,Shetty J,Tran B,Pepper M,Vahedi G,Jenkins MK,McGavern DB,Bosselut R
45-0454-82 was used in Flow Cytometry to identify a transcriptional program that links the CD4+ lineage with Tfh differentiation, a limiting factor for efficient B cell responses.
Tue Sep 17 00:00:00 EDT 2019
Cyclooxygenase-1 Regulates the Development of Follicular Th Cells via Prostaglandin E2.
Journal of immunology (Baltimore, Md. : 1950)
Liu T,Yang Q,Cao YJ,Yuan WM,Lei AH,Zhou P,Zhou W,Liu YD,Shi MH,Yang Q,Tang JY,Wang HK,Zhang H,Yu Y,Zhou J
45-0454-82 was used in Flow Cytometry to indicate that COX-1 plays an important role in the development of TFH cells.
Thu Aug 15 00:00:00 EDT 2019
Loss of NF-κB1 Causes Gastric Cancer with Aberrant Inflammation and Expression of Immune Checkpoint Regulators in a STAT-1-Dependent Manner.
Immunity
O'Reilly LA,Putoczki TL,Mielke LA,Low JT,Lin A,Preaudet A,Herold MJ,Yaprianto K,Tai L,Kueh A,Pacini G,Ferrero RL,Gugasyan R,Hu Y,Christie M,Wilcox S,Grumont R,Griffin MDW,O'Connor L,Smyth GK,Ernst M,Waring P,Gerondakis S,Strasser A
45-0454-82 was used in Flow Cytometry to provide mechanistic insight into how polymorphisms that attenuate NFKB1 expression predispose humans to epithelial cancers, highlighting the pro-tumorigenic activity of STAT1 and identifying targetable vulnerabilities in gastric cancer.
Tue Mar 20 00:00:00 EDT 2018
Insulin resistance causes inflammation in adipose tissue.
The Journal of clinical investigation
Shimobayashi M,Albert V,Woelnerhanssen B,Frei IC,Weissenberger D,Meyer-Gerspach AC,Clement N,Moes S,Colombi M,Meier JA,Swierczynska MM,Jenö P,Beglinger C,Peterli R,Hall MN
45-0454 was used in Flow cytometry/Cell sorting to elucidate the causal relationship between obesity-induced insulin resistance, and macrophage accumulation and inflammation in adipose tissue.
Mon Apr 02 00:00:00 EDT 2018
Effector CD4 T cells with progenitor potential mediate chronic intestinal inflammation.
The Journal of experimental medicine
Shin B,Kress RL,Kramer PA,Darley-Usmar VM,Bellis SL,Harrington LE
45-0454 was used in Flow cytometry/Cell sorting to indicate that the chronicity of T cell-mediated inflammation is perpetuated by specific effector CD4 T cells with stem-like properties.
Mon Jul 02 00:00:00 EDT 2018
The H3K4 methyltransferase Setd1b is essential for hematopoietic stem and progenitor cell homeostasis in mice.
eLife
Schmidt K,Zhang Q,Tasdogan A,Petzold A,Dahl A,Arneth BM,Slany R,Fehling HJ,Kranz A,Stewart AF,Anastassiadis K
Published figure using CD45.2 monoclonal antibody (Product # 45-0454-82) in Flow Cytometry
Tue Jun 19 00:00:00 EDT 2018
Differential requirement of kindlin-3 for T cell progenitor homing to the non-vascularized and vascularized thymus.
eLife
Moretti FA,Klapproth S,Ruppert R,Margraf A,Weber J,Pick R,Scheiermann C,Sperandio M,Fässler R,Moser M
Published figure using CD45.2 monoclonal antibody (Product # 45-0454-82) in Flow Cytometry
Thu Sep 06 00:00:00 EDT 2018
Type 2 Innate Lymphocytes Actuate Immunity Against Tumours and Limit Cancer Metastasis.
