视频

Invitrogen iBright 成像系统可轻松、高效地对您的免疫印迹和凝胶进行成像和数据分析。iBright 成像系统具有现代的设计和高性能,助力成像工作流程更加顺畅。

仪器概览和操作说明视频

请注意,我们会通过固件更新定期更新仪器体验和功能。正如所展示的那样,上述视频准确体现了仪器的大多数功能,但部分工作流程和功能增强可能未得到反映。

iBright 分析软件操作说明视频

请注意,我们更新了 iBright 分析软件界面,以进一步精简外观并提升用户体验。虽然下列视频中 iBright 分析软件界面的视觉元素可能存在一些差异,但所述的许多功能和操作均适用于当前版本的 iBright 分析软件。

1:00 – iBright 成像系统和 iBright 分析软件的简要概述

4:40 – “图库”选项卡概览(导入图像、图库整理、在托盘中添加和删除图像)

7:23 – “调整”选项卡概览(编辑功能:裁剪、拉直、旋转、翻转、反转、伪彩色、对比度、显示饱和度)

19:15 – “分析”选项卡概览(自动分析、分析框架、在分析中添加和删除条带、调整条带框架大小、分子量分析、数据表、自动增强、泳道分析图)

36:32 – “注释”选项卡概览(标记图像)

44:25 - 生成和导出分析报告 

47:42 – 图像导出 

51:30 – 重命名图像文件

52:15 – 问答环节

1:10 – iBright 成像系统及定量免疫印迹实现考虑因素概述

19:45 – “图库”选项卡功能和分析图像选择的简要概述

21:45 – “调整”选项卡功能简要概述

23:00 – “分析”选项卡(自动分析、泳道和条带调整)

26:30 – 使用管家蛋白 (HNP) 进行归一化分析

31:30 – 背景校正(局部背景校正、泳道分析图和滚动球背景校正)

37:50 – 相对定量

39:30 - 使用 No-Stain 免染型蛋白标记试剂进行总泳道蛋白 (TPN) 归一化

43:40 – 使用膜染色试剂对总泳道蛋白 (TPN) 进行“跨文件”归一化 

50:10 – 生成图像报告

53:00 – 问答环节


科学家: Guillaume Paidoux
地点: 法国
摘要: 我们的团队专注于心脏生理和病理生理条件下 cAMP 信号的时空调控。

 

心脏用于保证周围器官的供血和营养物质的提供。此功能发生任何变化均将导致心脏损伤和衰竭。A 型激酶锚定蛋白 (AKAP) 为锚定蛋白激酶 A (PKA) 的scaffolding蛋白家族,因此,在生理和病理条件下的心脏功能调节中具有核心作用。

 

我们专注于研究 AKAP 在心脏生理学和心肌疾病发生过程中的直接作用。利用分子生物学工具指导 shRNA 介导的敲低和重组分析以及生化分析(即免疫印迹、co-IP、TR-FRET 和 Alpha-Screen)。研究中还采用最先进的共聚焦成像(即活细胞 FRAP& FLIP、邻位连接技术和超高分辨率成像)。

 

此外,我们致力于开发蛋白质-蛋白质相互作用 (PPI) 干扰肽,以减缓或者抵消心脏病理过程中发生改变的anchored PKA 依赖性细胞过程。此类特异性 PPI 可作为新的潜在特异性心脏治疗剂。

 

iBright 系统的常用功能: 可采集高分辨率图像的易用界面。

 


文档和文献


学习和工具

蛋白电泳和免疫印迹学习中心

查找成功设计和进行免疫印迹实验所需的资源。查找详细的实验方案、提示技巧、指导视频、网络讲座等。

 

蛋白质电泳和免疫印迹故障排除指南 

进行免疫印迹时,通常并不容易直接获得高质量的结果 - 本指南提供的逐步提示和技巧可协助您获得高质量的Western Blot结果。

BlotBuilder 产品选择工具

获取专为您的目标蛋白和实验需求而设计的免疫印迹解决方案。使用此工具以自定义Western Blot实验方案。


 


固件和软件更新

我们会定期升级 iBright 成像系统和 iBright 分析软件的固件和软件。若要获取固件和软件更新并查看版本说明,请访问我们的更新页面。

 

 


