Product References
A plant-derived glucocorticoid receptor modulator with potency to attenuate the side effects of glucocorticoid therapy.
British journal of pharmacology
Wang Y,Gao J,Yu Y,Zhou L,Wang M,Xue W,Liu B,Wu X,Wu X,Gao H,Shen Y,Xu Q
12-5931-82 was used in flow cytometry to reveal that CA-e is a novel GR modulator with strong potency to attenuate the side effects of GC therapy and can be used as a potential molecular tool for deciphering GR signalling.
Sun Jan 01 00:00:00 EST 2023
Ste20-Like Kinase TAOK1 Positively Regulates Antiviral Responses by Controlling the TBK1-IRF3 Signaling Axis.
Journal of innate immunity
Luo X,Ji R,Liu Q,Xiao X,Song W,An H,Li Y,Zhou J
12-5931-82 was used in Flow Cytometry to provide novel insights into the function of TAOK1 in the antiviral innate immune response and its related clinical significance.
Tue Dec 26 00:00:00 EST 2023
Group 2 innate lymphoid cells protect mouse heart from myocardial infarction injury via interleukin 5, eosinophils, and dendritic cells.
Cardiovascular research
Liu T,Meng Z,Liu J,Li J,Zhang Y,Deng Z,Luo S,Wang M,Huang Q,Zhang S,Fendt P,Devouassoux J,Li D,McKenzie ANJ,Nahrendorf M,Libby P,Guo J,Shi GP
12-5931-82 was used in Flow cytometry/Cell sorting to reveal an indirect cardiac reparative role of ILC2 in post-MI hearts via the IL5, EOS, and DC mechanism.
Tue May 02 00:00:00 EDT 2023
Repositioning of the Angiotensin II Receptor Antagonist Candesartan as an Anti-Inflammatory Agent With NLRP3 Inflammasome Inhibitory Activity.
Frontiers in immunology
Lin WY,Li LH,Hsiao YY,Wong WT,Chiu HW,Hsu HT,Peng YJ,Ho CL,Chernikov OV,Cheng SM,Yang SP,Hua KF
12-5931-82 was used in Flow cytometry/Cell sorting to indicate that candesartan has board anti-inflammatory effects and has the potential to be repositioned to ameliorate inflammatory diseases or NLRP3-associated complications.
Wed Jun 08 00:00:00 EDT 2022
TPGS-based and S-thanatin functionalized nanorods for overcoming drug resistance in Klebsiella pneumonia.
Nature communications
Wang X,Xu X,Zhang S,Chen N,Sun Y,Ma K,Hong D,Li L,Du Y,Lu X,Jiang S
12-5931-82 was used in Flow cytometry/Cell sorting to design a D-alpha tocopheryl polyethylene glycol succinate-modified and S-thanatin peptide-functionalized nanorods based on calcium phosphate nanoparticles for tigecycline delivery and pneumonia therapy caused by tigecycline-resistant Klebsiella pneumoniae.
Wed Jun 29 00:00:00 EDT 2022
Ablation of NLRP3 inflammasome rewires MDSC function and promotes tumor regression.
Frontiers in immunology
Papafragkos I,Grigoriou M,Boon L,Kloetgen A,Hatzioannou A,Verginis P
12-5931-82 was used in Flow cytometry/Cell sorting to demonstrate an important role of NLRP3 inflammasome in the functional properties of MDSCs in tumor-bearing hosts.
Tue Aug 30 00:00:00 EDT 2022
Activated Neutrophils Secrete Chitinase-Like 1 and Attenuate Liver Inflammation by Inhibiting Pro-Inflammatory Macrophage Responses.
Frontiers in immunology
Lu Y,Chang N,Zhao X,Xue R,Liu J,Yang L,Li L
12-5931-82 was used in Flow cytometry/Cell sorting to indicate that A-Neu could inhibit the pro-inflammatory macrophage responses by secreting CHIL1, thereby effectively inhibiting liver inflammation.
Tue May 10 00:00:00 EDT 2022
Chronic T cell proliferation in brains after stroke could interfere with the efficacy of immunotherapies.
The Journal of experimental medicine
Heindl S,Ricci A,Carofiglio O,Zhou Q,Arzberger T,Lenart N,Franzmeier N,Hortobagyi T,Nelson PT,Stowe AM,Denes A,Edbauer D,Liesz A
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 12-5931-82) in Flow Cytometry
Mon Aug 02 00:00:00 EDT 2021
BRD4-mediated repression of p53 is a target for combination therapy in AML.
Nature communications
Latif AL,Newcombe A,Li S,Gilroy K,Robertson NA,Lei X,Stewart HJS,Cole J,Terradas MT,Rishi L,McGarry L,McKeeve C,Reid C,Clark W,Campos J,Kirschner K,Davis A,Lopez J,Sakamaki JI,Morton JP,Ryan KM,Tait SWG,Abraham SA,Holyoake T,Higgins B,Huang X,Blyth K,Copland M,Chevassut TJT,Keeshan K,Adams PD
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 12-5931-82) in Flow Cytometry
Mon Jan 11 00:00:00 EST 2021
Design, Synthesis and Biological Evaluation of Arylpyridin-2-yl Guanidine Derivatives and Cyclic Mimetics as Novel MSK1 Inhibitors. An Application in an Asthma Model.
Molecules (Basel, Switzerland)
Bollenbach M,Nemska S,Wagner P,Camelin G,Daubeuf F,Obrecht A,Villa P,Rognan D,Bihel F,Bourguignon JJ,Schmitt M,Frossard N
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 12-5931-82) in Flow Cytometry
Wed Jan 13 00:00:00 EST 2021
IFNγ-Producing γ/δ T Cells Accumulate in the Fetal Brain Following Intrauterine Inflammation.
Frontiers in immunology
Lewis EL,Tulina N,Anton L,Brown AG,Porrett PM,Elovitz MA
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 12-5931-82) in Flow Cytometry
Wed Jan 05 00:00:00 EST 2022
Lung mesenchymal stromal cells influenced by Th2 cytokines mobilize neutrophils and facilitate metastasis by producing complement C3.
Nature communications
Zheng Z,Li YN,Jia S,Zhu M,Cao L,Tao M,Jiang J,Zhan S,Chen Y,Gao PJ,Hu W,Wang Y,Shao C,Shi Y
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 12-5931-82) in Flow Cytometry
Wed Oct 27 00:00:00 EDT 2021
Retinoic Acid Inhibits Tumor-Associated Mesenchymal Stromal Cell Transformation in Melanoma.
Frontiers in cell and developmental biology
Lou Q,Zhao M,Xu Q,Xie S,Liang Y,Chen J,Yuan L,Wang L,Jiang L,Mou L,Lin D,Zhao M
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 12-5931-82) in Flow Cytometry
Sat Apr 24 00:00:00 EDT 2021
Comprehensive mutagenesis identifies the peptide repertoire of a p53 T-cell receptor mimic antibody that displays no toxicity in mice transgenic for human HLA-A*0201.
PloS one
Trenevska I,Anderson AP,Bentley C,Hassanali T,Wiblin S,Maguire S,Pezzella F,Banham AH,Li D
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 12-5931-82) in Flow Cytometry
Wed Sep 29 00:00:00 EDT 2021
Abraxane-induced bone marrow CD11b+ myeloid cell depletion in tumor-bearing mice is visualized by μPET-CT with 64Cu-labeled anti-CD11b and prevented by anti-CSF-1.
Theranostics
Cao Q,Huang Q,Wang YA,Li C
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 12-5931-82) in Flow Cytometry
Fri Jul 23 00:00:00 EDT 2021
USP12 downregulation orchestrates a protumourigenic microenvironment and enhances lung tumour resistance to PD-1 blockade.
Nature communications
Yang Z,Xu G,Wang B,Liu Y,Zhang L,Jing T,Tang M,Xu X,Jiao K,Xiang L,Fu Y,Tang D,Zhang X,Jin W,Zhuang G,Zhao X,Liu Y
12-5931-82 was used in Flow Cytometry to show that the deubiquitinase USP12 is commonly downregulated in the KrasG12D-driven mouse lung tumour and human non-small cell lung cancer owing to the activation of AKT-mTOR signalling.
Wed Aug 11 00:00:00 EDT 2021
E3 ligase Nedd4l promotes antiviral innate immunity by catalyzing K29-linked cysteine ubiquitination of TRAF3.
Nature communications
Gao P,Ma X,Yuan M,Yi Y,Liu G,Wen M,Jiang W,Ji R,Zhu L,Tang Z,Yu Q,Xu J,Yang R,Xia S,Yang M,Pan J,Yuan H,An H
12-5931 was used in Flow cytometry/Cell sorting to show that E3 ligase Nedd4l positively regulates antiviral immunity by catalyzing K29-linked cysteine ubiquitination of TRAF3.
Fri Feb 19 00:00:00 EST 2021
Single-cell analyses unravel cell type-specific responses to a vitamin D analog in prostatic precancerous lesions.
Science advances
Abu El Maaty MA,Grelet E,Keime C,Rerra AI,Gantzer J,Emprou C,Terzic J,Lutzing R,Bornert JM,Laverny G,Metzger D
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 12-5931-82) in Flow Cytometry
Thu Jul 01 00:00:00 EDT 2021
TNF-α-induced alterations in stromal progenitors enhance leukemic stem cell growth via CXCR2 signaling.
Cell reports
Agarwal P,Li H,Choi K,Hueneman K,He J,Welner RS,Starczynowski DT,Bhatia R
12-5931-82 was used in Flow Cytometry to find that TNF-α-mediated alterations in CML BM stromal niches enhance support of LSC maintenance and growth via CXCL1-CXCR2 signaling and that CXCR2 inhibition effectively depletes CML LSCs.
Tue Jul 13 00:00:00 EDT 2021
Construction, characterization, and immunization of nanoparticles that display a diverse array of influenza HA trimers.
PloS one
Cohen AA,Yang Z,Gnanapragasam PNP,Ou S,Dam KA,Wang H,Bjorkman PJ
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 12-5931-82) in Flow Cytometry
Fri Oct 15 00:00:00 EDT 2021
Calibration of cell-intrinsic interleukin-2 response thresholds guides design of a regulatory T cell biased agonist.
eLife
Glassman CR,Su L,Majri-Morrison SS,Winkelmann H,Mo F,Li P,Pérez-Cruz M,Ho PP,Koliesnik I,Nagy N,Hnizdilova T,Picton LK,Kovar M,Bollyky P,Steinman L,Meyer E,Piehler J,Leonard WJ,Garcia KC
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 12-5931-82) in Flow Cytometry
Tue May 18 00:00:00 EDT 2021
Multi-layered Spatial Transcriptomics Identify Secretory Factors Promoting Human Hematopoietic Stem Cell Development.
Cell stem cell
Crosse EI,Gordon-Keylock S,Rybtsov S,Binagui-Casas A,Felchle H,Nnadi NC,Kirschner K,Chandra T,Tamagno S,Webb DJ,Rossi F,Anderson RA,Medvinsky A
12-5931 was used in Flow cytometry/Cell sorting to identify secreted signals underlying human HSC development, combining spatial transcriptomics analysis of dorsoventral polarized signaling in the aorta with gene expression profiling of sorted cell populations and single cells.
Thu Nov 05 00:00:00 EST 2020
Transcriptional and cytopathological hallmarks of FSHD in chronic DUX4-expressing mice.
The Journal of clinical investigation
Bosnakovski D,Shams AS,Yuan C,da Silva MT,Ener ET,Baumann CW,Lindsay AJ,Verma M,Asakura A,Lowe DA,Kyba M
12-5931-82 was used in Flow Cytometry to demonstrate a pathophysiological similarity between disease in muscles of iDUX4pA-HSA mice and humans with FSHD, solidifying the value of chronic rare DUX4 expression in mice for modeling pathological mechanisms in FSHD and highlighting the importance FAPs in this disease.
Fri May 01 00:00:00 EDT 2020
Deregulated Notch and Wnt signaling activates early-stage myeloid regeneration pathways in leukemia.
The Journal of experimental medicine
Kang YA,Pietras EM,Passegué E
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 12-5931-82) in Flow Cytometry
Mon Mar 02 00:00:00 EST 2020
Long-term ex vivo expansion of mouse hematopoietic stem cells.
Nature protocols
Wilkinson AC,Ishida R,Nakauchi H,Yamazaki S
12-5931 was used in Flow cytometry/Cell sorting to describe a simple platform for the expansion of functional mouse hematopoietic stem cells ex vivo for >1 month under fully defined albumin-free conditions.
Sat Feb 01 00:00:00 EST 2020
In Situ Therapeutic Cancer Vaccination with an Oncolytic Virus Expressing Membrane-Tethered IL-2.
Molecular therapy oncolytics
Liu W,Dai E,Liu Z,Ma C,Guo ZS,Bartlett DL
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 12-5931-82) in Flow Cytometry
Fri Jun 26 00:00:00 EDT 2020
Deficiency of immunoglobulin E protects mice from experimental abdominal aortic aneurysms.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Li J,Deng Z,Zhang X,Liu F,Yang C,Shi GP
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 12-5931-82) in Flow Cytometry
Sat Feb 01 00:00:00 EST 2020
Flagellin-Stimulated Production of Interferon-β Promotes Anti-Flagellin IgG2c and IgA Responses.
Molecules and cells
Kang W,Park A,Huh JW,You G,Jung DJ,Song M,Lee HK,Kim YM
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 12-5931-82) in Flow Cytometry
Tue Mar 31 00:00:00 EDT 2020
Effects of Hypertonic Saline and Hydroxyethyl Starch on Myeloid-Derived Suppressor Cells in Hemorrhagic Shock Mice under Secondary Bacterial Attack.
BioMed research international
Jiang JK,Hong LJ,Lu YQ
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 12-5931-82) in Flow Cytometry
Wed Dec 16 00:00:00 EST 2020
Long Non-Coding RNA Hotairm1 Promotes S100A9 Support of MDSC Expansion during Sepsis.
Journal of clinical & cellular immunology
Alkhateeb T,Bah I,Kumbhare A,Youssef D,Yao ZQ,McCall CE,Gazzar ME
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 12-5931-82) in Flow Cytometry
Sat Aug 13 00:00:00 EDT 2022
The lysophospholipase D enzyme Gdpd3 is required to maintain chronic myelogenous leukaemia stem cells.