Scientific reports
Saranchova I,Han J,Zaman R,Arora H,Huang H,Fenninger F,Choi KB,Munro L,Pfeifer CG,Welch I,Takei F,Jefferies WA
45-0454 was used in Flow cytometry/Cell sorting to study the role of type 2 innate lymphoid cells in enhancing anti-cancer immunity and controlling metastasis.
Tue Feb 13 00:00:00 EST 2018
Low-Dose Radiotherapy Has No Harmful Effects on Key Cells of Healthy Non-Inflamed Joints.
International journal of molecular sciences
Deloch L,Rückert M,Fietkau R,Frey B,Gaipl US
45-0454 was used in Flow cytometry/Cell sorting to show that low-dose radiotherapy with particularly a single dose of 0.5 Gray has no harmful effects on cells of healthy joints.
Tue Oct 16 00:00:00 EDT 2018
Transcription factors early growth response gene (Egr) 2 and 3 control inflammatory responses of tolerant T cells.
Immunity, inflammation and disease
Omodho B,Miao T,Symonds ALJ,Singh R,Li S,Wang P
45-0454 was used in Flow cytometry/Cell sorting to show that despite impaired proliferation and IL2 production, tolerant T cells can display inflammatory responses in response to antigen stimulation and this is controlled at least partly by Egr2 and 3.
Fri Jun 01 00:00:00 EDT 2018
Limited Foxp3+ Regulatory T Cells Response During Acute Trypanosoma cruzi Infection Is Required to Allow the Emergence of Robust Parasite-Specific CD8+ T Cell Immunity.
Frontiers in immunology
Araujo Furlan CL,Tosello Boari J,Rodriguez C,Canale FP,Fiocca Vernengo F,Boccardo S,Beccaria CG,Adoue V,Joffre O,Gruppi A,Montes CL,Acosta Rodriguez EV
45-0454 was used in Flow cytometry/Cell sorting to study the role of regulatory T cells during Trypanosoma cruzi infection.
Thu Sep 26 00:00:00 EDT 2019
Egr2 and 3 control adaptive immune responses by temporally uncoupling expansion from T cell differentiation.
The Journal of experimental medicine
Miao T,Symonds ALJ,Singh R,Symonds JD,Ogbe A,Omodho B,Zhu B,Li S,Wang P
Published figure using CD45.2 monoclonal antibody (Product # 45-0454-82) in Flow Cytometry
Mon Jun 05 00:00:00 EDT 2017
Batf3-dependent CD8α+ Dendritic Cells Aggravates Atherosclerosis via Th1 Cell Induction and Enhanced CCL5 Expression in Plaque Macrophages.
EBioMedicine
Li Y,Liu X,Duan W,Tian H,Zhu G,He H,Yao S,Yi S,Song W,Tang H
Published figure using CD45.2 monoclonal antibody (Product # 45-0454-82) in Flow Cytometry
Sat Apr 01 00:00:00 EDT 2017
Recipient bone marrow assimilates the myeloid/lymphoid reconstitution of distinct fetal hematopoietic stem cells.
Oncotarget
Guo XL,Chu L,Ke F,Mu LL,Li Z,Cai JJ,Li HF,Hong DL
Published figure using CD45.2 monoclonal antibody (Product # 45-0454-82) in Flow Cytometry
Tue Dec 12 00:00:00 EST 2017
Pneumocystis-Driven Inducible Bronchus-Associated Lymphoid Tissue Formation Requires Th2 and Th17 Immunity.
Cell reports
Eddens T,Elsegeiny W,Garcia-Hernadez ML,Castillo P,Trevejo-Nunez G,Serody K,Campfield BT,Khader SA,Chen K,Rangel-Moreno J,Kolls JK
Published figure using CD45.2 monoclonal antibody (Product # 45-0454-82) in Flow Cytometry
Tue Mar 28 00:00:00 EDT 2017
Intratumoral modulation of the inducible co-stimulator ICOS by recombinant oncolytic virus promotes systemic anti-tumour immunity.