相关文献

在同行评审期刊中查找采用  iBright  智能成像平台生成的具体研究结果的相关引用。

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标题年份类别子类别
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Oswal N, et al.(2023) Diets Differently Regulate Pulmonary Pathogenesis and Immune Signaling in Mice during Acute and Chronic Mycobacterium tuberculosis Infection.Life (Basel) 13(1):228.2023微生物和模式生物
Hsu CL, et al.(2023) Neuroprotective Effects of Erinacine A on an Experimental Model of Traumatic Optic Neuropathy.Int J Mol Sci 24(2):1504.2023神经生物学
Chernikov IV, et al.(2023) siRNA-Mediated Timp1 Silencing Inhibited the Inflammatory Phenotype during Acute Lung Injury.Int J Mol Sci 24(2):1641.2023其他
Forte E, et al.(2023) Critical Role for the Human Cytomegalovirus Major Immediate Early Proteins in Recruitment of RNA Polymerase II and H3K27Ac To an Enhancer-Like Element in Ori Lyt.Microbiol Spectr Jan 16 doi: 10.1128/spectrum.03144-22.2023其他
Südfeld C, et al.(2023) Expression of glycerol-3-phosphate acyltransferase increases non-polar lipid accumulation in Nannochloropsis oceanica.Microb Cell Fact 22(1):12.2023其他
Sloas DC, et al.(2023) Tension-tuned receptors for synthetic mechanotransduction and intercellular force detection.Nat Biotechnol Jan 16 doi: 10.1038/s41587-022-01638-y.2023方法开发
Kong Y, et al.(2023) HIF2α activation and mitochondrial deficit due to iron chelation cause retinal atrophy.EMBO Mol Med Jan 16 doi: 10.15252/emmm.202216525.2023其他
Che Y, et al.(2023) Bile acids target mitofusin 2 to differentially regulate innate immunity in physiological versus cholestatic conditions.Cell Rep 42(1):112011.2023Mitochondrial studies
Yoshida M, et al.(2023) An antisense amido-bridged nucleic acid gapmer oligonucleotide targeting SRRM4 alters REST splicing and exhibits anti-tumor effects in small cell lung cancer and prostate cancer cells.Cancer Cell Int 23(1):8.2023癌症研究肺癌
Woodburn SC, et al.(2023) Depletion of microglial BDNF increases susceptibility to the behavioral and synaptic effects of chronic unpredictable stress.Brain Behav Immun Jan 18 doi: 10.1016/j.bbi.2023.01.014.2023神经生物学
Shang J, et al.(2023) Inhibition of Klf10 Attenuates Oxidative Stress-Induced Senescence of Chondrocytes via Modulating Mitophagy.Molecules 28(3)924.2023药物机制
Silva RM, et al.(2023) Anion exchange chromatography-based platform for the scalable purification of extracellular vesicles derived from human mesenchymal stromal cells.Sep Purif Technol 310:123238.2023方法开发
Foliaki ST, et al.(2023) Altered energy metabolism in Fatal Familial Insomnia cerebral organoids is associated with astrogliosis and neuronal dysfunction.PLoS Genet 19(1):e1010565.2023神经生物学
Jung YH, et al.(2023) A conformation-selective protein binder for a KRAS mutant inhibits the interaction between RAS and RAF.Biochem Biophys Res Commun 645:110-117.2023结构生物学/蛋白质相互作用
Wang W, et al.(2023) The impact of osmotic stresses on the biofilm formation, immunodetection, and morphology of Aeromonas hydrophila.Microbiol Res 269:127301.2023微生物和模式生物
Morales A, et al.(2023) PACAP and acetylcholine cause distinct Ca2+ signals and secretory responses in chromaffin cells.J Gen Physiol 155(2):e202213180.2023细胞信号
Ebelt ND and Manuel ER (2023) 5-Azacytidine-Mediated Modulation of the Immune Microenvironment in Murine Acute Myeloid Leukemia.Cancers 15(1):118.2023癌症研究普遍
AlZahrani S, et al.(2023) Anti-Inflammatory Effect of Specialized Proresolving Lipid Mediators on Mesenchymal Stem Cells: An In Vitro Study.Cells 12(1):122.2023干细胞
Wang L, et al.(2023) Nicotinamide Mononucleotide Ameliorates Silica-Induced Lung Injury through the Nrf2-Regulated Glutathione Metabolism Pathway in Mice.Nutrients 15(1): 143.2023其他
Kim YK, et al.(2023) Transcriptome Profile in the Mouse Brain of Hepatic Encephalopathy and Alzheimer's Disease.Int. J. Mol.Sci 24(1): 675.2023神经生物学
Marianna B, et al.(2023) Design, Synthesis and Antiproliferative Evaluation of Bis-Indole Derivatives with a Phenyl Linker: Focus on Autophagy.Molecules 28(1): 251.2023癌症研究肺癌
Kim JY, et al.(2023) Antioxidant, Anti-Apoptotic, and Anti-Inflammatory Effects of Farrerol in a Mouse Model of Obstructive Uropathy.Curr.Issues Mol.Biol 45(1): 337-352.2023药物机制
Montero‐Blay A, et al.(2023) Bacterial expression of a designed single‐chain IL‐10 prevents severe lung inflammation.Mol Syst Biol Jan 4 doi: 10.15252/msb.202211037.2023药物机制
Thangavel H, et al.(2023) Diets Differently Regulate Tumorigenesis in Young E0771 Syngeneic Breast Cancer Mouse Model.J. Clin.Med 12(2): 413.2023癌症研究乳腺癌
Verma A, et al.(2023) P. gingivalis-LPS Induces Mitochondrial Dysfunction Mediated by Neuroinflammation through Oxidative Stress.Int. J. Mol.Sci 24(2):950.2023Mitochondrial studies
Sokanovic SJ, et al.(2023) Common and female-specific roles of protein tyrosine phosphatase receptors N and N2 in mice reproduction.Sci Rep 13(1):355.2023其他
Hung SH, et al.(2023) Structural basis of Qng1-mediated salvage of the micronutrient queuine from queuosine-5′-monophosphate as the biological substrate.Nucleic Acids Res Jan 5 doi: 10.1093/nar/gkac1231.2023其他
Alway SE, et al.(2023) Mitochondria transplant therapy improves regeneration and restoration of injured skeletal muscle.J Cachexia Sarcopenia Muscle Jan 5 doi: 10.1002/jcsm.13153.2023Mitochondrial studies
Nielsen SSE, et al.(2023) Apicobasal transferrin receptor localization and trafficking in brain capillary endothelial cells.Fluids Barriers CNS 20(1):2.2023神经生物学
Woo JH, et al.(2023) Polypropylene nanoplastic exposure leads to lung inflammation through p38-mediated NF-κB pathway due to mitochondrial damage.Part Fibre Toxicol 20(1):2.2023Mitochondrial studies
Itoh T, et al.(2023) Phenolic Glycosides Citrulluside H and Citrulluside T Isolated From Young Watermelon (Citrullus lanatus) Fruit Have Beneficial Effects Against Cutibacterium acnes-Induced Skin Inflammation.Natural Product Communications 18(1).2023植物科学
Chen TW, et al.(2022) Vitamin B3 Provides Neuroprotection via Antioxidative Stress in a Rat Model of Anterior Ischemic Optic Neuropathy.Antioxidants (Basel) 11(12):2422.2022神经生物学
Dorajoo R, et al.(2022) Vascular smooth muscle cells in low SYNTAX scores coronary artery disease exhibit proinflammatory transcripts and proteins correlated with IL1B activation.Atherosclerosis Dec 17 doi: 10.1016/j.atherosclerosis.2022.12.005.2022其他
Ceyzériat K, et al.(2022) Low-dose brain irradiation normalizes TSPO and CLUSTERIN levels and promotes the non-amyloidogenic pathway in pre-symptomatic TgF344-AD rats.J Neuroinflammation 19(1):311.2022神经生物学
Erzurumlu Y, et al.(2022) 1, 25 (OH) 2 D3 induced vitamin D receptor signaling negatively regulates endoplasmic reticulum-associated degradation (ERAD) and androgen receptor signaling in human prostate cancer cells.Cell Signal Dec 22 doi: 10.1016/j.cellsig.2022.110577.2022细胞信号
van Vliet VJE, et al.(2022) Ubiquitin variants potently inhibit SARS-CoV-2 PLpro and viral replication via a novel site distal to the protease active site.PLoS Pathog 18(12):e1011065.2022微生物和模式生物
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Chen J, et al.(2022) Building bioorthogonal click-release capable artificial receptors on cancer cell surface for imaging, drug targeting and delivery.Acta Pharm Sin B. Dec 28 doi: 10.1016/j.apsb.2022.12.018.2022癌症研究普遍
Li Z, et al.(2022) Sodium para-aminosalicylic acid ameliorates brain neuroinflammation and behavioral deficits in juvenile lead-exposed rats by modulating MAPK signaling pathway and alpha-synuclein.Toxicol Lett Dec 28 doi: 10.1016/j.toxlet.2022.12.013.2022神经生物学
Cesaro G, et al.(2022) Trypanosoma brucei RRP44: a versatile enzyme for processing structured and non-structured RNA substrates.Nucleic Acids Res Dec 30 doi: 10.1093/nar/gkac1199.2022其他
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Kang H, et al.(2022) DGKB mediates radioresistance by regulating DGAT1-dependent lipotoxicity in glioblastoma.Cell Rep Med Dec 22 doi: 10.1016/j.xcrm.2022.100880.2022癌症研究脑癌
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Saghaug C, et al.(2022) Genetic diversity in the metronidazole metabolism genes nitroreductases and pyruvate ferredoxin oxidoreductases in susceptible and refractory clinical samples of Giardia lamblia.Int J Parasitol Drugs Drug Resist 21:51-60.2022微生物和模式生物
