GeneArt Gene Synthesis

I have questions before ordering

NEW Now get your genes up to 9 days sooner*

In addition to the faster service, we now offer the option of downloading your GeneArt™ project quality assurance data from Thermo Fisher Cloud, in lieu of receiving the data on CD with your shipment.

Order standard gene synthesis online

Standard gene synthesis uses our highly automated process with turnaround times starting at just 9 business days, depending on sequence length (quicker options available). It is appropriate for most constructs with uncomplicated secondary structure and without direct/indirect repeats or long polypurine/polypyrimidine runs. Like all GeneArt Gene Synthesis services, standard gene synthesis includes the following components to help assure that your construct meets all of your research, quality, and documentation requirements.

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If you are new to GeneArt Gene Synthesis, check out our online ordering quick start guide and our gene synthesis tutorials.

*1,201-7,000 bp 2 days faster, 7,001-9,000 bp 9 days faster
**Valid for standard gene synthesis (non-complex, GC content 10–80%). For complex sequences, add 5 business days.
***Subject to sequence assessment. Order must be placed by 3:00 p.m. CET.
****We will respond to your email in a 24hr time frame. Please use our Sequence Submission Form to transfer your sequence.

Please note: Rarely, requested sequences are found to be toxic and/or genetically unstable. These production times are only valid for nontoxic sequences that are genetically stable in E. coli.

View the GeneArt Gene Synthesis Conditions of Sale (PDF)

• Flexible, custom process: Obtain the exact sequence you need in the vector of your choice—including challenging, complex constructs, and custom vectors.
• Maximized protein yield: Optional sequence processing with GeneOptimizer software generates sequence variants with enhanced mRNA stability and translational efficiency.
• Rapid synthesis and assembly: Standard turnaround times start at 10 business days (accelerated options available).
• Economical: The cost of the GeneArt Gene Synthesis service rivals costs that would be incurred to purchase the oligonucleotides and molecular biology reagents required for gene synthesis, and outsourcing your gene synthesis and cloning means you can focus on your research.
• Excellent accuracy: All custom synthesized genes are sequenced as part of our ISO 9001:2008–certified quality management system; we only ship constructs with exact sequence agreement.
• Multiple options: We can synthesize ready-to-clone linear fragments, synthetic genes in circular plasmids, complete vectors, and more. Compare all gene synthesis options 
• GeneArt™ It: Save time and labor by outsourcing your gene synthesis and cloning so you can focus on your research.

Whether you have limited cloning experience or simply want to save time, the GeneArt Gene Synthesis service helps you move your ideas from the planning stage to the laboratory more quickly. Benefit from our experience in successfully producing over 180,000 constructs for customers as diverse as large pharmaceutical companies, biotechnology start-ups, and basic research institutions. The comparison shown below highlights the time and effort saved compared to traditional cloning.

The GeneOptimizer process has been shown to help deliver large increases in protein yield via a combination of factors that stabilize mRNA and maximize translation efficacy (see figure). Efficacy has been proven in a large comparative gene expression study (Multiparameter RNA and Codon Optimization: A Standardized Tool to Assess and Enhance Autologous Mammalian Gene Expression Fath et al., 2011 PLoS ONE).

Comparative expression analysis of wild type vs. an optimized human gene. Western blot analysis using α-His antibody. Expression levels of 2 independent transfections per wild type and optimized construct are displayed, showing a 3-fold difference in expression in this particular analysis. Standardization is based on endogenous protein.