Nature communications
Zamarin D,Holmgaard RB,Ricca J,Plitt T,Palese P,Sharma P,Merghoub T,Wolchok JD,Allison JP
Published figure using CD45.2 monoclonal antibody (Product # 45-0454-82) in Flow Cytometry
Mon Feb 13 00:00:00 EST 2017
Small molecule p300/catenin antagonist enhances hematopoietic recovery after radiation.
PloS one
Zhao Y,Wu K,Nguyen C,Smbatyan G,Melendez E,Higuchi Y,Chen Y,Kahn M
45-0454 was used in Flow cytometry/Cell sorting to report that the small molecule YH250 stimulates hematopoiesis in lethally or sublethally irradiated mice.
Tue Sep 26 00:00:00 EDT 2017
Host-Protozoan Interactions Protect from Mucosal Infections through Activation of the Inflammasome.
Cell
Chudnovskiy A,Mortha A,Kana V,Kennard A,Ramirez JD,Rahman A,Remark R,Mogno I,Ng R,Gnjatic S,Amir ED,Solovyov A,Greenbaum B,Clemente J,Faith J,Belkaid Y,Grigg ME,Merad M
Published figure using CD45.2 monoclonal antibody (Product # 45-0454-82) in Flow Cytometry
Thu Oct 06 00:00:00 EDT 2016
The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity.
Cell
Damgaard RB,Walker JA,Marco-Casanova P,Morgan NV,Titheradge HL,Elliott PR,McHale D,Maher ER,McKenzie ANJ,Komander D
Published figure using CD45.2 monoclonal antibody (Product # 45-0454-82) in Flow Cytometry
Thu Aug 25 00:00:00 EDT 2016
Chronic interleukin-1 exposure drives haematopoietic stem cells towards precocious myeloid differentiation at the expense of self-renewal.
Nature cell biology
Pietras EM,Mirantes-Barbeito C,Fong S,Loeffler D,Kovtonyuk LV,Zhang S,Lakshminarasimhan R,Chin CP,Techner JM,Will B,Nerlov C,Steidl U,Manz MG,Schroeder T,Passegué E
45-0454 was used in Flow cytometry/Cell sorting to identify a critical regulatory circuit that tailors HSC responses to acute needs, and is likely to underlie deregulated blood homeostasis in chronic inflammation conditions.
Wed Jun 01 00:00:00 EDT 2016
CD8+ T cells drive autoimmune hematopoietic stem cell dysfunction and bone marrow failure.
Journal of autoimmunity
Gravano DM,Al-Kuhlani M,Davini D,Sanders PD,Manilay JO,Hoyer KK
45-0454 was used in Flow cytometry/Cell sorting to investigate whether CD8+ T cells play a non-redundant role in driving bone marrow failure.
Thu Dec 01 00:00:00 EST 2016
Macrophages transfer antigens to dendritic cells by releasing exosomes containing dead-cell-associated antigens partially through a ceramide-dependent pathway to enhance CD4(+) T-cell responses.
Immunology
Xu Y,Liu Y,Yang C,Kang L,Wang M,Hu J,He H,Song W,Tang H
45-0454 was used in Flow cytometry/Cell sorting to identify a novel pathway of cross-talk between macrophages and dendritic cells.
Sat Oct 01 00:00:00 EDT 2016
Protein Translation Activity: A New Measure of Host Immune Cell Activation.
Journal of immunology (Baltimore, Md. : 1950)
Seedhom MO,Hickman HD,Wei J,David A,Yewdell JW
45-0454 was used in Flow cytometry/Cell sorting to describe the in vivo ribopuromycylation method.
Mon Aug 15 00:00:00 EDT 2016
Murine iPSC-Derived Macrophages as a Tool for Disease Modeling of Hereditary Pulmonary Alveolar Proteinosis due to Csf2rb Deficiency.
Stem cell reports
Mucci A,Kunkiel J,Suzuki T,Brennig S,Glage S,Kühnel MP,Ackermann M,Happle C,Kuhn A,Schambach A,Trapnell BC,Hansen G,Moritz T,Lachmann N
Published figure using CD45.2 monoclonal antibody (Product # 45-0454-82) in Flow Cytometry
Tue Aug 09 00:00:00 EDT 2016
Discovery of a Metastatic Immune Escape Mechanism Initiated by the Loss of Expression of the Tumour Biomarker Interleukin-33.