Bayaraa O, et al.(2022) Nanoceria-GO-intercalated multicellular spheroids revascularize and salvage critical ischemic limbs through anti-apoptotic and pro-angiogenic functions.Biomaterials Nov 14 doi: 10.1016/j.biomaterials.2022.121914.2022细胞信号
Zekri-Nechar K, et al.(2022) Spike Protein Subunits of SARS-CoV-2 Alter Mitochondrial Metabolism in Human Pulmonary Microvascular Endothelial Cells: Involvement of Factor Xa.Dis Markers Nov 18 doi: 10.1155/2022/1118195.2022Mitochondrial studies
Kim H, et al.(2022) Simultaneous Quantification of Apolipoprotein C-III O-Glycoforms by Protein-MRM.J Proteome Res Nov 21 doi: 10.1021/acs.jproteome.2c00490.2022结构生物学/蛋白质相互作用
Wu MY, et al.(2022) Role of non-neuronal cholinergic system in the early stage response of epithelial-mesenchymal transformation related markers in A549 cells induced by coal particles.Heliyon 8(11):e11751.2022疾病研究生物标记物研究
Jacquet S, et al.(2022) Adaptive duplication and genetic diversification of protein kinase R contribute to the specificity of bat-virus interactions.Sci Adv 8(47):eadd7540.2022疾病研究生物标记物研究
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Piras R, et al.(2022) circCsnk1g3-and circAnkib1-regulated interferon responses in sarcoma promote tumorigenesis by shaping the immune microenvironment.Nat Commun 13(1):7243.2022癌症研究普遍
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Kim J, et al.(2022) One‐step Preparation of an Injectable Hydrogel Scaffold System Capable of Sequential Dual‐growth Factor Release to Maximize Bone Regeneration.Adv Healthc Mater Dec 1 doi: 10.1002/adhm.202202401.2022干细胞
Ekundayo B, et al.(2022) Structural insights into the regulation of Cas7-11 by TPR-CHAT.Nat Struct Mol Biol Dec 5 doi: 10.1038/s41594-022-00894-5.2022结构生物学/蛋白质相互作用
Nguyen H, et al.(2023) Impact of physiological media and sterilization methods on the physicochemical characteristics of engineered CNCs, and the effects on nanomaterial-protein interactions and immunological activity.Colloid Interface Sci Commun 52: 100684.2023结构生物学/蛋白质相互作用
Reguigui A, et al.(2022) Nine-dimensional bioprofiles of Tunisian sages (Salvia officinalis, S. aegyptiaca and S. verbenaca) by high-performance thin-layer chromatography–effect-directed analyses.J Chromatogr A Dec 7 doi: 10.1016/j.chroma.2022.463704.2022植物科学
Ceccacci S, et al.(2022) Jasminum sambac Cell Extract as Antioxidant Booster against Skin Aging.Antioxidants 11(12): 2409.2022其他
Cheng D, et al.(2022) Emodin Alleviates Arthritis Pain through Reducing Spinal Inflammation and Oxidative Stress.Mol Pain Dec 6 doi: 10.1177/17448069221146398.2022其他
Beker M, et al.(2022) Dual action of exosomes derived from in vitro Aβ toxicity model: the role of age for pathological response.Arch Gerontol Geriatr 106:104874.2022神经生物学
Barilli A, et al.(2022) Growth Arrest of Alveolar Cells in Response to Cytokines from Spike S1-Activated Macrophages: Role of IFN-γ.Biomedicines 10 3085.2022细胞信号
Yoon SH, et al.(2022) Comparative study of lung toxicity of E-cigarette ingredients to investigate E-cigarette or Vaping Product associated Lung Injury.J Hazard Mater 445: 130454.2022其他
Chen X, et al.(2022) Liensinine, an Isoquinoline-Type Alkaloid in Lotus Seeds, Suppressed TGF-beta1-Induced Proliferation and Migration in Human Tenon Capsule Fibroblast Cells Through MAP3K7 Gene.Rev. Bras.Farmacogn Dec 6 doi: 10.1007/s43450-022-00334-x.2022细胞信号
Vetrovoy O, et al.(2022) Prenatal Hypoxia-Induced Adverse Reaction to Mild Stress is Associated with Depressive-Like Changes in the Glucocorticoid System of Rats.Neurochem Res Dec 10 doi: 10.1007/s11064-022-03837-0.2022神经生物学
Senthilvelan A, et al.(2022) Click-iT Trinucleotide Cap Analog: Synthesis, mRNA Translation, and Detection.Bioorg Med Chem 77:117128.2022方法开发
Shao W, et al.(2022) Expression of fibrinogen-like protein 2 (Fgl2) on Toll-like receptor 9 (TLR9) expression in autoimmune myelitis.Int Immunopharmacol 114:109539.2022细胞信号
Yang W, et al.(2022) Thermophilic archaeon orchestrates temporal expression of GDGT ring synthases in response to temperature and acidity stress.Environ Microbiol Dec 10 doi: 10.1111/1462-2920.16301.2022微生物和模式生物
Digby EM, et al.(2022) Photocaged DNA-Binding Photosensitizer Enables Photocontrol of Nuclear Entry for Dual-Targeted Photodynamic Therapy.J Med Chem 65(24):16679-16694.2022药物机制
Ji M, et al.(2022) Sirt6 attenuates chondrocyte senescence and osteoarthritis progression.Nat Commun 13(1):7658.2022细胞信号
Singh S, et al.(2022) Butyrate Ameliorates Intraocular Bacterial Infection by Promoting Autophagy and Attenuating the Inflammatory Response.Infect Immun Dec 14 doi: 10.1128/iai.00252-22.2022细胞信号
Smart K, et al.(2022) Fidgetin-like 2 depletion enhances cell migration by regulating GEF-H1, RhoA, and FAK.Biophys J Dec 15 doi: 10.1016/j.bpj.2022.12.018.2022其他
Wang YF, et al.(2022) Endoplasmic reticulum stress regulates autophagic response that is involved in Saikosaponin a-induced liver cell damage.Toxicol In Vitro Dec 17 doi: 10.1016/j.tiv.2022.105534.2022其他
Yang M, et al.(2022) Transcorneal but not transpalpebral electrical stimulation disrupts mucin homeostasis of the ocular surface.BMC Ophthalmol 22(1):490.2022神经生物学
Niwa R, et ail (2022) Experimental model of micronodular thymic neoplasm with lymphoid stroma.Thorac Cancer Dec 16 doi: 10.1111/1759-7714.14716.2022癌症研究普遍
Chen Y, et al.(2022) E2F1-mediated up-regulation of TOP2A promotes viability, migration, and invasion, and inhibits apoptosis of gastric cancer cells.J Biosci 47:84.2022癌症研究胃癌
Degnan RM, et al.(2022) Exogenous double‐stranded RNA inhibits the infection physiology of rust fungi to reduce symptoms in planta.Mol Plant Pathol Dec 17 doi: 10.1111/mpp.13286.2022植物科学
Luan Y, et al.(2022) TAp63 determines the fate of oocytes against DNA damage.Sci Adv 8(51):eade1846.2022细胞信号
Lee HL, et al.(2023) Anti-Amnesic Effect of Synbiotic Supplementation Containing Corni fructus and Limosilactobacillus reuteri in DSS-Induced Colitis Mice.Int Mol Sci 24(1):90.2023其他
Yan Y, et al.(2022) Thalamocortical Circuit Controls Neuropathic Pain via Up-regulation of HCN2 in the Ventral Posterolateral Thalamus.Neurosci Bull Dec 20 doi: 10.1007/s12264-022-00989-5.2022神经生物学
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Jousma J, et al.(2022) Alteration of the N6-methyladenosine epitranscriptomic profile in synthetic phthalate-treated human induced pluripotent stem cell-derived endothelial cells.Epigenomics Oct 31 doi: 10.2217/epi-2022-0110.2022疾病研究生物标记物研究
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Kim H, et al.(2022) Afrormosin exerts an anticancer effect via MAPK and AKT signaling pathways in B16F10 cells.Appl Biol Chem 65 71.2022癌症研究皮肤癌
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Jacob C, et al.(2022) Mediterranean G6PD variant mitigates expression of DNA methyltransferases and right heart pressure in experimental model of pulmonary hypertension.J Biol Chem Nov 10 doi: 10.1016/j.jbc.2022.102691.2022其他
Liu Y, et al.(2022) Melatonin alleviates heat stress-induced testicular damage in dairy goats by inhibiting the PI3K/AKT signaling pathway.Stress Biology 2: 47.2022细胞信号
Liu X, et al.(2022) CD16+ fibroblasts foster a trastuzumab-refractory microenvironment that is reversed by VAV2 inhibition.Cancer Cell 40(11):1341-1357.2022癌症研究乳腺癌
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Guidry G, et al.(2022) 17β-estradiol ameliorates delirium-like phenotypes in a murine model of urinary tract infection.Sci Rep 12(1):19622.2022神经生物学
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Sheriff A, et al.(2022) ABE8e adenine base editor precisely and efficiently corrects a recurrent COL7A1 nonsense mutation.Sci Rep 12(1):19643.2022DNA 修复过程
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Wu HF, et al.(2022) Norepinephrine transporter defects lead to sympathetic hyperactivity in Familial Dysautonomia models.Nat Commun 13(1):7032.2022神经生物学
Jamshidi-adegani F, et al.(2022) Comparative study of the cytotoxicity, apoptotic, and epigenetic effects of Boswellic acid derivatives on breast cancer.Sci Rep 12(1):19979.2022癌症研究乳腺癌
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Shin JY, et al.(2022) Priming mesenchymal stem cells with α-synuclein enhances neuroprotective properties through induction of autophagy in Parkinsonian models.Stem Cell Res Ther 13(1):483.2022神经生物学
Li W, et al.(2022) BdcSP10 is a prophenoloxidase-activating protease in Bactrocera dorsalis.Dev Comp Immunol 138:104558.2022其他