Nature communications
Naka K,Ochiai R,Matsubara E,Kondo C,Yang KM,Hoshii T,Araki M,Araki K,Sotomaru Y,Sasaki K,Mitani K,Kim DW,Ooshima A,Kim SJ
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 12-5931-82) in Flow Cytometry
Thu Sep 17 00:00:00 EDT 2020
Hyaluronan Degradation by Cemip Regulates Host Defense against Staphylococcus aureus Skin Infection.
Cell reports
Dokoshi T,Zhang LJ,Li F,Nakatsuji T,Butcher A,Yoshida H,Shimoda M,Okada Y,Gallo RL
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 12-5931-82) in Flow Cytometry
Tue Jan 07 00:00:00 EST 2020
Loss of testosterone impairs anti-tumor neutrophil function.
Nature communications
Markman JL,Porritt RA,Wakita D,Lane ME,Martinon D,Noval Rivas M,Luu M,Posadas EM,Crother TR,Arditi M
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 12-5931-82) in Flow Cytometry
Tue Mar 31 00:00:00 EDT 2020
Loss of testosterone impairs anti-tumor neutrophil function.
Nature communications
Markman JL,Porritt RA,Wakita D,Lane ME,Martinon D,Noval Rivas M,Luu M,Posadas EM,Crother TR,Arditi M
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 12-5931-82) in Flow Cytometry
Tue Mar 31 00:00:00 EDT 2020
Bacterial and Fungal Toll-Like Receptor Activation Elicits Type I IFN Responses in Mast Cells.
Frontiers in immunology
Kornstädt L,Pierre S,Weigert A,Ebersberger S,Schäufele TJ,Kolbinger A,Schmid T,Cohnen J,Thomas D,Ferreirós N,Brüne B,Ebersberger I,Scholich K
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 12-5931-82) in Flow Cytometry
Mon Jun 21 00:00:00 EDT 2021
Sensing and signaling of immunogenic extracellular RNAs restrain group 2 innate lymphoid cell-driven acute lung inflammation and airway hyperresponsiveness.
PloS one
She L,Alanazi HH,Yan L,Brooks EG,Dube PH,Xiang Y,Zhang F,Sun Y,Liu Y,Zhang X,Li XD
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 12-5931-82) in Flow Cytometry
Thu Sep 24 00:00:00 EDT 2020
BAD inactivation exacerbates rheumatoid arthritis pathology by promoting survival of sublining macrophages.
eLife
Li J,Zhang L,Zheng Y,Shao R,Liang Q,Yu W,Wang H,Zou W,Wang D,Xiang J,Lin A
12-5931-82 was used in Flow Cytometry to put forward a model in which inactivation of BAD confers the apoptosis resistance on synovial sublining macrophages, thereby contributing to the development of arthritis, suggesting that BAD may be a potential therapeutic target for RA.
Thu Dec 03 00:00:00 EST 2020
Curative in vivo hematopoietic stem cell gene therapy of murine thalassemia using large regulatory elements.
JCI insight
Wang H,Georgakopoulou A,Li C,Liu Z,Gil S,Bashyam A,Yannaki E,Anagnostopoulos A,Pande A,Izsvák Z,Papayannopoulou T,Lieber A
12-5931 was used in Flow cytometry/Cell sorting to demonstrate that hematopoietic stem/progenitor cell (HSPC) mobilization followed by intravenous injection of integrating, helper-dependent adenovirus HDAd5/35++ vectors resulted in efficient transduction of long-term repopulating cells and disease amelioration in mouse models after in vivo selection of transduced HSPCs.
Thu Aug 20 00:00:00 EDT 2020
Protocol for Flow Cytometric Detection of Immune Cell Infiltration in the Epidermis and Dermis of a Psoriasis Mouse Model.
STAR protocols
Lou F,Sun Y,Wang H
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 12-5931-82) in Flow Cytometry
Fri Dec 18 00:00:00 EST 2020
Loss of FGFR3 Delays Acute Myeloid Leukemogenesis by Programming Weakly Pathogenic CD117-Positive Leukemia Stem-Like Cells.
Frontiers in pharmacology
Guo C,Ran Q,Sun C,Zhou T,Yang X,Zhang J,Pang S,Xiao Y
12-5931-82 was used in Flow Cytometry to find that FGFR3 had a novel regulatory mechanism for the stemness of LSCs in AML, and provided a promising anti-leukemia approach by interrupting FGFR3.
Tue Feb 16 00:00:00 EST 2021
Glucocorticoids Promote the Onset of Acute Experimental Colitis and Cancer by Upregulating mTOR Signaling in Intestinal Epithelial Cells.
Cancers
Zhang Z,Dong L,Jia A,Chen X,Yang Q,Wang Y,Wang Y,Liu R,Cao Y,He Y,Bi Y,Liu G
12-5931 was used in Flow cytometry/Cell sorting to indicate that glucocorticoid-induced mTOR signaling in epithelial cells is required in the early stages of acute ulcerative colitis by modulating the dynamics of innate immune cell recruitment and activation.
Sat Apr 11 00:00:00 EDT 2020
NDRG2 regulates adherens junction integrity to restrict colitis and tumourigenesis.
EBioMedicine
Wei M,Ma Y,Shen L,Xu Y,Liu L,Bu X,Guo Z,Qin H,Li Z,Wang Z,Wu K,Yao L,Li J,Zhang J
12-5931 was used in Flow cytometry/Cell sorting to demonstrate that NDRG2 is an essential colonic epithelial barrier regulator and plays an important role in gut homeostasis maintenance and colitis-associated tumour development.
Sun Nov 01 00:00:00 EDT 2020
Interaction of Deubiquitinase 2A-DUB/MYSM1 with DNA Repair and Replication Factors.
International journal of molecular sciences
Kroeger C,Roesler R,Wiese S,Hainzl A,Gatzka MV
12-5931 was used in Flow cytometry/Cell sorting to provide additional evidence for an interaction between MYSM1 and key DNA replication and repair factors, and indicate a potential function of 2A-DUB/MYSM1 in DNA repair processes.
Tue May 26 00:00:00 EDT 2020
A Synthetic Small Molecule F240B Decreases NLRP3 Inflammasome Activation by Autophagy Induction.
Frontiers in immunology
Wu CH,Gan CH,Li LH,Chang JC,Chen ST,Menon MP,Cheng SM,Yang SP,Ho CL,Chernikov OV,Lin CH,Lam Y,Hua KF
12-5931-82 was used in Flow Cytometry to synthesize a new anti-inflammatory 4-HAB analogue, F240B, which has an IC50 of less than 1 µM. F240B dose-dependently induced autophagy by increasing autophagic flux, LC3 speck formation and acidic vesicular organelle formation.
Wed Jun 23 00:00:00 EDT 2021
Id1 and Id3 Maintain Steady-State Hematopoiesis by Promoting Sinusoidal Endothelial Cell Survival and Regeneration.
Cell reports
Gadomski S,Singh SK,Singh S,Sarkar T,Klarmann KD,Berenschot M,Seaman S,Jakubison B,Gudmundsson KO,Lockett S,Keller JR
12-5931 was used in Flow cytometry/Cell sorting to investigate the effects of loss of ld genes on adult endothelial cell.
Tue Apr 28 00:00:00 EDT 2020
Manipulation of the tumor microenvironment by cytokine gene transfection enhances dendritic cell-based immunotherapy.
FASEB bioAdvances
Wijesekera DPH,Yuba E,De Silva NH,Watanabe SI,Tsukamoto M,Ichida C,Izawa T,Itoh K,Kanegi R,Hatoya S,Yamate J,Inaba T,Sugiura K
12-5931-82 was used in Flow Cytometry to manipulate the microenvironment so as to elicit activation of T helper type 1 (Th1) responses and the maturation of dendritic cells (DCs).
Wed Jan 01 00:00:00 EST 2020
Long-term ex vivo haematopoietic-stem-cell expansion allows nonconditioned transplantation.
Nature
Wilkinson AC,Ishida R,Kikuchi M,Sudo K,Morita M,Crisostomo RV,Yamamoto R,Loh KM,Nakamura Y,Watanabe M,Nakauchi H,Yamazaki S
12-5931 was used in Flow cytometry/Cell sorting to identify polyvinyl alcohol as a functionally superior replacement for serum albumin that is compatible with good manufacturing practice.
Mon Jul 01 00:00:00 EDT 2019
Metabolic Imaging Reveals a Unique Preference of Symmetric Cell Division and Homing of Leukemia-Initiating Cells in an Endosteal Niche.
Cell metabolism
Hao X,Gu H,Chen C,Huang D,Zhao Y,Xie L,Zou Y,Shu HS,Zhang Y,He X,Lai X,Zhang X,Zhou BO,Zhang CC,Chen GQ,Yu Z,Yang Y,Zheng J
12-5931 was used in Flow cytometry/Cell sorting to provide a unique angle for the study of metabolisms in stem cells, and may lead to development of novel strategies for cancer treatment.
Tue Apr 02 00:00:00 EDT 2019
Immuno-subtyping of breast cancer reveals distinct myeloid cell profiles and immunotherapy resistance mechanisms.
Nature cell biology
Kim IS,Gao Y,Welte T,Wang H,Liu J,Janghorban M,Sheng K,Niu Y,Goldstein A,Zhao N,Bado I,Lo HC,Toneff MJ,Nguyen T,Bu W,Jiang W,Arnold J,Gu F,He J,Jebakumar D,Walker K,Li Y,Mo Q,Westbrook TF,Zong C,Rao A,Sreekumar A,Rosen JM,Zhang XH
12-5931 was used in Flow cytometry/Cell sorting to demonstrate diverse myeloid cell frequencies, functionality and potential roles in immunotherapies, and highlight the need to better understand the inter-patient heterogeneity of the myeloid compartment.
Sun Sep 01 00:00:00 EDT 2019
FLT3-ITD impedes retinoic acid, but not arsenic, responses in murine acute promyelocytic leukemias.
Blood
Esnault C,Rahmé R,Rice KL,Berthier C,Gaillard C,Quentin S,Maubert AL,Kogan S,de Thé H
12-5931 was used in Flow cytometry/Cell sorting to demonstrate that FLT3-ITD severely blunts ATRA response.
Thu Mar 28 00:00:00 EDT 2019
Ptpn21 Controls Hematopoietic Stem Cell Homeostasis and Biomechanics.
Cell stem cell
Ni F,Yu WM,Wang X,Fay ME,Young KM,Qiu Y,Lam WA,Sulchek TA,Cheng T,Scadden DT,Qu CK
12-5931 was used in Flow cytometry/Cell sorting to show that Ptpn21 maintains cellular mechanics, which is correlated with its important functions in HSC niche retention and preservation of hematopoietic regeneration capacity.
Thu Apr 04 00:00:00 EDT 2019
Mesenchymal Niche-Specific Expression of Cxcl12 Controls Quiescence of Treatment-Resistant Leukemia Stem Cells.
Cell stem cell
Agarwal P,Isringhausen S,Li H,Paterson AJ,He J,Gomariz Á,Nagasawa T,Nombela-Arrieta C,Bhatia R
12-5931-82 was used in Flow Cytometry to highlight a critical role of niche-specific effects of Cxcl12 expression in maintaining quiescence of TKI-resistant LSC populations.
Thu May 02 00:00:00 EDT 2019
Neutrophils contribute to spontaneous resolution of liver inflammation and fibrosis via microRNA-223.
The Journal of clinical investigation
Calvente CJ,Tameda M,Johnson CD,Del Pilar H,Lin YC,Adronikou N,De Mollerat Du Jeu X,Llorente C,Boyer J,Feldstein AE
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 12-5931-82) in Flow Cytometry
Thu Jul 11 00:00:00 EDT 2019
SIRT1 regulates metabolism and leukemogenic potential in CML stem cells.
The Journal of clinical investigation
Abraham A,Qiu S,Chacko BK,Li H,Paterson A,He J,Agarwal P,Shah M,Welner R,Darley-Usmar VM,Bhatia R
12-5931 was used in Flow cytometry/Cell sorting to demonstrate an important role for SIRT1 in leukemia development.
Mon Jun 10 00:00:00 EDT 2019
Cancer cells induce immune escape via glycocalyx changes controlled by the telomeric protein TRF2.
The EMBO journal
Cherfils-Vicini J,Iltis C,Cervera L,Pisano S,Croce O,Sadouni N,Győrffy B,Collet R,Renault VM,Rey-Millet M,Leonetti C,Zizza P,Allain F,Ghiringhelli F,Soubeiran N,Shkreli M,Vivier E,Biroccio A,Gilson E
12-5931 was used in functional assays to describe a mechanism by which cancer cells control myeloid-derived suppressor cells in human cancers by upregulating TRF2, a protein required for telomere stability.
Mon Jun 03 00:00:00 EDT 2019
STING signaling remodels the tumor microenvironment by antagonizing myeloid-derived suppressor cell expansion.
Cell death and differentiation
Zhang CX,Ye SB,Ni JJ,Cai TT,Liu YN,Huang DJ,Mai HQ,Chen QY,He J,Zhang XS,Zeng YX,Li J,Cui J
12-5931-82 was used in Flow Cytometry to investigate the role of stimulator of interferon genes (STING) in regulation of myeloid-derived suppressor cell differentiation and antitumor immunity in Epstein-Barr virus-associated nasopharyngeal carcinomas.
Fri Nov 01 00:00:00 EDT 2019
Low-Dose Apatinib Optimizes Tumor Microenvironment and Potentiates Antitumor Effect of PD-1/PD-L1 Blockade in Lung Cancer.
Cancer immunology research
Zhao S,Ren S,Jiang T,Zhu B,Li X,Zhao C,Jia Y,Shi J,Zhang L,Liu X,Qiao M,Chen X,Su C,Yu H,Zhou C,Zhang J,Camidge DR,Hirsch FR
12-5931 was used in Flow cytometry/Cell sorting to analyze the impact of apatinib, a smallmolecule VEGFR2-TKI, on the TME in murine Lewis lung carcinoma (LLC) models at different doses alone and in combination with an anti–PD-L1.
Mon Apr 01 00:00:00 EDT 2019
Extracellular RNAs from lung cancer cells activate epithelial cells and induce neutrophil extracellular traps.