Scientific reports
Saranchova I,Han J,Huang H,Fenninger F,Choi KB,Munro L,Pfeifer C,Welch I,Wyatt AW,Fazli L,Gleave ME,Jefferies WA
45-0454 was used in Flow cytometry/Cell sorting to investigate the role of IL-33 in cancer immune-surveillance against primary tumours.
Tue Sep 13 00:00:00 EDT 2016
Atypical chemokine receptor 1 deficiency reduces atherogenesis in ApoE-knockout mice.
Cardiovascular research
Wan W,Liu Q,Lionakis MS,Marino AP,Anderson SA,Swamydas M,Murphy PM
Published figure using CD45.2 monoclonal antibody (Product # 45-0454-82) in Flow Cytometry
Mon Jun 01 00:00:00 EDT 2015
The Extracellular Domains of IgG1 and T Cell-Derived IL-4/IL-13 Are Critical for the Polyclonal Memory IgE Response In Vivo.
PLoS biology
Turqueti-Neves A,Otte M,Schwartz C,Schmitt ME,Lindner C,Pabst O,Yu P,Voehringer D
45-0454 was used in Flow cytometry/Cell sorting to explore the relationship between repertoires of IgE and IgG1 in vivo.
Tue May 24 00:00:00 EDT 2016
Axitinib increases the infiltration of immune cells and reduces the suppressive capacity of monocytic MDSCs in an intracranial mouse melanoma model.
Oncoimmunology
Du Four S,Maenhout SK,De Pierre K,Renmans D,Niclou SP,Thielemans K,Neyns B,Aerts JL
Published figure using CD45.2 monoclonal antibody (Product # 45-0454-82) in Flow Cytometry
Wed Apr 01 00:00:00 EDT 2015
Determining Leukocyte Origins Using Parabiosis in the PyMT Breast Tumor Model.
Bio-protocol
Franklin RA,Li MO
45-0454 was used in Flow cytometry/Cell sorting to describe the use of parabiosis to define cell ontogeny in a mouse model of breast cancer.
Thu Aug 20 00:00:00 EDT 2015
Excessive proliferation and impaired function of primitive hematopoietic cells in bone marrow due to senescence post chemotherapy in a T cell acute lymphoblastic leukemia model.
Journal of translational medicine
Jiang C,Hu X,Wang L,Cheng H,Lin Y,Pang Y,Yuan W,Cheng T,Wang J
45-0454 was used in Flow cytometry/Cell sorting to conclude that primitive hematopoietic cells in bone marrow enter proliferation earlier than leukemic cells after chemotherapy, and gradually lose their regenerative capacity partly by senescence due to accelerated cycling.
Fri Jul 17 00:00:00 EDT 2015
STAT4 controls GM-CSF production by both Th1 and Th17 cells during EAE.
Journal of neuroinflammation
McWilliams IL,Rajbhandari R,Nozell S,Benveniste E,Harrington LE
45-0454 was used in Flow cytometry/Cell sorting to establish the role of STAT4 in the regulation of cytokine production during experimental autoimmune encephalomyelitis pathogenesis.
Tue Jun 30 00:00:00 EDT 2015
The miR-126-VEGFR2 axis controls the innate response to pathogen-associated nucleic acids.
Nature immunology
Agudo J,Ruzo A,Tung N,Salmon H,Leboeuf M,Hashimoto D,Becker C,Garrett-Sinha LA,Baccarini A,Merad M,Brown BD
45-0454 was used in Flow cytometry/Cell sorting to identify the miR-126-VEGFR2 axis as an important regulator of the innate response that operates through multiscale control of pDCs.
Wed Jan 01 00:00:00 EST 2014
WASH is required for the differentiation commitment of hematopoietic stem cells in a c-Myc-dependent manner.