Palmelund LB, et al.(2022) Development of a medium throughput whole-cell microtiter plate Thr286 autophosphorylation assay for CaMKIIα using ELISA.J Pharmacol Toxicol Methods 118:107226.2022方法开发
Menkhorst E, et al.(2022) Galectin-7 dysregulates renin-angiotensin-aldosterone and NADPH oxide synthase pathways in preeclampsia.Pregnancy Hypertens 30:130-136.2022细胞信号
Jovanović Stojanov S, et al.(2022) Autophagy Inhibition Enhances Anti-Glioblastoma Effects of Pyrazolo [3, 4-d] pyrimidine Tyrosine Kinase Inhibitors.Life 12(10):1503.2022癌症研究脑癌
Chan KL, et al.(2022) Inhibition of the CtBP complex and FBXO11 enhances MHC class II expression and anti-cancer immune responses.Cancer Cell Sep 19 doi: 10.1016/j.ccell.2022.09.007.2022癌症研究普遍
Jana A, et al.(2022) Increased Type I interferon signaling and brain endothelial barrier dysfunction in an experimental model of Alzheimer's disease.Sci Rep 12(1):16488.2022神经生物学
Tatara M, et al.(2023) ATAC-Seq Analysis of Accessible Chromatin: From Experimental Steps to Data Analysis.Methods Mol Biol 2577:65-81.2022方法开发
Tran NL, et al.(2022) Facile Construction of Tumour Spheroids with Induced M2 Macrophage Polarization for Anticancer Drug Screening.Biomed Mater Sep 27 doi: 10.1088/1748-605X/ac956c.2022癌症研究普遍
Xiong X, et al.(2022) MicroRNA-34b-5p targets PPP1R11 to inhibit proliferation and promote apoptosis in cattleyak Sertoli cells by regulating specific signaling pathways.Theriogenology 194:46-57.2022细胞信号
Hsueh SC, et al.(2022) Activity of a Novel Anti-Inflammatory Agent F-3, 6′-dithiopomalidomide as a Treatment for Traumatic Brain Injury.Biomedicines 10(10):2449.2022神经生物学
Qrareya AN, et al.(2022) HIV-1 Tat Upregulates the Receptor for Advanced Glycation End Products and Superoxide Dismutase-2 in the Heart of Transgenic Mice.Viruses 14(10):2191.2022其他
Chalise U, et al.(2022) Harnessing the Plasma Proteome to Mirror Current and Predict Future Cardiac Remodeling After Myocardial Infarction.J Cardiovasc Transl Res Oct 5 doi: 10.1007/s12265-022-10326-w.2022疾病研究生物标记物研究
Qin L, et al.(2022) The miR-21-5p enriched in the apoptotic bodies of M2 macrophage-derived extracellular vesicles alleviates osteoarthritis by inducing a change in the macrophage phenotype.Genes & Diseases Oct 5 doi: 10.1016/j.gendis.2022.09.010.2022其他
Pellavio G, et al.(2022) Aquaporin-6 May Increase the Resistance to Oxidative Stress of Malignant Pleural Mesothelioma Cells.Cells 11(12):1892.2022癌症研究肺癌
Tramonti A, et al.(2022) Characterization of the Escherichia coli pyridoxal 5'‐phosphate homeostasis protein (YggS): role of lysine residues in PLP binding and protein stability.Protein Sci Oct 11 doi: 10.1002/pro.4471.2022结构生物学/蛋白质相互作用
El Hamdaoui Y, et al.(2022) Analysis of hyperforin (St. John's wort) action at TRPC6 channel leads to the development of a new class of antidepressant drugs.Mol Psychiatry Oct 12 doi: 10.1038/s41380-022-01804-3.2022神经生物学
Durand-de Cuttoli R, et al.(2022) Distinct forms of regret linked to resilience versus susceptibility to stress are regulated by region-specific CREB function in mice.Sci Adv 8(42):eadd5579.2022神经生物学
Mills C, et al.(2022) A Novel CRISPR Interference Effector Enabling Functional Gene Characterization with Synthetic Guide RNAs.CRISPR J Oct 17 doi: 10.1089/crispr.2022.0056.2022CRISPR
Griem-Krey N, et al.(2022) The CaMKIIα hub ligand Ph-HTBA promotes neuroprotection after focal ischemic stroke by a distinct molecular interaction.Biomed Pharmacother 156:113895.2022神经生物学
Sun H, et al.(2022) Increased circulating microparticles contribute to severe infection and adverse outcomes of COVID-19 patients with diabetes.Am J Physiol Heart Circ Physiol Oct 21 doi: 10.1152/ajpheart.00409.2022.2022其他
Choi W, et al.(2022) Targeted thrombolysis by magnetoacoustic particles in photothrombotic stroke model.Biomater Res 26(1):58.2022药物机制
Lu X, et al.(2022) Silencing SNHG1 Suppresses Viability, Proliferation and Invasion of Gallbladder Carcinoma Cells via Targeting miR-194-5p.Ann Clin Lab Sci 52(5):707-720.2022癌症研究普遍
Li Z, et al.(2022) Enhancing Gasdermin-induced tumor pyroptosis through preventing ESCRT-dependent cell membrane repair augments antitumor immune response.Nat Commun 13(1):6321.2022癌症研究普遍
Park JS, et al.(2022) Isoform-specific inhibition of FGFR signaling achieved by a de-novo-designed mini-protein.Cell Rep 41(4):111545.2022结构生物学/蛋白质相互作用
Zhou G, et al.(2022) Co-alterations of circadian clock gene transcripts in human placenta in preeclampsia.Sci Rep 12(1):17856.2022其他
Cruz JA, et al.(2022) A pseudovirus-based platform to measure neutralizing antibodies in Mexico using SARS-CoV-2 as proof-of-concept.Sci Rep 12(1):17966.2022方法开发
Bergman H, et al.(2022) Establishment of Cytotoxic and Non-cytotoxic NK-92 Cell Clones–Evaluation of Their Function as Target Cells.Anticancer Res 42(9):4259-4264.2022癌症研究普遍
Okada C, et al.(2022) Establishment of Neutralizing Monoclonal Antibodies Against Severe Acute Respiratory Syndrome Coronavirus 2 by the Screening with Exosomes Expressing the Viral Spike Protein.Monoclon Antib Immunodiagn Immunother (4):173-180.2022方法开发
Cui S, et al.(2022) SIRT1 activation synergizes with FXR agonism in hepatoprotection via governing nucleocytoplasmic shuttling and degradation of FXR.Acta Pharmaceutica Sinica B Aug 27 doi: 10.1016/j.apsb.2022.08.019.2022其他
Chen Y, et al.(2022) Tumour-associated Mucin1 correlates with the procoagulant properties of cancer cells of epithelial origin.Thrombosis Update 9: 100123.2022癌症研究普遍
Stenvall CGA, et al.(2022) Cytoplasmic keratins couple with and maintain nuclear envelope integrity in colonic epithelial cells.Mol Biol Cell Aug 24 doi: 10.1091/mbc.E20-06-0387.2022结构生物学/蛋白质相互作用
Ju P, et al.(2022) Histone deacetylase 4 inhibition ameliorates the social deficits induced by Ephrin-B2 mutation.Prog Neuropsychopharmacol Biol Psychiatry Aug 24 doi: 10.1016/j.pnpbp.2022.110622.2022神经生物学
Spampinato SF, et al.(2022) Microglia Contributes to BAF-312 Effects on Blood–Brain Barrier Stability.Biomolecules 12(9): 1174.2022神经生物学
Pritchard Jr KA, et al.(2022) Role of endoplasmic reticulum stress in impaired neonatal lung growth and bronchopulmonary dysplasia.PLoS One 17(8):e0269564.2022其他
Zhang G, et al.(2022) ACOT7 protects epidermal stem cells against lipid peroxidation.In Vitro Cell Dev Biol Anim Aug 29 doi: 10.1007/s11626-022-00703-9.2022其他
Yin J, et al.(2022) Development of Whole-Cell Biosensors for Screening of Peptidoglycan-Targeting Antibiotics in a Gram-Negative Bacterium.Appl Environ Microbiol Aug 30 doi: 10.1128/aem.00846-22.2022方法开发
Han Z, et. al.(2022) Hsp20 Promotes Endothelial Progenitor Cell Angiogenesis via Activation of PI3K/Akt Signaling Pathway under Hypoxia.Tissue Eng Regen Med Aug 30 doi: 10.1007/s13770-022-00481-1.2022细胞信号
Basu S, et al.(2022) Negative Feedback Loop Mechanism between EAF1/2 and DBC1 in Regulating ELL Stability and Functions.Mol Cell Biol Aug 29 doi: 10.1128/mcb.00151-22.2022结构生物学/蛋白质相互作用
López‐Haber C, et al.(2022) The phagosomal solute transporter SLC15A4 promotes inflammasome activity via mTORC1 signaling and autophagy restraint in dendritic cells.EMBO J Aug 29 doi: 10.15252/embj.2022111161.2022其他
Fowler EW, et al.(2022) A TGFβR inhibitor represses keratin-7 expression in 3D cultures of human salivary gland progenitor cells.Sci Rep 12(1):15008.2022干细胞
Kuppa S, et al.(2022) Rtt105 regulates RPA function by configurationally stapling the flexible domains.Nat Commun 13(1):5152.2022DNA 修复过程
Sawai M, et al.(2022) Dihydropyrazine suppresses TLR4-dependent inflammatory responses by blocking MAPK signaling in human hepatoma HepG2 cells.J Toxicol Sci 47(9):381-387.2022细胞信号
Jin N, et al.(2022) Tau seeding activity in various regions of down syndrome brain assessed by two novel assays.Acta Neuropathol Commun 10(1):132.2022神经生物学
Shen H, et al.(2022) TRIM46 aggravated high glucose-induced hyper permeability and inflammatory response in human retinal capillary endothelial cells by promoting IκBα ubiquitination.Eye Vis (Lond) 9(1):35.2022其他
Gerhardy S, et al.(2022) Allosteric inhibition of HTRA1 activity by a conformational lock mechanism to treat age-related macular degeneration.Nat Commun 13(1):5222.2022结构生物学/蛋白质相互作用
Tiwari R, et al.(2022) Chemical inhibition of oxygen-sensing prolyl hydroxylases impairs angiogenic competence of human vascular endothelium through metabolic reprogramming. iScience Sep 6 doi: 10.1016/j.isci.2022.105086.2022其他