International journal of oncology
Li Y,Yang Y,Gan T,Zhou J,Hu F,Hao N,Yuan B,Chen Y,Zhang M
12-5931 was used in Flow cytometry/Cell sorting to investigate the cross‚talk of tumor exRNAs and neutrophil extracellular traps in lung cancer.
Mon Jul 01 00:00:00 EDT 2019
Ubiquitination of RIPK1 suppresses programmed cell death by regulating RIPK1 kinase activation during embryogenesis.
Nature communications
Zhang X,Zhang H,Xu C,Li X,Li M,Wu X,Pu W,Zhou B,Wang H,Li D,Ding Q,Ying H,Wang H,Zhang H
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 12-5931-82) in Flow Cytometry
Fri Sep 13 00:00:00 EDT 2019
Ubiquitination of RIPK1 suppresses programmed cell death by regulating RIPK1 kinase activation during embryogenesis.
Nature communications
Zhang X,Zhang H,Xu C,Li X,Li M,Wu X,Pu W,Zhou B,Wang H,Li D,Ding Q,Ying H,Wang H,Zhang H
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 12-5931-82) in Flow Cytometry
Fri Sep 13 00:00:00 EDT 2019
Inhibition of AIM2 inflammasome-mediated pyroptosis by Andrographolide contributes to amelioration of radiation-induced lung inflammation and fibrosis.
Cell death & disease
Gao J,Peng S,Shan X,Deng G,Shen L,Sun J,Jiang C,Yang X,Chang Z,Sun X,Feng F,Kong L,Gu Y,Guo W,Xu Q,Sun Y
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 12-5931-82) in Flow Cytometry
Fri Dec 20 00:00:00 EST 2019
Neutrophil extracellular traps induced by VP1 contribute to pulmonary edema during EV71 infection.
Cell death discovery
Wang N,Yang X,Sun J,Sun Z,Ma Q,Wang Z,Chen Z,Wang Z,Hu F,Wang H,Zhou L,Zhang M,Xu J
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 12-5931-82) in Flow Cytometry
Wed Sep 30 00:00:00 EDT 2020
Interconversion between Tumorigenic and Differentiated States in Acute Myeloid Leukemia.
Cell stem cell
McKenzie MD,Ghisi M,Oxley EP,Ngo S,Cimmino L,Esnault C,Liu R,Salmon JM,Bell CC,Ahmed N,Erlichster M,Witkowski MT,Liu GJ,Chopin M,Dakic A,Simankowicz E,Pomilio G,Vu T,Krsmanovic P,Su S,Tian L,Baldwin TM,Zalcenstein DA,DiRago L,Wang S,Metcalf D,Johnstone RW,Croker BA,Lancaster GI,Murphy AJ,Naik SH,Nutt SL,Pospisil V,Schroeder T,Wall M,Dawson MA,Wei AH,de Thé H,Ritchie ME,Zuber J,Dickins RA
12-5931 was used in Flow cytometry/Cell sorting to investigate cancer stem cell plasticity in acute myeloid leukemia.
Thu Aug 01 00:00:00 EDT 2019
Neural anti-inflammatory action mediated by two types of acetylcholine receptors in the small intestine.
Scientific reports
Kimura H,Imura YK,Tomiyasu H,Mihara T,Kaji N,Ohno K,Unno T,Tanahashi Y,Jan TR,Tsubone H,Ozaki H,Hori M
12-5931 was used in Flow cytometry/Cell sorting to clarify the anti-inflammatory mechanism underlying the serotonin-4 receptor agonist, mosapride citrate-induced anti-inflammatory action on postoperative ileus.
Wed Apr 10 00:00:00 EDT 2019
Targeted knock-in mice expressing the oxidase-fixed form of xanthine oxidoreductase favor tumor growth.
Nature communications
Kusano T,Ehirchiou D,Matsumura T,Chobaz V,Nasi S,Castelblanco M,So A,Lavanchy C,Acha-Orbea H,Nishino T,Okamoto K,Busso N
12-5931 was used in Flow cytometry/Cell sorting to show immune surveillance in tumor development is influenced by the homeostasis of xanthine dehydrogenase and oxidase and dsyregulation can favour tumour growth.
Mon Oct 28 00:00:00 EDT 2019
Characterization of Plaque-Sized Variants of Daniel's (DA) Strain in Theiler's Virus-Induced Epilepsy.
Scientific reports
Bijalwan M,Young CR,Tingling J,Zhou XJ,Rimmelin AR,Leibowitz JL,Welsh CJ
12-5931 was used in Flow cytometry/Cell sorting to investigate the neuropathogenesis of large (DA-CL) and small (DA-DS) plaque-size variants of Daniel's (DA) strain of Theiler's murine encephalomyelitis virus (TMEV)-induced seizures.
Tue Mar 05 00:00:00 EST 2019
E3 Ligase VHL Promotes Group 2 Innate Lymphoid Cell Maturation and Function via Glycolysis Inhibition and Induction of Interleukin-33 Receptor.
Immunity
Li Q,Li D,Zhang X,Wan Q,Zhang W,Zheng M,Zou L,Elly C,Lee JH,Liu YC
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 12-5931-82) in Flow Cytometry
Tue Feb 20 00:00:00 EST 2018
A Circular RNA Protects Dormant Hematopoietic Stem Cells from DNA Sensor cGAS-Mediated Exhaustion.
Immunity
Xia P,Wang S,Ye B,Du Y,Li C,Xiong Z,Qu Y,Fan Z
12-5931 was used in Flow cytometry/Cell sorting to study circular RNA-mediated maintenance of hematopoeitic stem cell homeostasis.
Tue Apr 17 00:00:00 EDT 2018
IL1RAP potentiates multiple oncogenic signaling pathways in AML.
The Journal of experimental medicine
Mitchell K,Barreyro L,Todorova TI,Taylor SJ,Antony-Debré I,Narayanagari SR,Carvajal LA,Leite J,Piperdi Z,Pendurti G,Mantzaris I,Paietta E,Verma A,Gritsman K,Steidl U
12-5931 was used in Flow cytometry/Cell sorting to show that targeting of interleukin-1 receptor accessory protein via RNA interference, genetic deletion, or antibodies inhibits acute myeloid leukaemia pathogenesis in vitro and in vivo.
Mon Jun 04 00:00:00 EDT 2018
Lenalidomide and Programmed Death-1 Blockade Synergistically Enhances the Effects of Dendritic Cell Vaccination in a Model of Murine Myeloma.
Frontiers in immunology
Vo MC,Jung SH,Chu TH,Lee HJ,Lakshmi TJ,Park HS,Kim HJ,Rhee JH,Lee JJ
12-5931 was used in Flow cytometry/Cell sorting to investigate the efficacy of dendritic cell vaccination in combination with lenalidomide and PD-1 blockade in a model of murine myeloma.
Sun Jan 03 00:00:00 EST 2021
IL-17 can be protective or deleterious in murine pneumococcal pneumonia.
PLoS pathogens
Ritchie ND,Ritchie R,Bayes HK,Mitchell TJ,Evans TJ
12-5931 was used in Flow cytometry/Cell sorting to study the IL-17 mediated neutrophil recruitment to the lungs in pneumococcal pneumonia.
Tue May 01 00:00:00 EDT 2018
Inactivation of mTORC1 Signaling in Osterix-Expressing Cells Impairs B-cell Differentiation.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Wang Y,Xiao M,Tao C,Chen J,Wang Z,Yang J,Chen Z,Zou Z,Liu A,Cai D,Jiang Y,Ding C,Li M,Bai X
12-5931 was used in Flow cytometry/Cell sorting to demonstrate a novel role for mechanistic target of rapamycin complex 1 in the regulation of bone marrow environments that support B-cell differentiation via regulating IL-7 expression.
Sun Apr 01 00:00:00 EDT 2018
Intraperitoneal neutrophils activated by KRAS-induced ovarian cancer exert antitumor effects by modulating adaptive immunity.
International journal of oncology
Yoshida M,Taguchi A,Kawana K,Ogishima J,Adachi K,Kawata A,Nakamura H,Sato M,Fujimoto A,Inoue T,Tomio K,Mori M,Nagamatsu T,Arimoto T,Koga K,Hiraike OW,Oda K,Kiyono T,Osuga Y,Fujii T
12-5931 was used in Flow cytometry/Cell sorting to evaluate the role of increased neutrophils in cancer progression.
Mon Oct 01 00:00:00 EDT 2018
PD-L1 Prevents the Development of Autoimmune Heart Disease in Graft-versus-Host Disease.
Journal of immunology (Baltimore, Md. : 1950)
Juchem KW,Sacirbegovic F,Zhang C,Sharpe AH,Russell K,McNiff JM,Demetris AJ,Shlomchik MJ,Shlomchik WD
12-5931 was used in Flow cytometry/Cell sorting to study whether effector memory T cells induce less graft-versus-host disease due to increased sensitivity to PD-ligands.
Mon Jan 15 00:00:00 EST 2018
Clonal expansion and myeloid leukemia progression modeled by multiplex gene editing of murine hematopoietic progenitor cells.
Experimental hematology
Shi X,Kitano A,Jiang Y,Luu V,Hoegenauer KA,Nakada D
12-5931 was used in Flow cytometry/Cell sorting to establish that the CRISPR/Cas9-mediated multiplex mutagenesis can be used to engineer a variety of murine models of hematological malignancies with complex genetic architectures seen in human disease.
Wed Aug 01 00:00:00 EDT 2018
Investigation of tumor-tumor interactions in a double human cervical carcinoma xenograft model in nude mice.
Oncotarget
Mertens B,Cristina de Araujo Nogueira T,Topalis D,Stranska R,Snoeck R,Andrei G
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 12-5931-82) in Flow Cytometry
Tue Apr 24 00:00:00 EDT 2018
Antiviral effects of ferric ammonium citrate.
Cell discovery
Wang H,Li Z,Niu J,Xu Y,Ma L,Lu A,Wang X,Qian Z,Huang Z,Jin X,Leng Q,Wang J,Zhong J,Sun B,Meng G
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 12-5931-82) in Flow Cytometry
Tue Sep 29 00:00:00 EDT 2020
Induction of neutrophil apoptosis by a Bcl-2 inhibitor reduces particulate matter-induced lung inflammation.
Aging
Geng X,Wang X,Luo M,Xing M,Wu Y,Li W,Chen Z,Shen H,Ying S
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 12-5931-82) in Flow Cytometry
Tue Jun 26 00:00:00 EDT 2018
Microbiota Reconstitution Does Not Cause Bone Loss in Germ-Free Mice.
mSphere
Quach D,Collins F,Parameswaran N,McCabe L,Britton RA
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 12-5931-82) in Flow Cytometry
Wed Nov 20 00:00:00 EST 2019
AICDA drives epigenetic heterogeneity and accelerates germinal center-derived lymphomagenesis.
Nature communications
Teater M,Dominguez PM,Redmond D,Chen Z,Ennishi D,Scott DW,Cimmino L,Ghione P,Chaudhuri J,Gascoyne RD,Aifantis I,Inghirami G,Elemento O,Melnick A,Shaknovich R
12-5931 was used in Flow cytometry/Cell sorting to show that activation-induced cytidine deaminase overexpression causes more aggressive disease in BCL2-driven murine lymphomas.
Mon Jan 15 00:00:00 EST 2018
POH1 deubiquitinates pro-interleukin-1β and restricts inflammasome activity.
Nature communications
Zhang L,Liu Y,Wang B,Xu G,Yang Z,Tang M,Ma A,Jing T,Xu X,Zhang X,Liu Y
12-5931 was used in Flow cytometry/Cell sorting to show that the deubiquitinase POH1 negatively regulates the immune response triggered by inflammasome activation.
Fri Oct 12 00:00:00 EDT 2018
Effector CD4+ T cells recognize intravascular antigen presented by patrolling monocytes.
Nature communications
Westhorpe CLV,Norman MU,Hall P,Snelgrove SL,Finsterbusch M,Li A,Lo C,Tan ZH,Li S,Nilsson SK,Kitching AR,Hickey MJ
12-5931 was used in Immunocytochemistry-immunoflourescence to determine how effector CD4+ T cells respond to intravascular antigens.
Wed Feb 21 00:00:00 EST 2018
Hydrogen sulfide inhibits NLRP3 inflammasome activation and reduces cytokine production both in vitro and in a mouse model of inflammation.
The Journal of biological chemistry
Castelblanco M,Lugrin J,Ehirchiou D,Nasi S,Ishii I,So A,Martinon F,Busso N
12-5931 was used in Flow cytometry/Cell sorting to study the effects of exogenous and endogenous hydorgen sulfide (H2S) on NLRP3 inflammasome activation.
Fri Feb 16 00:00:00 EST 2018
Global loss of leucine carboxyl methyltransferase-1 causes severe defects in fetal liver hematopoiesis.
The Journal of biological chemistry
Lee JA,Wang Z,Sambo D,Bunting KD,Pallas DC
12-5931 was used in Flow cytometry/Cell sorting to reveal a novel role for LCMT-1 as a key player in fetal liver hematopoiesis.
Fri Jun 22 00:00:00 EDT 2018
Colorectal cancer liver metastatic growth depends on PAD4-driven citrullination of the extracellular matrix.
Nature communications
Yuzhalin AE,Gordon-Weeks AN,Tognoli ML,Jones K,Markelc B,Konietzny R,Fischer R,Muth A,O'Neill E,Thompson PR,Venables PJ,Kessler BM,Lim SY,Muschel RJ
12-5931 was used in Flow cytometry/Cell sorting to examine the potential for peptidylarginine deiminase 4-dependant citrullination to drive the progression of colorectal cancer liver metastasis.
Wed Nov 14 00:00:00 EST 2018
CD157 Marks Tissue-Resident Endothelial Stem Cells with Homeostatic and Regenerative Properties.
Cell stem cell
Wakabayashi T,Naito H,Suehiro JI,Lin Y,Kawaji H,Iba T,Kouno T,Ishikawa-Kato S,Furuno M,Takara K,Muramatsu F,Weizhen J,Kidoya H,Ishihara K,Hayashizaki Y,Nishida K,Yoder MC,Takakura N
12-5931-82 was used in Flow cytometry/Cell sorting to show that tissue-resident VESCs display self-renewal capacity and that vascular regeneration potential exists in peripheral blood vessels.
Thu Mar 01 00:00:00 EST 2018
Eradication of Tumors through Simultaneous Ablation of CD276/B7-H3-Positive Tumor Cells and Tumor Vasculature.