The Journal of experimental medicine
Xia P,Wang S,Huang G,Zhu P,Li M,Ye B,Du Y,Fan Z
Published figure using CD45.2 monoclonal antibody (Product # 45-0454-82) in Flow Cytometry
Mon Sep 22 00:00:00 EDT 2014
S100a8/a9 released by CD11b+Gr1+ neutrophils activates cardiac fibroblasts to initiate angiotensin II-Induced cardiac inflammation and injury.
Hypertension (Dallas, Tex. : 1979)
Wu Y,Li Y,Zhang C,A X,Wang Y,Cui W,Li H,Du J
45-0454 was used in Flow cytometry/Cell sorting to elucidate the initial factors that trigger the inflammatory cascade during angiotensin II-induced cardiovascular injury.
Sun Jun 01 00:00:00 EDT 2014
The ability to rearrange dual TCRs enhances positive selection, leading to increased Allo- and Autoreactive T cell repertoires.
Journal of immunology (Baltimore, Md. : 1950)
Ni PP,Solomon B,Hsieh CS,Allen PM,Morris GP
45-0454 was used in Flow cytometry/Cell sorting to investigate how dual TCR rearrangements enhance positive selection and alter allo- and autoreactive T cell repertoires.
Fri Aug 15 00:00:00 EDT 2014
E and Id proteins influence invariant NKT cell sublineage differentiation and proliferation.
Journal of immunology (Baltimore, Md. : 1950)
D'Cruz LM,Stradner MH,Yang CY,Goldrath AW
45-0454 was used in Flow cytometry/Cell sorting to investigate the mechanism by which E and Id proteins control the development of invariant NKT sublineages after positive selection.
Sat Mar 01 00:00:00 EST 2014
Mechanisms of the immunosuppressive effects of mouse adipose tissue-derived mesenchymal stromal cells on mouse alloreactively stimulated spleen cells.
Experimental and therapeutic medicine
Nagaya R,Mizuno-Kamiya M,Takayama E,Kawaki H,Onoe I,Tanabe T,Nagahara K,Kondoh N
45-0454 was used in Flow cytometry/Cell sorting to demonstrate that adipose tissue-derived mesenchymal stromal cells have significant immune modulatory effects on alloreactively stimulated spleen cells.
Wed Jan 01 00:00:00 EST 2014
Leukocyte population dynamics and detection of IL-9 as a major cytokine at the mouse fetal-maternal interface.
PloS one
Habbeddine M,Verbeke P,Karaz S,Bobé P,Kanellopoulos-Langevin C
Published figure using CD45.2 monoclonal antibody (Product # 45-0454-82) in Flow Cytometry
Wed Jun 10 00:00:00 EDT 2015
Mutual expression of the transcription factors Runx3 and ThPOK regulates intestinal CD4⁺ T cell immunity.
Nature immunology
Reis BS,Rogoz A,Costa-Pinto FA,Taniuchi I,Mucida D
Published figure using CD45.2 monoclonal antibody (Product # 45-0454-82) in Flow Cytometry
Fri Mar 01 00:00:00 EST 2013
miR-126 and miR-126* repress recruitment of mesenchymal stem cells and inflammatory monocytes to inhibit breast cancer metastasis.
Nature cell biology
Zhang Y,Yang P,Sun T,Li D,Xu X,Rui Y,Li C,Chong M,Ibrahim T,Mercatali L,Amadori D,Lu X,Xie D,Li QJ,Wang XF
45-0454 was used in Flow cytometry/Cell sorting to investigate the role of miR-126 and miR-126* in tumour progression.
Fri Mar 01 00:00:00 EST 2013
Genome-wide mouse mutagenesis reveals CD45-mediated T cell function as critical in protective immunity to HSV-1.
PLoS pathogens
Caignard G,Leiva-Torres GA,Leney-Greene M,Charbonneau B,Dumaine A,Fodil-Cornu N,Pyzik M,Cingolani P,Schwartzentruber J,Dupaul-Chicoine J,Guo H,Saleh M,Veillette A,Lathrop M,Blanchette M,Majewski J,Pearson A,Vidal SM
45-0454 was used in Flow cytometry/Cell sorting to identify host factors involved in HSV-1 and herpes simplex encephalitis susceptibility in an in vivo HSV-1 infectious model.