Shi H, et al.(2022) Regulating microglial miR-155 transcriptional phenotype alleviates Alzheimer's-induced retinal vasculopathy by limiting Clec7a/Galectin-3+ neurodegenerative microglia.Acta Neuropathol Commun 10(1):136.2022神经生物学
Visigalli R, et al.(2022) Expression and Function of ABC Transporters in Human Alveolar Epithelial Cells.Biomolecules 12(9):1260.2022其他
Schon SB, et al.(2022) Obesity-related alterations in protein expression in human follicular fluid from women undergoing in-vitro fertilization (IVF).F S Sci Sep 9 doi: 10.1016/j.xfss.2022.09.002.2022疾病研究生物标记物研究
Yoon JY, et al.(2022) Chemically-induced osteogenic cells for bone tissue engineering and disease modeling.Biomaterials 289:121792.2022方法开发
Jang M, et al.(2022) Hyperglycemic Neurovasculature‐On‐A‐Chip to Study the Effect of SIRT1‐Targeted Therapy for the Type 3 Diabetes “Alzheimer's Disease”.Adv Sci (Weinh) Sep 8 doi: 10.1002/advs.202201882.2022神经生物学
Xue H, et al.(2022) A two-step mechanism governing PARP1-DNA retention by PARP inhibitors.Sci Adv 8(36):eabq0414.2022DNA 修复过程
Dai X, et al.(2022) KLF5-mediated aquaporin 3 activated autophagy to facilitate cisplatin resistance of gastric cancer.Immunopharmacol Immunotoxicol Sep 20 doi: 10.1080/08923973.2022.2122498.2022癌症研究胃癌
van Senten JR, et al.(2022) Use of CRISPR/Cas9-edited HEK293 cells reveals that both conventional and novel protein kinase C isozymes are involved in mGlu5a receptor internalization.J Biol Chem Sep 7 doi: 10.1016/j.jbc.2022.102466.2022CRISPR
Mallard J, et al.(2022) Development of skeletal muscle atrophy and intermuscular adipose tissue in early breast cancer patients treated with chemotherapy.Am J Physiol Cell Physiol Sep 12 doi: 10.1152/ajpcell.00373.2022.2022癌症研究乳腺癌
Uquillas JA, et al.(2022) An off-the-shelf decellularized and sterilized human bone-ACL-bone allograft for anterior cruciate ligament reconstruction.J Mech Behav Biomed Mater 135:105452.2022其他
Song W and Qiu N (2022) MiR-495-3p depletion contributes to myocardial ischemia/reperfusion injury in cardiomyocytes by targeting TNC.Regen Ther 21: 380-388.2022其他
Kane EI, et al.(2022) Redefining the Catalytic HECT Domain Boundaries for the HECT E3 Ubiquitin Ligase Family.Biosci Rep Sep 16 doi: 10.1042/BSR20221036.2022结构生物学/蛋白质相互作用
Zhang N, et al.(2022) Ameliorative effect of Lactobacillus plantarum Lp2 against cyclophosphamide-induced liver injury in mice.Food Chem Toxicol 169:113433.2022细胞信号
Wang S, et al.(2022) Ginseng polysaccharide attenuates red blood cells oxidative stress injury by regulating red blood cells glycolysis and liver gluconeogenesis.J Ethnopharmacol 300:115716.2022其他
Fonseca-Ornelas L, et al.(2022) Parkinson-causing mutations in LRRK2 impair the physiological tetramerization of endogenous α-synuclein in human neurons.NPJ Parkinsons Dis 8(1):118.2022神经生物学
Barilli A, et al.(2022) The JAK1/2 Inhibitor Baricitinib Mitigates the Spike-Induced Inflammatory Response of Immune and Endothelial Cells In Vitro.Biomedicines 10(9):2324.2022细胞信号
Zhu X, et al.(2022) Structural basis of adhesion GPCR GPR110 activation by stalk peptide and G-proteins coupling.Nat Commun 13(1):5513.2022结构生物学/蛋白质相互作用
Lim KM, et al.(2022) Advanced 3D Dynamic Culture System with Transforming Growth Factor-β3 Enhances Production of Potent Extracellular Vesicles with Modified Protein Cargoes via Upregulation of TGF-β Signaling.J Adv Res Sep 18 doi: 10.1016/j.jare.2022.09.005.2022方法开发
Huang Y, et al.(2022) Intracellular delivery of messenger RNA to macrophages with surfactant-derived lipid nanoparticles.Mater Today Adv 16: 100295.2022方法开发
Katifelis H, et al.(2022) Amniotic Fluid-Derived Mesenchymal Stem/Stromal Cell-Derived Secretome and Exosomes Improve Inflammation in Human Intestinal Subepithelial Myofibroblasts.Biomedicines 10(10): 2357.2022干细胞
Hauvermale AL, et al.(2022) GA signaling expands: the Plant UBX domain-containing protein 1 is a binding partner for the GA receptor.Plant Physiol Sep 23 doi: 10.1093/plphys/kiac406.2022植物科学
Donne R, et al.(2022) Replication stress triggered by nucleotide pool imbalance drives DNA damage and cGAS-STING pathway activation in NAFLD.Dev Cell Jun 23 doi: 10.1016/j.devcel.2022.06.003.2022DNA 修复过程
Stewart JA, et al.(2022) A redox-sensitive iron-sulfur cluster in murine FAM72A controls its ability to degrade the nuclear form of uracil-DNA glycosylase.DNA Repair (Amst) 118:103381.2022DNA 修复过程
Watkins JM, et al.(2022) An Engineered Monovalent Anti–TNF-α Antibody with pH-Sensitive Binding Abrogates Immunogenicity in Mice following a Single Intravenous Dose.J Immunol Jul 27 doi: 10.4049/jimmunol.2101180.2022其他
Armstrong Z, et al.(2022) Cryo-EM structures of human fucosidase FucA1 reveal insight into substrate recognition and catalysis.Structure Jul 19 doi: 10.1016/j.str.2022.07.001.2022结构生物学/蛋白质相互作用
Schlegel C, et al.(2022) Decreased expression of hypoxia-inducible factor 1α (HIF-1α) in cord blood monocytes under anoxia.Pediatr Res Jul 29 doi: 10.1038/s41390-022-02193-7.2022细胞信号
Crudele A, et al.(2022) Hydroxytyrosol Recovers SARS-CoV-2-PLpro-Dependent Impairment of Interferon Related Genes in Polarized Human Airway, Intestinal and Liver Epithelial Cells.Antioxidants 11(8):1466.2022其他
Fischer JA, et al.(2022) Opposing effects of genetic variation in MTCH2 for obesity versus heart failure.Hum Mol Genet Jul 29 doi: 10.1093/hmg/ddac176.2022疾病研究生物标记物研究
Hasegawa M, et al.(2022) Tumor suppressor effect of an antibody on xenotransplanted sarcomatoid mesothelioma cells.Thorac Cancer Aug 2 doi: 10.1111/1759-7714.14591.2022癌症研究普遍
Wang S, et al.(2022) Huanglian ointment alleviates eczema by maintaining the balance of c-Jun and JunB and inhibiting AGE-RAGE-mediated pro-inflammation signaling pathway.Phytomedicine 105:154372.2022细胞信号
Zhi Y, et al.(2022) The effects of air pollutants exposure on the transmission and severity of invasive infection caused by an opportunistic pathogen Streptococcus pyogenes.Environ Pollut Aug 3 doi: 10.1016/j.envpol.2022.119826.2022微生物和模式生物
Kolhe P, et al.(2022) Fabrication of an ultrasensitive electrochemical immunosensor coupled with biofunctionalized zero-dimensional graphene quantum dots for rapid detection of cephalexin.Food Chemistry 398:133846.2022方法开发
Nelczyk AT, et al.(2022) The nuclear receptor TLX (NR2E1) inhibits growth and progression of triple-negative breast cancer.Biochim Biophys Acta Mol Basis Dis Aug 3 doi: 10.1016/j.bbadis.2022.166515.2022癌症研究乳腺癌
Leng F, et al.(2022) The transcription factor FoxP3 can fold into two dimerization states with divergent implications for regulatory T cell function and immune homeostasis.Immunity 55(8):1354-1369.e8.2022结构生物学/蛋白质相互作用
Eccardt AM, et al.(2022) Stimulation of Akt Phosphorylation and Glucose Transport by Metalloporphyrins with Peroxynitrite Decomposition Catalytic Activity.Catalysts 12(8):849.2022细胞信号
El-Sayed D, et al.(2022) Evaluating the Phenotypic and Genomic Characterization of Some Egyptian Phages Infecting Shiga Toxin-Producing Escherichia coli O157: H7 for the Prospective Application in Food Bio-Preservation.Biology 11(8)1180.2022微生物和模式生物
Costa TC, et al.(2022) Ruminal undegradable protein enriched diet during late gestation of beef cows affects maternal metabolism and offspring's skeletal muscle development.Anim Feed Sci Technol 291:115400.2022其他
Metformin improves depressive-like behavior in experimental Parkinson's disease by inducing autophagy in the substantia nigra and hippocampus.Inflammopharmacology Aug 6 doi: 10.1007/s10787-022-01043-6.2022神经生物学
Sherlock D. and Fogg PCM.(2022) The archetypal gene transfer agent RcGTA is regulated via direct interaction with the enigmatic RNA polymerase omega subunit.Cell Rep 40(6):111183.2022其他
Desjardins CA, et al.(2022) Enhanced exon skipping and prolonged dystrophin restoration achieved by TfR1-targeted delivery of antisense oligonucleotide using FORCE conjugation in mdx mice.Nucleic Acids Res Aug 10 doi: 10.1093/nar/gkac641.2022神经生物学
Emdal KB, et al.(2022) Phosphoproteomics of primary AML patient samples reveals rationale for AKT combination therapy and p53 context to overcome selinexor resistance.Cell Rep 40(6):111177.2022神经生物学
Dupont V, et al.(2022) Impaired renal reserve contributes to preeclampsia via the kynurenine and soluble fms-like tyrosine kinase 1 pathway.J Clin Invest Aug 9 doi: 10.1172/JCI158346.2022细胞信号