Cancer cell
Seaman S,Zhu Z,Saha S,Zhang XM,Yang MY,Hilton MB,Morris K,Szot C,Morris H,Swing DA,Tessarollo L,Smith SW,Degrado S,Borkin D,Jain N,Scheiermann J,Feng Y,Wang Y,Li J,Welsch D,DeCrescenzo G,Chaudhary A,Zudaire E,Klarmann KD,Keller JR,Dimitrov DS,St Croix B
12-5931 was used in Flow cytometry/Cell sorting to demonstrate that the cell surface protein CD276/B7-H3 is broadly over-expressed by multiple tumour types on both cancer cells and tumour-infiltrating blood vessels, making it a potentially ideal dual-compartment therapeutic target.
Mon Apr 10 00:00:00 EDT 2017
Adipocyte Accumulation in the Bone Marrow during Obesity and Aging Impairs Stem Cell-Based Hematopoietic and Bone Regeneration.
Cell stem cell
Ambrosi TH,Scialdone A,Graja A,Gohlke S,Jank AM,Bocian C,Woelk L,Fan H,Logan DW,Schürmann A,Saraiva LR,Schulz TJ
12-5931 was used in Flow cytometry/Cell sorting to specify the cellular identities of the adipogenic and osteogenic lineages of the bone.
Thu Jun 01 00:00:00 EDT 2017
Brd4 modulates the innate immune response through Mnk2-eIF4E pathway-dependent translational control of IκBα.
Proceedings of the National Academy of Sciences of the United States of America
Bao Y,Wu X,Chen J,Hu X,Zeng F,Cheng J,Jin H,Lin X,Chen LF
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 12-5931-82) in Flow Cytometry
Tue May 16 00:00:00 EDT 2017
Double-stranded RNA promotes CTL-independent tumor cytolysis mediated by CD11b+Ly6G+ intratumor myeloid cells through the TICAM-1 signaling pathway.
Cell death and differentiation
Shime H,Matsumoto M,Seya T
12-5931 was used in Flow cytometry/Cell sorting to study the response of CD11b+Ly6G+ granulocytic myeloid-derived suppressor cells to polyI:C in an EL4 tumour implant model.
Wed Mar 01 00:00:00 EST 2017
Silybin attenuates LPS-induced lung injury in mice by inhibiting NF-κB signaling and NLRP3 activation.
International journal of molecular medicine
Zhang B,Wang B,Cao S,Wang Y,Wu D
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 12-5931-82) in Flow Cytometry
Mon May 01 00:00:00 EDT 2017
ADAR1 deletion induces NFκB and interferon signaling dependent liver inflammation and fibrosis.
RNA biology
Ben-Shoshan SO,Kagan P,Sultan M,Barabash Z,Dor C,Jacob-Hirsch J,Harmelin A,Pappo O,Marcu-Malina V,Ben-Ari Z,Amariglio N,Rechavi G,Goldstein I,Safran M
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 12-5931-82) in Flow Cytometry
Thu May 04 00:00:00 EDT 2017
MiR-125a Is a critical modulator for neutrophil development.
PLoS genetics
Qin Y,Wu L,Ouyang Y,Zhou P,Zhou H,Wang Y,Ma J,Zhang J,Chen Y,Qian J,Tang Y,Shen N
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 12-5931-82) in Flow Cytometry
Sun Oct 01 00:00:00 EDT 2017
Recipient bone marrow assimilates the myeloid/lymphoid reconstitution of distinct fetal hematopoietic stem cells.
Oncotarget
Guo XL,Chu L,Ke F,Mu LL,Li Z,Cai JJ,Li HF,Hong DL
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 12-5931-82) in Flow Cytometry
Tue Dec 12 00:00:00 EST 2017
BOT-4-one attenuates NLRP3 inflammasome activation: NLRP3 alkylation leading to the regulation of its ATPase activity and ubiquitination.
Scientific reports
Shim DW,Shin WY,Yu SH,Kim BH,Ye SK,Koppula S,Won HS,Kang TB,Lee KH
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 12-5931-82) in Flow Cytometry
Wed Nov 08 00:00:00 EST 2017
Cancer cell-secreted IGF2 instigates fibroblasts and bone marrow-derived vascular progenitor cells to promote cancer progression.
Nature communications
Xu WW,Li B,Guan XY,Chung SK,Wang Y,Yip YL,Law SY,Chan KT,Lee NP,Chan KW,Xu LY,Li EM,Tsao SW,He QY,Cheung AL
12-5931 was used in Flow cytometry/Cell sorting to investigate how the Id1/IGF2/VEGF/VEGFR1 cascade plays a critical role in tumour-driven pathophysiological processes underlying cancer progression.
Fri Feb 10 00:00:00 EST 2017
Cancer cell-secreted IGF2 instigates fibroblasts and bone marrow-derived vascular progenitor cells to promote cancer progression.
Nature communications
Xu WW,Li B,Guan XY,Chung SK,Wang Y,Yip YL,Law SY,Chan KT,Lee NP,Chan KW,Xu LY,Li EM,Tsao SW,He QY,Cheung AL
12-5931 was used in Flow cytometry/Cell sorting to investigate how the Id1/IGF2/VEGF/VEGFR1 cascade plays a critical role in tumour-driven pathophysiological processes underlying cancer progression.
Fri Feb 10 00:00:00 EST 2017
p190-B RhoGAP and intracellular cytokine signals balance hematopoietic stem and progenitor cell self-renewal and differentiation.
Nature communications
Hinge A,Xu J,Javier J,Mose E,Kumar S,Kapur R,Srour EF,Malik P,Aronow BJ,Filippi MD
12-5931 was used in Flow cytometry/Cell sorting to suggest intracellular cytokine signalling may serve as 'fate determinants' used by HSPCs to modulate their activity.
Wed Feb 08 00:00:00 EST 2017
Mouse IP-10 Gene Delivered by Folate-modified Chitosan Nanoparticles and Dendritic/tumor Cells Fusion Vaccine Effectively Inhibit the Growth of Hepatocellular Carcinoma in Mice.
Theranostics
Hu Z,Chen J,Zhou S,Yang N,Duan S,Zhang Z,Su J,He J,Zhang Z,Lu X,Zhao Y
12-5931 was used in Flow cytometry/Cell sorting to illustrate that the mIP-10 enhances the anti-tumor effect of DC/tumor cell fusion vaccine by alleviating the immunosuppressive tumor environment.
Mon Mar 19 00:00:00 EDT 2018
Mononuclear Phagocytes Are Dispensable for Cardiac Remodeling in Established Pressure-Overload Heart Failure.
PloS one
Patel B,Ismahil MA,Hamid T,Bansal SS,Prabhu SD
12-5931 was used in Flow cytometry/Cell sorting to assess for alterations in MPs.
Thu Aug 10 00:00:00 EDT 2017
Combinatorial hydrogel library enables identification of materials that mitigate the foreign body response in primates.
Nature biotechnology
Vegas AJ,Veiseh O,Doloff JC,Ma M,Tam HH,Bratlie K,Li J,Bader AR,Langan E,Olejnik K,Fenton P,Kang JW,Hollister-Locke J,Bochenek MA,Chiu A,Siebert S,Tang K,Jhunjhunwala S,Aresta-Dasilva S,Dholakia N,Thakrar R,Vietti T,Chen M,Cohen J,Siniakowicz K,Qi M,McGarrigle J,Graham AC,Lyle S,Harlan DM,Greiner DL,Oberholzer J,Weir GC,Langer R,Anderson DG
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 12-5931-82) in Flow Cytometry
Tue Mar 01 00:00:00 EST 2016
The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity.
Cell
Damgaard RB,Walker JA,Marco-Casanova P,Morgan NV,Titheradge HL,Elliott PR,McHale D,Maher ER,McKenzie ANJ,Komander D
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 12-5931-82) in Flow Cytometry
Thu Aug 25 00:00:00 EDT 2016
IL-17C is required for lethal inflammation during systemic fungal infection.
Cellular & molecular immunology
Huang J,Meng S,Hong S,Lin X,Jin W,Dong C
12-5931 was used in Flow cytometry/Cell sorting to elucidate the function of the IL-17 family members in anti-fungal immunity.
Fri Jul 01 00:00:00 EDT 2016
Multiple myeloma exosomes establish a favourable bone marrow microenvironment with enhanced angiogenesis and immunosuppression.
The Journal of pathology
Wang J,De Veirman K,Faict S,Frassanito MA,Ribatti D,Vacca A,Menu E
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 12-5931-82) in Flow Cytometry
Wed Jun 01 00:00:00 EDT 2016
Platelets Guide Leukocytes to Their Sites of Extravasation.
PLoS biology
Zuchtriegel G,Uhl B,Puhr-Westerheide D,Pörnbacher M,Lauber K,Krombach F,Reichel CA
12-5931 was used in Flow cytometry/Cell sorting to uncover a platelet-directed, spatiotemporally organised, multicellular crosstalk that is essential for effective trafficking of leukocytes to the site of inflammation.
Sun May 01 00:00:00 EDT 2016
Tumor-infiltrating monocytes/macrophages promote tumor invasion and migration by upregulating S100A8 and S100A9 expression in cancer cells.
Oncogene
Lim SY,Yuzhalin AE,Gordon-Weeks AN,Muschel RJ
12593182 was used in flow cytometry to implicate S100A8 and S100A9 messenger RNAs as important mediators of tumor cell aggressiveness, and highlights their therapeutic potential for interference of metastasis
Thu Nov 03 00:00:00 EDT 2016
Opposite Effects of Coinjection and Distant Injection of Mesenchymal Stem Cells on Breast Tumor Cell Growth.
Stem cells translational medicine
Zheng H,Zou W,Shen J,Xu L,Wang S,Fu YX,Fan W
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 12-5931-82) in Flow Cytometry
Thu Sep 01 00:00:00 EDT 2016
Macrophages transfer antigens to dendritic cells by releasing exosomes containing dead-cell-associated antigens partially through a ceramide-dependent pathway to enhance CD4(+) T-cell responses.
Immunology
Xu Y,Liu Y,Yang C,Kang L,Wang M,Hu J,He H,Song W,Tang H
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 12-5931-82) in Flow Cytometry
Sat Oct 01 00:00:00 EDT 2016
The Poly(C) Binding Protein Pcbp2 and Its Retrotransposed Derivative Pcbp1 Are Independently Essential to Mouse Development.
Molecular and cellular biology
Ghanem LR,Kromer A,Silverman IM,Chatterji P,Traxler E,Penzo-Mendez A,Weiss MJ,Stanger BZ,Liebhaber SA
12-5931 was used in Flow cytometry/Cell sorting to provide direct evidence that Pcbp1 and Pcpb2 individually provide an essential function in the mammalian genome.
Fri Jan 15 00:00:00 EST 2016
The miR-17∼92 cluster contributes to MLL leukemia through the repression of MEIS1 competitor PKNOX1.
Leukemia research
Mian YA,Zeleznik-Le NJ
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 12-5931-82) in Flow Cytometry
Fri Jul 01 00:00:00 EDT 2016
Murine iPSC-Derived Macrophages as a Tool for Disease Modeling of Hereditary Pulmonary Alveolar Proteinosis due to Csf2rb Deficiency.
Stem cell reports
Mucci A,Kunkiel J,Suzuki T,Brennig S,Glage S,Kühnel MP,Ackermann M,Happle C,Kuhn A,Schambach A,Trapnell BC,Hansen G,Moritz T,Lachmann N
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 12-5931-82) in Flow Cytometry
Tue Aug 09 00:00:00 EDT 2016
Activated c-Kit receptor in the heart promotes cardiac repair and regeneration after injury.
Cell death & disease
Di Siena S,Gimmelli R,Nori SL,Barbagallo F,Campolo F,Dolci S,Rossi P,Venneri MA,Giannetta E,Gianfrilli D,Feigenbaum L,Lenzi A,Naro F,Cianflone E,Mancuso T,Torella D,Isidori AM,Pellegrini M
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 12-5931-82) in Flow Cytometry
Thu Jul 28 00:00:00 EDT 2016
Influenza H3N2 infection of the collaborative cross founder strains reveals highly divergent host responses and identifies a unique phenotype in CAST/EiJ mice.
BMC genomics
Leist SR,Pilzner C,van den Brand JM,Dengler L,Geffers R,Kuiken T,Balling R,Kollmus H,Schughart K
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 12-5931-82) in Flow Cytometry
Sat Feb 27 00:00:00 EST 2016
Mll-AF4 Confers Enhanced Self-Renewal and Lymphoid Potential during a Restricted Window in Development.
Cell reports
Barrett NA,Malouf C,Kapeni C,Bacon WA,Giotopoulos G,Jacobsen SEW,Huntly BJ,Ottersbach K
12-5931 was used in Flow cytometry/Cell sorting to elucidate the contribution of MII-AF4 in B cell acute lymphoblastic leukaemia early development in the mouse embryo.
Tue Jul 26 00:00:00 EDT 2016
Characterisation of Neutropenia-Associated Neutrophil Elastase Mutations in a Murine Differentiation Model In Vitro and In Vivo.
PloS one
Wiesmeier M,Gautam S,Kirschnek S,Häcker G
12-5931 was used in Flow cytometry/Cell sorting to investigate the molecular mechanisms for neutrophil survival and maturation defects caused by mutant neutrophil elastase protein.
Wed Jun 28 00:00:00 EDT 2017
Characterisation of Neutropenia-Associated Neutrophil Elastase Mutations in a Murine Differentiation Model In Vitro and In Vivo.
PloS one
Wiesmeier M,Gautam S,Kirschnek S,Häcker G
12-5931 was used in Flow cytometry/Cell sorting to investigate the molecular mechanisms for neutrophil survival and maturation defects caused by mutant neutrophil elastase protein.
Wed Jun 28 00:00:00 EDT 2017
Transcription factor NFAT1 controls allergic contact hypersensitivity through regulation of activation induced cell death program.
Scientific reports
Kwon HK,Kim GC,Hwang JS,Kim Y,Chae CS,Nam JH,Jun CD,Rudra D,Surh CD,Im SH
12-5931 was used in Flow cytometry/Cell sorting to suggest that NFAT1 switches on activation induced cell death in CD4+/CD8+ T cells to maintain peripheral tolerance and prevent inflammatory skin disease.