Sun Sep 01 00:00:00 EDT 2013
Therapeutic evaluation of ex vivo-generated versus natural regulatory T-cells in a mouse model of chronic gut inflammation.
Inflammatory bowel diseases
Karlsson F,Martinez NE,Gray L,Zhang S,Tsunoda I,Grisham MB
45-0454 was used in Flow cytometry/Cell sorting to study the effect of ex vivo-generated and isolated Treg cells on a mouse model of chronic colitis, showing that ex-vivo Tregs were more potent at attenuating colitis, likely due to the associated decrease in IL-6 and IL-17A expression in the colon.
Tue Oct 01 00:00:00 EDT 2013
Distinct temporal requirements for Runx1 in hematopoietic progenitors and stem cells.
Development (Cambridge, England)
Tober J,Yzaguirre AD,Piwarzyk E,Speck NA
45-0454 was used in Flow cytometry/Cell sorting to study how the requirements for Runx1 in erythroid/myeloid progenitors and hematopoietic stem cell formation are temporally distinct.
Sun Sep 01 00:00:00 EDT 2013
Arrayed lentiviral barcoding for quantification analysis of hematopoietic dynamics.
Stem cells (Dayton, Ohio)
Grosselin J,Sii-Felice K,Payen E,Chretien S,Tronik-Le Roux D,Leboulch P
Published figure using CD45.2 monoclonal antibody (Product # 45-0454-82) in Flow Cytometry
Tue Oct 01 00:00:00 EDT 2013
SWAP-70 restricts spontaneous maturation of dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Ocaña-Morgner C,Götz A,Wahren C,Jessberger R
45-0454 was used in Flow cytometry/Cell sorting to study the mechanisms and signals that produce mature DCs.
Sat Jun 01 00:00:00 EDT 2013
The cardioprotective protein apolipoprotein A1 promotes potent anti-tumorigenic effects.
The Journal of biological chemistry
Zamanian-Daryoush M,Lindner D,Tallant TC,Wang Z,Buffa J,Klipfell E,Parker Y,Hatala D,Parsons-Wingerter P,Rayman P,Yusufishaq MSS,Fisher EA,Smith JD,Finke J,DiDonato JA,Hazen SL
Published figure using CD45.2 monoclonal antibody (Product # 45-0454-82) in Flow Cytometry
Fri Jul 19 00:00:00 EDT 2013
Thymus-autonomous T cell development in the absence of progenitor import.
The Journal of experimental medicine
Martins VC,Ruggiero E,Schlenner SM,Madan V,Schmidt M,Fink PJ,von Kalle C,Rodewald HR
45-0454 was used in Flow cytometry/Cell sorting to characterise the previously unrecognised capacity of the thymus to sustain T cell development during bone marrow progenitor deprivation.
Mon Jul 30 00:00:00 EDT 2012
Efficient capture of infected neutrophils by dendritic cells in the skin inhibits the early anti-leishmania response.
PLoS pathogens
Ribeiro-Gomes FL,Peters NC,Debrabant A,Sacks DL
45-0454 was used in Flow cytometry/Cell sorting to study how exploitation of immunosuppressive effects by L.major following rapid uptake by skin neutrophils allows inhibition of acquired resistance.
Wed Feb 01 00:00:00 EST 2012
Overexpression of Snai3 suppresses lymphoid- and enhances myeloid-cell differentiation.
European journal of immunology
Dahlem T,Cho S,Spangrude GJ,Weis JJ,Weis JH
45-0454 was used in Flow cytometry/Cell sorting to investigate the role of the transcriptional repressor Snai3 protein in the derivation of cells of the haematopoietic system.
Sun Apr 01 00:00:00 EDT 2012
Deletion of cIAP1 and cIAP2 in murine B lymphocytes constitutively activates cell survival pathways and inactivates the germinal center response.