Guo X, et al.(2022) Vasorin contributes to lung injury via FABP4-mediated inflammation.Mol Biol Rep Aug 10 doi: 10.1007/s11033-022-07780-9.2022其他
Lopes FBTP, et al.(2022) Temporal and sex-linked protein expression dynamics in a familial model of Alzheimer's Disease.Mol Cell Proteomics Aug 6 doi: 10.1016/j.mcpro.2022.100280.2022神经生物学
Gatticchi L, et al.(2022) CRISPR/Cas9-mediated knock-out of AGXT1 in HepG2 cells as a new in vitro model of Primary Hyperoxaluria Type 1.Biochimie Aug 11 doi: 10.1016/j.biochi.2022.08.005.2022CRISPR
Lazcano P, et al.(2022) Phosphatidic acid inhibits inositol synthesis by inducing nuclear translocation of kinase IP6K1 and repression of myo-inositol-3-P synthase.J Biol Chem Aug 10 doi: 10.1016/j.jbc.2022.102363.2022细胞信号
D'Acunzo P, et al.(2022) Isolation of mitochondria-derived mitovesicles and subpopulations of microvesicles and exosomes from brain tissues.Nat Protoc Aug 12. doi: 10.1038/s41596-022-00719-1.2022方法开发
H Fu, et al.(2023) The heated-induced gelation of soy protein isolate at subunit level: Exploring the impacts of α and α′ subunits on SPI gelation based on natural hybrid breeding varities.Food Hydrocolloids doi: 10.1016/j.foodhyd.2022.108008.2022植物科学
Xu Q, et al.(2022) CircSERPINA3 promoted cell proliferation, migration, and invasion of laryngeal squamous cell carcinoma by targeting miR‐885‐5p.Cell Biol Int Aug 16 doi: 10.1002/cbin.11872.2022癌症研究鳞状细胞癌
Tachibana N, et al.(2022) RSPO2 defines a distinct undifferentiated progenitor in the tendon/ligament and suppresses ectopic ossification.Sci Adv 8(33):eabn2138.2022其他
Kushwaha A, et al.(2022) Pseudomonas aeruginosa quorum-sensing molecule N-(3-oxododecanoyl) homoserine lactone induces calcium signaling-dependent crosstalk between autophagy and apoptosis in human macrophages.Cell Signal 99:110441.2022细胞信号
Zafferani M, et al.(2022) Multiassay Profiling of a Focused Small Molecule Library Reveals Predictive Bidirectional Modulation of the lncRNA MALAT1 Triplex Stability In Vitro.ACS Chem Biol Aug 19 doi: 10.1021/acschembio.2c00124.2022方法开发
Pozzi S, et al.(2022) MCP-1/CCR2 axis inhibition sensitizes the brain microenvironment against melanoma brain metastasis progression.JCI Insight Aug 18 doi: 10.1172/jci.insight.154804.2022癌症研究脑癌
Jia H, et al.(2022) Highly efficient and simple SSPER and rrPCR approaches for the accurate site-directed mutagenesis of large and small plasmids.N Biotechnol Aug 22 doi: 10.1016/j.nbt.2022.08.004.2022方法开发
Mukherjee D, et al.(2022) Fetal pulmonary hypertension: dysregulated microRNA-34c-Notch1 axis contributes to impaired angiogenesis in an ovine model.Pediatr Res Jun 18 doi: 10.1038/s41390-022-02151-3.2022其他
Zhang D, et al.(2022) Upregulation of miR‐144‐3p alleviates Doxorubicin‐induced heart failure and cardiomyocytes apoptosis via SOCS2/PI3K/AKT axis.Chem Biol Drug Des Jun 22. doi: 10.1111/cbdd.14104.2022细胞信号
He J, et al.(2022) Ruscogenin Ameliorated Sjögren's Syndrome by Inhibiting NLRP3 Inflammasome Activation.Evid Based Complement Alternat Med Jun 28 doi: 10.1155/2022/6425121.2022细胞信号
Fang CL, et al.(2022) Angelica dahurica attenuates melanogenesis in B16F0 cells by repressing Wnt/β-catenin signaling.Mol.Cell.Toxicol June 27 doi: 10.1007/s13273-022-00250-0.2022其他
Mohamed ISE, et al.(2022) Bovine Pancreatic RNase A: An Insight into the Mechanism of Antitumor Activity In Vitro and In Vivo.Pharmaceutics 14(6):1173.2022癌症研究皮肤癌
Lee EH, et al.(2022) Inhibition of TRPM7 suppresses migration and invasion of prostate cancer cells via inactivation of ERK1/2, Src and Akt pathway signaling.J. Mens Health 18(7):144.2022癌症研究普遍
Kim JH, et al.(2022) Increasing the resilience of plant immunity to a warming climate.Nature Jun 29 doi: 10.1038/s41586-022-04902-y.2022植物科学
Marcovich I, et al.(2033) Optimized AAV Vectors for TMC1 Gene Therapy in a Humanized Mouse Model of DFNB7/11.Biomolecules 12(7): 914.2022方法开发
Porcù E, et al.(2022) Identification of Homoharringtonine as a potent inhibitor of glioblastoma cell proliferation and migration.Transl Res Jul 1 doi: 10.1016/j.trsl.2022.06.017.2022癌症研究脑癌
Park SK, et al.(2022) Porphyra tenera Protects against PM2.5-Induced Cognitive Dysfunction with the Regulation of Gut Function.Mar. Drugs 20(7):439.2022神经生物学
Avila H, et al.(2022) Hydra-Elastin-like Polypeptides Increase Rapamycin Potency When Targeting Cell Surface GRP78.Biomacromolecules Jul 5 doi: 10.1021/acs.biomac.2c00048.2022药物机制
Han SM, et al.(2022) The Change in Circadian Rhythms in P301S Transgenic Mice is Linked to Variability in Hsp70-related Tau Disaggregation.Exp Neurobiol 31(3):196-207.2022神经生物学
Li Z, et al.(2022) Sodium para-aminosalicylic acid ameliorates lead-induced hippocampal neuronal apoptosis by suppressing the activation of the IP3R-Ca2+-ASK1-p38 signaling pathway.Ecotoxicol Environ Saf 241:113829.2022神经生物学
Pemberton K, et al.(2022) Differential Effects of the G Protein-Coupled Estrogen Receptor (GPER) on Rat Embryonic (E18) Hippocampal and Cortical Neurons. eNeuro Jun 30 doi: 10.1523/ENEURO.0475-21.2022.2022神经生物学
Poli E, et al.(2022) Immunoreactivity against fibroblast growth factor 8 in alveolar rhabdomyosarcoma patients and its involvement in tumor aggressiveness.Oncoimmunology 11(1):2096349.2022癌症研究普遍
Baglyas M, et al.(2022) High-performance thin-layer chromatography-antibacterial assay first reveals bioactive clerodane diterpenes in giant goldenrod (Solidago gigantea Ait.).J Chromatogr A July 9 doi: 10.1016/j.chroma.2022.463308.2022植物科学
Chu HS, et al.(2022) Integrated Stress Response Regulation of Corneal Epithelial Cell Motility and Cytokine Production.Invest Ophthalmol Vis Sci 63(8):1.2022细胞信号
Swain RM, et al.(2022) Two novel piperidones induce apoptosis and antiproliferative effects on human prostate and lymphoma cancer cell lines.Invest New Drugs Jul 6 doi: 10.1007/s10637-022-01266-y.2022癌症研究普遍
Wu LK, et al.(2022) Artemisia Leaf Extract protects against neuron toxicity by TRPML1 activation and promoting autophagy/mitophagy clearance in both in vitro and in vivo models of MPP+ and MPTP induced Parkinson’s disease.Phytomedicine 104:154250.2022神经生物学
Shahdeo D, et al.(2022) Graphene-Based Field-Effect Transistor for Ultrasensitive Immunosensing of SARS-CoV-2 Spike S1 Antigen.ACS Appl Bio Mater 5(7):3563-3572.2022方法开发
Duschmalé J, et al.(2022) Investigating discovery strategies and pharmacological properties of stereodefined phosphorodithioate LNA gapmers.Mol Ther Nucleic Acids 29:176-188.2022方法开发
Hu F, et al.(2022) Bioinformatics analysis of KLF2 as a potential prognostic factor in ccRCC and association with epithelial‑mesenchymal transition.Exp Ther Med 24:561.2022癌症研究普遍
Halle JL, et al.(2022) Short duration treadmill exercise improves physical function and skeletal muscle mitochondria protein expression after recovery from FOLFOX chemotherapy in male mice.FASEB J 36(8):e22437.2022Mitochondrial studies
Weinheimer AS, et al.(2022) Extended DNA binding interfaces beyond the canonical SAP domain contribute to the function of replication stress regulator SDE2 at DNA replication forks.J Biol Chem Jul 15 doi: 10.1016/j.jbc.2022.102268.2022DNA 修复过程
Guleria VS, et al.(2022) The intraflagellar transport protein IFT52 associated with short-rib thoracic dysplasia is essential for ciliary function in osteogenic differentiation in vitro and for sensory perception in Drosophila.Exp Cell Res 418(2):113273.2022神经生物学
Qin W, et al.(2022) Osteoglycin (OGN) promotes tumorigenesis of pancreatic cancer cell via targeting ID4.Tissue and Cell July 16 doi: 10.1016/j.tice.2022.101867.2022癌症研究胰腺癌
Ye Z, et al.(2022) LMCD1 facilitates the induction of pluripotency via cell proliferation, metabolism, and epithelial‐mesenchymal transition.Cell Biol Int Jul 16 doi: 10.1002/cbin.11858.2022其他
Demonbreun AR, et al.(2022) A conserved annexin A6–mediated membrane repair mechanism in muscle, heart, and nerve.JCI Insight 7(14):e158107.2022神经生物学
Singh N, et al.(2022) Targeted BACE-1 inhibition in microglia enhances amyloid clearance and improved cognitive performance.Sci Adv 8(29):eabo3610.2022神经生物学
Wang Z, et al.(2022) The N6-methyladenosine writer WTAP contributes to the induction of immune tolerance post kidney transplantation by targeting regulatory T cells.Lab Invest Jul 21 doi: 10.1038/s41374-022-00811-w.2022其他