Mon Jan 18 00:00:00 EST 2016
Functional-genetic dissection of HDAC dependencies in mouse lymphoid and myeloid malignancies.
Blood
Matthews GM,Mehdipour P,Cluse LA,Falkenberg KJ,Wang E,Roth M,Santoro F,Vidacs E,Stanley K,House CM,Rusche JR,Vakoc CR,Zuber J,Minucci S,Johnstone RW
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 12-5931-82) in Flow Cytometry
Thu Nov 19 00:00:00 EST 2015
miR-29a maintains mouse hematopoietic stem cell self-renewal by regulating Dnmt3a.
Blood
Hu W,Dooley J,Chung SS,Chandramohan D,Cimmino L,Mukherjee S,Mason CE,de Strooper B,Liston A,Park CY
12-5931 was used in Flow cytometry/Cell sorting to demonstrate that miR-29a is critical for maintaining HSC function through its negative regulation of Dnmt3a.
Thu Apr 02 00:00:00 EDT 2015
CD93 Marks a Non-Quiescent Human Leukemia Stem Cell Population and Is Required for Development of MLL-Rearranged Acute Myeloid Leukemia.
Cell stem cell
Iwasaki M,Liedtke M,Gentles AJ,Cleary ML
12-5931 was used in Flow cytometry/Cell sorting to study how CD93 expression may indicate leukaemia initiating stem cells that have a MLL gene rearrangement.
Thu Oct 01 00:00:00 EDT 2015
Hepatic DNA deposition drives drug-induced liver injury and inflammation in mice.
Hepatology (Baltimore, Md.)
Marques PE,Oliveira AG,Pereira RV,David BA,Gomides LF,Saraiva AM,Pires DA,Novaes JT,Patricio DO,Cisalpino D,Menezes-Garcia Z,Leevy WM,Chapman SE,Mahecha G,Marques RE,Guabiraba R,Martins VP,Souza DG,Mansur DS,Teixeira MM,Leite MF,Menezes GB
12-5931 was used in Flow cytometry/Cell sorting to examine whether DNA released from damaged hepatocytes accumulates into necrotic liver, and study the impact of its recognition by the immune system.
Thu Jan 01 00:00:00 EST 2015
Spatiotemporal expression dynamics of selectins govern the sequential extravasation of neutrophils and monocytes in the acute inflammatory response.
Arteriosclerosis, thrombosis, and vascular biology
Zuchtriegel G,Uhl B,Hessenauer ME,Kurz AR,Rehberg M,Lauber K,Krombach F,Reichel CA
12-5931 was used in Flow cytometry/Cell sorting to provide novel insights into the mechanisms initiating the sequential infiltration of the perivascular tissue by neutrophils and monocytes in the acute inflammatory response.
Wed Apr 01 00:00:00 EDT 2015
Systemically delivered adipose stromal vascular fraction cells disseminate to peripheral artery walls and reduce vasomotor tone through a CD11b+ cell-dependent mechanism.
Stem cells translational medicine
Morris ME,Beare JE,Reed RM,Dale JR,LeBlanc AJ,Kaufman CL,Zheng H,Ng CK,Williams SK,Hoying JB
12-5931 was used in Flow cytometry/Cell sorting to investigate the potential of SVF cells to therapeutically modulate small artery vasoactivity.
Wed Apr 01 00:00:00 EDT 2015
Rac1-dependent secretion of platelet-derived CCL5 regulates neutrophil recruitment via activation of alveolar macrophages in septic lung injury.
Journal of leukocyte biology
Hwaiz R,Rahman M,Syk I,Zhang E,Thorlacius H
12-5931 was used in Flow cytometry/Cell sorting to assess the role of platelet-derived CCL5 in facilitating sepsis-induced neutrophil accumulation in the lung.
Fri May 01 00:00:00 EDT 2015
Anti-alpha-toxin monoclonal antibody and antibiotic combination therapy improves disease outcome and accelerates healing in a Staphylococcus aureus dermonecrosis model.
Antimicrobial agents and chemotherapy
Hilliard JJ,Datta V,Tkaczyk C,Hamilton M,Sadowska A,Jones-Nelson O,O'Day T,Weiss WJ,Szarka S,Nguyen V,Prokai L,Suzich J,Stover CK,Sellman BR
12-5931 was used in Flow cytometry/Cell sorting to characterise MEDI4893* and its therapeutic activity in a dermonecrosis model, showing that MEDI4893* and antibiotic combination therapy improves disease outcome.
Thu Jan 01 00:00:00 EST 2015
Pretreatment of Mesenchymal Stem Cells Manipulates Their Vasculoprotective Potential While Not Altering Their Homing Within the Injured Gut.
Stem cells (Dayton, Ohio)
Kavanagh DP,Suresh S,Newsome PN,Frampton J,Kalia N
12-5931 was used in in vivo experiments to demonstrate that MSCs can limit leukocyte recruitment and improve tissue perfusion following intestinal ischemia-reperfusion injury.
Tue Sep 01 00:00:00 EDT 2015
The calcineurin-NFAT axis controls allograft immunity in myeloid-derived suppressor cells through reprogramming T cell differentiation.
Molecular and cellular biology
Wang X,Bi Y,Xue L,Liao J,Chen X,Lu Y,Zhang Z,Wang J,Liu H,Yang H,Liu G
12-5931 was used in Flow cytometry/Cell sorting to validate the calcineurin-NFAT-IDO signaling axis as a potential therapeutic target in transplantation.
Sun Feb 01 00:00:00 EST 2015
A far-red fluorescent probe for flow cytometry and image-based functional studies of xenobiotic sequestering macrophages.
Cytometry. Part A : the journal of the International Society for Analytical Cytology
Keswani RK,Yoon GS,Sud S,Stringer KA,Rosania GR
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 12-5931-82) in Flow Cytometry
Tue Sep 01 00:00:00 EDT 2015
Synergy of anti-CD40, CpG and MPL in activation of mouse macrophages.
Molecular immunology
Shi Y,Felder MA,Sondel PM,Rakhmilevich AL
12-5931 was used in Flow cytometry/Cell sorting to demonstrate that macrophages can be synergistically activated by anti-CD40, CpG and MPL.
Sat Aug 01 00:00:00 EDT 2015
Local delivery of VEGF and SDF enhances endothelial progenitor cell recruitment and resultant recovery from ischemia.
Tissue engineering. Part A
Anderson EM,Kwee BJ,Lewin SA,Raimondo T,Mehta M,Mooney DJ
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 12-5931-82) in Flow Cytometry
Wed Apr 01 00:00:00 EDT 2015
Interleukin-1 (IL-1) signaling in intestinal stromal cells controls KC/ CXCL1 secretion, which correlates with recruitment of IL-22- secreting neutrophils at early stages of Citrobacter rodentium infection.
Infection and immunity
Lee YS,Yang H,Yang JY,Kim Y,Lee SH,Kim JH,Jang YJ,Vallance BA,Kweon MN
12-5931 was used in Flow cytometry/Cell sorting to suggest that IL-1 signaling plays a pivotal role in activating mucosal stromal cells to secrete KC/CXCL1.
Sat Aug 01 00:00:00 EDT 2015
Reducing progression of experimental lupus nephritis via inhibition of the B7/CD28 signaling pathway.
Molecular medicine reports
Huang L,Kong Y,Wang J,Sun J,Shi Q,Qiu YH
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 12-5931-82) in Flow Cytometry
Tue Sep 01 00:00:00 EDT 2015
The bone marrow microenvironment enhances multiple myeloma progression by exosome-mediated activation of myeloid-derived suppressor cells.
Oncotarget
Wang J,De Veirman K,De Beule N,Maes K,De Bruyne E,Van Valckenborgh E,Vanderkerken K,Menu E
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 12-5931-82) in Flow Cytometry
Tue Dec 22 00:00:00 EST 2015
Glioma-associated microglia/macrophages display an expression profile different from M1 and M2 polarization and highly express Gpnmb and Spp1.
PloS one
Szulzewsky F,Pelz A,Feng X,Synowitz M,Markovic D,Langmann T,Holtman IR,Wang X,Eggen BJ,Boddeke HW,Hambardzumyan D,Wolf SA,Kettenmann H
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 12-5931-82) in Flow Cytometry
Tue Jan 12 00:00:00 EST 2016
Targeted Gene Correction in Osteopetrotic-Induced Pluripotent Stem Cells for the Generation of Functional Osteoclasts.
Stem cell reports
Neri T,Muggeo S,Paulis M,Caldana ME,Crisafulli L,Strina D,Focarelli ML,Faggioli F,Recordati C,Scaramuzza S,Scanziani E,Mantero S,Buracchi C,Sobacchi C,Lombardo A,Naldini L,Vezzoni P,Villa A,Ficara F
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 12-5931-82) in Flow Cytometry
Tue Oct 13 00:00:00 EDT 2015
Sunitinib depletes myeloid-derived suppressor cells and synergizes with a cancer vaccine to enhance antigen-specific immune responses and tumor eradication.
Oncoimmunology
Draghiciu O,Nijman HW,Hoogeboom BN,Meijerhof T,Daemen T
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 12-5931-82) in Flow Cytometry
Sun Mar 01 00:00:00 EST 2015
Virulence-Dependent Alterations in the Kinetics of Immune Cells during Pulmonary Infection by Mycobacterium tuberculosis.
PloS one
Kim WS,Kim JS,Cha SB,Han SJ,Kim H,Kwon KW,Kim SJ,Eum SY,Cho SN,Shin SJ
12-5931 was used in Flow cytometry/Cell sorting to compare the bacterial burden, inflammation and kinetics of immune cells during aerogenic infection in the lung between laboratory-adapted strains (Mtb H37Rv and H37Ra) and Mtb K strain.
Mon Jun 27 00:00:00 EDT 2016
Osteoblast-derived WNT16 represses osteoclastogenesis and prevents cortical bone fragility fractures.
Nature medicine
Movérare-Skrtic S,Henning P,Liu X,Nagano K,Saito H,Börjesson AE,Sjögren K,Windahl SH,Farman H,Kindlund B,Engdahl C,Koskela A,Zhang FP,Eriksson EE,Zaman F,Hammarstedt A,Isaksson H,Bally M,Kassem A,Lindholm C,Sandberg O,Aspenberg P,Sävendahl L,Feng JQ,Tuckermann J,Tuukkanen J,Poutanen M,Baron R,Lerner UH,Gori F,Ohlsson C
12-5931 was used in Flow cytometry/Cell sorting to open new avenues for the specific prevention or treatment of nonvertebral fractures, a substantial unmet medical need.
Sat Nov 01 00:00:00 EDT 2014
Sessile alveolar macrophages communicate with alveolar epithelium to modulate immunity.
Nature
Westphalen K,Gusarova GA,Islam MN,Subramanian M,Cohen TS,Prince AS,Bhattacharya J
12-5931 was used in Flow cytometry/Cell sorting to show that a subset of alveolar macrophages (AMs) attached to the alveolar wall form connexin 43 (Cx43)-containing gap junction channels with the epithelium.
Thu Feb 27 00:00:00 EST 2014
Host adaptation of a bacterial toxin from the human pathogen Salmonella Typhi.
Cell
Deng L,Song J,Gao X,Wang J,Yu H,Chen X,Varki N,Naito-Matsui Y,Galán JE,Varki A
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 12-5931-82) in Flow Cytometry
Thu Dec 04 00:00:00 EST 2014
Acquired initiating mutations in early hematopoietic cells of CLL patients.
Cancer discovery
Damm F,Mylonas E,Cosson A,Yoshida K,Della Valle V,Mouly E,Diop M,Scourzic L,Shiraishi Y,Chiba K,Tanaka H,Miyano S,Kikushige Y,Davi F,Lambert J,Gautheret D,Merle-Béral H,Sutton L,Dessen P,Solary E,Akashi K,Vainchenker W,Mercher T,Droin N,Ogawa S,Nguyen-Khac F,Bernard OA
12-5931 was used in Flow cytometry/Cell sorting to study the presence of mutations in multipotent hematopoietic progenitors from patients with chronic lymphocytic leukemia.
Mon Sep 01 00:00:00 EDT 2014
The miR-126-VEGFR2 axis controls the innate response to pathogen-associated nucleic acids.
Nature immunology
Agudo J,Ruzo A,Tung N,Salmon H,Leboeuf M,Hashimoto D,Becker C,Garrett-Sinha LA,Baccarini A,Merad M,Brown BD
12-5931 was used in Flow cytometry/Cell sorting to identify the miR-126-VEGFR2 axis as an important regulator of the innate response that operates through multiscale control of pDCs.
Wed Jan 01 00:00:00 EST 2014
Myeloid-derived suppressor cell function is diminished in aspirin-triggered allergic airway hyperresponsiveness in mice.
The Journal of allergy and clinical immunology
Shi M,Shi G,Tang J,Kong D,Bao Y,Xiao B,Zuo C,Wang T,Wang Q,Shen Y,Wang H,Funk CD,Zhou J,Yu Y
12-5931 was used in Flow cytometry/Cell sorting to characterise myeloid-derived suppressor cell accumulation and pathogenic functions in allergic airway inflammation mediated by COX-1 deficiency or aspirin treatment in mice.
Sat Nov 01 00:00:00 EDT 2014
Metastatic growth progression caused by PSGL-1-mediated recruitment of monocytes to metastatic sites.
Cancer research
Hoos A,Protsyuk D,Borsig L
12-5931 was used in Flow cytometry/Cell sorting to study the mechanisms by which endogenous selectin ligands contribute to metastasis.
Sat Feb 01 00:00:00 EST 2014
Macromolecular prodrug of dexamethasone prevents particle-induced peri-implant osteolysis with reduced systemic side effects.
Journal of controlled release : official journal of the Controlled Release Society
Ren K,Dusad A,Yuan F,Yuan H,Purdue PE,Fehringer EV,Garvin KL,Goldring SR,Wang D
12-5931 was used in Flow cytometry/Cell sorting to demonstrate the feasibility of utilising a macromolecular prodrug with reduced systemic toxicity to prevent wear particle-induced osteolysis.
Mon Feb 10 00:00:00 EST 2014
Macrophages contribute to the cyclic activation of adult hair follicle stem cells.