Blood
Gardam S,Turner VM,Anderton H,Limaye S,Basten A,Koentgen F,Vaux DL,Silke J,Brink R
45-0454 was used in Flow cytometry/Cell sorting to investigate the roles of cIAP1 and cIAP2 in controlling B-cell physiology.
Thu Apr 14 00:00:00 EDT 2011
Rara haploinsufficiency modestly influences the phenotype of acute promyelocytic leukemia in mice.
Blood
Welch JS,Klco JM,Varghese N,Nagarajan R,Ley TJ
45-0454 was used in Flow cytometry/Cell sorting to test the prediction that RARA (retinoic acid receptor alpha) haploinsufficiency would contribute to acute promyelocytic leukemia (APL) pathogenesis.
Thu Feb 24 00:00:00 EST 2011
PML-RARA can increase hematopoietic self-renewal without causing a myeloproliferative disease in mice.
The Journal of clinical investigation
Welch JS,Yuan W,Ley TJ
45-0454 was used in Flow cytometry/Cell sorting to study a platform for more accurately dissecting the early events in acute promyelocytic leukemia pathogenesis.
Fri Apr 01 00:00:00 EDT 2011
Virus-induced tumor inflammation facilitates effective DC cancer immunotherapy in a Treg-dependent manner in mice.
The Journal of clinical investigation
Woller N,Knocke S,Mundt B,Gürlevik E,Strüver N,Kloos A,Boozari B,Schache P,Manns MP,Malek NP,Sparwasser T,Zender L,Wirth TC,Kubicka S,Kühnel F
45-0454 was used in Flow cytometry/Cell sorting to highlight viruses as attractive tools for eliciting effective antitumour responses upon DC vaccination.
Fri Jul 01 00:00:00 EDT 2011
Cellular competition independent of BAFF/B lymphocyte stimulator results in low frequency of an autoreactive clonotype in mature polyclonal B cell compartments.
Journal of immunology (Baltimore, Md. : 1950)
Nikbakht N,Migone TS,Ward CP,Manser T
45-0454 was used in Flow cytometry/Cell sorting to investigate the role of the peripheral B cell pro-survival cytokine BAFF/BLyS in the regulation of immunological tolerance and autoreactive cells.
Fri Jul 01 00:00:00 EDT 2011
EBI2 operates independently of but in cooperation with CXCR5 and CCR7 to direct B cell migration and organization in follicles and the germinal center.
Journal of immunology (Baltimore, Md. : 1950)
Gatto D,Wood K,Brink R
45-0454 was used in Flow cytometry/Cell sorting to show EBI2-mediated chemotaxis provides a third dimension to B cell migration that balances and integrates with the inputs from CXCR5 and CCR7 to determine B cell positioning.
Tue Nov 01 00:00:00 EDT 2011
Infection-induced myelopoiesis during intracellular bacterial infection is critically dependent upon IFN-γ signaling.
Journal of immunology (Baltimore, Md. : 1950)
MacNamara KC,Oduro K,Martin O,Jones DD,McLaughlin M,Choi K,Borjesson DL,Winslow GM
45-0454 was used in Flow cytometry/Cell sorting to provide evidence that IFN-γ acts to control infection by directly promoting myeloid cell differentiation.
Sat Jan 15 00:00:00 EST 2011
Tumor masses support naive T cell infiltration, activation, and differentiation into effectors.
The Journal of experimental medicine
Thompson ED,Enriquez HL,Fu YX,Engelhard VH
45-0454 was used in Flow cytometry/Cell sorting to study the ways in which tumour masses support naive T cell functions.
Mon Aug 02 00:00:00 EDT 2010
Hierarchy of Notch-Delta interactions promoting T cell lineage commitment and maturation.
The Journal of experimental medicine
Besseyrias V,Fiorini E,Strobl LJ,Zimber-Strobl U,Dumortier A,Koch U,Arcangeli ML,Ezine S,Macdonald HR,Radtke F
45-0454 was used in Flow cytometry/Cell sorting to study the Notch-Delta interactions that promote T cell development.
Mon Feb 19 00:00:00 EST 2007