Simeone CA, et al.(2022) A dominant negative ADIPOQ mutation in a diabetic family with renal disease, hypoadiponectinemia, and hyperceramidemia.NPJ Genom Med 7(1):43.2022疾病研究生物标记物研究
Dong ZB, et al.(2022) Resveratrol ameliorates oxaliplatin‑induced neuropathic pain via anti‑inflammatory effects in rats.Exp Ther Med July 21 doi: 10.3892/etm.2022.11523.2022神经生物学
Zhang L, et al.(2022) Measuring Cytological Proximity of Chromosomal Loci to Defined Nuclear Compartments with TSA-seq. Methods Mol Biol 2532:145-186.2022方法开发
Song D, et al.(2022) Dual-hairpin ligation amplification enabled ultra-sensitive and selective ATP detection for cancer monitor.Biosens Bioelectron 212:114402.2022其他
John L, et al.(2022) Redirecting Imipramine against Bluetongue Virus Infection: Insights from a Genome-wide Haploid Screening Study.Pathogens 11(5):602.2022其他
Du Q, et al.(2022) Bioinformatics analysis of LMAN1 expression, clinical characteristics, and its effects on cell proliferation and invasion in glioma.Brain Res 1789:147952.2022癌症研究脑癌
Grismaldo Rodríguez A, et al.(2022) Effect of Platelet-Derived Growth Factor C on Mitochondrial Oxidative Stress Induced by High d-Glucose in Human Aortic Endothelial Cells.Pharmaceuticals (Basel) 15(5):639.2022细胞信号
Simões V, et al.(2022) Redox-sensitive E2 Rad6 controls cellular response to oxidative stress via K63-linked ubiquitination of ribosomes.Cell Rep 39(8):110860.2022其他
Altegoer F, et al.(2022) Structural insights into the mechanism of archaellar rotational switching.Nat Commun 13(1):2857.2022结构生物学/蛋白质相互作用
Gangopadhyay A, et al.(2022) NLRP3 licenses NLRP11 for inflammasome activation in human macrophages.Nat Immunol 23(6):892-903.2022细胞信号
Roy S, et al.(2022) Role of MrgprB2 in Rosacea-like Inflammation in Mice: Modulation by βarrestin2.J Invest Dermatol May 26 doi: 10.1016/j.jid.2022.05.005.2022细胞信号
Matyushkina D, et al.(2022) Autoimmune Effect of Antibodies against the SARS-CoV-2 Nucleoprotein.Viruses 14(6): 1141.2022微生物和模式生物
Zhang Q, et al.(2022) Down-Regulating Scar Formation by Microneedles Directly via a Mechanical Communication Pathway.ACS Nano May 26 doi: 10.1021/acsnano.1c11016.2022方法开发
Lin S, et al.(2022) TGF-β1 regulates chondrocyte proliferation and extracellular matrix synthesis via circPhf21a-Vegfa axis in osteoarthritis.Cell Commun Signal 20(1):75.2022细胞信号
Fan X, et al.(2022) Iron-Regulated Assembly of the Cytosolic Iron-Sulfur Cluster Biogenesis Machinery.J Biol Chem May 30 doi: 10.1016/j.jbc.2022.102094.2022结构生物学/蛋白质相互作用
Shin CH, et al.(2022) Cytosolic microRNA-inducible nuclear translocation of Cas9 protein for disease-specific genome modification.Nucleic Acids Res 50(10):5919-5933.2022CRISPR
Mohamed ISE, et al.(2022) Bovine Pancreatic RNase A: An Insight into the Mech-anism of Antitumor Activity In Vitro and In Vivo.Pharmaceutics 14:1173.2022癌症研究普遍
Onori ME, et al.(2022) Genetics and Sport Injuries: New Perspectives for Athletic Excellence in an Italian Court of Rugby Union Players.Genes 13(6):995.2022其他
Jiang L, et al.(2022) Salidroside attenuates sepsis-associated acute lung injury through PPP1R15A mediated endoplasmic reticulum stress inhibition.Bioorg Med Chem June 1 doi: 10.1016/j.bmc.2022.116865.2022其他
Chalise U, et al.(2022) MMP-12 polarizes the neutrophil signalome towards an apoptotic signature.J Proteomics Jun 1 doi: 10.1016/j.jprot.2022.104636.2022细胞信号
Siddoway AC, et al.(2022) Structural Stability and Antigenicity of Universal Equine H3N8 Hemagglutinin Trimer upon Release from Polyanhydride Nanoparticles and Pentablock Copolymer Hydrogels.ACS Biomater Sci Eng May 23 doi: 10.1021/acsbiomaterials.2c00219.2022其他
Yang HY, et al.(2022) Glycogen synthase kinase‐3β inhibition decreases inflammation and relieves cancer induced bone pain via reducing Drp1‐mediated mitochondrial damage.J Cell Mol Med Jun 10 doi: 10.1111/jcmm.17432.2022癌症研究普遍
Csizmarik A, et al.(2022) Proteome profiling of enzalutamide‐resistant cell lines and serum analysis identified ALCAM as marker of resistance in castration‐resistant prostate cancer.Int J Cancer Jun 11 doi: 10.1002/ijc.34159.2022癌症研究普遍
Hallacli E, et al.(2022) The Parkinson's disease protein alpha-synuclein is a modulator of processing bodies and mRNA stability.Cell 185(12):2035-2056.e33.2022神经生物学
Vasquez I, et al.(2022) Comparative Genomics of Typical and Atypical Aeromonas salmonicida Complete Genomes Revealed New Insights into Pathogenesis Evolution.Microorganisms 10(1):189.2022微生物和模式生物
Kim S, et al.(2022) Phosphorylation of GluA1-Ser831 by CaMKII activation in the caudate and putamen is required for behavioral sensitization after challenge nicotine in rats.Int J Neuropsychopharmacol Jun 9 doi: 10.1093/ijnp/pyac034.2022神经生物学
Yang J, et al.(2022) Mmu_circ_0000271 regulated the growth of ox-LDL-stimulated mouse vascular smooth muscle cells via sponging miR-5123.Genes Genomics Jun 6 doi: 10.1007/s13258-022-01268-3.2022其他
Peng Y, et al.(2022) The Drosophila hnRNP F/H homolog Glorund recruits dFMRP to inhibit nanos translation elongation.Nucleic Acids Res Jun 14 doi: 10.1093/nar/gkac500.2022其他
Chen N, et al.(2022) YAP1 maintains active chromatin state in head and neck squamous cell carcinomas that promotes tumorigenesis through cooperation with BRD4.Cell Rep 39(11):110970.2022癌症研究鳞状细胞癌
Guilloteau E, et al.(2022) Murine in utero exposure to simulated complex urban air pollution disturbs offspring gut maturation and microbiota during intestinal suckling-to-weaning transition in a sex-dependent manner.Part Fibre Toxicol 19(1):41.2022其他
Li W, et al.(2022) The downregulation of miR‐22 and miR‐372 may contribute to gestational diabetes mellitus through regulating glucose metabolism via the PI3K/AKT/GLUT4 pathway.J Clin Lab Anal Jun 17 doi: 10.1002/jcla.245572022细胞信号
Liu D, et al.(2022) Impact of schizophrenia GWAS loci converge onto distinct pathways in cortical interneurons vs glutamatergic neurons during development.Mol Psychiatry Jun 14 doi: 10.1038/s41380-022-01654-z.2022神经生物学
Suthon S, et al.(2022) GATA4 and estrogen receptor alpha bind at SNPs rs9921222 and rs10794639 to regulate AXIN1 expression in osteoblasts Hum Genet Jun 9 doi: 10.1007/s00439-022-02463-8.2022疾病研究生物标记物研究
Giuliani E, et al.(2022) Obesity-induced follicular phase endometrial proteome dysregulation in a well-phenotyped population.F S Sci Jun 13 doi: 10.1016/j.xfss.2022.06.002.2022其他
Lee BR, et al.(2022) Ascorbate peroxidase‐mediated in situ labelling of proteins in secreted exosomes.J Extracell Vesicles 11(6):e12239.2022方法开发
Singh N, et al.(2022) BACE-1 inhibition facilitates the transition from homeostatic microglia to DAM-1.Sci Adv 8(24):eabo1286.2022其他
Garcia-Gerique L, et al.(2022) MIF/CXCR4 signaling axis contributes to survival, invasion, and drug resistance of metastatic neuroblastoma cells in the bone marrow microenvironment.BMC Cancer 22(1):669.2022癌症研究普遍
Jiang N, et al.(2022) Inhibition of Cpt1a alleviates oxidative stress-induced chondrocyte senescence via regulating mitochondrial dysfunction and activating mitophagy.Mech Ageing Dev 205:111688.2022癌症研究普遍
Haworth AS, et al.(2022) Subcellular dynamics and functional activity of the cleaved intracellular domain of the Na+ channel β1 subunit.J Biol Chem Jun 22 doi: 10.1016/j.jbc.2022.102174.2022癌症研究乳腺癌
Figueiredo J, et al.(2022) Encapsulation of the septal cell wall protects Streptococcus pneumoniae from its major peptidoglycan hydrolase and host defenses.PLoS Pathog 18(6):e1010516.2022微生物和模式生物
Yang YY, et al.(2022) Moderate Dose Irradiation Induces DNA Damage and Impairments of Barrier and Host Defense in Nasal Epithelial Cells in vitro.J Inflamm Res 2022(15):3661—3675.2022DNA 修复过程
Othmène YB, et al.(2022) Triazole fungicide tebuconazole induces apoptosis through ROS-mediated endoplasmic reticulum stress pathway.Environ Toxicol Pharmacol Jun 23 doi: 10.1016/j.etap.2022.103919.2022细胞信号
TJ Yang TJ, et al.(2022) Tumor suppressor BAP1 nuclear import is governed by transportin-1.J Cell Biol 221(6):e202201094.2022癌症研究普遍
Sahu BP, et al.(2022) Genome-wide identification and characterization of microsatellite markers within the Avipoxviruses.3 Biotech 12(5):113.2022疾病研究生物标记物研究
West PK, et al.(2022) The cytokines interleukin-6 and interferon-α induce distinct microglia phenotypes.J Neuroinflammation 19(1):96.2022神经生物学