PLoS biology
Castellana D,Paus R,Perez-Moreno M
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 12-5931-82) in Flow Cytometry
Mon Dec 01 00:00:00 EST 2014
A mouse model of shigellosis by intraperitoneal infection.
The Journal of infectious diseases
Yang JY,Lee SN,Chang SY,Ko HJ,Ryu S,Kweon MN
12-5931 was used in Flow cytometry/Cell sorting to demonstrate that an intraperitoneal challenge with S. flexneri 2a can induce bacillary dysentery and severe pathogenesis in mice.
Wed Jan 15 00:00:00 EST 2014
Neutrophil depletion suppresses pulmonary vascular hyperpermeability and occurrence of pulmonary edema caused by hantavirus infection in C.B-17 SCID mice.
Journal of virology
Koma T,Yoshimatsu K,Nagata N,Sato Y,Shimizu K,Yasuda SP,Amada T,Nishio S,Hasegawa H,Arikawa J
12-5931 was used in Flow cytometry/Cell sorting to suggest that neutrophils are involved in the vascular hyperpermeability and development of pulmonary oedema in hantavirus infection.
Tue Jul 01 00:00:00 EDT 2014
Dexamethasone potentiates myeloid-derived suppressor cell function in prolonging allograft survival through nitric oxide.
Journal of leukocyte biology
Liao J,Wang X,Bi Y,Shen B,Shao K,Yang H,Lu Y,Zhang Z,Chen X,Liu H,Wang J,Chu Y,Xue L,Wang X,Liu G
12-5931 was used in Flow cytometry/Cell sorting to show MDSCs to be an essential component in the prolongation of allograft survival following Dex or RU486 treatment.
Sat Nov 01 00:00:00 EDT 2014
mTOR limits the recruitment of CD11b+Gr1+Ly6Chigh myeloid-derived suppressor cells in protecting against murine immunological hepatic injury.
Journal of leukocyte biology
Zhang Y,Bi Y,Yang H,Chen X,Liu H,Lu Y,Zhang Z,Liao J,Yang S,Chu Y,Yang R,Liu G
12-5931 was used in Flow cytometry/Cell sorting to demonstrate that mTOR signaling is a pivotal negative determinant of MDSC recruitment in IMH disease.
Sun Jun 01 00:00:00 EDT 2014
Exposure to cigarette smoke impacts myeloid-derived regulatory cell function and exacerbates airway hyper-responsiveness.
Laboratory investigation; a journal of technical methods and pathology
Wang Y,Jin TH,Farhana A,Freeman J,Estell K,Zmijewski JW,Gaggar A,Thannickal VJ,Schwiebert LM,Steyn AJ,Deshane JS
12-5931 was used in Flow cytometry/Cell sorting to assess the effects of exposing myeloid-derived regulatory cells to cigarette smoke on the production of nitric oxide.
Mon Dec 01 00:00:00 EST 2014
Hepatic stellate cells promote tumor progression by enhancement of immunosuppressive cells in an orthotopic liver tumor mouse model.
Laboratory investigation; a journal of technical methods and pathology
Zhao W,Zhang L,Xu Y,Zhang Z,Ren G,Tang K,Kuang P,Zhao B,Yin Z,Wang X
12-5931 was used in Flow cytometry/Cell sorting to study the complex tumor-host interactions in hepatocellular carcinoma, specifically how the immunosuppressive properties of hepatic stellate cells may contribute to hepatocellular carcinoma occurrence and development..
Sat Feb 01 00:00:00 EST 2014
Gr-1dimCD11b+ immature myeloid-derived suppressor cells but not neutrophils are markers of lethal tuberculosis infection in mice.
Journal of immunology (Baltimore, Md. : 1950)
Tsiganov EN,Verbina EM,Radaeva TV,Sosunov VV,Kosmiadi GA,Nikitina IY,Lyadova IV
12-5931 was used in Flow cytometry/Cell sorting to demonstrate the association of tuberculosis progression with the accumulation of cells expressing neutrophilic markers Gr-1 and Ly-6G, but which are not conventional neutrophils.
Thu May 15 00:00:00 EDT 2014
Sox17-mediated maintenance of fetal intra-aortic hematopoietic cell clusters.
Molecular and cellular biology
Nobuhisa I,Osawa M,Uemura M,Kishikawa Y,Anani M,Harada K,Takagi H,Saito K,Kanai-Azuma M,Kanai Y,Iwama A,Taga T
12-5931 was used in Flow cytometry/Cell sorting to investigate how cells in intra-aortic clusters maintain their HSC phenotype, showing that they are maintained by Sox17.
Sun Jun 01 00:00:00 EDT 2014
Caveolin-1 increases proinflammatory chemoattractants and blood-retinal barrier breakdown but decreases leukocyte recruitment in inflammation.
Investigative ophthalmology & visual science
Li X,Gu X,Boyce TM,Zheng M,Reagan AM,Qi H,Mandal N,Cohen AW,Callegan MC,Carr DJ,Elliott MH
12-5931 was used in Flow cytometry/Cell sorting to examine the effect of Caveolin-1 ablation on the sensitivity of the retina to inflammation.
Tue Aug 26 00:00:00 EDT 2014
Human thrombin-derived host defense peptides inhibit neutrophil recruitment and tissue injury in severe acute pancreatitis.
American journal of physiology. Gastrointestinal and liver physiology
Merza M,Rahman M,Zhang S,Hwaiz R,Regner S,Schmidtchen A,Thorlacius H
12-5931 was used in Flow cytometry/Cell sorting to suggest that thrombin-derived host defence proteins might be useful in the management of patients with severe acute pancreatitits.
Sat Nov 01 00:00:00 EDT 2014
Yersinia pseudotuberculosis efficiently escapes polymorphonuclear neutrophils during early infection.
Infection and immunity
Westermark L,Fahlgren A,Fällman M
12-5931 was used in Flow cytometry/Cell sorting to analyse bacterium-immune cell interactions in the intestinal lymphoid tissues of mice during early Yersinia pseudotuberculosis infection.
Sat Mar 01 00:00:00 EST 2014
Anti-tumor innate immunity activated by intermittent metronomic cyclophosphamide treatment of 9L brain tumor xenografts is preserved by anti-angiogenic drugs that spare VEGF receptor 2.
Molecular cancer
Doloff JC,Chen CS,Waxman DJ
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 12-5931-82) in Flow Cytometry
Thu Jun 26 00:00:00 EDT 2014
Activation of NLRP3 inflammasome by crystalline structures via cell surface contact.
Scientific reports
Hari A,Zhang Y,Tu Z,Detampel P,Stenner M,Ganguly A,Shi Y
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 12-5931-82) in Flow Cytometry
Tue Dec 02 00:00:00 EST 2014
HIF-α/MIF and NF-κB/IL-6 axes contribute to the recruitment of CD11b+Gr-1+ myeloid cells in hypoxic microenvironment of HNSCC.
Neoplasia (New York, N.Y.)
Zhu G,Tang Y,Geng N,Zheng M,Jiang J,Li L,Li K,Lei Z,Chen W,Fan Y,Ma X,Li L,Wang X,Liang X
12-5931 was used in Immunofluorescence to reveal HIF-α/MIF and NF-κB/IL-6 interaction plays a role in hypoxia-induced accumulation of CD11b+Gr-1+ myeloid cells and tumour growth.
Sat Feb 01 00:00:00 EST 2014
Gene targeting study reveals unexpected expression of brain-expressed X-linked 2 in endocrine and tissue stem/progenitor cells in mice.
The Journal of biological chemistry
Ito K,Yamazaki S,Yamamoto R,Tajima Y,Yanagida A,Kobayashi T,Kato-Itoh M,Kakuta S,Iwakura Y,Nakauchi H,Kamiya A
12-5931 was used in Flow cytometry/Cell sorting to investigate the precise role and expression pattern of brain-expressed X-linked genes in endocrine and tissue stem/progenitor cells in mice.
Fri Oct 24 00:00:00 EDT 2014
Steroids alone or as adjunctive therapy with doxycycline fail to improve oviduct damage in mice infected with Chlamydia muridarum.
Clinical and vaccine immunology : CVI
Corr TE,Sullivan J,Frazer LC,Andrews CW,O'Connell CM,Darville T
12-5931 was used in Flow cytometry/Cell sorting to test the ability of dexamethasone to inhibit inflammation and prevent oviduct scarring in mice genitally infected with Chlamydia muridarum, showing that it fails to improve oviduct damage.
Sun Jun 01 00:00:00 EDT 2014
Enhancing chemotherapy efficacy in Pten-deficient prostate tumors by activating the senescence-associated antitumor immunity.
Cell reports
Toso A,Revandkar A,Di Mitri D,Guccini I,Proietti M,Sarti M,Pinton S,Zhang J,Kalathur M,Civenni G,Jarrossay D,Montani E,Marini C,Garcia-Escudero R,Scanziani E,Grassi F,Pandolfi PP,Catapano CV,Alimonti A
12-5931 was used in Flow cytometry/Cell sorting to demonstrate that immune surveillance of senescent tumour cells can be suppressed in specific genetic backgrounds but also evoked by pharmacological treatments.
Thu Oct 09 00:00:00 EDT 2014
Hemozoin induces hepatic inflammation in mice and is differentially associated with liver pathology depending on the Plasmodium strain.
PloS one
Deroost K,Lays N,Pham TT,Baci D,Van den Eynde K,Komuta M,Prato M,Roskams T,Schwarzer E,Opdenakker G,Van den Steen PE
12-5931 was used in Flow cytometry/Cell sorting to elucidate the contribution of hemozoin to hepatic injury in mouse malaria models.
Tue Jan 26 00:00:00 EST 2016
Loss of p53 in enterocytes generates an inflammatory microenvironment enabling invasion and lymph node metastasis of carcinogen-induced colorectal tumors.
Cancer cell
Schwitalla S,Ziegler PK,Horst D,Becker V,Kerle I,Begus-Nahrmann Y,Lechel A,Rudolph KL,Langer R,Slotta-Huspenina J,Bader FG,Prazeres da Costa O,Neurath MF,Meining A,Kirchner T,Greten FR
12-5931 was used in Immunohistochemistry to demonstrate that loss of p53 alone is insufficient to initiate intestinal tumorigenesis but enhances carcinogen-induced tumor incidence.
Mon Jan 14 00:00:00 EST 2013
IL-6 trans-signaling promotes pancreatitis-associated lung injury and lethality.
The Journal of clinical investigation
Zhang H,Neuhöfer P,Song L,Rabe B,Lesina M,Kurkowski MU,Treiber M,Wartmann T,Regnér S,Thorlacius H,Saur D,Weirich G,Yoshimura A,Halangk W,Mizgerd JP,Schmid RM,Rose-John S,Algül H
12-5931 was used in Flow cytometry/Cell sorting to investigate how IL-6 trans-signalling may be an essential mediator of acute lung injury in severe acute pancreatitis.
Fri Mar 01 00:00:00 EST 2013
A type I IFN-Flt3 ligand axis augments plasmacytoid dendritic cell development from common lymphoid progenitors.
The Journal of experimental medicine
Chen YL,Chen TT,Pai LM,Wesoly J,Bluyssen HA,Lee CK
12-5931 was used in Flow cytometry/Cell sorting to define a critical role for the FL/IFN-I/Flt3 axis in plasmacytoid dendritic cell differentiation from common lymphoid progenitors.
Mon Nov 18 00:00:00 EST 2013
Inhibition of Janus activated kinase-3 protects against myocardial ischemia and reperfusion injury in mice.
Experimental & molecular medicine
Oh YB,Ahn M,Lee SM,Koh HW,Lee SH,Kim SH,Park BH
12-5931 was used in Flow cytometry/Cell sorting to indicate that the inhibition of JAK3 may reduce inflammation-mediated apoptotic damage from myocardial I/R injury.
Fri May 17 00:00:00 EDT 2013
Geranylgeranyl transferase regulates CXC chemokine formation in alveolar macrophages and neutrophil recruitment in septic lung injury.
American journal of physiology. Lung cellular and molecular physiology
Hasan Z,Rahman M,Palani K,Syk I,Jeppsson B,Thorlacius H
12-5931 was used in Flow cytometry/Cell sorting to conclude that inhibition of geranylgeranyl transferase might be a potent way to attenuate acute lung injury in abdominal sepsis.
Fri Feb 15 00:00:00 EST 2013
Arrayed lentiviral barcoding for quantification analysis of hematopoietic dynamics.
Stem cells (Dayton, Ohio)
Grosselin J,Sii-Felice K,Payen E,Chretien S,Tronik-Le Roux D,Leboulch P
12-5931-82 was used in Flow Cytometry to demonstrate arrayed lentiviral barcoding as a versatile and powerful approach to deconvolute cell dynamics in vivo with applications in hematology, embryology, and cancer biology.
Tue Oct 01 00:00:00 EDT 2013
Heme oxygenase-1 expression protects the heart from acute injury caused by inducible Cre recombinase.
Laboratory investigation; a journal of technical methods and pathology
Hull TD,Bolisetty S,DeAlmeida AC,Litovsky SH,Prabhu SD,Agarwal A,George JF
12-5931 was used in Flow cytometry/Cell sorting to demonstrate that HO-1 induction prevents the depression of cardiac function imposed by Cre-induced cardiac toxicity.
Thu Aug 01 00:00:00 EDT 2013
IL-33 signaling regulates innate and adaptive immunity to Cryptococcus neoformans.
Journal of immunology (Baltimore, Md. : 1950)
Flaczyk A,Duerr CU,Shourian M,Lafferty EI,Fritz JH,Qureshi ST
12-5931 was used in Flow cytometry/Cell sorting to study how allergic patterns of lung inflammation are mediated as a host response to Cryptococcus neoformans infection.
Sun Sep 01 00:00:00 EDT 2013
Intratumoral delivery of low doses of anti-CD40 mAb combined with monophosphoryl lipid a induces local and systemic antitumor effects in immunocompetent and T cell-deficient mice.
Journal of immunotherapy (Hagerstown, Md. : 1997)
Van De Voort TJ,Felder MA,Yang RK,Sondel PM,Rakhmilevich AL
12-5931 was used in Flow cytometry/Cell sorting to assess the immunomodulatory and antitumour synergy between an agonistic anti-CD40 monoclonal antibody and monophosphoryl lipid A in mice.
Tue Jan 01 00:00:00 EST 2013
The cardioprotective protein apolipoprotein A1 promotes potent anti-tumorigenic effects.
