Table 10.2 Rhodamine 110–based bis-peptide substrates.

Cat. No. Proteinase Substrate * Enzymes †
R22122(Asp)2-R110caspase-3 and other apoptosis-related proteases ref
R6506(CBZ-Ala-Ala-Ala-Ala)2-R110elastase ref
R33752(CBZ-Ala-Ala-Asp)2-R110granzyme B
R6508(CBZ-Ala-Arg)2-R110trypsin ref
R6501(CBZ-Arg)2-R110trypsin ref
R22120(CBZ-Asp-Glu-Val-Asp)2-R110caspase-3, -6, -7, -8, -10 ref
R6505(CBZ-Ile-Pro-Arg)2-R110trypsin ref
R22125
R22126
(CBZ-Ile-Glu-Thr-Asp)2-R110caspase-8
R33753(CBZ-Leu-Glu-Glu-Asp)2-R110caspase-13
R6502(CBZ-Phe-Arg)2-R110plasmin, cathepsin L ref
R33750(CBZ-Tyr-Val-Ala-Asp)2-R110caspase-1, -4
R33755(CBZ-Val-Asp-Val-Ala-Asp)2-R110caspase-2
R33754(CBZ-Val-Glu-Ile-Asp)2-R110caspase-6
R22124(p-tosyl-Gly-Pro-Arg)2-R110thrombin ref
* CBZ = benzyloxycarbonyl; R110 = rhodamine 110; SC = succinoyl; p-tosyl = p-toluenesulfonyl. † Caspase substrates can often be cleaved by multiple enzymes. The caspase most often associated with the given peptide sequence is listed first.

仅供科研使用,不可用于诊断目的。