M Diefenbacher M, et al.(2022) Interactions between Influenza A Virus Nucleoprotein and Gene Segment Untranslated Regions Facilitate Selective Modulation of Viral Gene Expression.J Virol Apr 25 doi: 10.1128/jvi.00205-22.2022微生物和模式生物
Xu WF, et al.(2022) Octreotide-based therapies effectively protect mice from acute and chronic gastritis.Eur J Pharmacol Apr 26 doi: 10.1016/j.ejphar.2022.174976.2022药物机制
Menna M, et al.(2022) Novel non-covalent LSD1 inhibitors endowed with anticancer effects in leukemia and solid tumor cellular models.Eur J Med Chem 237:114410.2022癌症研究普遍
Liu Y, et al.(2022) Whole-Exome Sequencing of Germline Variants in Non-BRCA Families with Hereditary Breast Cancer.Biomedicines 10(5):1004.2022癌症研究乳腺癌
Esfahani SA, et al.(2022) Hyperpolarized [1-13C] Pyruvate Magnetic Resonance Spectroscopic Imaging for Evaluation of Early Response to Tyrosine Kinase Inhibition Therapy in Gastric Cancer.Mol Imaging Biol Apr 25 doi: 10.1007/s11307-022-01727-z.2022癌症研究胃癌
Thompson L, et al.(2022) An eIF3d-dependent switch regulates HCMV replication by remodeling the infected cell translation landscape to mimic chronic ER stress.Cell Rep 39(5):110767.2022其他
Xue JB, et al.(2022) Heart failure in mice induces a dysfunction of the sinus node associated with reduced CaMKII signaling.J Gen Physiol 154(9):e202112895.2022细胞信号
Yang X, et al.(2022) MARCH8 attenuates cGAS-mediated innate immune responses through ubiquitylation.Sci Signal 15(732):eabk3067.2022其他
Butta GM, et al.(2022) Heterogeneity of Latency Establishment in the Different Human CD4+ T Cell Subsets Stimulated with IL-15.J Virol May 2 doi: 10.1128/jvi.00379-22.2022微生物和模式生物
Siddiqui SH, et al.(2022) Modulatory effects of cell–cell interactions between porcine skeletal muscle satellite cells and fibroblasts on the expression of myogenesis-related genes.Journal of Applied Animal Research 50(1):259-268.2022其他
Yin W, Qian S. (2022) Delivery of cisplatin and resiquimod in nanomicelles for the chemoimmunotherapy of ovarian cancer.Cancer Nano 13:82022癌症研究卵巢癌
Qiao J, et al.(2022) Neuroprotective effect of Ginsenoside Re against neurotoxin‑induced Parkinson's disease models via induction of Nrf2.Mol Med Rep 25(6):215.2022神经生物学
Dong C, et al.(2022) A genome-wide CRISPR-Cas9 knockout screen identifies essential and growth-restricting genes in human trophoblast stem cells.Nat Commun 13(1):2548.2022CRISPR
Mahari S, et al.(2022) Probe-Free Nanosensor for the Detection of Salmonella Using Gold Nanorods as an Electroactive Modulator.Food Chem 390:133219.2022方法开发
Mohammed HHH, et al.(2022) New 1, 2, 3-triazole linked ciprofloxacin-chalcones induce DNA damage by inhibiting human topoisomerase I& II and tubulin polymerization.J Enzyme Inhib Med Chem 37(1):1346-1363.2022癌症研究普遍
Kshirsagar PG, et al.(2022) DNA-gold nanoprobe-based integrated biosensing technology for non-invasive liquid biopsy of serum miRNA: A new frontier in prostate cancer diagnosis.Nanomedicine May 12 doi: 10.1016/j.nano.2022.102566.2022癌症研究普遍
Harbuzariu A, et al.(2022) Neuregulin-1/ErbB4 signaling modulate Plasmodium falciparum HRP2-induced damage to brain cortical organoids.ISCIENCE May 14 doi: https://doi.org/10.1016/j.isci.2022.104407.2022神经生物学
Jain RG, et al.(2022) Foliar application of clay-delivered RNA interference for whitefly control.Nat Plants 8(5):535-548.2022植物科学
Taniguchi H, et al.(2022) WEE1 inhibition enhances the antitumor immune response to PD-L1 blockade by the concomitant activation of STING and STAT1 pathways in SCLC.Cell Rep 39(7):110814.2022癌症研究肺癌
Lu Y, et al.(2022) Patchouli alcohol protects against myocardial ischaemia–reperfusion injury by regulating the Notch1/Hes1 pathway.Pharm Biol 60(1):949-957.2022细胞信号
Shahdeo D, et al.(2022) Label free detection of SARS CoV-2 Receptor Binding Domain (RBD) protein by fabrication of gold nanorods deposited on electrochemical immunosensor (GDEI).Biosens Bioelectron 212:114406.2022方法开发
Rouault AAJ, et al.(2022) MRAP2 inhibits β-arrestin recruitment to the ghrelin receptor by preventing GHSR1a phosphorylation.J Biol Chem May 20 doi: 10.1016/j.jbc.2022.102057.2022细胞信号
Parashar D, et al.(2022) Patient-Derived Ovarian Cancer Spheroids Rely on PI3K-AKT Signaling Addiction for Cancer Stemness and Chemoresistance.Cancers (Basel) 14(4):958.2022癌症研究卵巢癌
Ni C, et al.(2022) Labeling of heterochronic ribosomes reveals C1ORF109 and SPATA5 control a late step in human ribosome assembly.Cell Rep 38(13):110597.2022其他
Niemeyer CS, et al.(2022) VZV Infection of Primary Human Adrenal Cortical Cells Produces a Proinflammatory Environment without Cell Death.Viruses 14(4):674.2022其他
Leo IR, et al.(2022) Integrative multi-omics and drug response profiling of childhood acute lymphoblastic leukemia cell lines.Nat Commun 13(1):1691.2022癌症研究血癌
Donko A, et al.(2022) Interpretation of Dihydrorhodamine-1, 2, 3 Flow Cytometry in Chronic Granulomatous Disease: an Atypical Exemplar.J Clin Immunol Mar 28 doi: 10.1007/s10875-022-01217-5.2022其他
Jamieson F, et al.(2022) Ethylene signaling modulates Arabidopsis thaliana nitrate metabolism.Planta 255(5):94.2022植物科学
Lee HK, et al.(2022) Sinkihwan-gamibang ameliorates puromycin aminonucleoside-induced nephrotic syndrome.Chin J Nat Med 20(3):177-184.2022其他
Gomes C, et al.(2022) Neurotoxic Astrocytes Directly Converted from Sporadic and Familial ALS Patient Fibroblasts Reveal Signature Diversities and miR-146a Theragnostic Potential in Specific Subtypes.Cells 11(7):1186.2022神经生物学
Suzuki Y, et al.(2022) Rhodococcus equi U19 strain harbors a nonmobilizable virulence plasmid.Microbiol Immunol Mar 11 doi: 10.1111/1348-0421.12975.2022微生物和模式生物
Cilibrasi V, et al.(2022) Synthesis of 2H-Imidazo [2′, 1': 2, 3][,] thiazolo [4, 5-e] isoindol-8-yl-phenylureas with promising therapeutic features for the treatment of acute myeloid leukemia (AML) with FLT3/ITD mutations2022癌症研究普遍
Ghaleb Y, et al.(2022) Whole Exome/Genome Sequencing Joint Analysis of a Family with Oligogenic Familial Hypercholesterolemia.Metabolites 12(3):262.2022疾病研究生物标记物研究
Sun H, et al.(2022) TRIB2 regulates the expression of miR 33a 5p through the ERK/c Fos pathway to affect the imatinib resistance of chronic myeloid leukemia cells.Int J Oncol 60(5):49.2022癌症研究血癌
Wang YH, et al.(2022) Golgin Imh1 and GARP complex cooperate to restore the impaired SNARE recycling transport induced by ER stress.Cell Rep 38(12):110488.2022其他
Park H, et al.(2022) miR-200c suppression increases tau hyperphosphory-lation by targeting 14-3-3γ in early stage of 5xFAD mouse model of Alzheimer's disease.Int J Biol Sci 18(5):2220-2234.2022神经生物学
Mallard J, et al.(2022) Chemotherapy impairs skeletal muscle mitochondrial homeostasis in early breast cancer patients.J Cachexia Sarcopenia Muscle Apr 4 doi: 10.1002/jcsm.129912022癌症研究乳腺癌
Boltz F, et al.(2022) Nimodipine Exerts Beneficial Effects on the Rat Oligodendrocyte Cell Line OLN-93.Brain Sci 12(4):476.2022神经生物学
Zorzan E, et al.(2022) Hypermethylation-Mediated Silencing of CIDEA, MAL and PCDH17 Tumour Suppressor Genes in Canine DLBCL: From Multi-Omics Analyses to Mechanistic Studies.Int J Mol Sci 23(7):4021.2022癌症研究普遍
Park SK, et al.(2022) Peanut (Arachis hypogaea) sprout prevents high-fat diet-induced cognitive impairment by improving mitochondrial function.Sci Rep 12(1):6213.2022神经生物学
Zhang K, et al.(2022) Sevoflurane attenuates hepatic ischemia reperfusion injury by the miR-122/Nrf2 pathway.Ann Transl Med 10(6):350.2022其他
Ponterio G, et al.(2022) Alpha-Synuclein is Involved in DYT1 Dystonia Striatal Synaptic Dysfunction.Mov Disord Apr 14 doi: 10.1002/mds.29024.2022神经生物学
Yang HD, et al.(2022) Effect of Neiyi Prescription of QIU on autophagy and angiogenic ability of endometriosis via the PPARγ/NF-κB signaling pathway.Arch Gynecol Obstet Apr 3 doi: 10.1007/s00404-022-06537-w.2022细胞信号
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Zhao X, et al.(2019) Preventive effect of Lactobacillus plantarum KSFY02 isolated from naturally fermented yogurt from Xinjiang, China, on d-galactose-induced oxidative aging in mice.J Dairy Sci 102(7):5899−5912.2019微生物和模式生物
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Mishra R, et al.(2018) Can-miRn37a mediated suppression of ethylene response factors enhances the resistance of chilli against anthracnose pathogen Colletotrichum truncatum L. Plant Sci 267:135–147.2018植物科学
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