Ion Chromatography Mass Spectrometry (IC-MS)

Increase the power of IC with MS detection

Utilize mass detection when you need to ensure analytical confidence and dramatically improve the detection capability of your Thermo Scientific Dionex Integrion or ICS-6000 HPIC system. Ion chromatography with mass spectrometry (IC-MS) maximizes the ability to detect and quantify unexpected co-elutions of components and to confirm trace components.

Browse our complete portfolio below, or let one of our experts help you tailor a selection specific to your application and workflow needs.

Contact us

IC-MS systems

Coupling MS with your IC can give you more information from every sample:

  • Higher sensitivity
  • Accurate quantitation
  • Peak confirmation and evaluation of chromatographic peak purity
  • Increased efficiency
Single Quadrupole IC-MS

Easily master MS for your IC applications.

Triple Quadrupole IC-MS

Need sensitive, fast, and robust quantitation of a variety of molecule types? For complex samples, the high sensitivity and selectivity of MS/MS using selected reaction monitoring (SRM) provides the most precise and accurate quantitation using IC-MS.

Orbitrap IC-MS

Thermo Scientific Orbitrap mass spectrometers generate high-resolution and accurate-mass data, thereby enhancing sensitivity in trace analyte detection, characterization, and quantitation. That's why they are used in research applications—in particular, life science applications such as metabolomics.

Get a superior combination of scan speed, high resolution, mass accuracy, spectral quality and sensitivity for untargeted or targeted screening and a broad range of qualitative and quantitative applications in environmental, food safety and metabolomics.

Use this system for IC-MS in life science metabolomics research to analyze the most challenging low-abundance, high-complexity samples, to identify more compounds faster, quantify more accurately, and to elucidate structures more thoroughly.

Orbitrap Exploris Mass Spectrometers

Thermo Scientific Orbitrap Exploris mass spectrometry produces quantitative high-resolution, accurate-mass (HRAM) liquid chromatography mass spectrometry (LC-MS) with high quantitative accuracy and precision for your laboratory. You can meet your exact analytical requirements and translate your results more rapidly and simply than ever before with Orbitrap Exploris mass spectrometry.

Single Quadrupole IC-MS

Easily master MS for your IC applications.

Triple Quadrupole IC-MS

Need sensitive, fast, and robust quantitation of a variety of molecule types? For complex samples, the high sensitivity and selectivity of MS/MS using selected reaction monitoring (SRM) provides the most precise and accurate quantitation using IC-MS.

Orbitrap IC-MS

Thermo Scientific Orbitrap mass spectrometers generate high-resolution and accurate-mass data, thereby enhancing sensitivity in trace analyte detection, characterization, and quantitation. That's why they are used in research applications—in particular, life science applications such as metabolomics.

Get a superior combination of scan speed, high resolution, mass accuracy, spectral quality and sensitivity for untargeted or targeted screening and a broad range of qualitative and quantitative applications in environmental, food safety and metabolomics.

Use this system for IC-MS in life science metabolomics research to analyze the most challenging low-abundance, high-complexity samples, to identify more compounds faster, quantify more accurately, and to elucidate structures more thoroughly.

Orbitrap Exploris Mass Spectrometers

Thermo Scientific Orbitrap Exploris mass spectrometry produces quantitative high-resolution, accurate-mass (HRAM) liquid chromatography mass spectrometry (LC-MS) with high quantitative accuracy and precision for your laboratory. You can meet your exact analytical requirements and translate your results more rapidly and simply than ever before with Orbitrap Exploris mass spectrometry.

Which mass spectrometer do I choose?

Mass SpectrometerAnalyzerMode of OperationMSMS/MSSensitivityPeak ConfirmationStructural Elucidation
ISQ EC MSQuadrupoleSingle ion monitoring (SIM)
TSQ Altis MSTriple QuadrupoleSelected reaction monitoring (SRM)
TSQ Quantis MSTriple QuadrupoleSelected reaction monitoring (SRM)
Q Exactive MSOrbitrap mass analyzerHigh Resolution Accurate Mass (HRAM)
Orbitrap Fusion MSOrbitrap mass analyzerHigh Resolution Accurate Mass (HRAM)
Orbitrap Exploris MSOrbitrap mass analyzerHigh Resolution Accurate Mass (HRAM)
  = Not applicable  = Poor  = Good  = Better  = Best

IC-MS basics and benefits videos



Resources