The Journal of biological chemistry
Zamanian-Daryoush M,Lindner D,Tallant TC,Wang Z,Buffa J,Klipfell E,Parker Y,Hatala D,Parsons-Wingerter P,Rayman P,Yusufishaq MSS,Fisher EA,Smith JD,Finke J,DiDonato JA,Hazen SL
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 12-5931-82) in Flow Cytometry
Fri Jul 19 00:00:00 EDT 2013
Ectopic Runx1 expression rescues Tal-1-deficiency in the generation of primitive and definitive hematopoiesis.
PloS one
Tornack J,Seiler K,Grützkau A,Grün JR,Onodera M,Melchers F,Tsuneto M
12-5931 was used in Flow cytometry/Cell sorting to suggest that Tal-1 expression is needed to express Runx1 in the mesoderm.
Thu Aug 21 00:00:00 EDT 2014
Targeting Rac1 signaling inhibits streptococcal M1 protein-induced CXC chemokine formation, neutrophil infiltration and lung injury.
PloS one
Zhang S,Rahman M,Zhang S,Song L,Herwald H,Thorlacius H
12-5931 was used in Flow cytometry/Cell sorting to suggest that Rac1 signaling is a significant regulator of neutrophil infiltration and CXC chemokine production in the lung.
Thu Mar 06 00:00:00 EST 2014
DAP12 overexpression induces osteopenia and impaired early hematopoiesis.
PloS one
Despars G,Pandruvada SN,Anginot A,Domenget C,Jurdic P,Mazzorana M
12-5931 was used in Flow cytometry/Cell sorting to analyse the bone phenotype of mice overexpressing the human ITAM-bearing transmembrane signalling adaptor DAP12.
Thu Jan 16 00:00:00 EST 2014
The oxidase activity of vascular adhesion protein-1 (VAP-1) is essential for function.
American journal of clinical and experimental immunology
Noonan T,Lukas S,Peet GW,Pelletier J,Panzenbeck M,Hanidu A,Mazurek S,Wasti R,Rybina I,Roma T,Kronkaitis A,Shoultz A,Souza D,Jiang H,Nabozny G,Modis LK
12-5931 was used in Flow cytometry/Cell sorting to assess the relative contribution of the features of vascular adhesion protein-1 to its function.
Thu Jul 25 00:00:00 EDT 2013
Phenotypic differences in virulence and immune response in closely related clinical isolates of influenza A 2009 H1N1 pandemic viruses in mice.
PloS one
Camp JV,Chu YK,Chung DH,McAllister RC,Adcock RS,Gerlach RL,Wiemken TL,Peyrani P,Ramirez JA,Summersgill JT,Jonsson CB
12-5931 was used in Flow cytometry/Cell sorting to capture the possible genotypic and phenotypic differences of the 2009 influenza A virus H1N1 pandemic strains circulating in adult hospitalized patients.
Tue Aug 13 00:00:00 EDT 2013
Zinc sequestration by the neutrophil protein calprotectin enhances Salmonella growth in the inflamed gut.
Cell host & microbe
Liu JZ,Jellbauer S,Poe AJ,Ton V,Pesciaroli M,Kehl-Fie TE,Restrepo NA,Hosking MP,Edwards RA,Battistoni A,Pasquali P,Lane TE,Chazin WJ,Vogl T,Roth J,Skaar EP,Raffatellu M
12-5931 was used in Flow cytometry/Cell sorting to determine how Salmonella Typhimurium overcomes calprotectin-mediated zinc sequestration in the gut.
Thu Mar 15 00:00:00 EDT 2012
Up-regulation of a HOXA-PBX3 homeobox-gene signature following down-regulation of miR-181 is associated with adverse prognosis in patients with cytogenetically abnormal AML.
Blood
Li Z,Huang H,Li Y,Jiang X,Chen P,Arnovitz S,Radmacher MD,Maharry K,Elkahloun A,Yang X,He C,He M,Zhang Z,Dohner K,Neilly MB,Price C,Lussier YA,Zhang Y,Larson RA,Le Beau MM,Caligiuri MA,Bullinger L,Valk PJ,Delwel R,Lowenberg B,Liu PP,Marcucci G,Bloomfield CD,Rowley JD,Chen J
12-5931 was used in Flow cytometry/Cell sorting to study the prognostic impact of the four members of the miR-181 family in patients with CA-AML.
Thu Mar 08 00:00:00 EST 2012
Thymus-autonomous T cell development in the absence of progenitor import.
The Journal of experimental medicine
Martins VC,Ruggiero E,Schlenner SM,Madan V,Schmidt M,Fink PJ,von Kalle C,Rodewald HR
12-5931 was used in Flow cytometry/Cell sorting to characterise the previously unrecognised capacity of the thymus to sustain T cell development during bone marrow progenitor deprivation.
Mon Jul 30 00:00:00 EDT 2012
A TLR and non-TLR mediated innate response to lentiviruses restricts hepatocyte entry and can be ameliorated by pharmacological blockade.
Molecular therapy : the journal of the American Society of Gene Therapy
Agudo J,Ruzo A,Kitur K,Sachidanandam R,Blander JM,Brown BD
12-5931 was used in Flow cytometry/Cell sorting to characterise the transient innate immune reaction to lentiviral vector, and evaluate a means for its prevention during LV-mediated gene transfer.
Sat Dec 01 00:00:00 EST 2012
Enhancement of chemokine function as an immunomodulatory strategy employed by human herpesviruses.
PLoS pathogens
Viejo-Borbolla A,Martinez-Martín N,Nel HJ,Rueda P,Martín R,Blanco S,Arenzana-Seisdedos F,Thelen M,Fallon PG,Alcamí A
12-5931 was used in Flow cytometry/Cell sorting to demonstrate that secreted glycoprotein G from both HSV-1 and -2 binds chemokines, enhancing chemotaxis.
Wed Feb 01 00:00:00 EST 2012
Streptococcal M1 protein-provoked CXC chemokine formation, neutrophil recruitment and lung damage are regulated by Rho-kinase signaling.
Journal of innate immunity
Zhang S,Rahman M,Zhang S,Herwald H,Qi Z,Jeppsson B,Thorlacius H
12-5931 was used in Flow cytometry/Cell sorting to conclude that Ras-homologous-kinase-dependent neutrophil infiltration controls pulmonary tissue damage in response to streptococcal M1 protein.
Mon Oct 22 00:00:00 EDT 2012
Myeloid-derived suppressor cells from tumor-bearing mice impair TGF-β-induced differentiation of CD4+CD25+FoxP3+ Tregs from CD4+CD25-FoxP3- T cells.
Journal of leukocyte biology
Centuori SM,Trad M,LaCasse CJ,Alizadeh D,Larmonier CB,Hanke NT,Kartchner J,Janikashvili N,Bonnotte B,Larmonier N,Katsanis E
12-5931 was used in Flow cytometry/Cell sorting to indicate that gr-MDSCs from TB hosts have the unanticipated ability to restrict immunosuppressive Tregs.
Thu Nov 01 00:00:00 EDT 2012
Annexin A1 regulates neutrophil clearance by macrophages in the mouse bone marrow.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Dalli J,Jones CP,Cavalcanti DM,Farsky SH,Perretti M,Rankin SM
12-5931 was used in Flow cytometry/Cell sorting to identify a role of the anti-inflammatory molecule annexin A1 in the regulation of CXCR4(hi) neutrophil migration to bone marrow.
Sun Jan 01 00:00:00 EST 2012
Differential gene expression in mice infected with distinct Toxoplasma strains.
Infection and immunity
Hill RD,Gouffon JS,Saxton AM,Su C
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 12-5931-82) in Flow Cytometry
Thu Mar 01 00:00:00 EST 2012
Streptococcal m1 protein triggers farnesyltransferase-dependent formation of CXC chemokines in alveolar macrophages and neutrophil infiltration of the lungs.
Infection and immunity
Zhang S,Rahman M,Zhang S,Jeppsson B,Herwald H,Thorlacius H
12-5931 was used in Flow cytometry/Cell sorting to suggest that farnesyltransferase is a potent regulator of CXC chemokine formation in alveolar macrophages.
Thu Nov 01 00:00:00 EDT 2012
A model of GAG/MIP-2/CXCR2 interfaces and its functional effects.
Biochemistry
Rajasekaran D,Keeler C,Syed MA,Jones MC,Harrison JK,Wu D,Bhandari V,Hodsdon ME,Lolis EJ
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 12-5931-82) in Flow Cytometry
Tue Jul 17 00:00:00 EDT 2012
Evaluation of in vitro macrophage differentiation during space flight.
Advances in space research : the official journal of the Committee on Space Research (COSPAR)
Ortega MT,Lu N,Chapes SK
12-5931 was used in Flow cytometry/Cell sorting to confirm that space flight can impact the in vitro development of macrophages from mouse bone marrow cells.
Tue May 15 00:00:00 EDT 2012
Virotherapy of canine tumors with oncolytic vaccinia virus GLV-1h109 expressing an anti-VEGF single-chain antibody.
PloS one
Patil SS,Gentschev I,Adelfinger M,Donat U,Hess M,Weibel S,Nolte I,Frentzen A,Szalay AA
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 12-5931-82) in Flow Cytometry
Thu Mar 28 00:00:00 EDT 2013
In vivo inhibition of c-MYC in myeloid cells impairs tumor-associated macrophage maturation and pro-tumoral activities.
PloS one
Pello OM,Chèvre R,Laoui D,De Juan A,Lolo F,Andrés-Manzano MJ,Serrano M,Van Ginderachter JA,Andrés V
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 12-5931-82) in Flow Cytometry
Mon Feb 25 00:00:00 EST 2013
Prevention and mitigation of acute radiation syndrome in mice by synthetic lipopeptide agonists of Toll-like receptor 2 (TLR2).
PloS one
Shakhov AN,Singh VK,Bone F,Cheney A,Kononov Y,Krasnov P,Bratanova-Toshkova TK,Shakhova VV,Young J,Weil MM,Panoskaltsis-Mortari A,Orschell CM,Baker PS,Gudkov A,Feinstein E
12-5931 was used in Flow cytometry/Cell sorting to illustrate the strong potential of LP-based TLR2 agonists for anti-radiation prophylaxis and therapy in defence and medical scenarios.
Tue Aug 28 00:00:00 EDT 2012
Genetic deletion of chemokine receptor Ccr6 decreases atherogenesis in ApoE-deficient mice.
Circulation research
Wan W,Lim JK,Lionakis MS,Rivollier A,McDermott DH,Kelsall BL,Farber JM,Murphy PM
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 12-5931-82) in Flow Cytometry
Fri Aug 05 00:00:00 EDT 2011
Expression of the G-CSF receptor in monocytic cells is sufficient to mediate hematopoietic progenitor mobilization by G-CSF in mice.
The Journal of experimental medicine
Christopher MJ,Rao M,Liu F,Woloszynek JR,Link DC
12-5931 was used in Flow cytometry/Cell sorting to suggest a model in which G-CSFR signals in bone marrow monocytic cells inhibit the production of trophic factors required for osteoblast lineage cell maintenance.
Mon Feb 14 00:00:00 EST 2011
Anti-tumour synergy of cytotoxic chemotherapy and anti-CD40 plus CpG-ODN immunotherapy through repolarization of tumour-associated macrophages.
Immunology
Buhtoiarov IN,Sondel PM,Wigginton JM,Buhtoiarova TN,Yanke EM,Mahvi DA,Rakhmilevich AL
12-5931 was used in Flow cytometry/Cell sorting to show that chemotherapy and anti-CD40 + CpG-ODN IT synergise in the induction of anti-tumour effects which are associated with the phenotypic repolarisation of tumour-associated Mφ.
Tue Feb 01 00:00:00 EST 2011
Simvastatin antagonizes CD40L secretion, CXC chemokine formation, and pulmonary infiltration of neutrophils in abdominal sepsis.
Journal of leukocyte biology
Zhang S,Rahman M,Zhang S,Qi Z,Thorlacius H
12-5931 was used in Flow cytometry/Cell sorting to investigate the beneficial actions exerted by statins, such as simvastatin, in sepsis.
Sun May 01 00:00:00 EDT 2011
Simvastatin regulates CXC chemokine formation in streptococcal M1 protein-induced neutrophil infiltration in the lung.
American journal of physiology. Lung cellular and molecular physiology
Zhang S,Rahman M,Zhang S,Qi Z,Herwald H,Thorlacius H
12-5931 was used in Flow cytometry/Cell sorting to indicate that simvastatin is a powerful inhibitor of neutrophil infiltration in acute lung damage triggered by streptococcal M1 protein.
Wed Jun 01 00:00:00 EDT 2011
Hapten application to the skin induces an inflammatory program directing hapten-primed effector CD8 T cell interaction with hapten-presenting endothelial cells.
Journal of immunology (Baltimore, Md. : 1950)
Kish DD,Volokh N,Baldwin WM,Fairchild RL
12-5931 was used in Flow cytometry/Cell sorting to identify mechanisms mediating initial CD8+ T cell localisation and activation in hapten challenge sites of the skin.
Tue Feb 15 00:00:00 EST 2011
Infection-induced myelopoiesis during intracellular bacterial infection is critically dependent upon IFN-γ signaling.
Journal of immunology (Baltimore, Md. : 1950)
MacNamara KC,Oduro K,Martin O,Jones DD,McLaughlin M,Choi K,Borjesson DL,Winslow GM
12-5931 was used in Flow cytometry/Cell sorting to provide evidence that IFN-γ acts to control infection by directly promoting myeloid cell differentiation.
Sat Jan 15 00:00:00 EST 2011
Enhanced neutrophil longevity and recruitment contribute to the severity of oviduct pathology during Chlamydia muridarum infection.
Infection and immunity
Frazer LC,O'Connell CM,Andrews CW,Zurenski MA,Darville T
12-5931 was used in Flow cytometry/Cell sorting to investigate the role of neutrophils in chlamydia-induced pathology.
Sat Oct 01 00:00:00 EDT 2011
Interleukin-17 contributes to generation of Th1 immunity and neutrophil recruitment during Chlamydia muridarum genital tract infection but is not required for macrophage influx or normal resolution of infection.
Infection and immunity
Scurlock AM,Frazer LC,Andrews CW,O'Connell CM,Foote IP,Bailey SL,Chandra-Kuntal K,Kolls JK,Darville T
12-5931 was used in Flow cytometry/Cell sorting to investigate the role of IL-17 during C. muridarum genital tract infection.
Tue Mar 01 00:00:00 EST 2011
Unraveling molecular signatures of immunostimulatory adjuvants in the female genital tract through systems biology.
PloS one
Lindqvist M,Nookaew I,Brinkenberg I,Samuelson E,Thörn K,Nielsen J,Harandi AM
12-5931 was used in Flow cytometry/Cell sorting to identify molecular signatures that can be used as biomarkers for mucosal adjuvant potency.
Fri Dec 09 00:00:00 EST 2011
Role of myeloid-derived suppressor cells in amelioration of experimental autoimmune hepatitis following activation of TRPV1 receptors by cannabidiol.
PloS one
Hegde VL,Nagarkatti PS,Nagarkatti M
12-5931 was used in Flow cytometry/Cell sorting to ameliorate experimental autoimmune hepatitis following activation of TRPV1 receptors in myeloid-derived suppressor cells by cannabidiol.
Fri Apr 01 00:00:00 EDT 2011
Type 1 T helper cells induce the accumulation of myeloid-derived suppressor cells in the inflamed Tgfb1 knockout mouse liver.
Hepatology (Baltimore, Md.)
Cripps JG,Wang J,Maria A,Blumenthal I,Gorham JD
12-5931 was used in Flow cytometry/Cell sorting to demonstrate that Th1 liver inflammation mobilizes a myeloid-derived suppressor cell response that can inhibit T cell proliferation.
Fri Oct 01 00:00:00 EDT 2010
Flotillin microdomains interact with the cortical cytoskeleton to control uropod formation and neutrophil recruitment.
The Journal of cell biology
Ludwig A,Otto GP,Riento K,Hams E,Fallon PG,Nichols BJ
12-5931 was used in Flow cytometry/Cell sorting to study the role of flotillin microdomain-cortical cytoskeleton associations in neutrophil migration, urpopod formation, and regulation of myosin IIa.
Mon Nov 15 00:00:00 EST 2010
Cannabinoid receptor activation leads to massive mobilization of myeloid-derived suppressor cells with potent immunosuppressive properties.
European journal of immunology
Hegde VL,Nagarkatti M,Nagarkatti PS
12-5931 was used in Flow cytometry/Cell sorting to demonstrate that cannabinoid receptor signalling may play a crucial role in immune regulation via the induction of myeloid-derived suppressor cells.
Wed Dec 01 00:00:00 EST 2010
Local mesenchymal stem/progenitor cells are a preferential target for initiation of adult soft tissue sarcomas associated with p53 and Rb deficiency.
The American journal of pathology
Choi J,Curtis SJ,Roy DM,Flesken-Nikitin A,Nikitin AY
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 12-5931-82) in Flow Cytometry
Mon Nov 01 00:00:00 EDT 2010
Tissue inhibitor of metalloproteinases 3 regulates resolution of inflammation following acute lung injury.
The American journal of pathology
Gill SE,Huizar I,Bench EM,Sussman SW,Wang Y,Khokha R,Parks WC
12-5931 was used in Immunocytochemistry to demonstrate that TIMP3 regulates neutrophil influx in the lung following injury through metalloproteinase inhibition, promoting resolution of lung inflammation.
Fri Jan 01 00:00:00 EST 2010
The presence of professional phagocytes dictates the number of host cells targeted for Yop translocation during infection.
Cellular microbiology
Durand EA,Maldonado-Arocho FJ,Castillo C,Walsh RL,Mecsas J
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 12-5931-82) in Flow Cytometry
Sun Aug 01 00:00:00 EDT 2010
Regulation of granulocyte and macrophage populations of murine bone marrow cells by G-CSF and CD137 protein.
PloS one
Jiang D,Schwarz H
12-5931 was used in Flow cytometry/Cell sorting to confirm the role of CD137 ligand signalling in regulating myelopoiesis, and demonstrate that this growth promoting influence is restricted to the monocytic lineage.
Mon Dec 13 00:00:00 EST 2010
Hierarchical maintenance of MLL myeloid leukemia stem cells employs a transcriptional program shared with embryonic rather than adult stem cells.
Cell stem cell
Somervaille TC,Matheny CJ,Spencer GJ,Iwasaki M,Rinn JL,Witten DM,Chang HY,Shurtleff SA,Downing JR,Cleary ML
12-5931 was used in Flow cytometry/Cell sorting to link the frequency of aberrantly self-renewing progenitor-like cancer stem cells (CSCs) to prognosis in human cancer, namely myeloid leukemia.
Fri Feb 06 00:00:00 EST 2009
STAT6-mediated suppression of erythropoiesis in an experimental model of malarial anemia.
Haematologica
Thawani N,Tam M,Stevenson MM
12-5931 was used in Flow cytometry/Cell sorting to investigate the role of STAT6-mediated responses in erythropoietic suppression during acute malaria infection in mice.
Sun Feb 01 00:00:00 EST 2009
The cellular niche of Listeria monocytogenes infection changes rapidly in the spleen.
European journal of immunology
Aoshi T,Carrero JA,Konjufca V,Koide Y,Unanue ER,Miller MJ
12-5931 was used in Immunohistochemistry to illustrate the changeable nature of the cellular niche of Listeria monocytogenes.
Sun Feb 01 00:00:00 EST 2009
Effector mechanisms of interleukin-17 in collagen-induced arthritis in the absence of interferon-gamma and counteraction by interferon-gamma.
Arthritis research & therapy
Kelchtermans H,Schurgers E,Geboes L,Mitera T,Van Damme J,Van Snick J,Uyttenhove C,Matthys P
12-5931 was used in Flow cytometry/Cell sorting to analyse the mechanisms of action of IL-17 in arthritis and the effect of IFN-gamma on those mechanisms.
Wed Dec 16 00:00:00 EST 2009
Naive mouse macrophages become activated following recognition of L5178Y lymphoma cells via concurrent ligation of CD40, NKG2D, and CD18 molecules.
Journal of immunology (Baltimore, Md. : 1950)
Buhtoiarov IN,Rakhmilevich AL,Lanier LL,Ranheim EA,Sondel PM
12-5931 was used in Flow cytometry/Cell sorting to investigate the mechanisms of tumour-macrophage interactions leading to macrophage activation, showing that activation follows ligation of CD40, NKG2D, and CD18 molecules.
Sun Feb 15 00:00:00 EST 2009
TLR2 and its co-receptors determine responses of macrophages and dendritic cells to lipoproteins of Mycobacterium tuberculosis.
Cellular immunology
Drage MG,Pecora ND,Hise AG,Febbraio M,Silverstein RL,Golenbock DT,Boom WH,Harding CV
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 12-5931-82) in Flow Cytometry
Fri Jun 12 00:00:00 EDT 2009
Shifts in bone marrow cell phenotypes caused by spaceflight.
Journal of applied physiology (Bethesda, Md. : 1985)
Ortega MT,Pecaut MJ,Gridley DS,Stodieck LS,Ferguson V,Chapes SK
12-5931 was used in Flow cytometry/Cell sorting to determine how spaceflight affects differentiation of cells in the granulocytic lineage in mice.
Sun Feb 01 00:00:00 EST 2009
Critical role of the interleukin-17/interleukin-17 receptor axis in regulating host susceptibility to respiratory infection with Chlamydia species.
Infection and immunity
Zhou X,Chen Q,Moore J,Kolls JK,Halperin S,Wang J
12-5931 was used in Flow cytometry/Cell sorting to demonstrate that Chlamydia stimulates IL-17/IL-17R-associated responses in Chlamydia-resistant and Chlamydia-susceptible mice.
Sun Nov 01 00:00:00 EDT 2009
MGL2 Dermal dendritic cells are sufficient to initiate contact hypersensitivity in vivo.
PloS one
Kumamoto Y,Denda-Nagai K,Aida S,Higashi N,Irimura T
12-5931 was used in Flow cytometry/Cell sorting to investigate the functional and phenotypic differences between Langerhans and dermal dendritic cells, showing that macrophage galactose-type C-type lectin (MGL) 2 is only expression in dermal dendritic cells, which are sufficient to initiate contact hypersensitivity in vivo.
Thu Aug 06 00:00:00 EDT 2009
Tumor growth decreases NK and B cells as well as common lymphoid progenitor.
PloS one
Richards J,McNally B,Fang X,Caligiuri MA,Zheng P,Liu Y
12-5931 was used in Flow cytometry/Cell sorting to analyse the effects of tumour growth on lymphopoiesis in mice.
Thu Sep 11 00:00:00 EDT 2008
Presenilins regulate alphabeta T cell development by modulating TCR signaling.
The Journal of experimental medicine
Laky K,Fowlkes BJ
12-5931 was used in Flow cytometry/Cell sorting to suggest a model in which PS-dependent Notch signalling influences positive selection and the development of alphabeta T cells by modifying TCR signal transduction.
Mon Sep 03 00:00:00 EDT 2007
Dendritic cell expression of the transcription factor T-bet regulates mast cell progenitor homing to mucosal tissue.
The Journal of experimental medicine
Alcaide P,Jones TG,Lord GM,Glimcher LH,Hallgren J,Arinobu Y,Akashi K,Paterson AM,Gurish MA,Luscinskas FW
12-5931 was used in Flow cytometry/Cell sorting to examine whether T-bet influences homing in mast cell progenitors to peripheral tissues.
Mon Feb 19 00:00:00 EST 2007
Listeria monocytogenes promotes tumor growth via tumor cell toll-like receptor 2 signaling.
Cancer research
Huang B,Zhao J,Shen S,Li H,He KL,Shen GX,Mayer L,Unkeless J,Li D,Yuan Y,Zhang GM,Xiong H,Feng ZH
Tue May 01 00:00:00 EDT 2007
Immature hematopoietic cells display selective requirements for adhesion- and degranulation-promoting adaptor protein in development and homeostatsis.
European journal of immunology
Dluzniewska J,Zou L,Harmon IR,Ellingson MT,Peterson EJ
12-5931-82 was used in Flow Cytometry to highlight the dynamic regulation of ADAP during T cell maturation and document expression patterns that suggest a possible role for ADAP in development of non-T hematopoietic lineages.
Thu Nov 01 00:00:00 EDT 2007
Mouse neutrophilic granulocytes express mRNA encoding the macrophage colony-stimulating factor receptor (CSF-1R) as well as many other macrophage-specific transcripts and can transdifferentiate into macrophages in vitro in response to CSF-1.
Journal of leukocyte biology
Sasmono RT,Ehrnsperger A,Cronau SL,Ravasi T,Kandane R,Hickey MJ,Cook AD,Himes SR,Hamilton JA,Hume DA
Sun Jul 01 00:00:00 EDT 2007
Mouse neutrophilic granulocytes express mRNA encoding the macrophage colony-stimulating factor receptor (CSF-1R) as well as many other macrophage-specific transcripts and can transdifferentiate into macrophages in vitro in response to CSF-1.
Journal of leukocyte biology
Sasmono RT,Ehrnsperger A,Cronau SL,Ravasi T,Kandane R,Hickey MJ,Cook AD,Himes SR,Hamilton JA,Hume DA
Sun Jul 01 00:00:00 EDT 2007
The mouse mammary carcinoma 4T1: characterization of the cellular landscape of primary tumours and metastatic tumour foci.
International journal of experimental pathology
DuPré SA,Redelman D,Hunter KW
Published figure using Ly-6G/Ly-6C monoclonal antibody (Product # 12-5931-82) in Flow Cytometry
Mon Oct 01 00:00:00 EDT 2007
Enhanced engraftment of hematopoietic stem/progenitor cells by the transient inhibition of an adaptor protein, Lnk.
Blood
Takizawa H,Kubo-Akashi C,Nobuhisa I,Kwon SM,Iseki M,Taga T,Takatsu K,Takaki S
12-5931 was used in Flow cytometry/Cell sorting to investigate the potential of Lnk for augmented engraftment of HSCs.
Sat Apr 01 00:00:00 EST 2006
Proper levels of c-Myb are discretely defined at distinct steps of hematopoietic cell development.
Blood
Sakamoto H,Dai G,Tsujino K,Hashimoto K,Huang X,Fujimoto T,Mucenski M,Frampton J,Ogawa M
12-5931 was used in Flow cytometry/Cell sorting to investigate the functional role of c-Myb in hematopoietic cell development from endothelial cells, showing that proper levels of c-Myb are discretely defined at distinct steps of development.
Tue Aug 01 00:00:00 EDT 2006
Hemorrhagic shock-activated neutrophils augment TLR4 signaling-induced TLR2 upregulation in alveolar macrophages: role in hemorrhage-primed lung inflammation.
American journal of physiology. Lung cellular and molecular physiology
Fan J,Li Y,Vodovotz Y,Billiar TR,Wilson MA
Sat Apr 01 00:00:00 EST 2006
A role for IFNgamma in differential superantigen stimulation of conventional versus plasmacytoid DCs.
Cellular immunology
Muralimohan G,Vella AT
12-5931 was used in Flow cytometry/Cell sorting to demonstrate that staphylococcal enterotoxin A influences pDC activation, recruitment and chemokine induction through the action of IFNγ.
Sat Jul 01 00:00:00 EDT 2006
Arthritis suppressor genes TIA-1 and TTP dampen the expression of tumor necrosis factor alpha, cyclooxygenase 2, and inflammatory arthritis.
Proceedings of the National Academy of Sciences of the United States of America
Phillips K,Kedersha N,Shen L,Blackshear PJ,Anderson P
Tue Feb 17 00:00:00 EST 2004
Prevention of lipopolysaccharide-induced microangiopathy by gp49B1: evidence for an important role for gp49B1 expression on neutrophils.
The Journal of experimental medicine
Zhou JS,Friend DS,Feldweg AM,Daheshia M,Li L,Austen KF,Katz HR
12-5931 was used in Flow cytometry/Cell sorting to investigate the role of gp49B1 in neutrophils, showing that gp49B1 expression on neutrophils suppresses LPS-induced microangiopathy.
Mon Oct 20 00:00:00 EDT 2003
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-RB6-8C5-RE-AV-20170920122035.jpg?time=20220826?time=20220826 "Ly-6G/Ly-6C Antibody (12-5931-82)")
